Total colony-forming units are a strong, independent predictor of neutrophil and platelet engraftment after unrelated umbilical cord blood transplantation: A single-center analysis of 435 cord blood transplants

Biology of Blood and Marrow Transplantation

Volumn 17, Issue 9, 2011, Pages 1362-1374

  Page, Kristin M ^a   Zhang, Lijun ^b   Mendizabal, Adam ^b   Wease, Stephen ^b   Carter, Shelly ^b   Gentry, Tracy ^c   Balber, Andrew E ^c   Kurtzberg, Joanne ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b EMMES CORPORATION   (United States)

^c Aldagen Inc   (United States)

Author keywords

Colony forming units; Engraftment; Unrelated umbilical cord blood transplant

Indexed keywords

ARTICLE; CD34 SELECTION; CHILD; COLONY FORMING UNIT; CORD BLOOD STEM CELL TRANSPLANTATION; ENGRAFTMENT; FEMALE; GRAFT FAILURE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; MYELOABLATIVE CONDITIONING; NEUTROPHIL; PREDICTOR VARIABLE; THROMBOCYTE; UMBILICAL CORD BLOOD; UNIVARIATE ANALYSIS;

ADOLESCENT; ADULT; BLOOD PLATELETS; CELL COUNT; CHILD; CHILD, PRESCHOOL; CORD BLOOD STEM CELL TRANSPLANTATION; FEMALE; GRAFT SURVIVAL; HUMANS; INFANT; INFANT, NEWBORN; MALE; MIDDLE AGED; NEUTROPHILS; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; STEM CELLS; YOUNG ADULT;

EID: 80051673064     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2011.01.011     Document Type: Article

References (41)

1. Kurtzberg J., Prasad V.K., Carter S.L., et al. Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood 2008, 112:4318-4327.
2. Martin P.L., Carter S.L., Kernan N.A., et al. Results of the Cord Blood Transplantation Study (COBLT): outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with lysosomal and peroxisomal storage diseases. Biol Blood Marrow Transplant 2006, 12:184-194.
3. Eapen M., Rocha V., Sanz G., et al. Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis. Lancet Oncol 2010, 11:653-660.
4. Barker J.N., Scaradavou A., Stevens C.E. Combined effect of total nucleated cell dose and HLA match on transplantation outcome in 1061 cord blood recipients with hematologic malignancies. Blood 2010, 115:1843-1849.
5. Kurtzberg J., Laughlin M., Graham M.L., et al. Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N Engl J Med 1996, 335:157-166.
6. Gluckman E., Rocha V., Boyer-Chammard A., et al. Outcome of cord-blood transplantation from related and unrelated donors. N Engl J Med 1997, 337:373-381.
7. Rubinstein P., Carrier C., Scaradavou A., et al. Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N Engl J Med 1998, 339:1565-1577.
8. Laughlin M.J., Barker J., Bambach B., et al. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med 2001, 344:1815-1822.
9. Gluckman E., Rocha V., Arcese W., et al. Factors associated with outcomes of unrelated cord blood transplant: guidelines for donor choice. Exp Hematol 2004, 32:397-407.
10. Terakura S., Azuma E., Murata M., et al. Hematopoietic engraftment in recipients of unrelated donor umbilical cord blood is affected by the CD34+ and CD8+ cell doses. Biol Blood Marrow Transplant 2007, 13:822-830.
11. Lemarie C., Esterni B., Calmels B., et al. CD34+ progenitors are reproducibly recovered in thawed umbilical grafts, and positively influence haematopoietic reconstitution after transplantation. Bone Marrow Transplant 2007, 39:453-460.
12. Wagner J.E., Barker J.N., DeFor T.E., et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 2002, 100:1611-1618.
13. Rodrigues C.A., Sanz G., Brunstein C.G., et al. Analysis of risk factors for outcomes after unrelated cord blood transplantation in adults with lymphoid malignancies: a study by the Eurocord-Netcord and Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. J Clin Oncol 2009, 27:256-263.
14. Page K.M., Zhang L., Mendizabal A., Balber A.E., Gentry T., Kurtzberg J. A novel scoring system, the cord blood apgar, predicts engraftment after cord blood transplantation: optimization of selection of CBUs for transplantation. Cytotherapy 2010, 12:15.
15. Wall D.A., Carter S.L., Kernan N.A., et al. Busulfan/melphalan/antithymocyte globulin followed by unrelated donor cord blood transplantation for treatment of infant leukemia and leukemia in young children: The Cord Blood Transplantation Study (COBLT) experience. Biol Blood Marrow Transplant 2005, 11:637-646.
16. Prasad V.K., Mendizabal A., Parikh S.H., et al. Unrelated donor umbilical cord blood transplantation for inherited metabolic disorders in 159 pediatric patients from a single center: influence of cellular composition of the graft on transplantation outcomes. Blood 2008, 112:2979-2989.
17. Parikh S.H., Mendizabal A., Martin P.L., et al. Unrelated donor umbilical cord blood transplantation in pediatric myelodysplastic syndrome: a single-center experience. Biol Blood Marrow Transplant 2009, 15:948-955.
18. Page K.M., Mendizabal A.M., Prasad V.K., et al. Posttransplant autoimmune hemolytic anemia and other autoimmune cytopenias are increased in very young infants undergoing unrelated donor umbilical cord blood transplantation. Biol Blood Marrow Transplant 2008, 14:1108-1117.
19. Beam D., Poe M.D., Provenzale J.M., et al. Outcomes of unrelated umbilical cord blood transplantation for X-linked adrenoleukodystrophy. Biol Blood Marrow Transplant 2007, 13:665-674.
20. Staba S.L., Escolar M.L., Poe M., et al. Cord-blood transplants from unrelated donors in patients with Hurler's syndrome. N Engl J Med 2004, 350:1960-1969.
21. Escolar M.L., Poe M.D., Provenzale J.M., et al. Transplantation of umbilical-cord blood in babies with infantile Krabbe's disease. N Engl J Med 2005, 352:2069-2081.
22. Rubinstein P., Dobrila L., Rosenfield R.E., et al. Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution. Proc Natl Acad Sci U S A 1995, 92:10119-10122.
23. Filipovich A., Weisdorf D., Pavletic S., et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant 2005, 11:945-955.
24. Kaplan E., Meier P. Non parametric estimation from incomplete observations. J Am Stat Assoc 1958, 53:457-481.
25. Gooley T., Leisenring W., Crowley J., et al. Estimation of failure probabilities in the presence of competing risks: new representations of old estimators. Stat Med 1999, 18:695-706.
26. Gray R. A class of K-sample tests for comparing the cumulative incidence of a competing risk. Ann Stat 1988, 16:1141-1154.
27. Fine J., Gray R. A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc 1999, 94:496-509.
28. Gary M., Hermann E., Anneke B., et al. Multiple-laboratory comparison of in vitro assays utilized to characterize hematopoietic cells in cord blood. Transfusion 2006, 46:507-515.
29. Dzik W., Sniecinski I., Fischer J. Toward standardization of CD34+ cell enumeration: an international study. Transfusion 1999, 39:856-863.
30. Migliaccio A.R., Adamson J.W., Stevens C.E., Dobrila N.L., Carrier C.M., Rubinstein P. Cell dose and speed of engraftment in placental/umbilical cord blood transplantation: graft progenitor cell content is a better predictor than nucleated cell quantity. Blood 2000, 96:2717-2722.
31. Iori A.P., Cerretti R., De Felice L., et al. Pre-transplant prognostic factors for patients with high-risk leukemia undergoing an unrelated cord blood transplantation. Bone Marrow Transplant 2004, 33:1097-1105.
32. Yoo K.H., Lee S.H., Kim H.J., et al. The impact of post-thaw colony-forming units-granulocyte/macrophage on engraftment following unrelated cord blood transplantation in pediatric recipients. Bone Marrow Transplant 2007, 39:515-521.
33. Eapen M., Rubinstein P., Zhang M.-J., et al. Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet 2007, 369:1947-1954.
34. Lumley M.A., Burton A., Billingham L.J., McDonald D.F., Czarnecka H.M., Milligan D.W. Quality assurance of CFU-GM assays: inter-laboratory variation despite standard reagents. Eur J Haematol 1999, 62:32-37.
35. Lumley A., Burgess R., Billingham L., McDonald D., Milligan D. Colony counting is a major source of variation in CFU-GM results between centres. Br J Haematol 1997, 97:481-484.
36. Lamana M., Albella B., Rodriguez F., Regidor C., Bueren J. Conclusions of a national multicenter intercomparative study of in vitro cultures of human hematopoietic progenitors. Bone Marrow Transplant 1999, 23:373-380.
37. Wagner E., Duval M., Dalle J.H., et al. Assessment of cord blood unit characteristics on the day of transplant: comparison with data issued by cord blood banks. Transfusion 2006, 46:1190-1198.
38. Broxmeyer H.E., Srour E.F., Hangoc G., Cooper S., Anderson S.A., Bodine D.M. High-efficiency recovery of functional hematopoietic progenitor and stem cells from human cord blood cryopreserved for 15 years. Proc Natl Acad Sci U S A 2003, 100:645-650.
39. Alonso J.M., Regan D.M., Johnson C.E., et al. A simple and reliable procedure for cord blood banking, processing, and freezing: St Louis and Ohio Cord Blood Bank experiences. Cytotherapy 2001, 3:429-433.
40. Goodwin H.S., Grunzinger L.M., Regan D.M., et al. Long term cryostorage of UC blood units: ability of the integral segment to confirm both identity and hematopoietic potential. Cytotherapy 2003, 5:80-86.
41. Solves P., Planelles D., Mirabet V., et al. Utility of bag segment and cryovial samples for quality control and confirmatory HLA typing in umbilical cord blood banking. Clin Lab Haematol 2004, 26:413-418.