Delivery of alloantigens via apoptotic cells generates dendritic cells with an immature tolerogenic phenotype

Transplantation Proceedings

Volumn 43, Issue 6, 2011, Pages 2325-2333

  Gleisner, M A ^a   Rosemblatt, M ^a,b,c   Fierro, J A ^d   Bono, M R ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b Fundacion Ciencia para la Vida   (Chile)

^c UNIVERSIDAD ANDRÉS BELLO   (Chile)

^d CLÍNICA LAS CONDES   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; COLECALCIFEROL; FLT3 LIGAND; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DRUG EFFECT; IMMATURE TOLEROGENIC PHENOTYPE; IMMUNIZATION; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; APOPTOSIS; CELL DIFFERENTIATION; CELLS, CULTURED; CHOLECALCIFEROL; CYTOKINES; DENDRITIC CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNE TOLERANCE; IMMUNOPHENOTYPING; ISOANTIGENS; MALE; MELANOMA, EXPERIMENTAL; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NECROSIS; PHAGOCYTOSIS; PHENOTYPE; THYMOCYTES; TIME FACTORS; TRANSFECTION;

EID: 80051695034     PISSN: 00411345     EISSN: 18732623     Source Type: Journal    
DOI: 10.1016/j.transproceed.2011.06.007     Document Type: Article

References (29)

1. J. Banchereau, F. Briere, and C. Caux Immunobiology of dendritic cells Annu Rev Immunol 18 2000 767
2. A.E. Morelli, A.T. Larregina, and W.J. Shufesky Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production Blood 101 2003 611
3. D. Hawiger, K. Inaba, and Y. Dorsett Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo J Exp Med 194 2001 769
4. K. Mahnke, E. Schmitt, and L. Bonifaz Immature, but not inactive: the tolerogenic function of immature dendritic cells Immunol Cell Biol 80 2002 477
5. A.E. Morelli, H. Hackstein, and A.W. Thomson Potential of tolerogenic dendritic cells for transplantation Semin Immunol 13 2001 323
6. G. Penna, N. Giarratana, and S. Amuchastegui Manipulating dendritic cells to induce regulatory T cells Microbes Infect 7 2005 1033
7. S. Gallucci, M. Lolkema, and P. Matzinger Natural adjuvants: endogenous activators of dendritic cells Nat Med 5 1999 1249
8. B. Sauter, M.L. Albert, and L. Francisco Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells J Exp Med 191 2000 423
9. R.E. Voll, M. Herrmann, and E.A. Roth Immunosuppressive effects of apoptotic cells Nature 390 1997 350
10. Z. Wang, A.T. Larregina, and W.J. Shufesky Use of the inhibitory effect of apoptotic cells on dendritic cells for graft survival via T-cell deletion and regulatory T cells Am J Transplant 6 2006 1297
11. R.M. Steinman, S. Turley, and I. Mellman The induction of tolerance by dendritic cells that have captured apoptotic cells J Exp Med 191 2000 411
12. P.T. Coates, S.M. Barratt-Boyes, and L. Zhang Dendritic cell subsets in blood and lymphoid tissue of rhesus monkeys and their mobilization with Flt3 ligand Blood 102 2003 2513
13. A.E. Morelli The immune regulatory effect of apoptotic cells and exosomes on dendritic cells: its impact on transplantation Am J Transplant 6 2006 254
14. J.R. Mora, M.R. Bono, and N. Manjunath Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells Nature 424 2003 88
15. E. Maraskovsky, K. Brasel, and M. Teepe Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified J Exp Med 184 1996 1953
16. E. Maraskovsky, E. Daro, and E. Roux In vivo generation of human dendritic cell subsets by Flt3 ligand Blood 96 2000 878
17. M.M. Tiao, L. Lu, and R. Tao Prolongation of cardiac allograft survival by systemic administration of immature recipient dendritic cells deficient in NF-kappaB activity Ann Surg 241 2005 497
18. A.E. Morelli, and A.W. Thomson Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction Immunol Rev 196 2003 125
19. A.E. Morelli, and A.W. Thomson Tolerogenic dendritic cells and the quest for transplant tolerance Nat Rev Immunol 7 2007 610
20. G. Penna, and L. Adorini 1 Alpha, 25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation J Immunol 164 2000 2405
21. L. Piemonti, P. Monti, and M. Sironi Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells J Immunol 164 2000 4443
22. M.D. Griffin, W.H. Lutz, and V.A. Phan Potent inhibition of dendritic cell differentiation and maturation by vitamin D analogs Biochem Biophys Res Commun 270 2000 701
23. C.P. Larsen, E.T. Elwood, and D.Z. Alexander Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways Nature 381 1996 434
24. D.J. Lenschow, T.L. Walunas, and J.A. Bluestone CD28/B7 system of T cell costimulation Annu Rev Immunol 14 1996 233
25. I.S. Grewal, and R.A. Flavell CD40 and CD154 in cell-mediated immunity Annu Rev Immunol 16 1998 111
26. M.C. Rissoan, V. Soumelis, and N. Kadowaki Reciprocal control of T helper cell and dendritic cell differentiation Science 283 1999 1183
27. H. Hackstein, and A.W. Thomson Dendritic cells: emerging pharmacological targets of immunosuppressive drugs Nat Rev Immunol 4 2004 24
28. A.E. Morelli, and A.W. Thomson Dendritic cells under the spell of prostaglandins Trends Immunol 24 2003 108
29. S. Gregori, M. Casorati, and S. Amuchastegui Regulatory T cells induced by 1 alpha, 25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance J Immunol 167 2001 1945