Dendritic cells under the spell of prostaglandins

Trends in Immunology

Volumn 24, Issue 3, 2003, Pages 108-111

  Morelli, Adrian E ^a   Thomson, Angus W ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; INTERLEUKIN 12; PROSTAGLANDIN;

ANTIGEN PRESENTING CELL; APOPTOSIS; CELL MATURATION; CELL MIGRATION; CELL SECRETION; CYTOKINE PRODUCTION; DENDRITIC CELL; HELPER CELL; HUMAN; IMMUNE RESPONSE; IN VITRO STUDY; INFLAMMATION; NONHUMAN; REGULATORY MECHANISM; REVIEW; TH2 CELL;

EID: 0037373670     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(03)00023-1     Document Type: Review

References (22)

1. Bell D., et al. Dendritic cells. Adv. Immunol. 72:1999;255-324.
2. Harris S.G., et al. Prostaglandins as modulators of immunity. Trends Immunol. 23:2002;144-150.
3. Jonuleit H., et al. Proinflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal-calf serum-free conditions. Eur. J. Immunol. 27:1997;3135-3142.
4. + dendritic cells: the levels of IL-12 are determined during the final dendritic-cell maturation and are resistant to further modulation. J. Immunol. 161:1998;2804-2809.
5. 2, promote type 2 cytokine production in maturing human naïve T helper cells. J. Immunol. 159:1997;28-35.
6. Harizi H., et al. Cyclooxygenase-2-issued prostaglandin E2 enhances the production of endogenous IL-10, which downregulates dendritic-cell functions. J. Immunol. 168:2002;2255-2263.
7. 2 is a selective inducer of interleukin-12p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer. Blood. 97:2001;3466-3469.
8. Whittaker D.S., et al. Autoregulation of human monocyte-derived dendritic-cell maturation and IL-12 production by cyclooxygenase-2-mediated prostanoid production. J. Immunol. 165:2000;4298-4304.
9. 2 regulates the migratory capacity of specific DC subsets. Blood. 100:2002;1362-1372.
10. 2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. Blood. 100:2002;1354-1361.
11. Gilroy W.D., et al. Inducible cyclooxygenase may have anti-inflammatory properties. Nat. Med. 5:1999;698-701.
12. Willoughby D.A., et al. Cyclopentenone prostaglandins - new allies in the war on inflammation. Nat. Med. 6:2000;137-138.
13. Kliewer S.A., et al. Convergence of 9-cis retinoic acid and peroxisome proliferators signaling pathways through heterodimer formation of their receptors. Nature. 358:1992;771-774.
14. Nencioni A., et al. Dendritic cells immunogenicity is regulated by peroxisome proliferators-activated receptor-γ J. Immunol. 169:2002;1228-1235.
15. Faveeuw C., et al. Peroxisome proliferators-activated receptor-γ activators inhibit interleukin-12 production in murine dendritic cells. FEBS Lett. 486:2000;261-266.
16. Gosset P., et al. Peroxisome proliferators-activated receptor-γ activators affect the maturation of human monocyte-derived dendritic cells. Eur. J. Immunol. 31:2001;2857-2865.
17. Nencioni A., et al. Cyclopentenone prostaglandins induce caspase activation and apoptosis in dendritic cells by PPAR-γ-independent mechanism: regulation by inflammatory and T-cell-derived stimuli. Exp. Hematol. 30:2002;1020-1028.
18. Lawrence T., et al. Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nat. Rev. Immunol. 2:2002;787-795.
19. 2 formation and characterization of its synthetases in various tissues of adult rats. Arch. Biochem. Biophys. 260:1988;521-531.
20. 2 in the inhibition of epidermal Langerhans cell migration during schistosomiasis infection. J. Exp. Med. 193:2001;1135-1147.
21. 2, IL-10 and IL-11 generation in antigen-presenting cells. Clin. Exp. Immunol. 129:2002;438-445.
22. Sombroek C.C., et al. Prostanoids play a major role in the primary tumor-induced inhibition of dendritic-cell differentiation. J. Immunol. 168:2002;4333-4343.