Nitrate patch prevents steroid-related bone necrosis

Journal of Orthopaedic Research

Volumn 29, Issue 10, 2011, Pages 1517-1520

  Drescher, Wolf ^a   Beckmann, Rainer ^a   Kasch, Richard ^b   Pufe, Melanie ^a   Knobe, Matthias ^a   Kweider, Nisreen ^a   Hassenpflug, Joachim ^c   Tingart, Markus ^a   Pufe, Thomas ^a   Kadyrov, Mahmed ^d  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

nitric oxide; osteonecrosis; prevention; steroid treatment

Indexed keywords

METHYLPREDNISOLONE; NITRATE; PARAFFIN; PARAFORMALDEHYDE; PHOSPHATE BUFFERED SALINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; DRUG MECHANISM; FEMUR HEAD NECROSIS; HISTOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MORPHOMETRICS; NONHUMAN; OSTEOCYTE; PRIORITY JOURNAL; RABBIT; TISSUE SECTION;

ANIMALS; ENDOTHELIUM-DEPENDENT RELAXING FACTORS; FEMUR HEAD; FEMUR HEAD NECROSIS; GLUCOCORTICOIDS; MALE; METHYLPREDNISOLONE; NITRIC OXIDE; RABBITS;

EID: 80051544837     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21420     Document Type: Article

References (33)

1. Mont MA, Hungerford DS,. 1995. Non-traumatic avascular necrosis of the femoral head. J Bone Joint Surg Am 77: 459-474.
2. Drescher W, Schneider T, Becker C, et al. 2001. Selective reduction of bone blood flow by short-term treatment with high-dose methylprednisolone. An experimental study in pigs. J Bone Joint Surg Br 83: 274-277. (Pubitemid 32242030)
3. Drescher W, Li H, Lundgaard A, et al. 2006. Endothelin-1-induced femoral head epiphyseal artery constriction is enhanced by long-term corticosteroid treatment. J Bone Joint Surg Am 88 (Suppl 3): 173-179. (Pubitemid 44706500)
4. Brinker MR, Lippton HL, Cook SD, et al. 1990. Pharmacological regulation of the circulation of bone [published erratum appears in J Bone Joint Surg Am 1990 Sep; 72(8): 1270]. J Bone Joint Surg Am 72: 964-975.
5. Drescher W, Varoga D, Liebs TR, et al. 2006. Femoral artery constriction by norepinephrine is enhanced by methylprednisolone in a rat model. J Bone Joint Surg Am 88 (Suppl 3): 162-166. (Pubitemid 44706498)
6. Tran MA, Geral JP,. 1978. The influence of some vasoactive drugs on bone circulation. Eur J Pharmacol 52: 109-114. (Pubitemid 9197652)
7. Lundgaard A, Aalkjaer C, Holm-Nielsen P, et al. 1996. Method for assessment of vascular reactivity in bone: in vitro studies on resistance arteries isolated from porcine cancellous bone. J Orthop Res 14: 962-971. (Pubitemid 27044466)
8. Lundgaard A, Aalkjaer C, Bjurholm A, et al. 1997. Vasorelaxation in isolated bone arteries. Vasoactive intestinal peptide, substance P, calcitonin gene-related peptide, and bradykinin studied in pigs. Acta Orthop Scand 68: 481-489. (Pubitemid 27485117)
9. Driessens M, Vanhoutte PM,. 1981. Effect of calcitonin, hydrocortisone, and parathyroid hormone on canine bone blood vessels. Am J Physiol 241: H91-H94. (Pubitemid 11032648)
10. Fryer JP, Granger DK, Leventhal JR, et al. 1994. Steroid-related complications in the cyclosporine era. Clin Transplant 8: 224-229. (Pubitemid 24162292)
11. Fryer JP, Benedetti E, Gillingham K, et al. 1994. Steroid-related complications in pediatric kidney transplant recipients in the cyclosporine era. Transplant Proc 26: 91-92. (Pubitemid 24080431)
12. Trueta J,. 1957. The normal vascular anatomy of the human femoral head during growth. J Bone Joint Surg [Br] 39: 358-394.
13. Trueta J,. 1997. The normal vascular anatomy of the femoral head in adult man. 1953 [classical article]. Clin Orthop 334: 6-14.
14. Davis TR, Wood MB,. 1991. The effects of ischemia on long bone vascular resistance. J Orthop Res 9: 883-889.
15. Yamamoto T, Irisa T, Sugioka Y, et al. 1997. Effects of pulse methylprednisolone on bone and marrow tissues: corticosteroid-induced osteonecrosis in rabbits [see comments]. Arthritis Rheum 40: 2055-2064. (Pubitemid 27494667)
16. Tan T, Zhang Q, Anyadike C, et al. 2007. Chronic nitrates blunt the effects of not only nitric oxide but also natriuretic peptides in cardiac myocytes. Pharmacol Res 56: 49-55. (Pubitemid 46990930)
17. Yamamoto T, DiCarlo EF, Bullough PG,. 1999. The prevalence and clinicopathological appearance of extension of osteonecrosis in the femoral head. J Bone Joint Surg Br 81: 328-332. (Pubitemid 29327077)
18. Horwitz KB, Horwitz LD,. 1982. Canine vascular tissues are targets for androgens, estrogens, progestins, and glucocorticoids. J Clin Invest 69: 750-758. (Pubitemid 12157262)
19. Sessa WC, Nasjletti A,. 1990. Dexamethasone selectively attenuates prostanoid-induced vasoconstrictor responses in vitro. Circ Res 66: 383-388. (Pubitemid 20041169)
20. Altura BM,. 1966. Role of glucocorticoids in local regulation of blood flow. Am J Physiol 211: 1393-1397.
21. Wang GJ, Cui Q, Balian G,. 2000. The Nicolas Andry award. The pathogenesis and prevention of steroid- induced osteonecrosis. Clin Orthop Relat Res 370: 295-310. (Pubitemid 30059165)
22. Axelrod L,. 1983. Inhibition of prostacyclin production mediates permissive effect of glucocorticoids on vascular tone. Perturbations of this mechanism contribute to pathogenesis of Cushing's syndrome and Addison's disease. Lancet 1: 904-906. (Pubitemid 13112151)
23. Schomig A, Luth B, Dietz R, et al. 1976. Changes in vascular smooth muscle sensitivity to vasoconstrictor agents induced by corticosteroids, adrenalectomy and differing salt intake in rats. Clin Sci Mol Med Suppl 3: 61s-63s.
24. Yin K, Chu ZM, Beilin LJ,. 1992. Study of mechanisms of glucocorticoid hypertension in rats: endothelial related changes and their amelioration by dietary fish oils. Br J Pharmacol 106: 435-442.
25. Vendegh Z, Melly A, Toth B, et al. 2010. Calcitonin gene-related peptide, substance P, nitric oxide and epinephrine modulate bone marrow micro circulation of the rabbit tibia and femur. Clin Hemorheol Microcirc 45: 9-17.
26. Sanada M, Taguchi A, Higashi Y, et al. 2004. Forearm endothelial function and bone mineral loss in postmenopausal women. Atherosclerosis 176: 387-392. (Pubitemid 39369530)
27. El Kadri M, Sharaf-Dabbagh H, Ramsdale D,. 2010. Review: role of antiischemic agents in the management of non-ST elevation acute coronary syndrome (NSTEACS). Cardiovasc Ther DOI: 10.1111/j.1755-5922.2010.00225.x. [Epub ahead of print].
28. McCarthy ID, Andhoga M, Batten JJ, et al. 1997. Endothelium-dependent vasodilatation produced by the L-arginine/nitric oxide pathway in normal and ischemic bone. Acta Orthop Scand 68: 361-368. (Pubitemid 27397244)
29. Iwakiri K, Oda Y, Kaneshiro Y, et al. 2008. Effect of simvastatin on steroid-induced osteonecrosis evidenced by the serum lipid level and hepatic cytochrome P4503A in a rabbit model. J Orthop Sci 13: 463-468.
30. Cui Q, Wang GJ, Balian G,. 1997. Steroid-induced adipogenesis in a pluripotential cell line from bone marrow. J Bone Joint Surg Am 79: 1054-1063. (Pubitemid 27310576)
31. Pritchett JW,. 2001. Statin therapy decreases the risk of osteonecrosis in patients receiving steroids. Clin Orthop Relat Res 386: 173-178. (Pubitemid 32391291)
32. Ajmal M, Matas AJ, Kuskowski M, et al. 2009. Does statin usage reduce the risk of corticosteroid-related osteonecrosis in renal transplant population? Orthop Clin North Am 40: 235-239.
33. Takao M, Sakai T, Nishii T, et al. 2011. Incidence and predictors of osteonecrosis among cyclosporin- or tacrolimus-treated renal allograft recipients. Rheumatol Int 31 (2): 165-170.