Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression

Journal of Orthopaedic Research

Volumn 27, Issue 6, 2009, Pages 833-840

  Loiselle, Alayna E ^a   Bragdon, Gwynne A ^a   Jacobson, Justin A ^a   Hasslund, Sys ^a,c   Cortes, Zenia E ^a   Schwarz, Edward M ^a   Mitten, David J ^a   Awad, Hani A ^a,b   O'Keefe, Regis J ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b University of Rochester   (United States)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Adhesions; Biomechanics; Flexor tendon healing; Matrix metalloproteases; Mouse model

Indexed keywords

COLLAGEN FIBER; GROWTH DIFFERENTIATION FACTOR 5; MATRIX METALLOPROTEINASE; SMAD8 PROTEIN;

ADHESION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; C57BL 6 MOUSE; CATABOLISM; CONTROLLED STUDY; DIFFERENTIAL DISPLAY; FEMALE; FLEXOR REFLEX; FLEXOR TENDON; GENE EXPRESSION; GRANULATION TISSUE; HEALING; HISTOLOGY; IN SITU HYBRIDIZATION; METATARSOPHALANGEAL JOINT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RANGE OF MOTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCAR FORMATION; SYNOVIUM; TENDON INJURY; TENDON RECONSTRUCTION; TENSILE STRENGTH; TISSUE REACTION; TISSUE STRUCTURE;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOMECHANICS; CICATRIX; COLLAGEN TYPE I; COLLAGEN TYPE III; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED C57BL; SYNOVIAL MEMBRANE; TENDON INJURIES; TISSUE ADHESIONS; WOUND HEALING;

EID: 66249105636     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.20769     Document Type: Article

References (30)

1. Lilly SI, Messer TM. 2006. Complications after treatment of flexor tendon injuries. J Am Acad Orthop Surg 14:387-396.
2. Lundborg G, Rank F, Heinau B. 1985. Intrinsic tendon healing. A. new experimental model. Scand J Plast Reconstruct Surg 19:113-117. (Pubitemid 16218996)
3. Mass DP, Tuel RJ. 1991. Intrinsic healing of the laceration site in human superficialis flexor tendons in vitro. J Hand Surg [Am] 16:24-30.
4. Strickland J. 1995. Flexor tendon injuries: I. Foundations of treatment. J Am Acad Orthop Surg 3:44-54.
5. Gelberman RH, Botte MJ, Spiegelman JJ, et al. 1986. The excursion and deformation of repaired flexor tendons treated with protected early motion. J Hand Surg [Am] 11:106-110. (Pubitemid 16187933)
6. Gelberman RH, Woo SL, Lothringer K, et al. 1982. Effects of early intermittent passive mobilization on healing canine flexor tendons. J Hand Surg [Am] 7:170-175.
7. Lou J, Manske PR, Aoki M, et al. 1996. Adenovirus-mediated gene transfer into tendon and tendon sheath. J Orthop Res 14:513-517. (Pubitemid 26278086)
8. Matthews P, Richards H. 1974. The repair potential of digital flexor tendons. J Bone Joint Surg [Am] 56B:618-625.
9. Potenza AD. 1962. Tendon healing within the flexor digital sheath in the dog. J Bone Joint Surg [Am] 44-A:49-64.
10. Oshiro W, Lou J, Xing X, et al. 2003. Flexor tendon healing in the rat: a histologic and gene expression study. J Hand Surg [Am] 28:814-823. (Pubitemid 37175365)
11. Green DP, Hotchkiss RN, Pederson WC. 1999. Green's operative hand surgery, 4th ed. New York: Churchill Livingstone; p v.
12. Battaglia TC, Clark RT, Chhabra A, et al. 2003. Ultrastructural determinants of murine Achilles tendon strength during healing. Connect Tissue Res 44:218-224. (Pubitemid 38035554)
13. Chabbra A, Tsuo D, Clark RT, et al. 2003. GDF-5 deficiency in mice delays Achilles tendon healing. J Orthop Res 21:826-835. (Pubitemid 37045560)
14. Palmes D, Spiegel HU, Schneider TO, et al. 2002. Achilles tendon healing: long-term biomechanical effects of postoperative mobilization and immobilization in a new mouse model. J Orthop Res 20:939-946.
15. Carpenter JE, Thomopoulos S, Soslowsky LJ. 1999. Animal models of tendon and ligament injuries for tissue engineering applications. Clin Orthop Relat Res 367 (Suppl):S296-S311. (Pubitemid 29501509)
16. Wong J, Bennett W, Ferguson MW, et al. 2006. Microscopic and histological examination of the mouse hindpaw digit and flexor tendon arrangement with 3D reconstruction. J Anat 209:533-545. (Pubitemid 44473321)
17. Metsaranta M, Toman D, De Crombrugghe B, et al. 1991. Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs. Biochim Biophys Acta 1089:241-243.
18. Yi Z, Cohen-Barak O, Hagiwara N, et al. 2006. Sox6 directly silences epsilon globin expression in definitive erythropoiesis. PLoS Genet 2:129-139.
19. Hasslund S, Jacobson JA, Dadali T, et al. 2008. Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstruction. J Orthop Res 26:824-833.
20. Hoffmann A, Pelled G, Turgeman G, et al. 2006. Neotendon formation induced by manipulation of the Smad8 signaling pathway in mesenchymal stem cells. J Clin Invest 116:940-952.
21. Wolfman NM, Hattersley G, Cox K, et al. 1997. Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. J Clin Invest 100:321-330.
22. Aoki H, Fujii M, Imamura T, et al. 2001. Synergistic effects of different bone morphogenetic protein type I receptors on alkaline phosphatase induction. J Cell Sci 114 (Pt 8):1483-1489. (Pubitemid 32427835)
23. Schweitzer R, Chyung JH, Murtaugh LC, et al. 2001. Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments. Development 128:3855-3866. (Pubitemid 32998933)
24. Armstrong DG, Jude EB. 2002. The role of matrix metalloproteinases in wound healing. J Am Podiatr Med Assoc 92:12-18.
25. Tsubone T, Moran SL, Subramaniam M, et al. 2006. Effect of TGF-beta inducible early gene deficiency on flexor tendon healing. J Orthop Res 24:569-575. (Pubitemid 43773020)
26. Basile P, Dadali T, Jacobson J, et al. 2008. Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery. Mol Ther 16:466-473.
27. Murchison ND, Price BA, Conner DA, et al. 2007. Regulation of tendon differentiation by Scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons. Development 14:2697-2708. (Pubitemid 47225965)
28. Brent AE, Schweitzer R, Tabin CJ. 2003. A somitic compartment of tendon progenitors. Cell 113:235-248. (Pubitemid 36514974)
29. Shukunami C, Takimoto A, Oro M, et al. 2006. Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes. Dev Biol 298:234-247. (Pubitemid 44414808)
30. Wang QW, Chen ZL, Piao YJ. 2005. Mesenchymal stem cells differentiate into tenocytes by bone morphogenetic protein (BMP) 12 gene transfer. J Biosci Bioeng 100:418-422 (Pubitemid 43181271)