Clinicopathological implications of immunohistochemically demonstrated mucin core protein expression in hepatocellular carcinoma

Journal of Hepato-Biliary-Pancreatic Surgery

Volumn 13, Issue 3, 2006, Pages 245-251

  Ichikawa, Tsuyoshi ^a   Yamamoto, Takatsugu ^b   Uenishi, Takahiro ^a   Tanaka, Hiromu ^a   Takemura, Shigekazu ^a   Ogawa, Masao ^a   Tanaka, Shogo ^a   Suehiro, Shigefumi ^a   Hirohashi, Kazuhiro ^a   Kubo, Shoji ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Ishikiriseiki Hospital   (Japan)

Author keywords

Distant metastasis; Hepatocellular carcinoma; Lymph node metastasis; Mucin core protein

Indexed keywords

ALPHA FETOPROTEIN; CORE PROTEIN; MUCIN 1;

ADULT; AGED; ARTICLE; BILE DUCT TUMOR; CANCER RECURRENCE; CANCER SURVIVAL; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIVER CELL CARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION; TUMOR DIFFERENTIATION;

ADULT; AGED; ANTIGENS, NEOPLASM; CARCINOMA, HEPATOCELLULAR; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MUCINS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; SURVIVAL ANALYSIS; VIRAL CORE PROTEINS;

EID: 33646772519     PISSN: 09441166     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00534-005-1070-4     Document Type: Article

References (55)

1. T Uenishi S Kubo K Hirohashi T Yamamoto M Ogawa H Tanaka 2002 Expression of bile duct-type cytokeratin in hepatocellular carcinoma in patients with hepatitis C virus and prior hepatitis B virus infection Cancer Lett 178 107-12 11849748 1:CAS:528:DC%2BD38Xht1ahtrg%3D 10.1016/ S0304-3835(01)00813-8
2. T Uenishi S Kubo T Yamamoto T Shuto M Ogawa H Tanaka 2003 Cytokeratin 19 expression in hepatocellular carcinoma predicts early postoperative recurrence Cancer Sci 94 851-7 14556657 1:CAS:528:DC%2BD3sXpsFGhtL4%3D 10.1111/j.1349-7006.2003.tb01366.x
3. M Osborn G van Lessen K Weber G Kloppel M Altmannsberger 1986 Differential diagnosis of gastrointestinal carcinomas by using monoclonal antibodies specific for individual keratin polypeptides Lab Invest 55 497-504 2429069 1:STN:280:BiiD3MzgvFM%3D
4. YS Lai SN Thung MA Gerber ML Chen F Schaffner 1989 Expression of cytokeratins in normal and diseased livers and in primary liver carcinomas Arch Pathol Lab Med 113 134-8 2464975 1:STN:280:BiaC3sznt1E%3D
5. AJ Balaton M Nehama-Sibony C Gotheil P Callard EE Baviera 1988 Distinction between hepatocellular carcinoma, cholangiocarcinoma, and metastatic carcinoma based on immunohistochemical staining for carcinoembryonic antigen and for cytokeratin 19 on paraffin sections J Pathol 156 305-10 2465399 1:STN:280:BiaC2c7isFE%3D 10.1002/ path.1711560405
6. DE Johnson BG Herndier LJ Medeiros RA Warnke RV Rouse 1988 The dianostic utility of the keratin profiles of hepatocellular carcinoma and cholangiocarcinoma Am J Surg Pathol 12 187-97 2449824 1:STN:280:BieC2cfitVQ%3D
7. AS Leong RT Sormunen WM Tsui Liew CT. Hep 1998 Par 1 and selected antibodies in the immunohistological distinction of hepatocellular carcinoma from cholangiocarcinoma, combined tumours and metastatic carcinoma Histopathology 33 318-24 9822920 1:STN:280:DyaK1M%2FktVamtg%3D%3D 10.1046/j.1365-2559.1998.00522.x
8. P Van Eyken R Sciot A Paterson F Callea MC Kew VJ Desmet 1988 Cytokeratin expression in hepatocellular carcinoma: An immunohistochemical study Hum Pathol 19 562-8 2453442 1:STN:280:BieB38nmt1M%3D
9. HP Fischer M Aeltmannsberger K Weber M Osborn 1987 Keratin polypeptides in malignant epithelial liver tumors. Differerntial diagnostic and histogenetic aspects Am J Pathol 127 530-7 2438941 1:STN:280:BiiB3sfosVM%3D
10. PC Wu JW Fang VK Lau CL Lai CK Lo JY Lau 1996 Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers. Clinical and biological implications Am J Pathol 149 1167-75 8863666 1:STN:280:ByiD3MjgsFc%3D
11. SJ Gendler CA Lancaster J Taylor-Papadimitriou T Duhig N Peat J Burchell 1990 Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin J Biol Chem 265 15286-93 1697589 1:CAS:528:DyaK3MXlslKktA%3D%3D
12. JR Gum Jr 1995 Human mucin glycoproteins: Varied structures predict diverse properties and specific functions Biochem Soc Trans 23 795-9 8654840 1:CAS:528:DyaK28XhtVWlsr4%3D
13. SB Ho YS Kim 1991 Carbohydrate antigens on cancer-associated mucin-like molecules Semin Cancer Biol 2 389-400 1725730 1:CAS:528:DyaK3sXlsFOktLc%3D
14. SB Ho GA Niehans C Lyftogt PS Yan DL Cherwitz ET Gum 1993 Heterogeneity of mucin gene expression in normal and neoplastic tissues Cancer Res 53 641-51 7678777 1:CAS:528:DyaK3sXhsVClu7g%3D
15. Y Cao U Karsten G Otto P Bannasch 1999 Expression of MUC1, Thomsen-Friedenreich antigen, Tn, sialosyl-Tn, and alpha 2, 6-linked sialic acid in hepatocellular carcinomas and preneoplastic hepatocellular lesions Virchows Arch 434 503-9 10394884 1:CAS:528:DyaK1MXjtlektLw%3D 10.1007/s004280050375
16. YS Kim J Gum Jr I Brockhausen 1996 Mucin glycoproteins in neoplasia Glycoconj J 13 693-707 8909996 1:CAS:528:DyaK28XmslCls7Y%3D 10.1007/ BF00702333
17. S Yonezawa E Sato 1997 Expression of mucin antigens in human cancers and its relationship with malignancy potential Pathol Int 47 813-30 9503463 1:CAS:528:DyaK1cXhsVGrtLg%3D
18. S Yonezawa A Nakamura M Horinouchi E Sato 2002 The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms J Hepatobiliary Pancreat Surg 9 328-41 12353144 10.1007/ s005340200037
19. M Sasaki Y Nakanuma 1994 Expression of mucin core protein of mammary type in primary liver cancer Hepatology 20 1192-7 7523272 1:STN:280:ByqD3M3htlc%3D 10.1016/0270-9139(94)90756-0
20. T Utsunomiya S Yonezawa H Sakamoto H Kitamura S Hokita T Aiko 1998 Expression of MUC1 and MUC2 mucins in gastric carcinomas: Its relationship with the prognosis of the patients Clin Cancer Res 4 2605-14 9829723 1:STN:280:DyaK1M%2FksFWrug%3D%3D
21. S Nakamori DM Ota KR Cleary K Shirotani T Irimura 1994 MUC1 mucin expression as a marker of progression and metastasis of human colorectal carcinoma Gastroenterology 106 353-61 7905449 1:STN:280:ByuC3s7itlQ%3D
22. S Takao K Uchikura S Yonezawa H Shinchi T Aikou 1999 Mucin core protein expression in extrahepatic bile duct carcinoma is associated with metastases to the liver and poor prognosis Cancer 86 1966-75 10570420 1:CAS:528:DyaK1MXotVOgtr8%3D 10.1002/ (SICI)1097-0142(19991115)86:10<1966::AID-CNCR13>3.0.CO;2-M
23. S Tamada M Goto M Nomoto K Nagata T Shimizu S Tanaka 2002 Expression of MUC1 and MUC2 mucins in extrahepatic bile duct carcinomas: Its relationship with tumor progression and prognosis Pathol Int 52 713-23 12685548 10.1046/j.1440-1827.2002.01414.x
24. K Yamashita S Yonezawa S Tanaka H Shirahama K Sakoda K Imai 1993 Immunohistochemical study of mucin carbohydrates and core proteins in hepatolithiasis and cholangiocarcinoma Int J Cancer 55 82-91 8393843 1:STN:280:ByyA2cnht1E%3D
25. N Matsumura M Yamamoto A Aruga K Takasaki M Nakano 2002 Correlation between expression of MUC1 core protein and outcome after surgery in mass-forming intrahepatic cholangiocarcinoma Cancer 94 1770-6 11920540 10.1002/cncr.10398
26. T Uenishi S Kubo K Hirohashi H Tanaka T Shuto T Yamamoto 2003 Cytokeratin-19 fragments in serum (CYFRA 21-1) as a marker in primary liver cancer Br J Cancer 88 1894-9 12799633 1:STN:280:DC%2BD3szis1GntA%3D%3D 10.1038/sj.bjc.6601026
27. T Kashihara A Ohki T Kobayashi T Sato H Nishizawa K Ogawa 1998 Intrahepatic cholangiocarcinoma with increased serum CYFRA 21-1 level J Gastroenterol 33 447-53 9658330 1:STN:280:DyaK1czit1CltA%3D%3D 10.1007/ s005350050112
28. Liver Cancer Study Group of Japan 1992 The general rule for the clinical and pathological study of primary liver cancer (in Japanese) 3rd ed Kanehara Tokyo 1-76
29. S Kubo S Nishiguchi K Hirohashi T Shuto T Kuroki S Minamitani 1998 Clinical criteria for multicentricity of hepatocellular carcinoma and risk factors for such carcinogenesis Jpn J Cancer Res 89 419-26 9617348 1:CAS:528:DyaK1cXivFSntLg%3D
30. VJ Desmet M Gerber JH Hoofnagle M Manns PJ Scheuer 1994 Classification of chronic hepatitis: Diagnosis, grading and staging Hepatology 19 1513-20 8188183 1:STN:280:ByuB2crhtFU%3D 10.1016/0270-9139(94)90250-X
31. RG Knodell KG Ishak WC Black TS Chen R Craig N Kaplowitz 1981 Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis Hepatology 1 431-5 7308988 1:STN:280:Bi2D2svitlY%3D
32. E Sabattini K Bisgaard S Ascani S Poggi M Piccioli C Ceccarelli 1998 The En Vision++ system: A new immunohistochemical method for diagnostics and research. Critical comparison with the APAAP, ChemMate, CSA, LABC, and SABC techniques J Clin Pathol 51 506-11 9797726 1:STN:280:DyaK1M%2FhsVClsg%3D%3D
33. N Vyberg S Nielsen 1998 Dextran polymer conjugate two-step visualization system for immunohistochemistry. A comparison of En Vision+ with two three-step avidin biotin techniques Appl Immunohistochem Mol Morphol 6 3-10 1:CAS:528:DyaK1cXitlChtbk%3D 10.1097/00022744-199803000-00002
34. The Liver Cancer Study Group of Japan 1987 Primary liver cancer in Japan. Sixth report Cancer 60 1400-11
35. T Uenishi K Hirohashi S Kubo T Yamamoto O Yamazaki H Kinoshita 2001 Clinicopathological factors predicting outcome after resection of mass-forming intrahepatic cholangiocarcinoma Br J Surg 88 969-74 11442529 1:STN:280:DC%2BD3MzovVOktA%3D%3D 10.1046/ j.0007-1323.2001.01784.x
36. M Yamamoto K Takasaki T Otsubo H Katsuragawa S Katagiri 2001 Recurrence after surgical resection of intrahepatic cholangiocarcinoma J Hepatobiliary Pancreat Surg 8 154-7 11455472 1:STN:280:DC%2BD3MvgtFSntQ%3D%3D 10.1007/s005340170039
37. Y Morimoto Y Tanaka T Ito M Nakahara H Nakaba T Nishida 2003 Long-term survival and prognostic factors in the surgical treatment for intrahepatic cholangiocarcinoma J Hepatobiliary Pancreat Surg 10 432-40 14714164 10.1007/s00534-002-0842-3
38. K Inoue M Makuuchi T Takayama G Torzilli J Yamamoto K Shimada 2000 Long-term survival and prognostic factors in the surgical treatment of mass-forming type cholangiocarcinoma Surgery 127 498-505 10819057 1:STN:280:DC%2BD3c3nvFShuw%3D%3D
39. JR Madariaga S Iwatsuki S Todo RG Lee W Irish TE Starzl 1998 Liver resection for hilar and peripheral cholangiocarcinomas: A study of 62 cases Am Surg 227 70-9 1:STN:280:DyaK1c7gsFymug%3D%3D
40. LE Harrison Y Fong DS Klimstra SY Zee LH Blumgart 1998 Surgical treatment of 32 patients with peripheral intrahepatic cholangiocarcinoma Br J Surg 85 1068-70 9717998 1:STN:280:DyaK1czot1Squg%3D%3D 10.1046/ j.1365-2168.1998.00796.x
41. T Maeda E Adachi K Kajiyama K Sugimachi M Tsuneyoshi 1995 Combined hepatocellular and cholangiocarcinoma: Proposed criteria according to cytokeratin expression and analysis of clinicopathologic features Hum Pathol 26 956-64 7545644 1:STN:280:ByqH3c3psFc%3D 10.1016/ 0046-8177(95)90084-5
42. MJ Ligtenberg F Buijs HL Vos J Hilkens 1992 Suppression of cellular aggregation by high levels of episialin Cancer Res 52 2318-24 1559234 1:CAS:528:DyaK38Xitlaqtbg%3D
43. E van de Wiel-van de Kemena MJ Ligtenberg AJ De Boer F Buijs HL Vos 1993 Episialin (MUC1) inhibits cytotoxic lymphocyte-target cell interaction J Immunol 151 767-76 7687622 1:CAS:528:DyaK3sXmt1Cjur8%3D
44. Y Makiguchi Y Hinoda K Imai 1996 Effect of MUC1 mucin, an anti-adhesion molecule, on tumor cell growth Jpn J Cancer Res 87 505-11 8641988 1:CAS:528:DyaK28Xjt1Omsbw%3D
45. J Wesseling SW van de Valk HL Vos A Sonnenberg Hilkens J. Episialin 1995 MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components J Cell Biol 129 255-65 7698991 1:CAS:528:DyaK2MXkslKqt7s%3D 10.1083/jcb.129.1.255
46. J Wesseling SW van de Valk J Hilkens 1996 A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1 Mol Biol Cell 7 565-77 8730100 1:CAS:528:DyaK28Xit12qs70%3D
47. J Hilkens MJ Ligtenberg HL Vos SL Litvinov 1992 Cell membrane-associated mucins and their adhesion-modulating property Trends Biochem Sci 17 359-63 1412714 1:CAS:528:DyaK38Xls1Kjs7s%3D 10.1016/0968-0004(92)90315-Z
48. LB Tee Y Kirilak WH Huang PG Smith RH Morgan GC Yeoh 1996 Dual phenotypic expression of hepatocytes and bile ductular markers in developing and preneoplastic rat liver Carcinogenesis 17 251-9 8625446 1:CAS:528:DyaK28XhtFCnuro%3D
49. S Sell HA Dunsford 1989 Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma Am J Pathol 134 1347-63 2474256 1:STN:280:BiaA3szovVE%3D
50. L Libbrecht V Desmet B Van Damme T Roskams 2000 The immunohistochemical phenotype of dysplastic foci in human liver: Correlation with putative progenitor cells J Hepatol 33 76-84 10905589 1:STN:280:DC%2BD3M%2FktVKnsg%3D%3D 10.1016/S0168-8278(00)80162-2
51. K Shirabe T Kanematsu T Matsumata E Adachi K Akazawa K Sugimachi 1991 Factors linked to early recurrence of small hepatocellular carcinoma after hepatectomy: Univariate and multivariate analyses Hepatology 14 802-5 1657754 1:STN:280:By2D3sbltVU%3D
52. J Belghiti Y Panis O Farges JP Benhamou F Fekete 1991 Intrahepatic recurrence after resection of hepatocellular carcinoma complicating cirrhosis Am Surg 214 114-7 1:STN:280:By6A38flvFI%3D
53. SC Jwo JH Chiu GY Chau CC Loong WY Lui 1992 Risk factors linked to tumor recurrence of human hepatocellular carcinoma after hepatic resection Hepatology 16 1367-71 1332922 1:STN:280:ByyD2sjhtlU%3D
54. N Nagasue M Uchida Y Makino Y Takemoto A Yamanoi T Hayashi 1993 Incidence and factors associated with intrahepatic recurrence following resection of hepatocellular carcinoma Gastroenterology 105 488-94 8392955 1:STN:280:ByyA38fgsFQ%3D
55. S Kubo K Hirohashi H Tanaka T Tsukamoto T Shuto T Ikebe 2000 Risk factors for recurrence after resection of hepatitis C virus-related hepatocellular carcinoma World J Surg 24 1559-65 11193723 1:STN:280:DC%2BD3M3gtFKnsA%3D%3D 10.1007/s002680010277