Hepatocellular carcinoma expressing cholangiocyte phenotype is a novel subtype with highly aggressive behavior

Annals of Surgical Oncology

Volumn 18, Issue 8, 2011, Pages 2210-2217

  Lu, Xin Yuan ^a   Xi, Tao ^a   Lau, Wan Yee ^a,b   Dong, Hui ^a   Zhu, Zhen ^a   Shen, Feng ^a   Wu, Meng Chao ^a   Cong, Wen Ming ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; CA 19-9 ANTIGEN; CELL ANTIBODY; CYTOKERATIN 19; MUCIN 1;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER SIZE; CANCER SURVIVAL; CHILD; CONTROLLED STUDY; DUAL PHENOTYPE HEPATOCELLULAR CARCINOMA; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PARTIAL HEPATECTOMY; PHENOTYPE; PROGNOSIS; PROTEIN BLOOD LEVEL; RETROSPECTIVE STUDY; SCHOOL CHILD;

ADOLESCENT; ADULT; AGED; ALPHA-FETOPROTEINS; CARCINOMA, HEPATOCELLULAR; CHILD; CHOLANGIOCARCINOMA; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; HEPATECTOMY; HUMANS; KERATIN-19; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PHENOTYPE; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 80051552001     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-011-1585-7     Document Type: Article

References (28)

1. Bosman FT, Carneiro F, Hruban RH, et al., editors. WHO classification of tumours of the digestive system. 4th ed. Lyon: IARC; 2010. p. 205-27.
2. DM Parkin F Bray J Ferlay, et al. 2005 Global cancer statistics, 2002 CA Cancer J Clin. 55 74 108 15761078 10.3322/canjclin.55.2.74 (Pubitemid 40372904)
3. KC Koh H Lee MS Choi, et al. 2005 Clinicopathologic features and prognosis of combined hepatocellular cholangiocarcinoma Am J Surg. 189 120 125 15701504 10.1016/j.amjsurg.2004.03.018 (Pubitemid 40215518)
4. F Zhang XP Chen W Zhang, et al. 2008 Combined hepatocellular cholangiocarcinoma originating from hepatic progenitor cells: immunohistochemical and double-fluorescence immunostaining evidence Histopathology. 52 224 232 18184271 10.1111/j.1365-2559.2007.02929.x 1:STN:280:DC%2BD1c%2Fit1aqtg%3D%3D
5. D Alvaro 2009 Serum and bile biomarkers for cholangiocarcinoma Curr Opin Gastroenterol. 25 279 284 19396965 10.1097/MOG.0b013e328325a894 1:CAS:528:DC%2BD1MXkvVGlsrc%3D
6. W Cong L Tan S Zhang, et al. 2002 Immunohistochemical spectrum in the detection and differentiation of intrahepatic neoplasms Chin J Oncol. 24 553 556
7. PC Wu JW Fang VK Lau, et al. 1996 Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers. Clinical and biological implications Am J Pathol. 149 1167 1175 8863666 1:STN:280:DyaK2s%2FhslSmsQ%3D%3D (Pubitemid 26337236)
8. SJ Ding Y Li XX Shao, et al. 2004 Proteome analysis of hepatocellular carcinoma cell strains, MHCC97-H and MHCC97-L, with different metastasis potentials Proteomics. 4 982 994 15048980 10.1002/pmic.200300653 1:CAS:528:DC%2BD2cXjt1Smt7o%3D (Pubitemid 38445958)
9. T Uenishi S Kubo T Yamamoto, et al. 2003 Cytokeratin 19 expression in hepatocellular carcinoma predicts early postoperative recurrence Cancer Sci. 94 851 857 14556657 10.1111/j.1349-7006.2003.tb01366.x 1:CAS:528: DC%2BD3sXpsFGhtL4%3D (Pubitemid 37406966)
10. T Yamamoto T Uenishi M Ogawa, et al. 2005 Immunohistologic attempt to find carcinogenesis from hepatic progenitor cell in hepatocellular carcinoma Dig Surg. 22 364 370 16374007 10.1159/000090515 1:CAS:528:DC%2BD28Xhs1Wlurk%3D
11. XR Yang Y Xu GM Shi, et al. 2008 Cytokeratin 10 and cytokeratin 19: predictive markers for poor prognosis in hepatocellular carcinoma patients after curative resection Clin Cancer Res. 14 3850 3859 18559605 10.1158/1078-0432. CCR-07-4338 1:CAS:528:DC%2BD1cXntlWrtrc%3D
12. H Kim C Park KH Han, et al. 2004 Primary liver carcinoma of intermediate (hepatocyte-cholangiocyte) phenotype J Hepatol. 40 298 304 14739102 10.1016/j.jhep.2003.10.023 1:CAS:528:DC%2BD2cXltVChsw%3D%3D (Pubitemid 38115836)
13. KH Lee YB Kim SB Cho, et al. 2009 Hepatocellular carcinoma with characteristic mucin production: a case report Cases J. 2 6789 19918544 10.4076/1757-1626-2-6789
14. A Durnez C Verslype F Nevens, et al. 2006 The clinicopathological and prognostic relevance of cytokeratin 7 and 19 expression in hepatocellular carcinoma A possible progenitor cell origin Histopathology. 49 138 151 16879391 10.1111/j.1365-2559.2006.02468.x 1:STN:280:DC%2BD28vls1KrsQ%3D%3D (Pubitemid 44079697)
15. S Aishima Y Nishihara Y Kuroda, et al. 2007 Histologic characteristics and prognostic significance in small hepatocellular carcinoma with biliary differentiation: subdivision and comparison with ordinary hepatocellular carcinoma Am J Surg Pathol. 31 783 791 17460464 10.1097/01.pas.0000213421.53750. 0a (Pubitemid 46684220)
16. SC Ward J Huang SK Tickoo SN Thung M Ladanyi DS Klimstra 2010 Fibrolamellar carcinoma of the liver exhibits immunohistochemical evidence of both hepatocyte and bile duct differentiation Mod Pathol. 23 1180 1190 20495535 10.1038/modpathol.2010.105 1:CAS:528:DC%2BC3cXhtV2hu73L
17. H Dong WL Cong ZZ Zhu, et al. 2008 Evaluation of immunohistochemical markers for differential diagnosis of hepatocellular carcinoma from intrahepatic cholangiocarcinoma Chin J Oncol. 30 702 705 1:CAS:528:DC%2BD1cXhsVGhsb3N
18. T Ichikawa T Yamamoto T Uenishi, et al. 2006 Clinicopathological implications of immunohistochemically demonstrated mucin core protein expression in hepatocellular carcinoma J Hepatobiliary Pancreat Surg. 13 245 251 16708303 10.1007/s00534-005-1070-4
19. PY Zhuang JB Zhang XD Zhu, et al. 2008 Two pathologic types of hepatocellular carcinoma with lymph node metastasis with distinct prognosis on the basis of CK19 expression in tumor Cancer. 112 2740 2748 18412155 10.1002/cncr.23488 (Pubitemid 351969219)
20. Y Yu Q Lang Z Chen, et al. 2009 The efficacy for unresectable hepatocellular carcinoma may be improved by transcatheter arterial chemoembolization in combination with a traditional Chinese herbal medicine formula: a retrospective study Cancer. 115 5132 5138 19672999 10.1002/cncr.24567
21. J Tan P Hytiroglou R Wieczorek, et al. 2002 Immunohistochemical evidence for hepatic progenitor cells in liver diseases Liver. 22 365 373 12390471 10.1034/j.1600-0676.2002.01622.x (Pubitemid 35331396)
22. HA Crosby DA Kelly AJ Strain 2001 Human hepatic stem-like cells isolated using c-kit or CD34 can differentiate into biliary epithelium Gastroenterology. 120 534 544 11159894 10.1053/gast.2001.21175 1:CAS:528:DC%2BD3MXhtlKltbs%3D (Pubitemid 32147651)
23. T Roskams 2006 Liver stem cells and their implication in hepatocellular and cholangiocarcinoma Oncogene. 25 3818 3822 16799623 10.1038/sj.onc.1209558 1:CAS:528:DC%2BD28XmtFCntLs%3D (Pubitemid 43980477)
24. M Komuta B Spee S Vander Borght, et al. 2008 Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin Hepatology. 47 1544 1556 18393293 10.1002/hep.22238 1:CAS:528: DC%2BD1cXmvVChsL0%3D (Pubitemid 351702738)
25. L Mishra T Banker J Murray, et al. 2009 Liver stem cells and hepatocellular carcinoma Hepatology. 49 318 329 19111019 10.1002/hep.22704
26. HC Fiegel S Gluer B Roth, et al. 2004 Stem-like cells in human hepatoblastoma J Histochem Cytochem. 52 1495 1501 15505344 10.1369/jhc.4A6297. 2004 1:CAS:528:DC%2BD2cXhtVWgs7bI (Pubitemid 39518685)
27. C Liu J Wang QJ Ou 2004 Possible stem cell origin of human cholangiocarcinoma World J Gastroenterol. 10 3374 3376 15484322 (Pubitemid 39585486)
28. SC Ward SN Thung KH Lim, et al. 2010 Hepatic progenitor cells in liver cancers from Asian children Liver Int. 30 102 111 19793197 10.1111/j.1478-3231. 2009.02126.x