Response properties of nociceptive neurons in the caudal ventrolateral medulla (CVLM) in monoarthritic and healthy control rats: Modulation of responses by the paraventricular nucleus of the hypothalamus (PVN)

Brain Research Bulletin

Volumn 86, Issue 1-2, 2011, Pages 82-90

  Pinto Ribeiro, Filipa ^a,b   Ansah, Osei B ^a   Almeida, Armando ^b   Pertovaara, Antti ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF MINHO   (Portugal)

Author keywords

Arthritic pain; Caudal ventrolateral medulla; Descending modulation; Hypothalamus

Indexed keywords

GLUTAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN REGION; CAUDAL VENTROLATERAL MEDULLA; CELL TYPE; COLD; CONTROLLED STUDY; EVOKED RESPONSE; HEAT; HYPOTHALAMUS; MALE; MONARTHRITIS; NERVE CELL EXCITABILITY; NOCICEPTION; NONHUMAN; PAIN; PARAVENTRICULAR THALAMIC NUCLEUS; PRIORITY JOURNAL; RAT; STIMULUS RESPONSE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ELECTROPHYSIOLOGY; GLUTAMIC ACID; MALE; MEDULLA OBLONGATA; MICROINJECTIONS; NOCICEPTORS; PAIN; PAIN MEASUREMENT; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, WISTAR;

EID: 80051591705     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2011.06.014     Document Type: Article

References (40)

1. Anderson R.H., Ness T.J., Gebhart G.F. A distension control device useful for quantitative studies of hollow organ sensation. Physiol. Behav. 1987, 41:635-638.
2. Ansah O.B., Pertovaara A. Peripheral suppression of arthritic pain by intraarticular fadolmidine, an α2-adrenoceptor agonist, in the rat. Anesth. Analg. 2007, 105:245-250.
3. Armario A. The hypothalamic-pituitary-adrenal axis: what can it tell us about stressors?. CNS Neurol. Disord. Drug Targets 2006, 5:485-501.
4. Condés-Lara M., Rojas-Piloni G., Martínez-Lorenzana G., Rodríguez-Jiménez J., Lopéz-Hidalgo M., Freund-Mercier M.J. Paraventricular hypothalamic influences on spinal nociceptive processing. Brain Res. 2006, 1081:126-137.
5. Condés-Lara M., Rojas-Piloni G., Martínez-Lorenzana G., Rodríguez-Jiménez J. Paraventricular hypothalamic oxytocinergic cells responding to noxious stimulation and projecting to the spinal dorsal horn represent a homeostatic analgesic mechanism. Eur. J. Neurosci. 2009, 30:1056-1063.
6. DelaTorre S., Rojas-Piloni G., Martínez-Lorenzana G., Rodríguez-Jiménez J., Villanueva L., Condés-Lara M. Paraventricular oxytocinergic hypothalamic prevention or interruption of long-term potentiation in dorsal horn nociceptive neurons: electrophysiological and behavioral evidence. Pain 2009, 144:320-328.
7. Fields H.L., Bry J., Hentall I., Zorman G. The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat. J. Neurosci. 1983, 3:2545-2552.
8. Fields H.L., Basbaum A.I., Heinricher M.M. Central nervous system mechanisms of pain modulation. Wall and Melzack's Textbook of Pain 2006, 125-142. Elsevier, China. 5th ed. S.B. McMahon, M. Koltzenburg (Eds.).
9. Foong F.W., Duggan A.W. Brain-stem areas tonically inhibiting dorsal horn neurones: studies with microinjection of the GABA analogue piperidine-4-sulphonic acid. Pain 1986, 27:361-371.
10. Gall O., Bouhassira D., Chitour D., Le Bars D. Involvement of the caudal medulla in negative feedback mechanisms triggered by spatial summation of nociceptive inputs. J. Neurophysiol. 1998, 79:304-311.
11. Gebhart G.F., Ossipov M.H. Characterization of inhibition of the spinal nociceptive tail-flick reflex in the rat from the medullary lateral reticular nucleus. J. Neurosci. 1986, 6:701-713.
12. Gonçalves L., Almeida A., Pertovaara A. Pronociceptive changes in response properties of rostroventromedial medullary neurons in a rat model of peripheral neuropathy. Eur. J. Neurosci. 2007, 26:2188-2195.
13. Hall J.G., Duggan A.W., Morton C.R., Johnson S.M. The location of brainstem neurons tonically inhibiting dorsal horn neurons of the cat. Brain Res. 1982, 244:215-222.
14. Heinricher M.M., Cheng Z., Fields H.L. Evidence for two classes of nociceptive modulating neurons in the periaqueductal gray. J. Neurosci. 1987, 7:271-278.
15. Heinricher M.M., Tavares I., Leith J.L., Lumb B.M. Descending control of nociception: specificity, recruitment and plasticity. Brain Res. Rev. 2009, 60:214-225.
16. Janss A.J., Gebhart G.F. Spinal monoaminergic receptors mediate the antinociception produced by glutamate in the medullary lateral reticular nucleus. J. Neurosci. 1987, 7:2862-2873.
17. Kawano H., Masuko S. Neurons in the caudal ventrolateral medulla projecting to the paraventricular hypothalamic nucleus receive synaptic inputs from the nucleus of the solitary tract: a light and electron microscopic double-labeling study in the rat. Neurosci. Lett. 1996, 218:33-36.
18. Krukoff T.L., Harris K.H., Linetsky E., Jhamandas J.H. Expression of c-fos protein in rat brain elicited by electrical and chemical stimulation of the hypothalamic paraventricular nucleus. Neuroendocrinology 1994, 59:590-602.
19. Le Bars D., Gozariu M., Cadden S.W. Animal models in nociception. Pharmacol. Rev. 2001, 53:597-652.
20. Lima D., Albino-Teixeira A., Tavares I. The caudal medullary ventrolateral reticular formation in nociceptive-cardiovascular integration. An experimental study in the rat. Exp. Physiol. 2002, 8(7):267-274.
21. Mansikka H., Pertovaara A. The role of alpha-2-adrenoceptors of the medullary lateral reticular nucleus in spinal antinociception in rats. Brain Res. Bull. 1995, 37:633-638.
22. Mansikka H., Idänpään-Heikkilä J.J., Pertovaara A. Different roles of alpha-2-adrenoceptors of the medulla versus the spinal cord in modulation of mustard oil-induced central hyperalgesia in rats. Eur. J. Pharmacol. 1996, 297:19-26.
23. Marques-Lopes J., Pinto M., Morato M., Patinha D., Albino-Teixeira A., Tavares I. Microinjection of angiotensin II in the caudal ventrolateral medulla induces hyperalgesia. Neuroscience 2009, 158:1301-1310.
24. Marques-Lopes J., Pinho D., Albino-Teixeira A., Tavares I. The hyperalgesic effects induced by the injection of angiotensin II into the caudal ventrolateral medulla are mediated by the pontine A5 noradrenergic cell group. Brain Res. 2010, 1325:41-52.
25. Martins I., Cabral L., Pinto A., Wilson S.P., Lima D., Tavares I. Reversal of inflammatory pain by HSV-1-mediated overexpression of enkephalin in the caudal ventrolateral medulla reverses inflammatory pain. Eur. J. Pain 2011, 10.1016/j.ejpain.2011.04.007.
26. Miki K., Zhou Q.Q., Guo W., Guan Y., Terayama R., Dubner R., Ren K. Changes in gene expression and neuronal phenotype in brain stem pain modulatory circuitry after inflammation. J. Neurophysiol. 2002, 87:750-760.
27. Montagne-Clavel J., Olivéras J.L. Are ventromedial medulla neuronal properties modified by chronic peripheral inflammation? A single-unit study in the awake, freely moving polyarthritic rat. Brain Res. 1994, 657:92-104.
28. Myers R.D. Injection of solutions into cerebral tissue: relation between volume and diffusion. Physiol. Behav. 1966, 1:171-174.
29. Ness T.J., Randich A., Gebhart G.F. Further behavioral evidence that colorectal distension is a 'noxious' visceral stimulus in rats. Neurosci. Lett. 1991, 131:113-116.
30. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 2005, Academic Press, Sydney.
31. Pinto-Ribeiro F., Ansah O.B., Almeida A., Pertovaara A. Influence of arthritis on descending modulation of nociception from the paraventricular nucleus of the hypothalamus. Brain Res. 2008, 1197:63-75.
32. Radhakrishnan R., Moore S.A., Sluka K.A. Unilateral carrageenan injection into muscle or joint induces chronic bilateral hyperalgesia in rats. Pain 2003, 104:567-577.
33. Rojas-Piloni G., Martínez-Lorenzana G., Dela Torre S., Condés-Lara M. Nociceptive spinothalamic tract and postsynaptic dorsal column neurons are modulated by paraventricular hypothalamic activation. Eur. J. Neurosci. 2008, 28:546-558.
34. Schaible H.G., Richter F., Ebersberger A., Boettger M.K., Vanegas H., Natura G., Vazquez E., Segond von Banchet G. Joint pain. Exp. Brain Res. 2009, 196:153-162.
35. Schnell C., Ulucan C., Ellrich J. Atypical on-, off- and neutral cells in the rostral ventromedial medulla oblongata in rat. Exp. Brain Res. 2002, 145:64-75.
36. Tavares I., Almeida A., Albino-Teixeira A., Lima D. Lesions of the caudal ventrolateral medulla block the hypertension-induced inhibition of noxious-evoked c-fos expression in the rat spinal cord. Eur. J. Pain 1997, 1:149-160.
37. Tavares I., Lima D., Coimbra A. The pontine A5 noradrenergic cells which project to the spinal cord dorsal horn are reciprocally connected with the caudal ventrolateral medulla in the rat. Eur. J. Neurosci. 1997, 9:2452-2461.
38. Tavares I., Lima D. The caudal ventrolateral medulla as an important inhibitory modulator of pain transmission in the spinal cord. J. Pain 2002, 3:337-346.
39. Wilcox G.L., Giesler G.J. An instrument using a multiple layer Peltier device to change skin temperature rapidly. Brain Res. Bull. 1984, 12:143-146.
40. Yirmiya R., Ben-Eliyahu S., Shavit Y., Marek P., Liebeskind J.C. Stimulation of the hypothalamic paraventricular nucleus produces analgesia not mediated by vasopressin or endogenous opioids. Brain Res. 1990, 537:169-174.