Sustained release optimized formulation of anastrozole-loaded chitosan microspheres: In vitro and in vivo evaluation

Journal of Materials Science: Materials in Medicine

Volumn 22, Issue 4, 2011, Pages 865-878

  Shavi, Gopal V ^a   Nayak, Usha Y ^a   Sreenivasa Reddy, M ^a   Karthik, A ^a   Deshpande, Praful B ^a   Ranjith Kumar, A ^b   Udupa, N ^a  

^a MANIPAL COLLEGE OF PHARMACEUTICAL SCIENCES   (India)

^b SOUTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER; CHEMICAL INTERACTIONS; CHITOSAN MICROSPHERES; CORRELATION COEFFICIENT; CROSS LINKING AGENTS; DIFFUSION CONTROLLED MECHANISM; DRUG RELEASE; ENCAPSULATION EFFICIENCY; FTIR ANALYSIS; GLUTARALDEHYDES; HIGUCHI MODEL; IN-VITRO; MEAN PARTICLE SIZE; PHARMACOKINETIC PARAMETERS; PHOSPHATE BUFFERS; RAT PLASMA; REVERSE PHASE HPLC; SEM ANALYSIS; SLOW RELEASE; SUSTAINED RELEASE; SWELLING CAPACITIES; TRIPOLYPHOSPHATES;

ALDEHYDES; BODY FLUIDS; CHEMICAL ANALYSIS; CHITOSAN; CROSSLINKING; DRUG INTERACTIONS; DRUG PRODUCTS; EMULSIFICATION; ENCAPSULATION; EROSION; PARTICLE SIZE ANALYSIS; RATS;

MICROSPHERES;

ANASTROZOLE; CHITOSAN; GLUTARALDEHYDE; MICROSPHERE; TRIPOLYPHOSPHATE;

AREA UNDER THE CURVE; ARTICLE; BREAST CANCER; CHEMICAL INTERACTION; CONTROLLED STUDY; CROSS LINKING; DIFFERENTIAL SCANNING CALORIMETRY; DIFFUSION; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; EMULSION; EXCIPIENT COMPATIBILITY; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MICROENCAPSULATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SUSTAINED DRUG RELEASE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANTINEOPLASTIC AGENTS, HORMONAL; AREA UNDER CURVE; BREAST NEOPLASMS; CHITOSAN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; DIFFUSION; GLUTARAL; HUMANS; HYDROGEN-ION CONCENTRATION; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; NITRILES; PARTICLE SIZE; POLYMERS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TRIAZOLES;

RATTUS;

EID: 80051664113     PISSN: 09574530     EISSN: 15734838     Source Type: Journal    
DOI: 10.1007/s10856-011-4274-y     Document Type: Article

References (41)

1. Nicolini A, Giardino R, Carpi A, Ferrari P, Anselmi L, Colosimo S, Conte M, Fini M, Giavaresi G, Berti P, Miccoli P. Metastatic breast cancer: an updating. Biomed Pharmacother. 2006;60(9):548-56.
2. Thomas RJ, Williams M, Glen J, Callam M. Comparing the cost of adjuvant anastrozole with the benefits of managing less patients with relapsed breast cancer. Breast Cancer Res Treat. 2009;117(2):289-95.
3. Goss PE, Tye LM. Anastrozole: a new selective nonsteroidal aromatase inhibitor. Oncology (Williston Park). 1997;11(11):1697-703. (Pubitemid 27505666)
4. Hortobagyi GN, Buzdar AU. Anastrozole (Arimidex), a new aromatase inhibitor for advanced breast cancer: mechanism of action and role in management. Cancer Invest. 1998;16(6):385-90. (Pubitemid 128721386)
5. Wiseman LR, Adkins JC. Anastrozole. A review of its use in the management of postmenopausal women with advanced breast cancer. Drugs Aging. 1998;13(4):321-32. (Pubitemid 28493010)
6. Peter K, Vladimira S, Karol K, Gabriela N, Daniela O, Katarina A. Chemopreventive effects of anastrozole in a premenopausal breast cancer model. Anticancer Res. 2008;28:2819-24.
7. Sinha VR, Singla AK, Wadhawan S, Kaushik R, Kumaria R, Bansal K, Dhawan S. Chitosan microspheres as a potential carrier for drugs. Int J Pharm. 2004;274:1-33. (Pubitemid 38457003)
8. Philippe M, Marie-Claire V, Erik G, Jean-Paul SA, Ghassan H, Eric J, Dominique F, Gilles G, Jean-Pierre B. Local and sustained delivery of 5-fluorouracil from biodegradable microspheres for the radiosensitization of glioblastoma. A Pilot study. Cancer. 1999;86(2):325-30. (Pubitemid 29327590)
9. Yu C-Y, Zhang X-C, Zhou F-Z, Zhang X-Z, Cheng S-X, Zhuo R-X. Sustained release of antineoplastic drugs from chitosanreinforced alginate microparticle drug delivery systems. Int J Pharm. 2008;357:15-21.
10. Jameela SR, Kumary TV, Lal AV, Jayakrishnan A. Progesteroneloaded chitosan microspheres: a long acting biodegradable controlled delivery system. J Control Release. 1998;52:17-24. (Pubitemid 28123169)
11. Rowe RC, Sheskey PJ, Owen SC. Handbook of pharmaceutical excipients. 5th ed. London, UK: Pharmaceutical Press; 2006. p. 159-61.
12. Sinha VR, Singla AK, Wadhawan S, Kaushik R, Kumria R, Bansal K, Dhawan S. Chitosan microspheres as a potential carrier for drugs. Int J Pharm. 2004;274:1-33. (Pubitemid 38457003)
13. Genta I, Perugini P, Pavanetto F. Different molecular weight chitosan microspheres: influence on drug loading and drug release. Drug Dev Ind Pharm. 1998;24:779-84. (Pubitemid 28346453)
14. Yuan Y, Chesnutt BM, Utturkar G, Haggard WO, Yang Y, Ong JL, Bumgardner JD. The effect of cross-linking of chitosan microspheres with genipin on protein release. Carbohydr Polym. 2007;68:561-7. (Pubitemid 46365939)
15. Hiriyanna SG, Basavaiah K. Isolation and characterization of process related impurities in anastrozole active pharmaceutical ingredient. J Braz Chem Soc. 2008;19(3):397-404.
16. Thanoo BC, Sunny MC, Jayakrishnan A. Crosslinked chitosan microspheres: preparation and evaluation as a matrix for the controlled release of pharmaceuticals. J Pharm Pharmacol. 1992;44:283-6.
17. Zidan AS, Sammour OA, Hammad MA, Megrab NA, Habib MJ, Khan MA. Process analytical technology: non-destructive assessment of anastrozole entrapment within PLGA microparticles by near infrared spectroscopy and chemical imaging. J Microencapsul. 2008;25(3):145-53.
18. Patil SB, Murthy RSR. Preparation and In vitro evaluation of mucoadhesive chitosan microspheres of amlodipine besylate for nasal administration. Indian J Pharm Sci. 2006;68(1):64-7.
19. Akbuga J, Bergiseadi N. Effect of formulation variables on cisplatin loaded chitosan microsphere properties. J Microencapsul. 1999;16(6):697-703. (Pubitemid 29478949)
20. Akbuga J, Bergisadi N. 5-Fluorouracil-loaded chitosan microspheres: preparation and release characteristics. J Microencapsul. 1996;13:161-8. (Pubitemid 26121877)
21. Nayak UY, Gopal VS, Mutalik S, Ranjith AK, Reddy MS, Gupta P, Udupa N. Glutaraldehyde cross-linked chitosan microspheres for controlled delivery of Zidovudine. J Microencapsul. 2008;24:1-9.
22. Ritger PL, Peppas NA. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. J Control Release. 1987;5:37-42. (Pubitemid 17106644)
23. Peppas NA. Analyses of Fickian and non-Fickian drug release from polymers. Pharm Acta Helv. 1985;60:110-1.
24. Food and Drug Administration, Center for Drug Evaluation and Research, Guidance for Industry, Bioanalytical Method Validation. 2001. http://www.fda.gov/cder/guidance/4252fnl.pdf.
25. Chilukuri DM, Sunkara G, Young D. Pharmaceutical product development: in vitro-in vivo correlation. 1st ed. New York: Informa Healthcare Publishers; 2007. p. 210-24.
26. Uppoor VR. Regulatory perspectivesoninvitro (dissolution)/in vivo (bioavailability) correlations. J Control Release. 2001;72(1-3):127-32. (Pubitemid 32522350)
27. Rajesh RD, Rajesh HP. Two-stage optimization process for formulation of chitosan microspheres. AAPS PharmSciTech. 2004;5(1):Article 5.
28. Bock MJ, Bara I, LeDonne N, Martz A, Dyroff M. Validated assay for the quantification of anastrozole in human plasma by capillary gas chromatography-63Ni electron capture detection. J Chromatogr. 1997;24:131-8. (Pubitemid 27473985)
29. Nishioka Y, Kyotani S, Okamura M, Miyazaki M, Okazaki K, Ohnishi S, Yamamoto Y, Ito K. Release characteristics of cisplatin chitosan microspheres and effect of containing chitin. Chem Pharm Bull (Tokyo). 1990;38:2871-3. (Pubitemid 20386072)
30. FDA. Center for Drug Evaluation and Research, Guidance for Industry. 1997. http://www.fda.gov/downloads/Drugs/ GuidanceComplianceRegulatoryInformation/Guidances/ucm070237.pdf.
31. Jameela SR, Misra A, Jayakrishnan A. Cross-linked chitosan microspheres as carriers for prolonged delivery of macromolecular drugs. J Biomater Sci. 1994;6(7):621-32.
32. Ahmed SZ, Omaima AS, Mohammed AH, Nagia AM, Muhammad DH, Mansoor AK, Muhammad JH. Formulation of anastrozole microparticles as biodegradable anticancer drug carriers. AAPS PharmSciTech. 2006;7:E1-9.
33. Mareck U, Geyer H, Guddat S, Haenelt N, Koch A, Kohler M, Opfermann G, Thevis M, Schanzer W. Identification of the aromatase inhibitors anastrozole and exemestane in human urine using liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2006;20(12):1954-62. (Pubitemid 43893351)
34. Desai KGH, Park HJ. Preparation of cross-linked chitosan microspheres by spray drying: effect of cross-linking agent on the properties of spray dried microspheres. J Microencapsul. 2005;22(4):377-95. (Pubitemid 41581877)
35. Wang YM, Sato H, Adachi I, Horikoshi I. Optimization of the formulation design of chitosan microspheres containing cisplatin. J Pharm Sci. 1996;85:1204-10. (Pubitemid 26372889)
36. Kumbar SG, Kulkarni AR, Aminabhavi TM. Crosslinked chitosan microspheres for encapsulation diclofenac sodium: effect of crosslinking agent. J Microencapsul. 2002;19(2):173-80. (Pubitemid 34100610)
37. Dhawan S, Singla AK. Nifedipine loaded chitosan microspheres prepared by emulsification phase-separation. Biotech Histochem. 2003;78:243-54. (Pubitemid 38208269)
38. Berger J, Reist M, Mayer JM, Felt O, Peppas NA, Gurny R. Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications. Eur J Pharm Biopharm. 2004;57:19-34. (Pubitemid 38058801)
39. Wei W, Wang L-Y, Yuan L, Yang X-D, Su ZG, Ma G-H. Bioprocess of uniform-sized crosslinked chitosan microspheres in rats following oral administration. Eur J Pharm Biopharm. 2008;69:878-86.
40. Deshpande PB, Dandagi P, Udupa N, Gopal SV, Jain SS, Vasanth SG. Controlled release polymeric ocular delivery of acyclovir. Pharm Dev Technol. 2010;15(4):369-78.
41. Mandala Rayabandla SK, Kiran A, Aravind A, Gopal S, Udupa N, Karthik A, Prashant M, Krishnamoorthy B, Satish R, Bola S. Preparation, in vitro characterization, pharmacokinetic and pharmacodynamic evaluation of chitosan-based plumbagin microspheres in mice bearing B16F1 melanoma. Drug Deliv. 2010;17(3):103-13.