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Volumn 6, Issue 1, 2011, Pages 53-59

Rehabilitating a brain with Alzheimer's: A proposal

Author keywords

Alzheimer; Drugs; Rehabilitation

Indexed keywords

CATECHIN; DONEPEZIL; FOLIC ACID; GALANTAMINE; GINKGO BILOBA EXTRACT; MEMANTINE; NIMESULIDE; OMEGA 3 FATTY ACID; RESVERATROL; RIVASTIGMINE; TACRINE; NOOTROPIC AGENT; VITAMIN;

EID: 80051646406     PISSN: 11769092     EISSN: 11781998     Source Type: Journal    
DOI: 10.2147/CIA.S14008     Document Type: Review
Times cited : (13)

References (52)
  • 1
    • 0034673009 scopus 로고    scopus 로고
    • Genetics and Alzheimer's disease
    • Perez-Tur J. Genetics and Alzheimer's disease. Rev Neurol. 2000;30:161-169.
    • (2000) Rev Neurol , vol.30 , pp. 161-169
    • Perez-Tur, J.1
  • 2
    • 0031716075 scopus 로고    scopus 로고
    • Classification of mitochondrial diseases
    • Lopez de Munain A. Classification of mitochondrial diseases. Rev Neurol. 1998;26 Suppl 1:S9-S14.
    • (1998) Rev Neurol , vol.26 , Issue.SUPPL. 1
    • Lopez de Munain, A.1
  • 3
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy J, Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci. 1991;12:383-388.
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 4
    • 0027195933 scopus 로고
    • Seeding "one-dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
    • Jarrett JT, Lansbury PTJ. Seeding "one-dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie? Cell. 1993;73:1055-1058.
    • (1993) Cell , vol.73 , pp. 1055-1058
    • Jarrett, J.T.1    Lansbury, P.T.J.2
  • 5
    • 33845236399 scopus 로고    scopus 로고
    • BACE1 modulates myelination in the central and peripheral nervous system
    • Hu X, Hicks CW, He W, et al. BACE1 modulates myelination in the central and peripheral nervous system. Nat Neurosci. 2006;9:1520-1525.
    • (2006) Nat Neurosci , vol.9 , pp. 1520-1525
    • Hu, X.1    Hicks, C.W.2    He, W.3
  • 6
    • 63949088562 scopus 로고    scopus 로고
    • Function, regulation and therapeutic properties of beta-secretase (BACE1)
    • Willem M, Lammich S, Haass C. Function, regulation and therapeutic properties of beta-secretase (BACE1). Semin Cell Dev Biol. 2009;20:175-182.
    • (2009) Semin Cell Dev Biol , vol.20 , pp. 175-182
    • Willem, M.1    Lammich, S.2    Haass, C.3
  • 7
    • 33646195986 scopus 로고    scopus 로고
    • Loss of nicastrin elicits an apoptotic phenotype in mouse embryos
    • Nguyen V, Hawkins C, Bergeron C, et al. Loss of nicastrin elicits an apoptotic phenotype in mouse embryos. Brain Res. 2006;1086:76-84.
    • (2006) Brain Res , vol.1086 , pp. 76-84
    • Nguyen, V.1    Hawkins, C.2    Bergeron, C.3
  • 8
    • 71549133049 scopus 로고    scopus 로고
    • Can we do better in developing new drugs for Alzheimer's disease?
    • Gauthier S, Scheltens P. Can we do better in developing new drugs for Alzheimer's disease? Alzheimers Dement. 2009;5:489-491.
    • (2009) Alzheimers Dement , vol.5 , pp. 489-491
    • Gauthier, S.1    Scheltens, P.2
  • 10
    • 38449122934 scopus 로고    scopus 로고
    • Tacrine-induced liver damage: An analysis of 19 candidate genes
    • Alfirevic A, Mills T, Carr D, et al. Tacrine-induced liver damage: An analysis of 19 candidate genes. Pharmacogenet Genomics. 2007;17:1091-1100.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 1091-1100
    • Alfirevic, A.1    Mills, T.2    Carr, D.3
  • 11
    • 66349111984 scopus 로고    scopus 로고
    • Donepezil in the treatment of patients with Alzheimer's disease
    • Tsuno N. Donepezil in the treatment of patients with Alzheimer's disease. Expert Rev Neurother. 2009;9:591-598.
    • (2009) Expert Rev Neurother , vol.9 , pp. 591-598
    • Tsuno, N.1
  • 12
    • 68149089518 scopus 로고    scopus 로고
    • Donepezil in severe Alzheimer's disease
    • Winblad B. Donepezil in severe Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2009;24:185-192.
    • (2009) Am J Alzheimers Dis Other Demen , vol.24 , pp. 185-192
    • Winblad, B.1
  • 15
    • 63349094728 scopus 로고    scopus 로고
    • Galantamine inhibits betaamyloid aggregation and cytotoxicity
    • Matharu B, Gibson G, Parsons R, et al. Galantamine inhibits betaamyloid aggregation and cytotoxicity. J Neurol Sci. 2009;280:49-58.
    • (2009) J Neurol Sci , vol.280 , pp. 49-58
    • Matharu, B.1    Gibson, G.2    Parsons, R.3
  • 16
    • 59149090400 scopus 로고    scopus 로고
    • Galantamine protects against oxidative stress induced by amyloid-beta peptide in cortical neurons
    • Melo JB, Sousa C, Garcao P, Oliveira CR, Agostinho P. Galantamine protects against oxidative stress induced by amyloid-beta peptide in cortical neurons. Eur J Neurosci. 2009;29:455-464.
    • (2009) Eur J Neurosci , vol.29 , pp. 455-464
    • Melo, J.B.1    Sousa, C.2    Garcao, P.3    Oliveira, C.R.4    Agostinho, P.5
  • 17
    • 76149120867 scopus 로고    scopus 로고
    • Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice
    • Martinez-Coria H, Green KN, Billings LM, et al. Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice. Am J Pathol. 2010;176:870-880.
    • (2010) Am J Pathol , vol.176 , pp. 870-880
    • Martinez-Coria, H.1    Green, K.N.2    Billings, L.M.3
  • 18
    • 0033566628 scopus 로고    scopus 로고
    • Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells
    • Aranda-Abreu GE, Behar L, Chung S, Furneaux H, Ginzburg I. Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells. J Neurosci. 1999;19:6907-6917.
    • (1999) J Neurosci , vol.19 , pp. 6907-6917
    • Aranda-Abreu, G.E.1    Behar, L.2    Chung, S.3    Furneaux, H.4    Ginzburg, I.5
  • 19
    • 0035448939 scopus 로고    scopus 로고
    • Axonal tau mRNA localization coincides with tau protein in living neuronal cells and depends on axonal targeting signal
    • Aronov S, Aranda G, Behar L, Ginzburg I. Axonal tau mRNA localization coincides with tau protein in living neuronal cells and depends on axonal targeting signal. J Neurosci. 2001;21:6577-6587.
    • (2001) J Neurosci , vol.21 , pp. 6577-6587
    • Aronov, S.1    Aranda, G.2    Behar, L.3    Ginzburg, I.4
  • 20
    • 39449138356 scopus 로고    scopus 로고
    • Tau inhibits anterograde axonal transport and perturbs stability in growing axonal neurites in part by displacing kinesin cargo: Neurofilaments attenuate tau-mediated neurite instability
    • Dubey M, Chaudhury P, Kabiru H, Shea TB. Tau inhibits anterograde axonal transport and perturbs stability in growing axonal neurites in part by displacing kinesin cargo: Neurofilaments attenuate tau-mediated neurite instability. Cell Motil Cytoskeleton. 2008;65:89-99.
    • (2008) Cell Motil Cytoskeleton , vol.65 , pp. 89-99
    • Dubey, M.1    Chaudhury, P.2    Kabiru, H.3    Shea, T.B.4
  • 21
    • 62349133507 scopus 로고    scopus 로고
    • Tau aggregation in Alzheimer's disease: What role for phosphorylation?
    • Lippens G, Sillen A, Landrieu I, et al. Tau aggregation in Alzheimer's disease: What role for phosphorylation? Prion. 2007;1:21-25.
    • (2007) Prion , vol.1 , pp. 21-25
    • Lippens, G.1    Sillen, A.2    Landrieu, I.3
  • 22
    • 0027296559 scopus 로고
    • Dietary N-3 fatty acids inhibit ischaemic and excitotoxic brain damage in the rat
    • Relton JK, Strijbos PJ, Cooper AL, Rothwell NJ. Dietary N-3 fatty acids inhibit ischaemic and excitotoxic brain damage in the rat. Brain Res Bull. 1993;32:223-226.
    • (1993) Brain Res Bull , vol.32 , pp. 223-226
    • Relton, J.K.1    Strijbos, P.J.2    Cooper, A.L.3    Rothwell, N.J.4
  • 23
    • 0038653431 scopus 로고    scopus 로고
    • Dietary (n-3) polyunsaturated fatty acids remodel mouse T-cell lipid rafts
    • Fan YY, McMurray DN, Ly LH, Chapkin RS. Dietary (n-3) polyunsaturated fatty acids remodel mouse T-cell lipid rafts. J Nutr. 2003;133:1913-1920.
    • (2003) J Nutr , vol.133 , pp. 1913-1920
    • Fan, Y.Y.1    McMurray, D.N.2    Ly, L.H.3    Chapkin, R.S.4
  • 25
    • 0037996880 scopus 로고    scopus 로고
    • Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability
    • Hering H, Lin CC, Sheng M. Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability. J Neurosci. 2003;23:3262-3271.
    • (2003) J Neurosci , vol.23 , pp. 3262-3271
    • Hering, H.1    Lin, C.C.2    Sheng, M.3
  • 28
    • 77950337738 scopus 로고    scopus 로고
    • Oxidative stress resistance in hippocampal cells is associated with altered membrane fluidity and enhanced nonamyloidogenic cleavage of endogenous amyloid precursor protein
    • Clement AB, Gimpl G, Behl C. Oxidative stress resistance in hippocampal cells is associated with altered membrane fluidity and enhanced nonamyloidogenic cleavage of endogenous amyloid precursor protein. Free Radic Biol Med. 2010;48:1236-1241.
    • (2010) Free Radic Biol Med , vol.48 , pp. 1236-1241
    • Clement, A.B.1    Gimpl, G.2    Behl, C.3
  • 29
    • 67650729973 scopus 로고    scopus 로고
    • Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: Suppression by omega-3 fatty acids and curcumin
    • Ma QL, Yang F, Rosario ER, et al. Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J Neurosci. 2009;29:9078-9089.
    • (2009) J Neurosci , vol.29 , pp. 9078-9089
    • Ma, Q.L.1    Yang, F.2    Rosario, E.R.3
  • 30
    • 80755145058 scopus 로고    scopus 로고
    • Structural basis for the differential effects of omega-3 and omega-6 fatty acids on Abeta production and amyloid plaques
    • Oct 22. [Epub ahead of print]
    • Amtul Z, Uhrig M, Rozmahel RF, Beyreuther K. Structural basis for the differential effects of omega-3 and omega-6 fatty acids on Abeta production and amyloid plaques. J Biol Chem. 2010 Oct 22. [Epub ahead of print].
    • (2010) J Biol Chem
    • Amtul, Z.1    Uhrig, M.2    Rozmahel, R.F.3    Beyreuther, K.4
  • 31
    • 38949158786 scopus 로고    scopus 로고
    • Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells
    • Wang JW, David DJ, Monckton JE, Battaglia F, Hen R. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci. 2008;28:1374-1384.
    • (2008) J Neurosci , vol.28 , pp. 1374-1384
    • Wang, J.W.1    David, D.J.2    Monckton, J.E.3    Battaglia, F.4    Hen, R.5
  • 32
    • 77949523855 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitors potentiate the rapid antidepressant-like effects of serotonin4 receptor agonists in the rat
    • Lucas G, Du J, Romeas T, et al. Selective serotonin reuptake inhibitors potentiate the rapid antidepressant-like effects of serotonin4 receptor agonists in the rat. PLoS One. 2010;5:e9253.
    • (2010) PLoS One , vol.5
    • Lucas, G.1    Du, J.2    Romeas, T.3
  • 33
    • 65649150326 scopus 로고    scopus 로고
    • Folic acid, neurodegenerative and neuropsychiatric disease
    • Kronenberg G, Colla M, Endres M. Folic acid, neurodegenerative and neuropsychiatric disease. Curr Mol Med. 2009;9:315-323.
    • (2009) Curr Mol Med , vol.9 , pp. 315-323
    • Kronenberg, G.1    Colla, M.2    Endres, M.3
  • 34
    • 0031788259 scopus 로고    scopus 로고
    • The efficacy of Ginkgo biloba on cognitive function in Alzheimer's disease
    • Oken BS, Storzbach DM, Kaye JA. The efficacy of Ginkgo biloba on cognitive function in Alzheimer's disease. Arch Neurol. 1998;55:1409-1415.
    • (1998) Arch Neurol , vol.55 , pp. 1409-1415
    • Oken, B.S.1    Storzbach, D.M.2    Kaye, J.A.3
  • 35
    • 0034122940 scopus 로고    scopus 로고
    • The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: Involvement of its flavonoid constituents and protein kinase C
    • Bastianetto S, Zheng WH, Quirion R. The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: Involvement of its flavonoid constituents and protein kinase C. J Neurochem. 2000;74:2268-2277.
    • (2000) J Neurochem , vol.74 , pp. 2268-2277
    • Bastianetto, S.1    Zheng, W.H.2    Quirion, R.3
  • 36
    • 0036084541 scopus 로고    scopus 로고
    • Antioxidant strategies for Alzheimer's disease
    • Grundman M, Grundman M, Delaney P. Antioxidant strategies for Alzheimer's disease. Proc Nutr Soc. 2002;61:191-202.
    • (2002) Proc Nutr Soc , vol.61 , pp. 191-202
    • Grundman, M.1    Grundman, M.2    Delaney, P.3
  • 37
    • 0022550514 scopus 로고
    • Preparation and definition of Ginkgo biloba extract
    • Drieu K. Preparation and definition of Ginkgo biloba extract. Presse Med. 1986;15:1455-1457.
    • (1986) Presse Med , vol.15 , pp. 1455-1457
    • Drieu, K.1
  • 38
    • 0035910374 scopus 로고    scopus 로고
    • The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from beta-amyloid-induced cell death by inhibiting the formation of beta-amyloid-derived diffusible neurotoxic ligands
    • Yao Z, Drieu K, Papadopoulos V. The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from beta-amyloid-induced cell death by inhibiting the formation of beta-amyloid-derived diffusible neurotoxic ligands. Brain Res. 2001;889:181-190.
    • (2001) Brain Res , vol.889 , pp. 181-190
    • Yao, Z.1    Drieu, K.2    Papadopoulos, V.3
  • 39
    • 33845220134 scopus 로고    scopus 로고
    • Protection by EGb 761 against beta-amyloid-induced neurotoxicity: Involvement of NF-kappaB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation
    • Longpre F, Garneau P, Christen Y, Ramassamy C. Protection by EGb 761 against beta-amyloid-induced neurotoxicity: Involvement of NF-kappaB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation. Free Radic Biol Med. 2006;41:1781-1794.
    • (2006) Free Radic Biol Med , vol.41 , pp. 1781-1794
    • Longpre, F.1    Garneau, P.2    Christen, Y.3    Ramassamy, C.4
  • 40
    • 0034901818 scopus 로고    scopus 로고
    • Grape extract, resveratrol, and its analogs: A review
    • Sovak M. Grape extract, resveratrol, and its analogs: A review. J Med Food. 2001;4:93-105.
    • (2001) J Med Food , vol.4 , pp. 93-105
    • Sovak, M.1
  • 41
    • 0142195765 scopus 로고    scopus 로고
    • Synergistic protection of PC12 cells from beta-amyloid toxicity by resveratrol and catechin
    • Conte A, Pellegrini S, Tagliazucchi D. Synergistic protection of PC12 cells from beta-amyloid toxicity by resveratrol and catechin. Brain Res Bull. 2003;62:29-38.
    • (2003) Brain Res Bull , vol.62 , pp. 29-38
    • Conte, A.1    Pellegrini, S.2    Tagliazucchi, D.3
  • 42
    • 56349157854 scopus 로고    scopus 로고
    • Benefits from dietary polyphenols for brain aging and Alzheimer's disease
    • Rossi L, Mazzitelli S, Arciello M, Capo CR, Rotilio G. Benefits from dietary polyphenols for brain aging and Alzheimer's disease. Neurochem Res. 2008;33:2390-2400.
    • (2008) Neurochem Res , vol.33 , pp. 2390-2400
    • Rossi, L.1    Mazzitelli, S.2    Arciello, M.3    Capo, C.R.4    Rotilio, G.5
  • 43
    • 0034089991 scopus 로고    scopus 로고
    • Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: Implication in Alzheimer's disease
    • Scali C, Prosperi C, Vannucchi MG, Pepeu G, Casamenti F. Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: Implication in Alzheimer's disease. Eur J Neurosci. 2000;12:1900-1912.
    • (2000) Eur J Neurosci , vol.12 , pp. 1900-1912
    • Scali, C.1    Prosperi, C.2    Vannucchi, M.G.3    Pepeu, G.4    Casamenti, F.5
  • 44
    • 0037174843 scopus 로고    scopus 로고
    • Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia
    • Candelario-Jalil E, Alvarez D, Gonzalez-Falcon A, et al. Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia. Eur J Pharmacol. 2002;453:189-195.
    • (2002) Eur J Pharmacol , vol.453 , pp. 189-195
    • Candelario-Jalil, E.1    Alvarez, D.2    Gonzalez-Falcon, A.3
  • 45
    • 77956009908 scopus 로고    scopus 로고
    • Serotonin: A regulator of neuronal morphology and circuitry
    • Daubert EA, Condron BG. Serotonin: A regulator of neuronal morphology and circuitry. Trends Neurosci. 2010;33:424-434.
    • (2010) Trends Neurosci , vol.33 , pp. 424-434
    • Daubert, E.A.1    Condron, B.G.2
  • 46
    • 0023183875 scopus 로고
    • Evidence for a possible functional interaction between serotonergic and cholinergic mechanisms in memory retrieval
    • Altman HJ, Stone WS, Ogren SO. Evidence for a possible functional interaction between serotonergic and cholinergic mechanisms in memory retrieval. Behav Neural Biol. 1987;48:49-62.
    • (1987) Behav Neural Biol , vol.48 , pp. 49-62
    • Altman, H.J.1    Stone, W.S.2    Ogren, S.O.3
  • 47
    • 0034100397 scopus 로고    scopus 로고
    • Role of serotonin in memory impairment
    • Buhot MC, Martin S, Segu L. Role of serotonin in memory impairment. Ann Med. 2000;32:210-221.
    • (2000) Ann Med , vol.32 , pp. 210-221
    • Buhot, M.C.1    Martin, S.2    Segu, L.3
  • 48
    • 67549118802 scopus 로고    scopus 로고
    • Cross-regulation between colocalized nicotinic acetylcholine and 5-HT3 serotonin receptors on presynaptic nerve terminals
    • Dougherty JJ, Nichols RA. Cross-regulation between colocalized nicotinic acetylcholine and 5-HT3 serotonin receptors on presynaptic nerve terminals. Acta Pharmacol Sin. 2009;30:788-794.
    • (2009) Acta Pharmacol Sin , vol.30 , pp. 788-794
    • Dougherty, J.J.1    Nichols, R.A.2
  • 49
    • 84865074847 scopus 로고    scopus 로고
    • National Institutes of Health, Available from:, Accessed on January 18, 2010
    • National Institutes of Health. Alzheimer's Disease Medications. 2008. Available from: http://www.nia.nih.gov/Alzheimers/Publications/medicationsfs.htm. Accessed on January 18, 2010.
    • (2008) Alzheimer's Disease Medications
  • 50
    • 70350091259 scopus 로고    scopus 로고
    • Turbocharging the brain
    • Stix G. Turbocharging the brain. Sci Am. 2009;301:46-49.
    • (2009) Sci Am , vol.301 , pp. 46-49
    • Stix, G.1
  • 51
    • 77949886403 scopus 로고    scopus 로고
    • Assessment of cytotoxic and clastogenic effects of nimesulide: An NSAID drug in somatic cells of BALB/c mice in vivo
    • Jha AM, Abha. Assessment of cytotoxic and clastogenic effects of nimesulide: An NSAID drug in somatic cells of BALB/c mice in vivo. Drug Chem Toxicol. 2010;33:204-208.
    • (2010) Drug Chem Toxicol , vol.33 , pp. 204-208
    • Jha, A.M.1    Abha2


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