Development of a Reliable Non-Union Model in Mice

Journal of Surgical Research

Volumn 147, Issue 1, 2008, Pages 84-91

  Garcia, Patric ^a   Holstein, Jörg H ^a   Maier, Sabrina ^a   Schaumlöffel, Hagen ^a   Al Marrawi, Fuad ^a   Hannig, Matthias ^a   Pohlemann, Tim ^a   Menger, Michael D ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

animal model; bone; bone healing; delayed union; fracture healing; mouse; musculoskeletal; non union; pseudarthrosis; vascularization

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALLUS; CONTROLLED STUDY; FEMALE; FRACTURE HEALING; FRACTURE NONUNION; HISTOPATHOLOGY; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; PERIOSTEUM GRAFT; PRIORITY JOURNAL; RADIODIAGNOSIS; SCORING SYSTEM;

ANIMALS; ANTIGENS, CD31; DISEASE MODELS, ANIMAL; FEMALE; FEMUR; FRACTURE HEALING; FRACTURES, UNUNITED; MALE; MICE;

EID: 43049173508     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2007.09.013     Document Type: Article

References (34)

1. Einhorn T.A. Enhancement of fracture-healing. J Bone Joint Surg Am 77 (1995) 940
2. Megas P. Classification of non-union. Injury 36 Suppl 4 (2005) S30
3. Hayda R.A., and Bosse M.J. Moderators' summary: Management of segmental bone defects. J Am Acad Orthop Surg 14 (2006) S142
4. Reed A.A., Joyner C.J., Brownlow H.C., et al. Human atrophic fracture non-unions are not avascular. J Orthop Res 20 (2002) 593
5. Reed A.A., Joyner C.J., Isefuku S., et al. Vascularity in a new model of atrophic nonunion. J Bone Joint Surg Br 85 (2003) 604
6. Brownlow H.C., Reed A., and Simpson A.H. Growth factor expression during the development of atrophic non-union. Injury 32 (2001) 519
7. Hietaniemi K., Peltonen J., and Paavolainen P. An experimental model for non-union in rats. Injury 26 (1995) 681
8. Harrison L.J., Cunningham J.L., Stromberg L., et al. Controlled induction of a pseudarthrosis: A study using a rodent model. J Orthop Trauma 17 (2003) 11
9. Oni O.O. A non-union model of the rabbit tibial diaphysis. Injury 26 (1995) 619
10. Fujita M., Matsui N., Tsunoda M., et al. Establishment of a non-union model using muscle interposition without osteotomy in rats. Kobe J Med Sci 44 (1998) 217
11. Brownlow H.C., and Simpson A.H. Metabolic activity of a new atrophic non-union model in rabbits. J Orthop Res 18 (2000) 438
12. Brownlow H.C., Reed A., and Simpson A.H. The vascularity of atrophic non-unions. Injury 33 (2002) 145
13. Choi P., Ogilvie C., Thompson Z., et al. Cellular and molecular characterization of a murine non-union model. J Orthop Res 22 (2004) 1100
14. Audige L., Griffin D., Bhandari M., et al. Path analysis of factors for delayed healing and nonunion in 416 operatively treated tibial shaft fractures. Clin Orthop Relat Res 438 (2005) 221
15. Goldberg V.M., Powell A., Shaffer J.W., et al. Bone grafting: Role of histocompatibility in transplantation. J Orthop Res 3 (1985) 389
16. Vecchi A., Garlanda C., Lampugnani M.G., et al. Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium. Eur J Cell Biol 63 (1994) 247
17. dos Santos-Neto F.L., and Volpon J.B. Experimental nonunion in dogs. Clin Orthop Relat Res 260 (1984)
18. Utvag S.E., Grundnes O., and Reikeras O. Graded exchange reaming and nailing of non-unions. Strength and mineralization in rat femoral bone. Arch Orthop Trauma Surg 118 (1998) 1
19. Volpon J.B. Non-union using a canine model. Arch Orthop Trauma Surg 113 (1994) 312
20. Einhorn T.A., Lane J.M., Burstein A.H., et al. The healing of segmental bone defects induced by demineralized bone matrix. A radiographic and biomechanical study. J Bone Joint Surg Am 66 (1984) 274
21. den Boer F.C., Patka P., Bakker F.C., et al. New segmental long bone defect model in sheep: Quantitative analysis of healing with dual energy X-ray absorptiometry. J Orthop Res 17 (1999) 654
22. Manigrasso M.B., and O'Connor J.P. Characterization of a closed femur fracture model in mice. J Orthop Trauma 18 (2004) 687
23. Holstein J.H., Menger M.D., Culemann U., et al. Development of a locking femur nail for mice. J Biomech 40 (2007) 215
24. Schmidhammer R., Zandieh S., Mittermayr R., et al. Assessment of bone union/nonunion in an experimental model using microcomputed technology. J Trauma 61 (2006) 199
25. Utvag S.E., Grundnes O., and Reikeraos O. Effects of periosteal stripping on healing of segmental fractures in rats. J Orthop Trauma 10 (1996) 279
26. Oni O.O., Stafford H., and Gregg P.J. An experimental study of the patterns of periosteal and endosteal damage in tibial shaft fractures using a rabbit trauma model. J Orthop Trauma 3 (1989) 142
27. Rhinelander F.W. Tibial blood supply in relation to fracture healing. Clin Orthop Relat Res 34 (1974)
28. Utvag S.E., and Reikeras O. Effects of nail rigidity on fracture healing. Strength and mineralization in rat femoral bone. Arch Orthop Trauma Surg 118 (1998) 7
29. Utvag S.E., Rindal D.B., and Reikeras O. Effects of torsional rigidity on fracture healing: Strength and mineralization in rat femora. J Orthop Trauma 13 (1999) 212
30. Perren S.M. Physical and biological aspects of fracture healing with special reference to internal fixation. Clin Orthop Relat Res 175 (1979)
31. Claes L., Augat P., Suger G., et al. Influence of size and stability of the osteotomy gap on the success of fracture healing. J Orthop Res 15 (1997) 577
32. Markel M.D., Wikenheiser M.A., and Chao E.Y. Formation of bone in tibial defects in a canine model. Histomorphometric and biomechanical studies. J Bone Joint Surg Am 73 (1991) 914
33. Claes L., Grass R., Schmickal T., et al. Monitoring and healing analysis of 100 tibial shaft fractures. Langenbecks Arch Surg 387 (2002) 146
34. Sturmer K.M. [Pathophysiology of disrupted bone healing]. Orthopade 25 (1996) 386