Identification of the aromatase inhibitors anastrozole and exemestane in human urine using liquid chromatography/tandem mass spectrometry

Rapid Communications in Mass Spectrometry

Volumn 20, Issue 12, 2006, Pages 1954-1962

  Mareck, Ute ^a   Geyer, Hans ^a   Guddat, Sven ^a   Haenelt, Nadine ^a   Koch, Anja ^a   Kohler, Maxie ^a   Opfermann, Georg ^a   Thevis, Mario ^a   Schänzer, Wilhelm ^a  

^a GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; DISEASES; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

ADVERSE EFFECT; AROMATASE INHIBITORS; BREAST CANCER; DETECTION SYSTEM; HUMAN URINE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; POSTMENOPAUSAL WOMEN; TESTOSTERONE; URINE SAMPLE;

ENZYMATIC HYDROLYSIS;

EID: 33745157551     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.2545     Document Type: Article

References (32)

1. Lombardi P. Biochim. Biophys. Acta 2002; 1587: 326.
2. Raman JD, Schlegel PN. J. Urol. 2002; 167: 624.
3. Clinical Trial. Decreased testosterone levels in men over 65. Available: http://www.clinicaltrials.gov/ct/ show/NCT00104572?order=18 (online 15.3.05).
4. ICI Pakistan Limited. Pharmaceutical and Animal Health - Arimidex. Available: http://www.ici.com.pk/html/ products/pharma:arimidex.html (online 25.06.02).
5. Lonning PE. Breast Cancer Res. Treat. 1998; 49: 45.
6. Mauras N, O'Brien KO, Hayes V. J. Clin. Endocrinol. Metab. 2000; 85: 2370.
7. Mauras N, Lima J, Patel D, Rini A, di Salle E, Kwok A, Lippe B. J. Clin. Endocrinol. Metab. 2003; 88: 5951.
8. Fachinformation: Aromasin. Available: http://www. aromasin.ch/deutsch/ fachinfo.html (online 27.01.2005).
9. Produktinformation: Exemestan. Available: http:// www.deutscher- apotheker-verlag.de/cgi-bin/daz/show. cgi?show=intern/na/2000/05na_189. html&words= exemestan (online 27.01.2005).
10. Grimm SW, Dyroff MC. Drug Metabol. Dispos. 1997; 25: 598.
11. Dowsett M, Lonning PE. Oncology 1997; 54: 11.
12. Plourde PV, Dyroff M, Dukes M. Breast Cancer Res. Treat. 1994; 30: 103.
13. Plourde PV, Dyroff M, Dowsett M, Demers L, Yates R, Webster A. J. Steroid Biochem. Mol. Biol. 1995; 53: 175.
14. Roberts B. Meso-Rx: anabolic-androgenic steroid education. Anastrozole (Arimidex). Available: http://www.mesomorphis. com/steroid-profiles/arimides. html (online 27.3.03).
15. World Anti-Doping Agency: The World Anti-Doping Code. The 2006 Prohibited List. International Standard. Available: http://www.wada-ama.org/rtecontent/ document/2006_LIST.pdf (online 02.01.06).
16. Mareck-Engelke U, Sigmund G, Opfermann G, Geyer H, Schänzer W. Screening for tamoxifen, clomiphene and cyclofenil in doping analysis. In Recent Advances in Doping Analysis, vol. 9, Schänzer W, Geyer H, Gotzmann A, Mareck-Engelke U (eds). Sport und Buch Strauß: Cologne, 2001; 53-62.
17. Mareck U, Sigmund G, Opfermann G, Geyer H, Schänzer W. Rapid Commun. Mass Spectrom. 2002; 16: 2209.
18. Mareck U, Sigmund G, Opfermann G, Geyer H, Thevis M, Schänzer W. Rapid Commun. Mass Spectrom. 2005; 19: 3689.
19. Allievi C, Zugnoni P, Strolin Benedetti M, Dorstert P. J. Mass Spectrom. 1995; 30: 693.
20. Cenacchi V, Barattè S, Cicioni P, Frigerio E, Long J, James C. J. Pharm. Biomed. Anal. 2000; 22: 451.
21. Bock MJ, Bara I, LeDonne N, Martz A, Dyroff M. J. Chromatogr. B Biomed. Sci. Appl. 1997; 24: 131.
22. Yuan J, Wang PQ, Ge SR, An FR, Shi AG, Chen J, Liang JY. Acta Pharmakol. Sin. 2001; 22: 573.
23. Duan G, Liang J, Zuo M. Biomed. Chromatogr. 2002; 16: 400.
24. Schänzer W, Donike M. Synthesis of deuterated steroids for GC/MS quantification of endogenous steroids. In Recent Advances in Doping Analysis, vol. 2, Donike M, Geyer H, Gotzmann A, Mareck-Engelke U (eds). Sport und Buch Strauß: Cologne, 1994; 93-112.
25. Thevis M, Opfermann G, Schmickler H, Schänzer W. J. Mass Spectrom. 2001; 36: 159.
26. Donike M, Geyer H, Gotzmann A, Kraft M, Mandel F, Nolteernsting E, Opfermann G, Sigmund G, Schänzer W, Zimmermann J. Dope analysis. In Official Proceedings of the International Athletic Foundation World Symposium on Doping in Sport, Bellotti P, Benzi G, Ljungquist A (eds). IAAF: Florence, 1988; 53-87.
27. Geyer H, Schänzer W, Mareck-Engelke U, Nolternsting E, Opfermann G. Screening procedure for anabolic steroids - the control of the hydrolysis with deuterated androsterone glucuronide and studies with direct hydrolysis. In Recent Advances in Doping Analysis, vol. 5, Schänzer W, Geyer H, Gotzmann A, Mareck-Engelke U (eds). Sport und Buch Strauß: Cologne, 1998; 99-101.
28. Mareck U, Thevis M, Guddat S, Gotzmann A, Bredehöft M, Geyer H, Schänzer W. Comprehensive sample preparation for anabolic steroids, glucocorticsteroids, beta-receptor blocking agents, selected anabolic androgenic steroids and buprenorphine in human urine. In Recent Advances in Doping Analysis, vol. 12, Schänzer W, Geyer H, Gotzmann A, Mareck U (eds). Sport und Buch Strauß: Cologne, 2004; 65-68.
29. Kromidas S. Validierung in der Analytik. Wiley-VCH: Weinheim, 1999.
30. Geyer H, Mareck-Engelke U, Schänzer W, Donike M. Simple purification of urine samples for improved detection of anabolic and endogenous steroids. In Recent Advances in Doping Analysis, vol. 1, Donike M, Geyer H, Gotzmann A, Mareck-Engelke U, Rauth S (eds). Sport und Buch Strauß: Cologne, 1993; 97-103.
31. Mareck-Engelke U, Geyer H, Schänzer W. 19-Norandrosterone - criteria for the decision making process. In Recent Advances in Doping Analysis, vol. 6, Schänzer W, Geyer H, Gotzmann A, Mareck-Engelke U (eds). Sport und Buch Strauß: Cologne, 1998; 119-129.
32. Thevis M, Schänzer W. J. Am. Soc. Mass Spectrom. 2005; 16: 1660.