Hypothesis: Epigenetic effects will require a review of the genetics of child development

Journal of Community Genetics

Volumn 2, Issue 2, 2011, Pages 91-96

  Kosztolányi, György ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Developmental disorders; Epigenetics; Gene environment interaction; Genetics in health; Nature vs nurture

Indexed keywords

CELL DIFFERENTIATION; CHILD DEVELOPMENT; DEVELOPMENTAL DISORDER; DEVELOPMENTAL GENETICS; DNA METHYLATION; ECOLOGICAL GENETICS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PUBLIC HEALTH; REVIEW; RISK FACTOR;

EID: 80051618625     PISSN: 1868310X     EISSN: 18686001     Source Type: Journal    
DOI: 10.1007/s12687-011-0044-2     Document Type: Review

References (47)

1. Bjornsson HT, Sigurdsson ML, Fallin MD et al (2008) Intra-individual change over time in DNA methylation with familial clustering. JAMA 299:2877-2883 (Pubitemid 351930887)
2. Bollati V, Baccarelli A (2010) Environmental epigenetics. Heredity 105:105-112
3. Bonasio R, Tu S, Reinberg D (2010) Molecular signals of epigenetic states. Science 330:612-616
4. Breton CV, Byun HM, Wenten M et al (2009) Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. Am J Respir Crit Care Med 180:462-467
5. Butler D (2010) Human genome at ten: science after the sequence. Nature 465:1000-1001
6. Cavallaro S, D'Agata V, Manickam P et al (2002) Memory specific temporal profiles of gene expression int he hippocampus. Proc Natl Acad Sci 99:16279-16284 (Pubitemid 35462786)
7. Clarke A, Cooper DN (2010) GWAS: heritability missing in action? Eur J Hum Genet 18:859-861
8. Dolinay DC, Weidman JR, Jirtle RL (2007) Epigenetic gene regulation: linking early developmental environment to adult disease. Reprod Toxicol 23:297-307 (Pubitemid 46602921)
9. Feinberg AP (2007) Phenotypic plasticity and the epigenetics of human disease. Nature 447:433-440 (Pubitemid 46816750)
10. Feinberg AP, Irizarry RA (2010) Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease. Proc Natl Acad Sci 107:1757-1764
11. Flintoft L (2010) Complex disease: adding epigenetics to the mix. Nat Rev Genet 11:94-95
12. Fraga MF, Ballestar E, Paz MF et al (2005) Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci 102:10604-10609 (Pubitemid 41061601)
13. Franklin TB, Russig H, Weiss IC et al (2010) Epigenetic transmission of the impact of early stress across generations. Biol Psychiatry 68:408-415
14. Gluckman PD, Hanson MA, Cooper C, Thornburg KL (2008) Effect of in utero and early-life condition on adult health and disease. New Engl J Med 359:61-73
15. Grafodatskaya D, Chung B, Szatmari P, Weksberg R (2010) Autism spectrum disorders and epigenetics. J Am Acad Child Adolesc Psychiatr 49:794-809
16. Grant ME (2008) The epigenetic origins of mental retardation. Clin Genet 73:528-530 (Pubitemid 351663931)
17. Hall J (2007) The importance of the fetal origins of adult disease for geneticists. Clin Genet 72:67-73
18. Heijmans BT, Tobi EW, Stein AD et al (2008) Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci 105:17046-17049
19. Jirtle RL, Skinner MK (2007) Environmental epigenomics and disease susceptibility. Nat Rev Genet 8:253-262 (Pubitemid 46439287)
20. Johnstone SE, Baylin SB (2010) Stress and the epigenetic landscape: a link to the pathobiology of human diseases? Nat Rev Genet 11:806-812
21. Kargul J, Laurent GJ (2009) Epigenetics and human disease. Int J Biochem Cell Biol 41:1-1
22. Kosztolányi Gy, Cassiman J-J (2010) The medical geneticist as expert in the transgenerational and developmental aspects of diseases. Eur J Hum Genet 18:1075-1076
23. Kramer JM, van Bokhoven H (2009) Genetic and epigenetic defects in mental retardation. Int J Biochem 41:96-107
24. Lister R, Pelizzola M, Dowen RH et al (2009) Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462:315-322
25. Liu L, van Groen T, Kadish I, Tollefsbol TO (2009) DNA methylation impacts on learning and memory in aging. Neurobiol Aging 30:549-560
26. Manolio TA, Collins FS, Cox NJ et al (2009) Finding the missing heritability of complex diseases. Nature 461:747-753
27. Mark M, Rijli FM, Chambon P (1997) Homeobox genes in embryogenesis and pathogenesis. Pediatr Res 42:421-429 (Pubitemid 27411145)
28. Martinez-FriasML (2010) Can our understanding of epigenetics assist with primary prevention of congenital defects? J Med Genet 47:73-80
29. Maunakea AK, Nagarajan RP, Bilenky M et al (2010) Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature 466:253-257
30. McGowan PO, Sasaki A, D'Alessio AC et al (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12:342-348
31. Mill J, Tang T, Kaminsky Z et al (2008) Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. Am J Hum Genet 82:696-711 (Pubitemid 351726115)
32. Miller G (2010) The seductive allure of behavioral epigenetics. Science 329:24-27
33. Murgatroyd C, Patchev AV, Wu YH et al (2009) Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci 12:1559-U108
34. Peleg S, Sananbenesi F, Zovoilis A et al (2010) Altered histone acetylation is associated with age-dependent memory impairment in mice. Science 328:753-756
35. Pembrey M (2010) A decade of progress and misunderstandings. BioNews 564, 28 June 2010
36. Pembrey ME, Bygren LO, Kaati G et al (2006) Sex-specific, male-line transgenerational responses in humans. Eur J Hum Genet 14:159-166 (Pubitemid 43135858)
37. Relton CL, Smith GD (2010) Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment. PLoS Med 7(10):e100356. doi:10.1371/journal.pmed.1000356
38. Roth TL, Lubin FD, Funk AJ, Sweatt JD (2009) Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry 65:760-769
39. Skinner MK (2008) What is an epigenetic transgenerational phenotype: F3 or F2? Reprod Toxicol 25:2-6
40. Slatkin M (2009) Epigenetic inheritance and the missing heritability problem. Genetics 182:845-850
41. Thomas D (2010) Gene-environment-wide association studies: emerging approaches. Nat Rev Genet 11:259-272
42. Varmus H (2010) Ten years on-the human genome and medicine. New Engl J Med 362:2028-2029
43. Waterland RA (2009) Is epigenetics an important link between early life events and adult disease? Horm Res 71:13-16
44. Waterland RA, Dolinoy DC, Lin JR et al (2006) Maternal methyl supplements increase offspring DNA methylation at axin fused. Genesis 44:401-406 (Pubitemid 44454044)
45. Weaver ICG, Meaney MJ, Szyf M (2006) Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviours in the offspring that are reversible in adulthood. Proc Nat Acad Sci USA 103:3480-3485 (Pubitemid 43346494)
46. Xu M, Long C, Chen X et al (2010) Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly. Science 328:94-98
47. Zhang D, Cheng L, Badner JA et al (2010) Genetic control of individual differences in gene-specific methylation in human brain. Am J Hum Genet 86:411-419