Amide bonds to the nitrogen atoms of cysteine and serine as "weak points" in the backbones of proteins

Biochemistry

Volumn 50, Issue 33, 2011, Pages 7259-7264

  Lewis, Charles A ^a   Wolfenden, Richard ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE BOND; BASE CATALYST; ELEVATED TEMPERATURE; HEDGEHOG SIGNALING; MODEL REACTIONS; N-ACETYLCYSTEINE; NEUTRAL SOLUTION; NITROGEN ATOM; NUCLEOPHILIC ATTACK; OH GROUP; PEPTIDE BONDS; RATE ENHANCEMENT; SELF-SPLICING; SERINE RESIDUES; SH GROUPS; SIDE-CHAINS; THIOESTERS; WEAK POINTS;

AMIDES; ATOMS; CATALYSTS; ENZYMES; HYDROLYSIS; NITROGEN; PEPTIDES; REACTION INTERMEDIATES;

AMINO ACIDS;

ACETYLCYSTEINE; AMIDE; ASPARAGINASE; CYSTEINE; HYDROXYL GROUP; NITROGEN; PEPTIDE; SERINE; SONIC HEDGEHOG PROTEIN; THIOESTER;

ARTICLE; ATOM; CATALYST; CHEMICAL BOND; NUCLEOPHILICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN HYDROLYSIS; PROTEIN PROCESSING; TEMPERATURE;

AMIDES; AMINO ACIDS; CYSTEINE; HYDROLYSIS; NITROGEN; PROTEIN SPLICING; PROTEINS; SERINE;

ERINACEIDAE;

EID: 80051707071     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200813s     Document Type: Article

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