Combining molecular modeling with experimental methodologies: Mechanism of membrane permeation and accumulation of ofloxacin

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 12, 2002, Pages 3871-3889

  Fresta, Massimo ^a   Guccione, Salvatore ^b   Beccari, Andrea R ^b   Furneri, Pio M ^b   Puglisi, Giovanni ^b  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; DIPALMITOYLPHOSPHATIDYLCHOLINE; ENZYME; MAGNESIUM ION; OFLOXACIN; QUINOLONE DERIVATIVE;

ACIDITY; ALKALINITY; ARTICLE; BACTERIAL CELL; BACTERIAL STRAIN; CHEMICAL ENVIRONMENT; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ACCUMULATION; DRUG DIFFUSION; DRUG PENETRATION; DRUG SPECIFICITY; ENZYME INHIBITION; ESCHERICHIA COLI; EXPERIMENTATION; HYDROPHOBICITY; IONIC STRENGTH; MEMBRANE MODEL; MEMBRANE PERMEABILITY; METHODOLOGY; MOLECULAR MODEL; MOLECULE; NONHUMAN; PHYSICAL CHEMISTRY; PROTON TRANSPORT;

1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE; BIOLOGICAL TRANSPORT; CALORIMETRY, DIFFERENTIAL SCANNING; CATIONS, DIVALENT; CELL MEMBRANE PERMEABILITY; FLUOROQUINOLONES; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; LIPID BILAYERS; MODELS, MOLECULAR; OFLOXACIN; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0036975799     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00350-4     Document Type: Article

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