Treatment with rhBMP12 or rhBMP13 increase the rate and the quality of rat Achilles tendon repair

Journal of Orthopaedic Research

Volumn 29, Issue 10, 2011, Pages 1604-1612

  Jelinsky, Scott A ^a   Li, Li ^a   Ellis, Debra ^a   Archambault, Joanne ^a   Li, Jian ^a   St Andre, Michael ^a   Morris, Carl ^a   Seeherman, Howard ^a  

^a PFIZER INC   (United States)

Author keywords

BMP12; BMP13; microarray; tendon

Indexed keywords

ACYL COENZYME A LONG CHAIN FAMILY MEMBER 1; ADIPONECTIN; COL12A1 PROTEIN; COLLAGENASE 3; FIBRILLIN 2; FIBROBLAST GROWTH FACTOR; FIBROMODULIN; GELATINASE A; GELATINASE B; GRANULOCYTE CHEMOTACTIC PROTEIN 2; INTERLEUKIN 6; MACROPHAGE ELASTASE; MATRIX METALLOPROTEASE 23; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; PROTEIN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 12; RECOMBINANT BONE MORPHOGENETIC PROTEIN 13; RECOMBINANT GROWTH FACTOR; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN C; STROMELYSIN 3; TENOMODULIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG; VASCULOTROPIN B; VASCULOTROPIN C;

ACHILLES TENDON; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL CYCLE REGULATION; CELL INFILTRATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FIBROBLAST; GENE EXPRESSION PROFILING; GENETIC REGULATION; HISTOPATHOLOGY; INFLAMMATION; MACROPHAGE; MALE; MESENCHYMAL STEM CELL; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPINDLE CELL; TENDON INJURY; TISSUE REPAIR; UPREGULATION;

ACHILLES TENDON; ANIMALS; BONE MORPHOGENETIC PROTEINS; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION PROFILING; GROWTH DIFFERENTIATION FACTOR 6; GROWTH DIFFERENTIATION FACTORS; HUMANS; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; TENDON INJURIES; WOUND HEALING;

EID: 80051550321     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21427     Document Type: Article

References (25)

1. Praemer A, Furner S, Rice DP,. 1992. Musculoskeletal conditions in the United States American Academy of Orthopedic Surgeons. Park Ridge, IL: American Academy of Orthopaedic Surgeons.
2. Praemer A, Furner S, Rice DP,. 1999. Musculoskeletal conditions in the United States American Academy of Orthopedic Surgeons. Park Ridge, IL: American Academy of Orthopaedic Surgeons.
3. Buckwalter JA, Woo SL, Goldberg VM, et al. 1993. Soft-tissue aging and musculoskeletal function. J Bone Joint Surg Am 75: 1533-1548. (Pubitemid 23358242)
4. Horan M, Little R, editors. 1998. Injury in the ageing. New York: Cambridge University Press.
5. Gurtner GC, Werner S, Barrandon Y, et al. 2008. Wound repair and regeneration. Nature 453: 314-321. (Pubitemid 351693137)
6. Martin P,. 1997. Wound healing-aiming for perfect skin regeneration. Science 276: 75-81. (Pubitemid 27161246)
7. Rokito AS, Cuomo F, Gallagher MA, et al. 1999. Long-term functional outcome of repair of large and massive chronic tears of the rotator cuff. J Bone Joint Surg Am 81: 991-997. (Pubitemid 29355009)
8. Wolfman NM, Hattersley G, Cox K, et al. 1997. Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. J Clin Invest 100: 321-330. (Pubitemid 27349078)
9. Aspenberg P, Forslund C,. 1999. Enhanced tendon healing with GDF 5 and 6. Acta Orthop Scand 70: 51-54. (Pubitemid 29119121)
10. Forslund C,. 2003. BMP treatment for improving tendon repair. Studies on rat and rabbit Achilles tendons. Acta Orthop Scand Suppl 74 (I): 1-30.
11. Forslund C, Aspenberg P,. 2002. CDMP-2 induces bone or tendon-like tissue depending on mechanical stimulation. J Orthop Res 20: 1170-1174. (Pubitemid 35363973)
12. Forslund C, Rueger D, Aspenberg P,. 2003. A comparative dose-response study of cartilage-derived morphogenetic protein (CDMP)-1, -2 and -3 for tendon healing in rats. J Orthop Res 21: 617-621. (Pubitemid 36758205)
13. Li X, Leo BM, Beck G, et al. 2004. Collagen and proteoglycan abnormalities in the GDF-5-deficient mice and molecular changes when treating disk cells with recombinant growth factor. Spine 29: 2229-2234. (Pubitemid 40362216)
14. Mikic B,. 2004. Multiple effects of GDF-5 deficiency on skeletal tissues: implications for therapeutic bioengineering. Ann Biomed Eng 32: 466-476.
15. Mikic B, Bierwert L, Tsou D,. 2006. Achilles tendon characterization in GDF-7 deficient mice. J Orthop Res 24: 831-841. (Pubitemid 43804979)
16. Mikic B, Entwistle R, Rossmeier K, et al. 2008. Effect of GDF-7 deficiency on tail tendon phenotype in mice. J Orthop Res 26: 834-839.
17. Settle SH Jr, Rountree RB, Sinha A, et al. 2003. Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Dev Biol 254: 116-130. (Pubitemid 36259876)
18. Jelinsky SA, Turner TT, Bang HJ, et al. 2007. The rat epididymal transcriptome: comparison of segmental gene expression in the rat and mouse epididymides. Biol Reprod 76: 561-570. (Pubitemid 46466512)
19. Livak KJ, Schmittgen TD,. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25: 402-408. (Pubitemid 34164012)
20. Williams MD, Ladermann A, Melis B, et al. 2009. Fatty infiltration of the supraspinatus: a reliability study. J Shoulder Elbow Surg 18: 581-587.
21. Loiselle AE, Bragdon GA, Jacobson JA, et al. 2009. Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression. J Orthop Res 27: 833-840.
22. Clark RT, Johnson TL, Schalet BJ, et al. 2001. GDF-5 deficiency in mice leads to disruption of tail tendon form and function. Connect Tissue Res 42: 175-186. (Pubitemid 33040958)
23. Chhabra A, Tsou D, Clark RT, et al. 2003. GDF-5 deficiency in mice delays Achilles tendon healing. J Orthop Res 21: 826-835. (Pubitemid 37045560)
24. Eliasson P, Fahlgren A, Aspenberg P,. 2008. Mechanical load and BMP signaling during tendon repair: a role for follistatin? Clin Orthop Relat Res 466: 1592-1597.
25. Greenbaum MA, Kanat IO,. 1993. Current concepts in bone healing. Review of the literature. J Am Podiatr Med Assoc 83: 123-129.