Topical embryonic stem cells enhance wound healing in diabetic rats

Journal of Orthopaedic Research

Volumn 29, Issue 10, 2011, Pages 1554-1562

  Lee, Keun Bae ^a   Choi, Jin ^a   Cho, Seong Beom ^a   Chung, Jae Yoon ^a   Moon, Eun Sun ^a   Kim, Nack Sung ^a   Han, Ho Jae ^b  

^a Chonnam National University Medical School   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

diabetes induced rats model; diabetic wound healing; embryonic stem cells

Indexed keywords

EPIDERMAL GROWTH FACTOR; FIBRONECTIN; INSULIN; MESSENGER RNA; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL POPULATION; CLONE; CONTROLLED STUDY; DIABETES CONTROL; DIABETES MELLITUS; DISEASE MODEL; EMBRYONIC STEM CELL; EXTRACELLULAR MATRIX; GRANULATION TISSUE; HISTOPATHOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; STEM CELL TRANSPLANTATION; WOUND HEALING;

ANIMALS; BLOOD GLUCOSE; BLOOD UREA NITROGEN; CREATININE; DIABETES MELLITUS, TYPE 1; EMBRYONIC STEM CELLS; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR MATRIX; FIBRONECTINS; GRANULATION TISSUE; HEMOGLOBIN A, GLYCOSYLATED; LEUKOCYTE COUNT; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 80051550177     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21385     Document Type: Article

References (32)

1. Falanga V,. 2005. Wound healing and its impairment in the diabetic foot. Lancet 366: 1736-1743. (Pubitemid 41587454)
2. Martin P,. 1997. Wound healing-aiming for perfect skin regeneration. Science 276: 75-81. (Pubitemid 27161246)
3. Singer AJ, Clark RA,. 1999. Cutaneous wound healing. N Engl J Med 341: 738-746. (Pubitemid 29407375)
4. Wu Y, Chen L, Scott PG, et al. 2007. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells 25: 2648-2659. (Pubitemid 47582758)
5. Pecoraro RE, Reiber GE, Burqess EM,. 1990. Pathway to diabetic limb amputation. Basis for prevention. Diabetes Care 13: 513-521. (Pubitemid 20145956)
6. Chien KR, Moretti A, Laugwitz KL,. 2004. Development. ES cells to the rescue. Science 306 (5694): 239-240.
7. Stocum DL,. 2001. Stem cells in regenerative biology and medicine. Wound Repair Regen 9: 429-442. (Pubitemid 34266724)
8. Hodgson DM, Behfar A, Zingman LV, et al. 2004. Stable benefit of embryonic stem cell therapy in myocardial infarction. Am J Physiol Heart Circ Physiol 287: H471-H479. (Pubitemid 38955274)
9. Laflamme MA, Chen KY, Naumova AV, et al. 2007. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol 25: 1015-1024. (Pubitemid 47517637)
10. Lateef H, Aslam MN, Stevens MJ, et al. 2005. Pretreatment of diabetic rats with lipoic acid improves healing of subsequently-induced abrasion wounds. Arch Dermatol Res 297: 75-83. (Pubitemid 41431546)
11. Qiu JG, Chang TH, Steinberg JJ, et al. 1998. Single local instillation of Staphylococcus aureus peptidoglycan prevents diabetes-induced impaired wound healing. Wound Repair Regen 6: 449-456. (Pubitemid 128657158)
12. Smith AG, Hooper MLL,. 1987. Buffalo rat liver cells produce a diffusible activity which inhibit the differentiation of murine embryonal carcinoma and embryonic stem cells. Dev Biol 121: 1-9. (Pubitemid 17076824)
13. Koenig RJ, Peterson CM, Jones RL, et al. 1976. Correlation of glucose regulation and hemoglobin A1c in diabetes mellitus. N Engl J Med 295: 417-420.
14. Haghpanah S, Bogie K, Wang X, et al. 2006. Reliability of electronic versus manual wound measurement techniques. Arch Phys Med Rehabil 87: 1396-1402. (Pubitemid 44470758)
15. Lowry OH, Rosebrough NJ, Farr AL, et al. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.
16. Altavilla D, Saitta A, Cucinotta D, et al. 2001. Inhibition of lipid peroxidation restores impaired vascular endothelial growth factor expression and stimulates wound healing and angiogenesis in the genetically diabetic mouse. Diabetes 50: 667-674. (Pubitemid 32195234)
17. Gallagher KA, Goldstein LJ, Thom SR, et al. 2006. Hyperbaric oxygen and bone marrow-derived endothelial progenitor cells in diabetic wound healing. Vascular 14: 328-337. (Pubitemid 46579399)
18. Bennett SP, Griffiths GD, Schor AM, et al. 2003. Growth factors in the treatment of diabetic foot ulcers. Br J Surg 90: 133-146. (Pubitemid 36237887)
19. Greenhalgh DG,. 1996. The role of growth factors in wound healing. J Trauma 41: 159-167. (Pubitemid 26255276)
20. Dogan S, Demirer S, Kepenekci I, et al. 2009. Epidermal growth factor-containing wound closure enhances wound healing in non-diabetic and diabetic rats. Int Wound J 6: 107-115.
21. Frazier KS, Williams S, Kothapalli D, et al. 1996. Stimulation of fibroblast cell growth, matrix production and granulation tissue formation by connective tissue growth factor. J Invest Dermatol 107: 404-411. (Pubitemid 26284351)
22. Steed DL,. 1995. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity diabetic ulcers. Diabetic Ulcer Study Group. J Vasc Surg 21: 71-81.
23. Galeano M, Altavilla D, Cucinotta D, et al. 2004. Recombinant human erythropoietin stimulates angiogenesis and wound healing in the genetically diabetic mouse. Diabetes 53: 2509-2517. (Pubitemid 39145612)
24. Hamed S, Ullmann Y, Masoud M, et al. 2010. Topical erythropoietin promotes wound repair in diabetic rats. J Invest Dermatol 130: 287-294.
25. Fraidenraich D, Stillwell E, Romero E, et al. 2004. Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells. Science 306: 247-252. (Pubitemid 39336864)
26. Moriya K, Yoshikawa M, Saito K, et al. 2007. Embryonic stem cells develop into hepatocytes after intrasplenic transplantation in CCl4-treated mice. World J Gastroenterol 13: 866-873. (Pubitemid 46470296)
27. Chinzei R, Tanaka Y, Shimizu-Saito K, et al. 2002. Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes. Hepatology 36 (1): 22-29. (Pubitemid 34700758)
28. Corral CJ, Siddiqui A, Wu L, et al. 1999. Vascular endothelial growth factor is more important than basic fibroblast growth factor during ischemic wound healing. Arch Surg 134: 200-205. (Pubitemid 29088975)
29. Clark RA, Lanigan JMz, DellaPelle P, et al. 1982. Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization. J Invest Dermatol 79: 264-269. (Pubitemid 12005678)
30. Ferguson MW, Herrick SE, Spencer MJ, et al. 1996. The histology of diabetic foot ulcers. Diabet Med 13 (Suppl 1), 30S-33S.
31. Loots MA, Lamme EN, Zeegelaar J, et al. 1998. Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds. J Invest Dermatol 111: 850-857. (Pubitemid 28509329)
32. Klimanskaya I, Chung Y, Becker S, et al. 2006. Human embryonic stem cell lines derived from single blastomeres. Nature 444: 481-485. (Pubitemid 44809064)