Effects of acute carbohydrate supplementation on endurance performance: A meta-analysis

Sports Medicine

Volumn 41, Issue 9, 2011, Pages 773-792

  Vandenbogaerde, Tom J ^a   Hopkins, Will G ^a  

^a AUCKLAND UNIVERSITY OF TECHNOLOGY   (New Zealand)

Author keywords

Carbohydrates; Endurance training; Exercise performance; Sports medicine

Indexed keywords

FRUCTOSE;

ATHLETIC PERFORMANCE; CARBOHYDRATE DIET; DIET SUPPLEMENTATION; DRUG EFFECT; ENDURANCE; FATIGUE; FEMALE; HUMAN; MALE; META ANALYSIS; OXYGEN CONSUMPTION; PUBLISHING; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW;

ATHLETIC PERFORMANCE; DIETARY CARBOHYDRATES; DIETARY SUPPLEMENTS; FATIGUE; FEMALE; FRUCTOSE; HUMANS; MALE; OXYGEN CONSUMPTION; PHYSICAL ENDURANCE; PUBLICATION BIAS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 80051710328     PISSN: 01121642     EISSN: 11792035     Source Type: Journal    
DOI: 10.2165/11590520-000000000-00000     Document Type: Review

References (114)

1. Bosch AN. Carbohydrate ingestion during exercise: an aid to endurance performance [review]. Int Sportmed J 2007; 8: 24-30.
2. Jeukendrup AE. Carbohydrate feeding during exercise. Eur J Sport Sci 2008; 8: 77-86.
3. Foster C, Costill DL, FinkWJ. Effects of preexercise feedings on endurance performance. Med Sci Sports 1979; 11: 1-5. (Pubitemid 9251606)
4. Ivy JL, Costill DL, Fink WJ, et al. Influence of caffeine and carbohydrate feedings on endurance performance. Med Sci Sports 1979; 11: 6-11. (Pubitemid 9251607)
5. Felig P, Cherif A, Minagawa A, et al. Hypoglycemia during prolonged exercise in normal men. N Engl J Med 1982; 306: 895-900. (Pubitemid 12148550)
6. Coyle EF, Hagberg JM, Hurley BF, et al. Carbohydrate feeding during prolonged strenuous exercise can delay fatigue. J Appl Physiol 1983; 55: 230-5. (Pubitemid 13075346)
7. Bjorkman O. Influence of glucose and fructose ingestion on the capacity for long-term exercise in well-trained men. Clin Physiol 1984; 4: 483-94. (Pubitemid 15175900)
8. Decombaz J, Sartori D, Arnaud MJ, et al. Oxidation and metabolic effects of fructose or glucose ingested before exercise. Int J Sports Med 1985; 6: 282-6. (Pubitemid 16244797)
9. Coyle EF, Coggan AR, Hemmert MK, et al. Muscle glycogen utilization during prolonged strenuous exercise when fed carbohydrate. J Appl Physiol 1986; 61: 165-72. (Pubitemid 16055673)
10. Gleeson M, Maughan RJ, Greenhaff PL. Comparison of the effects of pre-exercise feeding of glucose, glycerol and placebo on endurance and fuel homeostasis in man. Eur J Appl Physiol 1986; 55: 645-53. (Pubitemid 17034997)
11. Flynn MG, Costill DL, Hawley JA, et al. Influence of selected carbohydrate drinks on cycling performance and glycogen use. Med Sci Sports Exerc 1987; 19: 37-40. (Pubitemid 17026326)
12. Hargreaves M, Costill DL, Fink WJ, et al. Effect of preexercise carbohydrate feedings on endurance cycling performance. Med Sci Sports Exerc 1987; 19: 33-6. (Pubitemid 17026325)
13. Murray R, Eddy DE, Murray TW, et al. The effect of fluid and carbohydrate feedings during intermittent cycling exercise. Med Sci Sports Exerc 1987; 19: 597-604. (Pubitemid 18010438)
14. Neufer PD, Costill DL, Flynn MG, et al. Improvements in exercise performance: effects of carbohydrate feedings and diet. J Appl Physiol 1987; 62: 983-8. (Pubitemid 17073892)
15. Sasaki H, Maeda J, Usui S, et al. Effect of sucrose and caffeine ingestion on performance of prolonged strenuous running. Int J Sports Med 1987; 8: 261-5. (Pubitemid 17127923)
16. Davis JM, Burgess WA, Slentz CA, et al. Effects of ingesting 6% and 12% glucose/electrolyte beverages during prolonged intermittent cycling in the heat. Eur J Appl Physiol 1988; 57: 563-9.
17. Davis JM, Lamb DR, Pate RR, et al. Carbohydrateelectrolyte drinks: effects on endurance cycling in the heat. Am J Clin Nutr 1988; 48: 1023-30.
18. Mitchell JB, Costill DL, Houmard JA, et al. Effects of carbohydrate ingestion on gastric emptying and exercise performance. Med Sci Sports Exerc 1988; 20: 110-5.
19. Coggan AR, Coyle EF. Metabolism and performance following carbohydrate ingestion late in exercise. Med Sci Sports Exerc 1989; 21: 59-65. (Pubitemid 19062849)
20. Maughan RJ, Fenn CE, Leiper JB. Effects of fluid, electrolyte and substrate ingestion on endurance capacity. Eur J Appl Physiol 1989; 58: 481-6. (Pubitemid 19089959)
21. Mitchell JB, Costill DL, Houmard JA, et al. Influence of carbohydrate dosage on exercise performance and glycogen metabolism. J Appl Physiol 1989; 67: 1843-9. (Pubitemid 20039391)
22. Murray R, Seifert JG, Eddy DE, et al. Carbohydrate feeding and exercise: effect of beverage carbohydrate content. Eur J Appl Physiol 1989; 59: 152-8. (Pubitemid 19214882)
23. Murray R, Paul GL, Seifert JG, et al. The effects of glucose, fructose, and sucrose ingestion during exercise. Med Sci Sports Exerc 1989; 21: 275-82. (Pubitemid 19152070)
24. Sherman WM, Brodowicz G, Wright DA, et al. Effects of 4 h preexercise carbohydrate feedings on cycling performance. Med Sci Sports Exerc 1989; 21: 598-604. (Pubitemid 19260168)
25. Powers SK, Lawler J, Dodd S, et al. Fluid replacement drinks during high intensity exercise effects on minimizing exercise-induced disturbances in homeostasis. Eur J Appl Physiol 1990; 60: 54-60. (Pubitemid 20056262)
26. Williams C, Nute MG, Broadbank L, et al. Influence of fluid intake on endurance running performance. Eur J Appl Physiol 1990; 60: 112-9.
27. Murray R, Paul GL, Seifert JG, et al. Responses to varying rates of carbohydrate ingestion during exercise. Med Sci Sports Exerc 1991; 23: 713-8.
28. Sherman WM, Peden MC, Wright DA. Carbohydrate feedings 1 h before exercise improves cycling performance. Am J Clin Nutr 1991; 54: 866-70. (Pubitemid 21899008)
29. Thomas DE, Brotherhood JR, Brand JC. Carbohydrate feeding before exercise: effect of glycemic index. Int J Sports Med 1991; 12: 180-6.
30. Wright DA, Sherman WM, Dernbach AR. Carbohydrate feedings before, during, or in combination improve cycling endurance performance. J Appl Physiol 1991; 71: 1082-8.
31. Millard-Stafford ML, Sparling PB, Rosskopf LB, et al. Carbohydrate-electrolyte replacement improves distance running performance in the heat. Med Sci Sports Exerc 1992; 24: 934-40.
32. Wilber RL, Moffatt RJ. Influence of carbohydrate ingestion on blood glucose and performance in runners. Int J Sport Nutr 1992; 2: 317-27.
33. Zachwieja JJ, Costill DL, Beard GC, et al. The effects of a carbonated carbohydrate drink on gastric emptying, gastrointestinal distress, and exercise performance. Int J Sport Nutr 1992; 2: 239-50.
34. Cole KJ, Grandjean PW, Sobszak RJ, et al. Effect of carbohydrate composition on fluid balance, gastric emptying, and exercise performance. Int J Sport Nutr 1993; 3: 408-17.
35. Nishibata I, Sadamoto T, Mutoh Y, et al. Glucose ingestion before and during exercise does not enhance performance of daily repeated endurance exercise. Eur J Appl Physiol 1993; 66: 65-9. (Pubitemid 23045056)
36. Tsintzas K, Liu R, Williams C, et al. The effect of carbohydrate ingestion on performance during a 30-km race. Int J Sport Nutr 1993; 3: 127-39.
37. Widrick JJ, Costill DL, FinkWJ, et al. Carbohydrate feedings and exercise performance: effect of initial muscle glycogen concentration. J Appl Physiol 1993; 74: 2998-3005. (Pubitemid 23201335)
38. Bacharach DW, Von Duvillard SP, Rundell KW, et al. Carbohydrate drinks and cycling performance. J Sports Med Phys Fit 1994; 34: 161-8. (Pubitemid 24297168)
39. Chryssanthopoulos C, Hennessy LC, Williams C. The influence of pre-exercise glucose ingestion on endurance running capacity. Br J Sports Med 1994; 28: 105-9. (Pubitemid 24209850)
40. Anantaraman R, Carmines AA, Gaesser GA, et al. Effects of carbohydrate supplementation on performance during 1 hour of high-intensity exercise. Int J Sports Med 1995; 16: 461-5.
41. Ball TC, Headley SA, Vanderburgh PM, et al. Periodic carbohydrate replacement during 50 min of high-intensity cycling improves subsequent sprint performance. Int J Sport Nutr 1995; 5: 151-8.
42. Below PR, Mora-Rodriguez R, Gonzalez-Alonso J, et al. Fluid and carbohydrate ingestion independently improve performance during 1 h of intense exercise. Med Sci Sports Exerc 1995; 27: 200-10.
43. El-Sayed MS, Rattu AJM, Roberts I. Effects of carbohydrate feeding before and during prolonged exercise on subsequent maximal exercise performance capacity. Int J Sport Nutr 1995; 5: 215-24.
44. Kang J, Robertson RJ, Denys BG, et al. Effect of carbohydrate ingestion subsequent to carbohydrate supercompensation on endurance performance. Int J Sport Nutr 1995; 5: 329-43.
45. Tsintzas OK, Williams C, Singh R, et al. Influence of carbohydrate-electrolyte drinks on marathon running performance. Eur J Appl Physiol 1995; 70: 154-60.
46. Madsen K, Maclean DA, Kiens B, et al. Effects of glucose, glucose plus branched-chain amino acids, or placebo on bike performance over 100 km. J Appl Physiol 1996; 81: 2644-50. (Pubitemid 27043383)
47. Maughan RJ, Bethell LR, Leiper JB. Effects of ingested fluids on exercise capacity and on cardiovascular and metabolic responses to prolonged exercise in man. Exp Physiol 1996; 81: 847-59. (Pubitemid 26332084)
48. McConell G, Kloot K, Hargreaves M. Effect of timing of carbohydrate ingestion on endurance exercise performance. Med Sci Sports Exerc 1996; 28: 1300-4. (Pubitemid 26347808)
49. Tsintzas OK, Williams C, Wilson W, et al. Influence of carbohydrate supplementation early in exercise on endurance running capacity. Med Sci Sports Exerc 1996; 28: 1373-9. (Pubitemid 26389897)
50. Tsintzas OK, Williams C, Boobis L, et al. Carbohydrate ingestion and single muscle fiber glycogen metabolism during prolonged running in men. J Appl Physiol 1996; 81: 801-9. (Pubitemid 26303234)
51. El-Sayed MS, Balmer J, Rattu AJM. Carbohydrate ingestion improves endurance performance during a 1 h simulated cycling time trial. J Sports Sci 1997; 15: 223-30. (Pubitemid 27207965)
52. Jeukendrup A, Brouns F, Wagenmakers AJM, et al. Carbohydrate-electrolyte feedings improve 1 h time trial cycling performance. Int J Sports Med 1997; 18: 125-9.
53. Millard-Stafford M, Rosskopf LB, Snow TK, et al. Water versus carbohydrate-electrolyte ingestion before and during a 15-km run in the heat. Int J Sport Nutr 1997; 7: 26-38.
54. Jeukendrup AE, Thielen JJ, Wagenmakers AJ, et al. Effect of medium-chain triacylglycerol and carbohydrate ingestion during exercise on substrate utilization and subsequent cycling performance. Am J Clin Nutr 1998; 67: 397-404. (Pubitemid 28110459)
55. Kovacs EMR, Stegen J, Brouns F. Effect of caffeinated drinks on substrate metabolism, caffeine excretion, and performance. J Appl Physiol 1998; 85: 709-15. (Pubitemid 28365841)
56. Palmer GS, Clancy MC, Hawley JA, et al. Carbohydrate ingestion immediately before exercise does not improve 20 km time trial performance in well trained cyclists. Int J Sports Med 1998; 19: 415-8. (Pubitemid 28444673)
57. Sugiura K, Kobayashi K. Effect of carbohydrate ingestion on sprint performance following continuous and intermittent exercise. Med Sci Sports Exerc 1998; 30: 1624-30. (Pubitemid 28520528)
58. Jarvis AT, Felix SD, Sims S, et al. Carbohydrate supplementation fails to improve the sprint performance of female cyclists. J Exerc Physiol 1999; 1: 1424-40.
59. McConell G, Snow RJ, Proietto J, et al. Muscle metabolism during prolonged exercise in humans: influence of carbohydrate availability. J Appl Physiol 1999; 87: 1083-6. (Pubitemid 29436987)
60. Angus DJ, Hargreaves M, Dancey J, et al. Effect of carbohydrate or carbohydrate plus medium-chain triglyceride ingestion on cycling time trial performance. J Appl Physiol 2000; 88: 113-9. (Pubitemid 30053835)
61. Febbraio MA, Chiu A, Angus DJ, et al. Effects of carbohydrate ingestion before and during exercise on glucose kinetics and performance. J Appl Physiol 2000; 89: 2220-6.
62. McConell GK, Canny BJ, Daddo MC, et al. Effect of carbohydrate ingestion on glucose kinetics and muscle metabolism during intense endurance exercise. J Appl Physiol 2000; 89: 1690-8.
63. Mitchell JB, Braun WA, Pizza FX, et al. Pre-exercise carbohydrate and fluid ingestion: influence of glycemic response on 10-km treadmill running performance in the heat. J Sports Med Phys Fit 2000; 40: 41-50. (Pubitemid 30241012)
64. Bishop NC, Blannin AK, Walsh NP, et al. Carbohydrate beverage ingestion and neutrophil degranulation responses following cycling to fatigue at 75% VO2max. Int J Sports Med 2001; 22: 226-31. (Pubitemid 32336878)
65. Chinevere TD, Sawyer RD, Creer AR, et al. Effects of L-tyrosine and carbohydrate ingestion on endurance exercise performance. J Appl Physiol 2002; 93: 1590-7. (Pubitemid 36082968)
66. Chryssanthopoulos C, Williams C, Nowitz A, et al. The effect of a high carbohydrate meal on endurance running capacity. Int J Sport Nutr Exerc Metab 2002; 12: 157-71.
67. Carter J, Jeukendrup AE, Mundel T, et al. Carbohydrate supplementation improves moderate and high-intensity exercise in the heat. Pflugers Arch 2003; 446: 211-9. (Pubitemid 36683585)
68. Jentjens R, Cale C, Gutch C, et al. Effects of pre-exercise ingestion of differing amounts of carbohydrate on subsequent metabolism and cycling performance. Eur J Appl Physiol 2003; 88: 444-52. (Pubitemid 36747997)
69. Desbrow B, Anderson S, Barrett J, et al. Carbohydrateelectrolyte feedings and 1 h time trial cycling performance. Int J Sport Nutr Exerc Metab 2004; 14: 541-9. (Pubitemid 39391914)
70. Nikolopoulos V, Arkinstall MJ, Hawley JA. Reduced neuromuscular activity with carbohydrate ingestion during constant load cycling. Int J Sport Nutr Exerc Metab 2004; 14: 161-70. (Pubitemid 38478798)
71. SaundersMJ, Kane MD, ToddM. Effects of a carbohydrateprotein beverage on cycling endurance and muscle damage. Med Sci Sports Exerc 2004; 36: 1233-8. (Pubitemid 38879001)
72. Burke LM, Wood C, Pyne DB, et al. Effect of carbohydrate intake on half-marathon performance of well-trained runners. Int J Sport Nutr Exerc Metab 2005; 15: 573-89. (Pubitemid 43036730)
73. Van Nieuwenhoven MA, Brouns F, Kovacs EMR. The effect of two sports drinks and water on GI complaints and performance during an 18-km run. Int J Sports Med 2005; 26: 281-5. (Pubitemid 40637946)
74. Gusbakti R. Ingestion of carbohydrate-electrolyte beverage improves exercise performance. Biomed Res 2006; 17: 183-7. (Pubitemid 44902495)
75. Romano-Ely BC, Todd M, Saunders MJ, et al. Effect of an isocaloric carbohydrate-protein-antioxidant drink on cycling performance. Med Sci Sports Exerc 2006; 38: 1608-16. (Pubitemid 44373780)
76. Van Essen M, Gibala MJ. Failure of protein to improve time trial performance when added to a sports drink. Med Sci Sports Exerc 2006; 38: 1476-83. (Pubitemid 44215757)
77. Saunders MJ, Luden ND, Herrick JE. Consumption of an oral carbohydrate-protein gel improves cycling endurance and prevents postexercise muscle damage. J Strength Cond Res 2007; 21: 678-84.
78. Abbiss CR, Peiffer JJ, Peake JM, et al. Effect of carbohydrate ingestion and ambient temperature on muscle fatigue development in endurance-trained male cyclists. J Appl Physiol 2008; 104: 1021-8. (Pubitemid 351507940)
79. Campbell C, Prince D, Braun M, et al. Carbohydratesupplement form and exercise performance. Int J Sport Nutr Exerc Metab 2008; 18: 179-90.
80. Currell K, Jeukendrup AE. Superior endurance performance with ingestion of multiple transportable carbohydrates. Med Sci Sports Exerc 2008; 40: 275-81.
81. Hulston CJ, Jeukendrup AE. Substrate metabolism and exercise performance with caffeine and carbohydrate intake. Med Sci Sports Exerc 2008; 40: 2096-104.
82. Jeukendrup AE, Hopkins S, Aragó n-Vargas LF, et al. No effect of carbohydrate feeding on 16 km cycling time trial performance. Eur J Appl Physiol 2008; 104: 831-7.
83. Osterberg KL, Zachwieja JJ, Smith JW. Carbohydrate and carbohydrate+protein for cycling time-trial performance. J Sports Sci 2008; 26: 227-33. (Pubitemid 350302167)
84. Peake J, Peiffer JJ, Abbiss CR, et al. Carbohydrate gel ingestion and immunoendocrine responses to cycling in temperate and hot conditions. Int J Sport Nutr Exerc Metab 2008; 18: 229-46.
85. Valentine RJ, Saunders MJ, Todd MK, et al. Influence of carbohydrate-protein beverage on cycling endurance and indices of muscle disruption. Int J Sport Nutr Exerc Metab 2008; 18: 363-78.
86. Breen L, Tipton KD, Jeukendrup AE. No effect of carbohydrate-protein on cycling performance and indices of recovery. Med Sci Sports Exerc 2010; 42: 1140-8.
87. Hulston CJ, Jeukendrup AE. No placebo effect from carbohydrate intake during prolonged exercise. Int J Sport Nutr Exerc Metab 2009; 19: 275-84.
88. Lacerda ACR, Alecrim P, Damasceno WC, et al. Carbohydrate ingestion during exercise does not delay the onset of fatigue during submaximal cycle exercise. J Strength Cond Res 2009; 23: 1276-81.
89. Robson-Ansley P, BarwoodM, Eglin C, et al. The effect of carbohydrate ingestion on the interleukin-6 response to a 90-minute run time trial. Int J Sports Physiol Perform 2009; 4: 186-94.
90. Saunders MJ, Moore RW, Kies AK, et al. Carbohydrate and protein hydrolysate coingestions improvement of late-exercise time-trial performance. Int J Sport Nutr Exerc Metab 2009; 19: 136-49.
91. Hopkins WG, Schabort EJ, Hawley JA. Reliability of power in physical performance tests. Sports Med 2001; 31: 211-34. (Pubitemid 32270053)
92. Hinckson EA, Hopkins WG. Reliability of time to exhaustion analyzed with critical-power and log-log modeling. Med Sci Sports Exerc 2005; 37: 696-701. (Pubitemid 40478479)
93. Leger L, Mercier D. Gross energy cost of horizontal treadmill and track running. Sports Med 1984; 1: 270-7. (Pubitemid 14033634)
94. Billat LV, Koralsztein JP. Significance of the velocity at VO2max and time to exhaustion at this velocity. Sports Med 1996; 22: 90-108. (Pubitemid 26265634)
95. Easterbrook PJ, Gopalan R, Berlin JA, et al. Publication bias in clinical research. Lancet 1991; 337: 867-72.
96. Hopkins WG, Marshall SW, Batterham AM, et al. Progressive statistics for studies in sports medicine and exercise science. Med Sci Sports Exerc 2009; 41: 3-12.
97. Hopkins WG. Competitive performance of elite track-andfield athletes: variability and smallest worthwhile enhancements. Sportscience 2005; 9: 17-20.
98. Paton CD, Hopkins WG. Variation in performance of elite cyclists from race to race. Eur J Sport Sci 2006; 6: 25-31.
99. Jeukendrup AE, Jentjens R. Oxidation of carbohydrate feedings during prolonged exercise: current thoughts, guidelines and directions for future research. Sports Med 2000; 29: 407-24. (Pubitemid 30392021)
100. Shi X, Horn MK, Osterberg KL, et al. Gastrointestinal discomfort during intermittent high-intensity exercise: effect of carbohydrate-electrolyte beverage. Int J Sport Nutr Exerc Metab 2004; 14: 673-83. (Pubitemid 40095832)
101. Massicotte D, Peronnet F, Brisson G, et al. Oxidation of a glucose polymer during exercise: comparison with glucose and fructose. J Appl Physiol 1989; 66: 179-83. (Pubitemid 19056074)
102. Rowlands DS, Thorburn MS, Thorp RM, et al. Effect of graded fructose coingestion with maltodextrin on exogenous 14C-fructose and 13C-glucose oxidation efficiency and high-intensity cycling performance. J Appl Physiol 2008; 104: 1709-19.
103. O'Brien W, Rowlands D. Fructose-maltodextrin ratio in a carbohydrate-electrolyte solution differentially affects exogenous carbohydrate oxidation rate, gut comfort and performance. Am J Physiol Gastrointest Liver Physiol 2011; 300: G181-9.
104. Blomstrand E. A role for branched-chain amino acids in reducing central fatigue. J Nutr 2006; 136: 544S-7S. (Pubitemid 43228317)
105. Hunt JN, Stubbs DF. The volume and energy content of meals as determinants of gastric emptying. J Physiol 1975; 245: 209-25.
106. Rehrer NJ. The maintenance of fluid balance during exercise. Int J Sports Med 1994; 15: 122-5. (Pubitemid 24116323)
107. Rehrer NJ, Beckers EJ, Brouns F, et al. Effects of electrolytes in carbohydrate beverages on gastric emptying and secretion. Med Sci Sports Exerc 1993; 25: 42-51. (Pubitemid 23027682)
108. Morris JG, Nevill ME, Thompson D, et al. The influence of a 6.5% carbohydrate-electrolyte solution on performance of prolonged intermittent high-intensity running at 30 degrees C. J Sports Sci 2003; 21: 371-81. (Pubitemid 36625951)
109. Jentjens R, Wagenmakers AJM, Jeukendrup AE. Heat stress increases muscle glycogen use but reduces the oxidation of ingested carbohydrates during exercise. J Appl Physiol 2002; 92: 1562-72. (Pubitemid 34670912)
110. Burke LM, Collier GR, Davis PG, et al. Muscle glycogen storage after prolonged exercise: effect of the frequency of carbohydrate feedings. Am J Clin Nutr 1996; 64: 115-9. (Pubitemid 26241965)
111. Chambers ES, BridgeMW, Jones DA. Carbohydrate sensing in the human mouth: effects on exercise performance and brain activity. J Physiol 2009; 587: 1779-94.
112. Wong SH, Chan OW, Chen YJ, et al. Effect of preexercise glycemic-index meal on running when CHO-electrolyte solution is consumed during exercise. Int J Sport Nutr Exerc Metab 2009; 19: 222-42.
113. Hopkins WG. Research designs: choosing and fine-tuning a design for your study. Sportscience 2008; 12: 12-21.
114. Rowlands DS, Thorp RM, Rossler K, et al. Effect of proteinrich feeding on recovery following intense exercise. Int J Sport Nutr Exerc Metab 2007; 17: 521-43