Allopurinol: A new anti-ischemic role for an old drug

Journal of the American College of Cardiology

Volumn 58, Issue 8, 2011, Pages 829-830

  Stone, Peter H ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

allopurinol; endothelial dysfunction; vascular oxidative stress; xanthine oxidase

Indexed keywords

ALLOPURINOL; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIANGINA PECTORIS AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; NICORANDIL; NITRATE; PLACEBO; RANOLAZINE; TRIMETAZIDINE;

BLOOD PRESSURE; DRUG HYPERSENSITIVITY; DRUG MEGADOSE; EXERCISE; GOUT; HEART MUSCLE BLOOD FLOW; HEART MUSCLE CONTRACTILITY; HEART MUSCLE METABOLISM; HEART RATE; HUMAN; ISCHEMIC HEART DISEASE; NOTE; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SKIN DISEASE; STABLE ANGINA PECTORIS; STEVENS JOHNSON SYNDROME; SYSTOLIC BLOOD PRESSURE; TOXIC EPIDERMAL NECROLYSIS; UNSPECIFIED SIDE EFFECT;

EID: 80051657256     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2011.02.072     Document Type: Editorial

References (18)

1. J. Abrams Clinical practice Chronic stable angina N Engl J Med 352 2005 2524 2533 (Pubitemid 41007868)
2. S. Epstein, D.R. Redwood, and R.E. Goldstein Angina pectoris: pathophysiology, evaluation, and treatment Ann Intern Med 75 1971 263 296
3. P.H. Stone, B.R. Chaitman, and K. Stocke The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease J Am Coll Cardiol 56 2010 934 942
4. A. MacInnes, D.A. Fairman, and P. Binding The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase Circ Res 93 2003 e26 e32
5. D. Simpson, and K. Wellington Nicorandil: a review of its use in the management of stable angina pectoris, including high-risk patients Drugs 64 2004 1941 1955 (Pubitemid 39263662)
6. S. Spiekermann, U. Landmesser, and S. Dikalov Electron spin resonance characterization of vascular xanthine and NAD(P)H oxidase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation Circulation 107 2003 1383 1389 (Pubitemid 36350736)
7. P. Higgins, J. Dawson, and M. Walters The potential for xanthine oxidase inhibition in the prevention and treatment of cardiovascular and cerebrovascular disease Cardiovasc Psychiatry Neurol 2009 2009 282059
8. L.B. Stull, M.K. Leppo, and L. Szweda Chronic treatment with allopurinol boosts survival and cardiac contractility in murine postischemic cardiomyopathy Circ Res 95 2004 1005 1011 (Pubitemid 39534412)
9. J. George, E. Carr, J. Davies, J.J. Belch, and A. Struthers High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid Circulation 114 2006 2508 2516 (Pubitemid 44901524)
10. 2+ -sensitizing property of xanthine oxidase inhibitors Circ Res 83 1998 423 430 (Pubitemid 28389972)
11. T.P. Cappola, D.A. Kass, and G.S. Nelson Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy Circulation 104 2001 2407 2411 (Pubitemid 33108372)
12. U.E. Ekelund, R.W. Harrison, and O. Shokek Intravenous allopurinol decreases myocardial oxygen consumption and increases mechanical efficiency in dogs with pacing-induced heart failure Circ Res 85 1999 437 445 (Pubitemid 29409620)
13. J.M. Hare, B. Mangal, and J. Brown Impact of oxypurinol in patients with symptomatic heart failure Results of the OPT-CHF study J Am Coll Cardiol 51 2008 2301 2309 (Pubitemid 351783365)
14. J. George, and A. Struthers The OPT-CHF (Oxypurinol Therapy for Congestive Heart Failure) trial: a question of dose J Am Coll Cardiol 53 2009 2405
15. S. Baldus, R. Koster, and P. Chumley Oxypurinol improves coronary and peripheral endothelial function in patients with coronary artery disease Free Radic Biol Med 39 2005 1184 1190 (Pubitemid 41407712)
16. A. Noman, D.S. Ang, and S. Ogston Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial Lancet 375 2010 2161 2167
17. N.S. Rajendra, S. Ireland, J. George, J.J.F. Belch, C.C. Lang, and A.D. Struthers Mechanistic insights into the therapeutic use of high-dose allopurinol in angina pectoris J Am Coll Cardiol 58 2011 820 828
18. K.R. Hande, R.M. Noone, and W.J. Stone Severe allopurinol toxicity Description and guidelines for prevention in patients with renal insufficiency Am J Med 76 1984 47 56 (Pubitemid 14216359)