Cellular accumulation of fluoroquinolones is not predictive of their intracellular activity: Studies with gemifloxacin, moxifloxacin and ciprofloxacin in a pharmacokinetic/pharmacodynamic model of uninfected and infected macrophages

International Journal of Antimicrobial Agents

Volumn 38, Issue 3, 2011, Pages 249-256

  Vallet, Coralie M ^a   Marquez, Béatrice ^a,b   Ngabirano, Eva ^a   Lemaire, Sandrine ^a   Mingeot Leclercq, Marie Paule ^a   Tulkens, Paul M ^a   Van Bambeke, Françoise ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

Author keywords

Ciprofloxacin; Gemifloxacin; Listeria monocytogenes; Macrophages; Moxifloxacin; Mrp4; Staphylococcus aureus

Indexed keywords

ADENOSINE TRIPHOSPHATE; CIPROFLOXACIN; GEMFIBROZIL; GEMIFLOXACIN; MOXIFLOXACIN; MULTIDRUG RESISTANCE PROTEIN 4; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG ACCUMULATION; DRUG EFFICACY; DRUG POTENCY; DRUG TRANSPORT; EXPERIMENTAL INFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LISTERIA MONOCYTOGENES; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; MONOCYTE; NONHUMAN; PHAGOLYSOSOME; PHARMACOKINETICS; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; TRANSPORT KINETICS;

ANIMALS; ANTI-BACTERIAL AGENTS; AZA COMPOUNDS; CELL LINE; CIPROFLOXACIN; FLUOROQUINOLONES; HUMANS; LISTERIA MONOCYTOGENES; MACROPHAGES; MICE; MICROBIAL SENSITIVITY TESTS; NAPHTHYRIDINES; QUINOLINES; STAPHYLOCOCCUS AUREUS;

EID: 80051549778     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2011.05.011     Document Type: Article

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