메뉴 건너뛰기




Volumn 25, Issue 3, 2009, Pages 279-284

Serum and bile biomarkers for cholangiocarcinoma

Author keywords

Biliary biomarkers; Cholangiocarcinoma; Primitive sclerosing cholangitis; Proteomic; Serum biomarkers

Indexed keywords

AMYLASE; BIOLOGICAL MARKER; CYTOKERATIN 19 FRAGMENT; CYTOKINE; ELASTASE; ENZYME; GROWTH FACTOR; INTERLEUKIN 6; MINICHROMOSOME MAINTENANCE PROTEIN; MUCIN 4; MUCIN 5AC; SOMATOMEDIN C; TRYPSINOGEN; TUMOR MARKER;

EID: 67651096190     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e328325a894     Document Type: Review
Times cited : (75)

References (33)
  • 1
    • 47149112544 scopus 로고    scopus 로고
    • Cholangiocarcinoma: Advances in pathogenesis, diagnosis, and treatment
    • DOI 10.1002/hep.22310
    • Blechacz B, Gores GJ. Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment. Hepatology 2008; 48:308-321. An excellent and extensive review on the modern aspects of the pathogenetic and clinical aspects of CCA. (Pubitemid 351975555)
    • (2008) Hepatology , vol.48 , Issue.1 , pp. 308-321
    • Blechacz, B.1    Gores, G.J.2
  • 4
    • 34147192199 scopus 로고    scopus 로고
    • Cholangiocarcinoma: Emerging approaches to a challenging cancer
    • DOI 10.1097/MOG.0b013e3280495451, PII 0000157420070500000016
    • Patel T, Singh P. Cholangiocarcinoma: emerging approaches to a challenging cancer. Curr Opin Gastroenterol 2007; 23:317-323. (Pubitemid 46573149)
    • (2007) Current Opinion in Gastroenterology , vol.23 , Issue.3 , pp. 317-323
    • Patel, T.1    Singh, P.2
  • 5
    • 38349149554 scopus 로고    scopus 로고
    • Cholangiocarcinoma: Natural history, treatment, and strategies for surveillance in high-risk patients
    • An excellent review on the natural history, treatment and strategies of CCA in high-risk patients
    • Yachimski P, Pratt DS. Cholangiocarcinoma: natural history, treatment, and strategies for surveillance in high-risk patients. J Clin Gastroenterol 2008; 42:178-190. An excellent review on the natural history, treatment and strategies of CCA in high-risk patients.
    • (2008) J Clin Gastroenterol , vol.42 , pp. 178-190
    • Yachimski, P.1    Pratt, D.S.2
  • 6
    • 44349099172 scopus 로고    scopus 로고
    • Cholangiocarcinoma complicating primary sclerosing cholangitis: A 24-year experience
    • This study describes the prevalence and outcome of CCA arising in patients with PSC
    • Morris-Stiff G, Bhati C, Olliff S, et al. Cholangiocarcinoma complicating primary sclerosing cholangitis: a 24-year experience. Dig Surg 2008; 25:126-132. This study describes the prevalence and outcome of CCA arising in patients with PSC.
    • (2008) Dig Surg , vol.25 , pp. 126-132
    • Morris-Stiff, G.1    Bhati, C.2    Olliff, S.3
  • 7
    • 39149132145 scopus 로고    scopus 로고
    • Primary sclerosing cholangitis: Detection of cancer in strictures
    • Schulick RD. Primary sclerosing cholangitis: detection of cancer in strictures. J Gastrointest Surg 2008; 12:420-422.
    • (2008) J Gastrointest Surg , vol.12 , pp. 420-422
    • Schulick, R.D.1
  • 8
    • 55949100449 scopus 로고    scopus 로고
    • Elevation of carbohydrate antigen 19.9 in benign hepatobiliary conditions and its correlation with serum bilirubin concentration
    • Ong SL, Sachdeva A, Garcea G, et al. Elevation of carbohydrate antigen 19.9 in benign hepatobiliary conditions and its correlation with serum bilirubin concentration. Dig Dis Sci 2008; 53:3213-3217.
    • (2008) Dig Dis Sci , vol.53 , pp. 3213-3217
    • Ong, S.L.1    Sachdeva, A.2    Garcea, G.3
  • 9
    • 54449084021 scopus 로고    scopus 로고
    • Utility of serum tumor markers, imaging, and biliary cytology for detecting cholangiocarcinoma in primary sclerosing cholangitis
    • The authors proposed the combination of serum carbohydrate antigen 19-29 (cutoff value of 20 U/ml) and abdominal ultrasound at 12-month intervals as useful strategy for screening/surveillance of CCA in PSC
    • Charatcharoenwitthaya P, Enders FB, Halling KC, Lindor KD. Utility of serum tumor markers, imaging, and biliary cytology for detecting cholangiocarcinoma in primary sclerosing cholangitis. Hepatology 2008; 48:1106-1117. The authors proposed the combination of serum carbohydrate antigen 19-29 (cutoff value of 20 U/ml) and abdominal ultrasound at 12-month intervals as useful strategy for screening/surveillance of CCA in PSC.
    • (2008) Hepatology , vol.48 , pp. 1106-1117
    • Charatcharoenwitthaya, P.1    Enders, F.B.2    Halling, K.C.3    Lindor, K.D.4
  • 10
    • 48149099081 scopus 로고    scopus 로고
    • Surgical management and prognostic factors of hilar cholangiocarcinoma: Experience with 115 cases in China
    • Yubin L, Chihua F, Zhixiang J, et al. Surgical management and prognostic factors of hilar cholangiocarcinoma: experience with 115 cases in China. Ann Surg Oncol 2008; 15:2113-2119.
    • (2008) Ann Surg Oncol , vol.15 , pp. 2113-2119
    • Yubin, L.1    Chihua, F.2    Zhixiang, J.3
  • 11
    • 45249091292 scopus 로고    scopus 로고
    • Chemoprevention and screening in primary sclerosing cholangitis
    • This review summarizes the incidence of malignancies in patients with PSC and discusses potential strategies for its early detection
    • Kitiyakara T, Chapman RW. Chemoprevention and screening in primary sclerosing cholangitis. Postgrad Med J 2008; 84:228-237. This review summarizes the incidence of malignancies in patients with PSC and discusses potential strategies for its early detection.
    • (2008) Postgrad Med J , vol.84 , pp. 228-237
    • Kitiyakara, T.1    Chapman, R.W.2
  • 12
    • 46049090963 scopus 로고    scopus 로고
    • Current diagnosis and management of primary sclerosing cholangitis
    • DOI 10.1002/lt.21456
    • Tischendorf JJ, Geier A, Trautwein C. Current diagnosis and management of primary sclerosing cholangitis. Liver Transpl 2008; 14:735-746. (Pubitemid 351895502)
    • (2008) Liver Transplantation , vol.14 , Issue.6 , pp. 735-746
    • Tischendorf, J.J.W.1    Geier, A.2    Trautwein, C.3
  • 13
    • 34848815007 scopus 로고    scopus 로고
    • Diagnostic utility of interleukin-6 (IL-6) for primary bile duct cancer and changes in serum IL-6 levels following photodynamic therapy
    • This study describes that the elevation of IL-6 serum has a good sensitivity and specificity for CCA and that IL-6 decreased after photodynamic therapy. This observation may have implications in terms of diagnosis as well in the evaluation of response to treatment
    • Cheon YK, Cho YD, Moon JH, et al. Diagnostic utility of interleukin-6 (IL-6) for primary bile duct cancer and changes in serum IL-6 levels following photodynamic therapy. Am J Gastroenterol 2007; 102:2164-2170. This study describes that the elevation of IL-6 serum has a good sensitivity and specificity for CCA and that IL-6 decreased after photodynamic therapy. This observation may have implications in terms of diagnosis as well in the evaluation of response to treatment.
    • (2007) Am J Gastroenterol , vol.102 , pp. 2164-2170
    • Cheon, Y.K.1    Cho, Y.D.2    Moon, J.H.3
  • 14
    • 48849090158 scopus 로고    scopus 로고
    • Prognosis of resected ampullary adenocarcinoma by preoperative serum CA19-9 levels and platelet-lymphocyte ratio
    • Smith RA, Ghaneh P, Sutton R, et al. Prognosis of resected ampullary adenocarcinoma by preoperative serum CA19-9 levels and platelet-lymphocyte ratio. J Gastrointest Surg 2008; 12:1422-1428.
    • (2008) J Gastrointest Surg , vol.12 , pp. 1422-1428
    • Smith, R.A.1    Ghaneh, P.2    Sutton, R.3
  • 15
    • 43049141078 scopus 로고    scopus 로고
    • The platelet-lymphocyte ratio improves the predictive value of serum CA19-9 levels in determining patient selection for staging laparoscopy in suspected periampullary cancer
    • Smith RA, Bosonnet L, Ghaneh P, et al. The platelet-lymphocyte ratio improves the predictive value of serum CA19-9 levels in determining patient selection for staging laparoscopy in suspected periampullary cancer. Surgery 2008; 143:658-666.
    • (2008) Surgery , vol.143 , pp. 658-666
    • Smith, R.A.1    Bosonnet, L.2    Ghaneh, P.3
  • 16
    • 34848886866 scopus 로고    scopus 로고
    • Enhanced detection of cholangiocarcinoma with serum trypsinogen-2 in patients with severe bile duct strictures
    • In this study, serum trypsinogen-2 discriminates between PSC with or without CCA and was unaffected by the severity of cholestasis suggesting that this marker should be tested for the surveillance of patients with PSC
    • Lempinen M, Isoniemi H, Mäkisalo H, et al. Enhanced detection of cholangiocarcinoma with serum trypsinogen-2 in patients with severe bile duct strictures. J Hepatol 2007; 47:677-683. In this study, serum trypsinogen-2 discriminates between PSC with or without CCA and was unaffected by the severity of cholestasis suggesting that this marker should be tested for the surveillance of patients with PSC.
    • (2007) J Hepatol , vol.47 , pp. 677-683
    • Lempinen, M.1    Isoniemi, H.2    Mäkisalo, H.3
  • 17
    • 33646265264 scopus 로고    scopus 로고
    • Distinct evolution of the human carcinoma-associated transmembrane mucins, MUC1, MUC4 and MUC16
    • Duraisamy S, Ramasamy S, Kharbanda S, et al. Distinct evolution of the human carcinoma-associated transmembrane mucins, MUC1, MUC4 AND MUC16. Gene 2006; 373:28-34.
    • (2006) Gene , vol.373 , pp. 28-34
    • Duraisamy, S.1    Ramasamy, S.2    Kharbanda, S.3
  • 18
    • 33846922357 scopus 로고    scopus 로고
    • A new mucin antibody/enzyme-linked lectin-sandwich assay of serum MUC5AC mucin for the diagnosis of cholangiocarcinoma
    • The authors developed a sandwich ELISA of serum MUC5AC, which seems promising for the diagnosis and monitoring of CCA patients
    • Bamrungphon W, Prempracha N, Bunchu N, et al. A new mucin antibody/enzyme-linked lectin-sandwich assay of serum MUC5AC mucin for the diagnosis of cholangiocarcinoma. Cancer Lett 2007; 247:301-308. The authors developed a sandwich ELISA of serum MUC5AC, which seems promising for the diagnosis and monitoring of CCA patients.
    • (2007) Cancer Lett , vol.247 , pp. 301-308
    • Bamrungphon, W.1    Prempracha, N.2    Bunchu, N.3
  • 19
    • 43649106488 scopus 로고    scopus 로고
    • MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer
    • This study indicates that biliary MUC4 and serum MUC5AC are highly specific CCA-associated mucins with prognostic values, although the sensitivity is not currently satisfactory
    • Matull WR, Andreola F, Loh A, et al. MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer. Br J Cancer 2008; 98:1675-1681. This study indicates that biliary MUC4 and serum MUC5AC are highly specific CCA-associated mucins with prognostic values, although the sensitivity is not currently satisfactory.
    • (2008) Br J Cancer , vol.98 , pp. 1675-1681
    • Matull, W.R.1    Andreola, F.2    Loh, A.3
  • 21
    • 38549097102 scopus 로고    scopus 로고
    • Circulating markers of biliary malignancy: Opportunities in proteomics?
    • An excellent review focusing on the recent advances on proteomic techniques applied to identify CCA biomarkers
    • Bonney GK, Craven RA, Prasad R, et al. Circulating markers of biliary malignancy: opportunities in proteomics? Lancet Oncol 2008; 9:149-158. An excellent review focusing on the recent advances on proteomic techniques applied to identify CCA biomarkers.
    • (2008) Lancet Oncol , vol.9 , pp. 149-158
    • Bonney, G.K.1    Craven, R.A.2    Prasad, R.3
  • 23
    • 33748946887 scopus 로고    scopus 로고
    • Proteomic profiling of cholangiocarcinoma: Diagnostic potential of SELDI-TOF MS in malignant bile duct stricture
    • DOI 10.1002/hep.21294
    • Scarlett CJ, Saxby AJ, Nielsen A, et al. Proteomic profiling of cholangiocarcinoma: diagnostic potential of SELDI-TOF MS in malignant bile duct stricture. Hepatology 2006; 44:658-666. (Pubitemid 44433722)
    • (2006) Hepatology , vol.44 , Issue.3 , pp. 658-666
    • Scarlett, C.J.1    Saxby, A.J.2    Nielsen, A.3    Bell, C.4    Samra, J.S.5    Hugh, T.6    Baxter, R.C.7    Smith, R.C.8
  • 24
    • 39849106455 scopus 로고    scopus 로고
    • New insights on the molecular and cell biology of human cholangiopathies
    • Alvaro D, Mancino MG. New insights on the molecular and cell biology of human cholangiopathies. Mol Aspects Med 2008; 29:50-57.
    • (2008) Mol Aspects Med , vol.29 , pp. 50-57
    • Alvaro, D.1    Mancino, M.G.2
  • 25
    • 58149214162 scopus 로고    scopus 로고
    • Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor
    • Mancino A, Mancino MG, Glaser SS, et al. Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor. Dig Liver Dis 2009; 41:156-163.
    • (2009) Dig Liver Dis , vol.41 , pp. 156-163
    • Mancino, A.1    Mancino, M.G.2    Glaser, S.S.3
  • 26
    • 33846205222 scopus 로고    scopus 로고
    • Proliferating Cholangiocytes: A Neuroendocrine Compartment in the Diseased Liver
    • DOI 10.1053/j.gastro.2006.07.023, PII S0016508506016660
    • Alvaro D, Mancino MG, Glaser S, et al. Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver. Gastroenterology 2007; 132:415-431. (Pubitemid 46108729)
    • (2007) Gastroenterology , vol.132 , Issue.1 , pp. 415-431
    • Alvaro, D.1    Mancino, M.G.2    Glaser, S.3    Gaudio, E.4    Marzioni, M.5    Francis, H.6    Alpini, G.7
  • 28
    • 34848926887 scopus 로고    scopus 로고
    • Serum and biliary insulin-like growth factor I and vascular endothelial growth factor in determining the cause of obstructive cholestasis
    • This study demonstrated that bile IGF1 levels is absolutely sensitive and specific for extrahepatic CCA suggesting a role of this biomarkers in the differential diagnosis of patients submitted to ERCP for obstructive cholestasis
    • Alvaro D, Macarri G, Mancino MG, et al. Serum and biliary insulin-like growth factor I and vascular endothelial growth factor in determining the cause of obstructive cholestasis. Ann Intern Med 2007; 2:451-459. This study demonstrated that bile IGF1 levels is absolutely sensitive and specific for extrahepatic CCA suggesting a role of this biomarkers in the differential diagnosis of patients submitted to ERCP for obstructive cholestasis.
    • (2007) Ann Intern Med , vol.2 , pp. 451-459
    • Alvaro, D.1    Macarri, G.2    Mancino, M.G.3
  • 29
    • 46249109809 scopus 로고    scopus 로고
    • Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma
    • Nishino R, Honda M, Yamashita T, et al. Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma. J Hepatol 2008; 49:207-216.
    • (2008) J Hepatol , vol.49 , pp. 207-216
    • Nishino, R.1    Honda, M.2    Yamashita, T.3
  • 30
    • 39649094498 scopus 로고    scopus 로고
    • Diagnostic role of biliary pancreatic elastase for cholangiocarcinoma in patients with cholestasis
    • The study indicates that ratio of pancreatic elastase/amylase in bile distinguish malignant from benign causes of biliary obstruction with a good sensitivity and specificity
    • Chen CY, Tsai WL, Wu HC, et al. Diagnostic role of biliary pancreatic elastase for cholangiocarcinoma in patients with cholestasis. Clin Chim Acta 2008; 390:82-89. The study indicates that ratio of pancreatic elastase/amylase in bile distinguish malignant from benign causes of biliary obstruction with a good sensitivity and specificity.
    • (2008) Clin Chim Acta , vol.390 , pp. 82-89
    • Chen, C.Y.1    Tsai, W.L.2    Wu, H.C.3
  • 33
    • 67651135847 scopus 로고    scopus 로고
    • Detection of cholangiocarcinoma with magnetic resonance spectroscopy of bile in patients with and without primary sclerosing cholangitis
    • Albiin N, Smith IC, Arnelo U, et al. Detection of cholangiocarcinoma with magnetic resonance spectroscopy of bile in patients with and without primary sclerosing cholangitis. Acta Radiol 2008; 18:1-8.
    • (2008) Acta Radiol , vol.18 , pp. 1-8
    • Albiin, N.1    Smith, I.C.2    Arnelo, U.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.