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1
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47149112544
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Cholangiocarcinoma: Advances in pathogenesis, diagnosis, and treatment
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DOI 10.1002/hep.22310
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Blechacz B, Gores GJ. Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment. Hepatology 2008; 48:308-321. An excellent and extensive review on the modern aspects of the pathogenetic and clinical aspects of CCA. (Pubitemid 351975555)
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(2008)
Hepatology
, vol.48
, Issue.1
, pp. 308-321
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Blechacz, B.1
Gores, G.J.2
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4
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34147192199
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Cholangiocarcinoma: Emerging approaches to a challenging cancer
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DOI 10.1097/MOG.0b013e3280495451, PII 0000157420070500000016
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Patel T, Singh P. Cholangiocarcinoma: emerging approaches to a challenging cancer. Curr Opin Gastroenterol 2007; 23:317-323. (Pubitemid 46573149)
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(2007)
Current Opinion in Gastroenterology
, vol.23
, Issue.3
, pp. 317-323
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Patel, T.1
Singh, P.2
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5
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38349149554
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Cholangiocarcinoma: Natural history, treatment, and strategies for surveillance in high-risk patients
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An excellent review on the natural history, treatment and strategies of CCA in high-risk patients
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Yachimski P, Pratt DS. Cholangiocarcinoma: natural history, treatment, and strategies for surveillance in high-risk patients. J Clin Gastroenterol 2008; 42:178-190. An excellent review on the natural history, treatment and strategies of CCA in high-risk patients.
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(2008)
J Clin Gastroenterol
, vol.42
, pp. 178-190
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Yachimski, P.1
Pratt, D.S.2
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6
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44349099172
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Cholangiocarcinoma complicating primary sclerosing cholangitis: A 24-year experience
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This study describes the prevalence and outcome of CCA arising in patients with PSC
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Morris-Stiff G, Bhati C, Olliff S, et al. Cholangiocarcinoma complicating primary sclerosing cholangitis: a 24-year experience. Dig Surg 2008; 25:126-132. This study describes the prevalence and outcome of CCA arising in patients with PSC.
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(2008)
Dig Surg
, vol.25
, pp. 126-132
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Morris-Stiff, G.1
Bhati, C.2
Olliff, S.3
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7
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39149132145
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Primary sclerosing cholangitis: Detection of cancer in strictures
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Schulick RD. Primary sclerosing cholangitis: detection of cancer in strictures. J Gastrointest Surg 2008; 12:420-422.
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(2008)
J Gastrointest Surg
, vol.12
, pp. 420-422
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Schulick, R.D.1
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8
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55949100449
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Elevation of carbohydrate antigen 19.9 in benign hepatobiliary conditions and its correlation with serum bilirubin concentration
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Ong SL, Sachdeva A, Garcea G, et al. Elevation of carbohydrate antigen 19.9 in benign hepatobiliary conditions and its correlation with serum bilirubin concentration. Dig Dis Sci 2008; 53:3213-3217.
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(2008)
Dig Dis Sci
, vol.53
, pp. 3213-3217
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Ong, S.L.1
Sachdeva, A.2
Garcea, G.3
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9
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54449084021
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Utility of serum tumor markers, imaging, and biliary cytology for detecting cholangiocarcinoma in primary sclerosing cholangitis
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The authors proposed the combination of serum carbohydrate antigen 19-29 (cutoff value of 20 U/ml) and abdominal ultrasound at 12-month intervals as useful strategy for screening/surveillance of CCA in PSC
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Charatcharoenwitthaya P, Enders FB, Halling KC, Lindor KD. Utility of serum tumor markers, imaging, and biliary cytology for detecting cholangiocarcinoma in primary sclerosing cholangitis. Hepatology 2008; 48:1106-1117. The authors proposed the combination of serum carbohydrate antigen 19-29 (cutoff value of 20 U/ml) and abdominal ultrasound at 12-month intervals as useful strategy for screening/surveillance of CCA in PSC.
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(2008)
Hepatology
, vol.48
, pp. 1106-1117
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Charatcharoenwitthaya, P.1
Enders, F.B.2
Halling, K.C.3
Lindor, K.D.4
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10
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48149099081
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Surgical management and prognostic factors of hilar cholangiocarcinoma: Experience with 115 cases in China
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Yubin L, Chihua F, Zhixiang J, et al. Surgical management and prognostic factors of hilar cholangiocarcinoma: experience with 115 cases in China. Ann Surg Oncol 2008; 15:2113-2119.
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(2008)
Ann Surg Oncol
, vol.15
, pp. 2113-2119
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Yubin, L.1
Chihua, F.2
Zhixiang, J.3
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11
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45249091292
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Chemoprevention and screening in primary sclerosing cholangitis
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This review summarizes the incidence of malignancies in patients with PSC and discusses potential strategies for its early detection
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Kitiyakara T, Chapman RW. Chemoprevention and screening in primary sclerosing cholangitis. Postgrad Med J 2008; 84:228-237. This review summarizes the incidence of malignancies in patients with PSC and discusses potential strategies for its early detection.
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(2008)
Postgrad Med J
, vol.84
, pp. 228-237
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Kitiyakara, T.1
Chapman, R.W.2
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12
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46049090963
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Current diagnosis and management of primary sclerosing cholangitis
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DOI 10.1002/lt.21456
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Tischendorf JJ, Geier A, Trautwein C. Current diagnosis and management of primary sclerosing cholangitis. Liver Transpl 2008; 14:735-746. (Pubitemid 351895502)
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(2008)
Liver Transplantation
, vol.14
, Issue.6
, pp. 735-746
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Tischendorf, J.J.W.1
Geier, A.2
Trautwein, C.3
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13
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34848815007
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Diagnostic utility of interleukin-6 (IL-6) for primary bile duct cancer and changes in serum IL-6 levels following photodynamic therapy
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This study describes that the elevation of IL-6 serum has a good sensitivity and specificity for CCA and that IL-6 decreased after photodynamic therapy. This observation may have implications in terms of diagnosis as well in the evaluation of response to treatment
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Cheon YK, Cho YD, Moon JH, et al. Diagnostic utility of interleukin-6 (IL-6) for primary bile duct cancer and changes in serum IL-6 levels following photodynamic therapy. Am J Gastroenterol 2007; 102:2164-2170. This study describes that the elevation of IL-6 serum has a good sensitivity and specificity for CCA and that IL-6 decreased after photodynamic therapy. This observation may have implications in terms of diagnosis as well in the evaluation of response to treatment.
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(2007)
Am J Gastroenterol
, vol.102
, pp. 2164-2170
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Cheon, Y.K.1
Cho, Y.D.2
Moon, J.H.3
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14
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48849090158
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Prognosis of resected ampullary adenocarcinoma by preoperative serum CA19-9 levels and platelet-lymphocyte ratio
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Smith RA, Ghaneh P, Sutton R, et al. Prognosis of resected ampullary adenocarcinoma by preoperative serum CA19-9 levels and platelet-lymphocyte ratio. J Gastrointest Surg 2008; 12:1422-1428.
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(2008)
J Gastrointest Surg
, vol.12
, pp. 1422-1428
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Smith, R.A.1
Ghaneh, P.2
Sutton, R.3
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15
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43049141078
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The platelet-lymphocyte ratio improves the predictive value of serum CA19-9 levels in determining patient selection for staging laparoscopy in suspected periampullary cancer
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Smith RA, Bosonnet L, Ghaneh P, et al. The platelet-lymphocyte ratio improves the predictive value of serum CA19-9 levels in determining patient selection for staging laparoscopy in suspected periampullary cancer. Surgery 2008; 143:658-666.
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(2008)
Surgery
, vol.143
, pp. 658-666
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Smith, R.A.1
Bosonnet, L.2
Ghaneh, P.3
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16
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34848886866
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Enhanced detection of cholangiocarcinoma with serum trypsinogen-2 in patients with severe bile duct strictures
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In this study, serum trypsinogen-2 discriminates between PSC with or without CCA and was unaffected by the severity of cholestasis suggesting that this marker should be tested for the surveillance of patients with PSC
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Lempinen M, Isoniemi H, Mäkisalo H, et al. Enhanced detection of cholangiocarcinoma with serum trypsinogen-2 in patients with severe bile duct strictures. J Hepatol 2007; 47:677-683. In this study, serum trypsinogen-2 discriminates between PSC with or without CCA and was unaffected by the severity of cholestasis suggesting that this marker should be tested for the surveillance of patients with PSC.
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(2007)
J Hepatol
, vol.47
, pp. 677-683
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Lempinen, M.1
Isoniemi, H.2
Mäkisalo, H.3
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17
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33646265264
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Distinct evolution of the human carcinoma-associated transmembrane mucins, MUC1, MUC4 and MUC16
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Duraisamy S, Ramasamy S, Kharbanda S, et al. Distinct evolution of the human carcinoma-associated transmembrane mucins, MUC1, MUC4 AND MUC16. Gene 2006; 373:28-34.
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(2006)
Gene
, vol.373
, pp. 28-34
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Duraisamy, S.1
Ramasamy, S.2
Kharbanda, S.3
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18
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33846922357
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A new mucin antibody/enzyme-linked lectin-sandwich assay of serum MUC5AC mucin for the diagnosis of cholangiocarcinoma
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The authors developed a sandwich ELISA of serum MUC5AC, which seems promising for the diagnosis and monitoring of CCA patients
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Bamrungphon W, Prempracha N, Bunchu N, et al. A new mucin antibody/enzyme-linked lectin-sandwich assay of serum MUC5AC mucin for the diagnosis of cholangiocarcinoma. Cancer Lett 2007; 247:301-308. The authors developed a sandwich ELISA of serum MUC5AC, which seems promising for the diagnosis and monitoring of CCA patients.
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(2007)
Cancer Lett
, vol.247
, pp. 301-308
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Bamrungphon, W.1
Prempracha, N.2
Bunchu, N.3
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19
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43649106488
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MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer
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This study indicates that biliary MUC4 and serum MUC5AC are highly specific CCA-associated mucins with prognostic values, although the sensitivity is not currently satisfactory
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Matull WR, Andreola F, Loh A, et al. MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer. Br J Cancer 2008; 98:1675-1681. This study indicates that biliary MUC4 and serum MUC5AC are highly specific CCA-associated mucins with prognostic values, although the sensitivity is not currently satisfactory.
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(2008)
Br J Cancer
, vol.98
, pp. 1675-1681
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Matull, W.R.1
Andreola, F.2
Loh, A.3
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20
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40649084361
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Serum cytokeratin 19 fragment (CYFRA21-1) as a prognostic factor in intrahepatic cholangiocarcinoma
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DOI 10.1245/s10434-007-9650-y
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Uenishi T, Yamazaki O, Tanaka H, et al. Serum cytokeratin 19 fragment (CYFRA21-1) as a prognostic factor in intrahepatic cholangiocarcinoma. Ann Surg Oncol 2008; 15:583-589. (Pubitemid 351643031)
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(2008)
Annals of Surgical Oncology
, vol.15
, Issue.2
, pp. 583-589
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Uenishi, T.1
Yamazaki, O.2
Tanaka, H.3
Takemura, S.4
Yamamoto, T.5
Tanaka, S.6
Nishiguchi, S.7
Kubo, S.8
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21
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38549097102
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Circulating markers of biliary malignancy: Opportunities in proteomics?
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An excellent review focusing on the recent advances on proteomic techniques applied to identify CCA biomarkers
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Bonney GK, Craven RA, Prasad R, et al. Circulating markers of biliary malignancy: opportunities in proteomics? Lancet Oncol 2008; 9:149-158. An excellent review focusing on the recent advances on proteomic techniques applied to identify CCA biomarkers.
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(2008)
Lancet Oncol
, vol.9
, pp. 149-158
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Bonney, G.K.1
Craven, R.A.2
Prasad, R.3
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22
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45149123775
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Serum levels of variants of transthyretin down-regulation in cholangiocarcinoma
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DOI 10.1002/jcb.21661
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Liu L, Wang J, Liu B, Dai S, et al. Serum levels of variants of transthyretin downregulation in cholangiocarcinoma. J Cell Biochem 2008; 104:745-755. (Pubitemid 351830826)
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(2008)
Journal of Cellular Biochemistry
, vol.104
, Issue.3
, pp. 745-755
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Liu, L.1
Wang, J.2
Liu, B.3
Dai, S.4
Wang, X.5
Chen, J.6
Huang, L.7
Xiao, X.8
He, D.9
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23
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33748946887
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Proteomic profiling of cholangiocarcinoma: Diagnostic potential of SELDI-TOF MS in malignant bile duct stricture
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DOI 10.1002/hep.21294
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Scarlett CJ, Saxby AJ, Nielsen A, et al. Proteomic profiling of cholangiocarcinoma: diagnostic potential of SELDI-TOF MS in malignant bile duct stricture. Hepatology 2006; 44:658-666. (Pubitemid 44433722)
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(2006)
Hepatology
, vol.44
, Issue.3
, pp. 658-666
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Scarlett, C.J.1
Saxby, A.J.2
Nielsen, A.3
Bell, C.4
Samra, J.S.5
Hugh, T.6
Baxter, R.C.7
Smith, R.C.8
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24
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39849106455
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New insights on the molecular and cell biology of human cholangiopathies
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Alvaro D, Mancino MG. New insights on the molecular and cell biology of human cholangiopathies. Mol Aspects Med 2008; 29:50-57.
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(2008)
Mol Aspects Med
, vol.29
, pp. 50-57
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Alvaro, D.1
Mancino, M.G.2
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25
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58149214162
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Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor
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Mancino A, Mancino MG, Glaser SS, et al. Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor. Dig Liver Dis 2009; 41:156-163.
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(2009)
Dig Liver Dis
, vol.41
, pp. 156-163
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Mancino, A.1
Mancino, M.G.2
Glaser, S.S.3
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26
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33846205222
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Proliferating Cholangiocytes: A Neuroendocrine Compartment in the Diseased Liver
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DOI 10.1053/j.gastro.2006.07.023, PII S0016508506016660
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Alvaro D, Mancino MG, Glaser S, et al. Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver. Gastroenterology 2007; 132:415-431. (Pubitemid 46108729)
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(2007)
Gastroenterology
, vol.132
, Issue.1
, pp. 415-431
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Alvaro, D.1
Mancino, M.G.2
Glaser, S.3
Gaudio, E.4
Marzioni, M.5
Francis, H.6
Alpini, G.7
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27
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33745710682
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Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma
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DOI 10.2353/ajpath.2006.050464
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Alvaro D, Barbaro B, Franchitto A, et al. Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma. Am J Pathol 2006; 169:877-888. (Pubitemid 44411954)
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(2006)
American Journal of Pathology
, vol.169
, Issue.3
, pp. 877-888
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Alvaro, D.1
Barbaro, B.2
Franchitto, A.3
Onori, P.4
Glaser, S.S.5
Alpini, G.6
Francis, H.7
Marucci, L.8
Sterpetti, P.9
Ginanni-Corradini, S.10
Muda, A.O.11
Dostal, D.E.12
De Santis, A.13
Attili, A.F.14
Benedetti, A.15
Gaudio, E.16
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28
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34848926887
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Serum and biliary insulin-like growth factor I and vascular endothelial growth factor in determining the cause of obstructive cholestasis
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This study demonstrated that bile IGF1 levels is absolutely sensitive and specific for extrahepatic CCA suggesting a role of this biomarkers in the differential diagnosis of patients submitted to ERCP for obstructive cholestasis
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Alvaro D, Macarri G, Mancino MG, et al. Serum and biliary insulin-like growth factor I and vascular endothelial growth factor in determining the cause of obstructive cholestasis. Ann Intern Med 2007; 2:451-459. This study demonstrated that bile IGF1 levels is absolutely sensitive and specific for extrahepatic CCA suggesting a role of this biomarkers in the differential diagnosis of patients submitted to ERCP for obstructive cholestasis.
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(2007)
Ann Intern Med
, vol.2
, pp. 451-459
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Alvaro, D.1
Macarri, G.2
Mancino, M.G.3
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29
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46249109809
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Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma
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Nishino R, Honda M, Yamashita T, et al. Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma. J Hepatol 2008; 49:207-216.
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(2008)
J Hepatol
, vol.49
, pp. 207-216
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Nishino, R.1
Honda, M.2
Yamashita, T.3
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30
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39649094498
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Diagnostic role of biliary pancreatic elastase for cholangiocarcinoma in patients with cholestasis
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The study indicates that ratio of pancreatic elastase/amylase in bile distinguish malignant from benign causes of biliary obstruction with a good sensitivity and specificity
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Chen CY, Tsai WL, Wu HC, et al. Diagnostic role of biliary pancreatic elastase for cholangiocarcinoma in patients with cholestasis. Clin Chim Acta 2008; 390:82-89. The study indicates that ratio of pancreatic elastase/amylase in bile distinguish malignant from benign causes of biliary obstruction with a good sensitivity and specificity.
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(2008)
Clin Chim Acta
, vol.390
, pp. 82-89
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Chen, C.Y.1
Tsai, W.L.2
Wu, H.C.3
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31
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43249095653
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Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in bile aspirates
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DOI 10.1038/sj.bjc.6604342, PII 6604342
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Ayaru L, Stoeber K, Webster GJ, et al. Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in bile aspirates. Br J Cancer 2008; 6:1548-1554. (Pubitemid 351652335)
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(2008)
British Journal of Cancer
, vol.98
, Issue.9
, pp. 1548-1554
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Ayaru, L.1
Stoeber, K.2
Webster, G.J.3
Hatfield, A.R.W.4
Wollenschlaeger, A.5
Okoturo, O.6
Rashid, M.7
Williams, G.8
Pereira, S.P.9
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32
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34548056212
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Two-dimensional electrophoresis for comparative proteomic analysis of human bile
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Chen B, Dong JQ, Chen YJ, et al. Two-dimensional electrophoresis for comparative proteomic analysis of human bile. Hepatobiliary Pancreat Dis Int 2007; 6:402-406. (Pubitemid 47288125)
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(2007)
Hepatobiliary and Pancreatic Diseases International
, vol.6
, Issue.4
, pp. 402-406
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Chen, B.1
Dong, J.-Q.2
Chen, Y.-J.3
Wang, J.-M.4
Tian, J.5
Wang, C.-B.6
Zou, S.-Q.7
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33
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67651135847
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Detection of cholangiocarcinoma with magnetic resonance spectroscopy of bile in patients with and without primary sclerosing cholangitis
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Albiin N, Smith IC, Arnelo U, et al. Detection of cholangiocarcinoma with magnetic resonance spectroscopy of bile in patients with and without primary sclerosing cholangitis. Acta Radiol 2008; 18:1-8.
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(2008)
Acta Radiol
, vol.18
, pp. 1-8
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Albiin, N.1
Smith, I.C.2
Arnelo, U.3
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