Laser-captured microdissection-microarray analysis of the genes involved in endometrial carcinogenesis: Stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria and its functional relevance

Human Pathology

Volumn 42, Issue 9, 2011, Pages 1265-1274

  Miyamoto, Tsutomu ^a   Kashima, Hiroyasu ^a   Suzuki, Akihisa ^a   Kikuchi, Norihiko ^a   Konishi, Ikuo ^b   Seki, Naohiko ^c   Shiozawa, Tanri ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

Endometrial carcinoma; Endometrium; Laser captured microdissection; Lipocalin2; Microarray

Indexed keywords

AZACITIDINE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN;

ADULT; AGED; ARTICLE; CARCINOGENESIS; CELL INVASION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; ENDOMETRIUM CARCINOMA; FEMALE; GENE; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LASER MICRODISSECTION; LCN2 GENE; METHYLATION; MICROARRAY ANALYSIS; NUCLEUS ACCUMBENS; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ACUTE-PHASE PROTEINS; ADULT; AGED; AGED, 80 AND OVER; CELLS, CULTURED; ENDOMETRIAL HYPERPLASIA; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LASERS; LIPOCALINS; MICROARRAY ANALYSIS; MICRODISSECTION; MIDDLE AGED; PROTO-ONCOGENE PROTEINS;

EID: 80051680833     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2010.07.027     Document Type: Article

References (29)

1. Ronnett B.M., Zaino R.J., Ellenson L.H., and Kurman R.J. Endometrial carcinoma R.J. Kurman, Blaustein's pathology of the female genital tract 5th ed 2002 Springer-Verlag New York, Inc New York 501 559
2. Barakat R., Grisby P., and Sabbatini P. Corpus Epithelial tumors. Principles and practice of gynecologic oncology 3rd ed 2000 Lippincott Williams & Wilkins Philadelphia 919 959
3. Konishi I. Japan society of obstetrics and gynecology. Annual report Acta Obstet Gynecol Japonica 61 2009 939 963
4. Lax S.F. Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification Virchows Arch 444 2004 213 223 (Pubitemid 38446432)
5. Fend F., and Raffeld M. Laser capture microdissection in pathology J Clin Pathol 53 2000 666 672
6. Flower D.R., North A.C., and Sansom C.E. The lipocalin protein family: structural and sequence overview Biochim Biophys Acta 1482 2000 9 24
7. Grzyb J., Latowski D., and Strzalka K. Lipocalins-a family portrait J Plant Physiol 163 2006 895 915
8. Bratt T. Lipocalins and cancer Biochim Biophys Acta 1482 2000 318 326
9. Shiozawa T., Horiuchi A., and Kato K. Up-regulation of p27Kip1 by progestins is involved in the growth suppression of the normal and malignant human endometrial glandular cells Endocrinology 142 2001 4182 4188 (Pubitemid 32907043)
10. Kikuchi N., Horiuchi A., and Osada R. Nuclear expression of S100A4 is associated with aggressive behavior of epithelial ovarian carcinoma: an important autocrine/paracrine factor in tumor progression Cancer Sci 97 2006 1061 1069 (Pubitemid 44322555)
11. Seth P., Porter D., Lahti-Domenici J., Geng Y., Richardson A., and Polyak K. Cellular and molecular targets of estrogen in normal human breast tissue Cancer Res 62 2002 4540 4544
12. Horiuchi A., Kikuchi N., and Osada R. Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer Cancer Sci 99 2008 2532 2539
13. Lee H.J., Lee E.K., Lee K.J., Hong S.W., Yoon Y., and Kim J.S. Ectopic expression of neutrophil gelatinase-associated lipocalin suppresses the invasion and liver metastasis of colon cancer cells Int J Cancer 118 2006 2490 2497
14. Sato N., Fukushima N., Matsubayashi H., and Goggins M. Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling Oncogene 23 2004 1531 1538 (Pubitemid 38406515)
15. Huang H.L., Chu S.T., and Chen Y.H. Ovarian steroids regulate 24p3 expression in mouse uterus during the natural estrous cycle and the preimplantation period J Endocrinol 162 1999 11 19 (Pubitemid 29336350)
16. Playford R.J., Belo A., and Poulsom R. Effects of mouse and human lipocalin homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin on gastrointestinal mucosal integrity and repair Gastroenterology 131 2006 809 817 (Pubitemid 44307059)
17. Jones C., Mackay A., and Grigoriadis A. Expression profiling of purified normal human luminal and myoepithelial breast cells: identification of novel prognostic markers for breast cancer Cancer Res 64 2004 3037 3045 (Pubitemid 38581402)
18. Taylor-Papadimitriou J., and Lane E.B. Keratin expression in the mammary gland K.C. Neville, The mammary gland. Development, regulation and function 1987 Plenum Press New York 185 215
19. Leng X., Lin H., and Ding T. Lipocalin 2 is required for BCR-ABL-induced tumorigenesis Oncogene 27 2008 6110 6119
20. Friedl A., Stoesz S.P., Buckley P., and Gould M.N. Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression Histochem J 31 1999 433 441 (Pubitemid 29369301)
21. Stoesz S.P., Friedl A., Haag J.D., Lindstrom M.J., Clark G.M., and Gould M.N. Heterogeneous expression of the lipocalin NGAL in primary breast cancers Int J Cancer 79 1998 565 572 (Pubitemid 28549466)
22. Cho H., and Kim J.H. Lipocalin2 expressions correlate significantly with tumor differentiation in epithelial ovarian cancer J Histochem Cytochem 57 2009 513 521
23. Paine P.L., Moore L.C., and Horowitz S.B. Nuclear envelope permeability Nature 254 1975 109 114
24. Iannetti A., Pacifico F., and Acquaviva R. The neutrophil gelatinase-associated lipocalin (NGAL), a NF-kappaB-regulated gene, is a survival factor for thyroid neoplastic cells Proc Natl Acad Sci U S A 105 2008 14058 14063
25. Cui L., Xu L.Y., and Shen Z.Y. NGALR is overexpressed and regulated by hypomethylation in esophageal squamous cell carcinoma Clin Cancer Res 14 2008 7674 7681
26. Hu L., Hittelman W., and Lu T. NGAL decreases E-cadherin-mediated cell-cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells Lab Invest 89 2009 531 548
27. Yang J., Bielenberg D.R., and Rodig S.J. Lipocalin 2 promotes breast cancer progression Proc Natl Acad Sci U S A 106 2009 3913 3918
28. Hanai J., Mammoto T., and Seth P. Lipocalin 2 diminishes invasiveness and metastasis of Ras-transformed cells J Biol Chem 280 2005 13641 13647 (Pubitemid 40517258)
29. Devireddy L.R., Gazin C., Zhu X., and Green M.R. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake Cell 123 2005 1293 1305 (Pubitemid 41821786)