Increasing vascularity to improve healing of a segmental defect of the rat femur

Journal of Orthopaedic Trauma

Volumn 25, Issue 8, 2011, Pages 472-476

  Stewart, Rena ^a   Goldstein, Jessica ^a   Eberhardt, Alan ^b   Gabriel Chu, Gabe Tien Min ^c   Gilbert, Shawn ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b and Radiation Oncology   (United States)

^c INDIANA UNIVERSITY SCHOOL OF DENTISTRY   (United States)

Author keywords

desferrioxamine; hypoxia inducible factor; polypropylene fumarate; segmental defect

Indexed keywords

DEFEROXAMINE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE RADIOGRAPHY; CONTROLLED STUDY; FEMUR FRACTURE; FRACTURE FIXATION; FRACTURE HEALING; HISTOPATHOLOGY; LOW DRUG DOSE; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULARIZATION; WEIGHT BEARING;

ANGIOGENESIS INDUCING AGENTS; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; DEFEROXAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMORAL FRACTURES; FRACTURE HEALING; NEOVASCULARIZATION, PHYSIOLOGIC; POLYPHARMACY; RATS; RECOMBINANT PROTEINS; TRANSFORMING GROWTH FACTOR BETA; TREATMENT OUTCOME;

EID: 80051544017     PISSN: 08905339     EISSN: 15312291     Source Type: Journal    
DOI: 10.1097/BOT.0b013e31822588d8     Document Type: Article

References (11)

1. Tzioupis C, Giannoudis P. Prevalence of long-bone non-unions. Injury. 2007;38(suppl 2):S3-S9. (Pubitemid 47498401)
2. Martin D, Semple J, Sefton M. Poly(methacrylic acid-co-methyl methacrylate) beads promote vascularization and wound repair in diabetic mice. J Biomed Mater Res A. 2010;93:484-492.
3. Shen X, Wan C, Ramaswamy G, et al. Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice. J Orthop Res. 2009;27:1298-1305.
4. Garcia P, Holstein J, Maier S, et al. Development of a reliable non-union model in mice. J Surg Res. 2008;147:84-91. (Pubitemid 351635799)
5. Wan C, Gilbert S, Wang Y, et al. Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration. Proc Natl Acad Sci U S A. 2008;105:686-691. (Pubitemid 351171769)
6. Chu T, Warden S, Turner C, et al. Segmental bone regeneration using a load-bearing biodegradable carrier of bone morphogenetic protein-2. Biomaterials. 2007;28:459-467. (Pubitemid 44602234)
7. Stewart RL, Cox JT, Volgas D, et al. The use of a biodegradable, loadbearing scaffold as a carrier for antibiotics in an infected open fracture model. J Orthop Trauma. 2010;24:587-591.
8. Street J, Bao M, deGuzman L, et al. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci U S A. 2002;99:9656-9661. (Pubitemid 34831103)
9. Geiger F, Bertram H, Berger I, et al. Vascular endothelial growth factor gene-activated matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects. J Bone Miner Res. 2005; 20:2028-2035. (Pubitemid 41532788)
10. Majmundar AJ, Wong WJ, Simon MC. Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell. 2010;40:294-309.
11. Asikainen T, Ahmad A, Schneider B, et al. Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells. Free Radic Biol Med. 2005;38: 1002-1013. (Pubitemid 40386546)