Beta-adrenergic signals regulate cardiac differentiation of mouse embryonic stem cells via mitogen-activated protein kinase pathways

Development Growth and Differentiation

Volumn 53, Issue 6, 2011, Pages 772-779

  Yan, Lihui ^a   Jia, Zhuqing ^b   Cui, Jingjing ^a   Yang, Hongtao ^a   Yang, Huangtian ^c   Zhang, Yongzhen ^a   Zhou, Chunyan ^b  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

adrenergic receptor; Cardiac differentiation; Embryonic stem cell; Extracellular signal regulated kinase pathway; P38 mitogen activated protein kinase

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BIOLOGICAL MARKER; ISOPRENALINE; MAJOR HISTOCOMPATIBILITY ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROPRANOLOL; TRANSCRIPTION FACTOR GATA 4; TROPONIN T;

ANIMAL CELL; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BETA ADRENERGIC STIMULATION; CELL DIFFERENTIATION; EMBRYO; EMBRYOID BODY; EMBRYONIC STEM CELL; EMBRYONIC STEM CELL DERIVED CARDIOMYOCYTE; HEART DEVELOPMENT; HEART MUSCLE CELL; MOUSE; MOUSE EMBRYO; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELL DIFFERENTIATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC STEM CELLS; FLUORESCENT ANTIBODY TECHNIQUE; ISOPROTERENOL; MAP KINASE SIGNALING SYSTEM; MICE; MICROSCOPY, CONFOCAL; MYOCYTES, CARDIAC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROPRANOLOL; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; TROPONIN T;

EID: 80051664899     PISSN: 00121592     EISSN: 1440169X     Source Type: Journal    
DOI: 10.1111/j.1440-169X.2011.01284.x     Document Type: Article

References (24)

1. Ali, N. N., Xu, X., Brito-Martins, M., Poole-Wilson, P. A., Harding, S. E. & Fuller, S. J. 2004. Beta-adrenoceptor subtype dependence of chronotropy in mouse embryonic stem cell-derived cardiomyocytes. Basic Res. Cardiol. 99, 382-391.
2. Bost, F., Caron, L., Marchetti, I., Dani, C., Le Marchand-Brustel, Y. & Binetruy, B. 2002. Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage. Biochem. J. 361, 621-627.
3. Cai, C. L., Liang, X., Shi, Y, Chu, P. H., Pfaff, S. L., Chen, J. & Evans, S. 2003. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev. Cell 5, 877-889.
4. Chau, M. D., Tuft, R., Fogarty, K. & Bao, Z. Z. 2006. Notch signaling plays a key role in cardiac cell differentiation. Mech. Dev. 123, 626-640.
5. Chakir, K., Xiang, Y., Yang, D., Zhang, S. J., Cheng, H., Kobilka, B. K. & Xiao, R. P. 2003. The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor. Mol. Pharmacol. 64, 1048-1058.
6. Chruscinski, A. J., Rohrer, D. K., Schauble, E., Desai, K. H., Bernstein, D. & Kobilka, B. K. 1999. Targeted disruption of the beta2 adrenergic receptor gene. J. Biol. Chem. 274, 16694-16700.
7. Ebert, S. N. & Thompson, R. P. 2001. Embryonic epinephrine synthesis in the rat heart before innervation: association with pacemaking and conduction tissue development. Circ. Res. 88, 117-124.
8. Engel, F. B., Hsieh, P. C., Lee, R. T. & Keating, M. T. 2006. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proc. Natl Acad. Sci. USA 103, 15546-15551.
9. Engel, F. B., Schebesta, M., Duong, M. T., Lu, G., Ren, S., Madwed, J. B., Jiang, H., Wang, Y. & Keating, M. T. 2005. p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev. 19, 1175-1187.
10. Eriksson, M. & Leppa, S. 2002. Mitogen-activated protein kinases and activator protein 1 are required for proliferation and cardiomyocyte differentiation of P19 embryonal carcinoma cells. J Biol. Chem. 277, 15992-16001.
11. Graichen, R., Xu, X., Braam, S. R, Balakrishnan, T., Norfiza, S., Sieh, S., Soo, S. Y., Tham, S. C., Mummery, C., Colman, A., Zweigerdt, R. & Davidson, B. P. 2008. Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK. Differentiation 76, 357-370.
12. Hakuno, D., Fukuda, K., Makino, S., Konishi, F., Tomita, Y., Manabe, T., Suzuki, Y., Umezawa, A. & Ogawa, S. 2002. Bone marrow-derived regenerated cardiomyocytes (CMG Cells) express functional adrenergic and muscarinic receptors. Circulation 105, 380-386.
13. Kassel, K. M., Wyatt, T. A., Panettieri Jr, R. A. & Toews, M. L. 2008. Inhibition of human airway smooth muscle cell proliferation by beta 2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvement. Am. J. Physiol. Lung Cell. Mol. Physiol. 294, L131-L138.
14. Klug, S., Thiel, R., Schwabe, R., Merker, H. J. & Neubert, D. 1994. Toxicity of beta-blockers in a rat whole embryo culture: concentration-response relationships and tissue concentrations. Arch. Toxicol. 68, 375-384.
15. Li, H., Fong, C., Chen, Y., Cai, G. & Yang, M. 2010. Beta2- and beta3-, but not beta1-adrenergic receptors are involved in osteogenesis of mouse mesenchymal stem cells via cAMP/PKA signaling. Arch. Biochem. Biophys. 496, 77-83.
16. Paige, S. L., Osugi, T., Afanasiev, O. K., Pabon, L., Reinecke, H. & Murry, C. E. 2010. Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells. PLoS ONE 5, e11134.
17. Reppel, M., Boettinger, C. & Hescheler, J. 2004. Beta-adrenergic and muscarinic modulation of human embryonic stem cell-derived cardiomyocytes. Cell Physiol. Biochem. 14, 187-196.
18. Rohrer, D. K., Desai, K. H., Jasper, J. R., Stevens, M. E., Regula Jr, D. P., Barsh, G. S., Bernstein, D. & Kobilka, B. K. 1996. Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects. Proc. Natl Acad. Sci. USA 93, 7375-7380.
19. Srivastava, S., Chandrasekar, B., Gu, Y., Luo, J., Hamid, T., Hill, B. G. & Prabhu, S. D. 2007. Downregulation of CuZn-superoxide dismutase contributes to beta-adrenergic receptor-mediated oxidative stress in the heart. Cardiovasc. Res. 74, 445-455.
20. Taha, M. F., Valojerdi, M. R. & Mowla, S. J. 2007. Effect of bone morphogenetic protein-4 (BMP-4) on cardiomyocyte differentiation from mouse embryonic stem cell. Int. J. Cardiol. 120, 92-101.
21. Tseng, Y. T., Kopel, R., Stabila, J. P., McGonnigal, B. G., Nguyen, T. T., Gruppuso, P. A. & Padbury, J. F. 2001. Beta-adrenergic receptors (betaAR) regulate cardiomyocyte proliferation during early postnatal life. FASEB J. 15, 1921-1926.
22. Wang, Y. 2007. Mitogen-activated protein kinases in heart development and diseases. Circulation 116, 1413-1423.
23. Wobus, A. M., Guan, K., Yang, H. T. & Boheler, K. R. 2002. Embryonic stem cells as a model to study cardiac, skeletal muscle, and vascular smooth muscle cell differentiation. Methods Mol. Biol. 185, 127-156.
24. Yang, H., Zhang, Y., Liu, Z., Chen, P., Ma, K. & Zhou, C. 2008. Mouse embryonic stem cell-derived cardiomyocytes express functional adrenoceptors. Biochem. Biophys. Res. Commun. 368, 887-892.