All-trans retinoic acid results in irregular repair of septa and fails to inhibit proinflammatory macrophages

European Respiratory Journal

Volumn 38, Issue 2, 2011, Pages 425-439

  Seifart, C ^a   Muyal, J P ^b,g   Plagens, A ^a   Yildirim, A O ^b,c   Kohse, K ^c   Grau, V ^d   Sandu, S ^b   Reinke, C ^a   Tschernig, T ^e   Vogelmeier, C ^a   Fehrenbach, H ^b,f  

^a UNIVERSITY HOSPITAL MARBURG   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d JUSTUS LIEBIG UNIVERSITY   (Germany)

^e HANNOVER MEDICAL SCHOOL   (Germany)

^f RESEARCH CENTER BORSTEL   (Germany)

^g GAUTAM BUDDHA UNIVERSITY   (India)

Author keywords

All trans retinol; Emphysema; Macrophages; Matrix metalloproteinases; Pulmonary alveoli; Regeneration

Indexed keywords

ELASTASE; ELASTIN; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MACROPHAGE ELASTASE; MATRILYSIN; MONOCYTE CHEMOTACTIC PROTEIN 1; OLIVE OIL; RETINOIC ACID; SODIUM CHLORIDE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMPHYSEMA; ENZYME INDUCTION; INCUBATION TIME; INHIBITION KINETICS; LUNG ALVEOLUS CELL TYPE 2; LUNG ALVEOLUS WALL; LUNG RESECTION; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TISSUE REPAIR;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELL LINE; ECTODYSPLASINS; ELASTIN; EMPHYSEMA; INTERLEUKIN-1BETA; LUNG; MACROPHAGES; MALE; MATRIX METALLOPROTEINASE 12; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 7; MATRIX METALLOPROTEINASE 9; PANCREATIC ELASTASE; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TRETINOIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80051541289     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00123809     Document Type: Article

References (57)

1. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1995; 152: S77-S121.
2. Massaro GD, Massaro D. Postnatal treatment with retinoic acid increases the number of pulmonary alveoli in rats. Am J Physiol 1996; 270: L305-L310.
3. Hind M, Maden M. Retinoic acid induces alveolar regeneration in the adult mouse lung. Eur Respir J 2004; 23: 20-27. (Pubitemid 38088491)
4. Garber SJ, Zhang H, Foley JP, et al. Hormonal regulation of alveolarization: structure-function correlation. Respir Res 2006; 7: 47.
5. Stinchcombe SV, Maden M. Retinoic acid induced alveolar regeneration: critical differences in strain sensitivity. Am J Respir Cell Mol Biol 2008; 38: 185-191. (Pubitemid 351162840)
6. Belloni PN, Garvin L, Mao CP, et al. Effects of all-trans-retinoic acid in promoting alveolar repair. Chest 2000; 117: 235S-241S. (Pubitemid 30326965)
7. Massaro GD, Massaro D. Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats. Nat Med 1997; 3: 675-677. (Pubitemid 27264979)
8. Ofulue AF, Xiang AF, Yang Y, et al. Retinoids reverse cigarette smoke induced emphysema in rats. Am J Respir Crit Care Med 2002; 165: A137.
9. Fujita M, Ye Q, Ouchi H, et al. Retinoic acid fails to reverse emphysema in adult mouse models. Thorax 2004; 59: 224-230. (Pubitemid 38339879)
10. Lucey EC, Goldstein RH, Breuer R, et al. Retinoic acid does not affect alveolar septation in adult FVB mice with elastase-induced emphysema. Respiration 2003; 70: 200-205. (Pubitemid 36578790)
11. March TH, Cossey PY, Esparza DC, et al. Inhalation administration of all-trans-retinoic acid for treatment of elastase-induced pulmonary emphysema in Fischer 344 rats. Exp Lung Res 2004; 30: 383-404. (Pubitemid 38925125)
12. March TH, Bowen LE, Finch GL, et al. Effects of strain and treatment with inhaled all-trans-retinoic acid on cigarette smoke-induced pulmonary emphysema in mice. COPD 2005; 2: 289-302. (Pubitemid 43879445)
13. Meshi B, Vitalis TZ, Ionescu D, et al. Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory response. Am J Respir Cell Mol Biol 2002; 26: 52-57. (Pubitemid 34029820)
14. Yoshimatsu A, Nan-ya K, Miki I. Effect of nartograstim, a recombinant human granulocyte colony-stimulating factor on elastase-induced emphysema in rats. Arzneimittelforschung 2009; 59: 248-253.
15. Frankenberger M, Heimbeck I, Moller W, et al. Inhaled all-trans retinoic acid in an individual with severe emphysema. Eur Respir J 2009; 34: 1487-1489.
16. Mao JT, Tashkin DP, Belloni PN, et al. All-trans retinoic acid modulates the balance of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in patients with emphysema. Chest 2003; 124: 1724-1732. (Pubitemid 37433565)
17. Mao JT, Goldin JG, Dermand J, et al. A pilot study of all-transretinoic acid for the treatment of human emphysema. Am J Respir Crit Care Med 2002; 165: 718-723. (Pubitemid 34194764)
18. Roth MD, Connett JE, D'Armiento JM, et al. Feasibility of retinoids for the treatment of emphysema study. Chest 2006; 130: 1334-1345. (Pubitemid 44786724)
19. Massaro D, Massaro GD. Toward therapeutic pulmonary alveolar regeneration in humans. Proc Am Thorac Soc 2006; 3: 709-712. (Pubitemid 44788229)
20. Liebeskind A, Srinivasan S, Kaetzel D, et al. Retinoic acid stimulates immature lung fibroblast growth via a PDGF-mediated autocrine mechanism. Am J Physiol Lung Cell Mol Physiol 2000; 279: L81-L90. (Pubitemid 30619527)
21. Maden M. Retinoids have differing efficacies on alveolar regeneration in a dexamethasone-treated mouse. Am J Respir Cell Mol Biol 2006; 35: 260-267. (Pubitemid 44175327)
22. Zhao L, Leung JK, Yamamoto H, et al. Identification of p311 as a potential gene regulating alveolar generation. Am J Respir Cell Mol Biol 2006; 35: 48-54. (Pubitemid 43993153)
23. Clerch LB, Baras AS, Massaro GD, et al. DNA microarray analysis of neonatal mouse lung connects regulation of KDR with dexamethasone-induced inhibition of alveolar formation. Am J Physiol Lung Cell Mol Physiol 2004; 286: L411-L419. (Pubitemid 38129523)
24. Burri PH. Structural aspects of postnatal lung development - alveolar formation and growth. Biol Neonate 2006; 89: 313-322. (Pubitemid 43886947)
25. Greenlee KJ, Werb Z, Kheradmand F. Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted. Physiol Rev 2007; 87: 69-98. (Pubitemid 46209991)
26. Ryu J, Vicencio AG, Yeager ME, et al. Differential expression of matrix metalloproteinases and their inhibitors in human and mouse lung development. Thromb Haemost 2005; 94: 175-183. (Pubitemid 40974722)
27. Belvisi MG, Bottomley KM. The role of matrix metalloproteinases (MMPs) in the pathophysiology of chronic obstructive pulmonary disease (COPD): a therapeutic role for inhibitors of MMPs? Inflamm Res 2003; 52: 95-100. (Pubitemid 36470068)
28. Elkington PT, Friedland JS. Matrix metalloproteinases in destructive pulmonary pathology. Thorax 2006; 61: 259-266.
29. Baraldo S, Bazzan E, Zanin ME, et al. Matrix metalloproteinase-2 protein in lung periphery is related to COPD progression. Chest 2007; 132: 1733-1740.
30. Parks WC. Matrix metalloproteinases in lung repair. Eur Respir J 2003; 22: 36S-38S. (Pubitemid 37222061)
31. Parks WC, Shapiro SD. Matrix metalloproteinases in lung biology. Respir Res 2001; 2: 10-19. (Pubitemid 34187902)
32. Shifren A, Durmowicz AG, Knutsen RH, et al. Elastin protein levels are a vital modifier affecting normal lung development and susceptibility to emphysema. Am J Physiol Lung Cell Mol Physiol 2007; 292: L778-L787. (Pubitemid 46376996)
33. Fehrenbach H, Zimmermann G, Starke E, et al. Nitrogen dioxide induces apoptosis and proliferation but not emphysema in rat lungs. Thorax 2007; 62: 438-446. (Pubitemid 46698395)
34. Hirschburger M, Zakrzewicz A, Kummer W, et al. Nicotine attenuates macrophage infiltration in rat lung allografts. J Heart Lung Transplant 2009; 28: 493-500.
35. Fehrenbach H, Kasper M, Tschernig T, et al. Keratinocyte growth factor-induced hyperplasia of rat alveolar type II cells in vivo is resolved by differentiation into type I cells and by apoptosis. Eur Respir J 1999; 14: 534-544. (Pubitemid 29479716)
36. Hsia CC, Hyde DM, Ochs M, et al. An official research policy statement of the American Thoracic Society/European Respiratory Society: standards for quantitative assessment of lung structure. Am J Respir Crit Care Med 2010; 181: 394-418.
37. Muyal JP, Muyal V, Kaistha BP, et al. Systematic comparison of RNA extraction techniques from frozen and fresh lung tissues: checkpoint towards gene expression studies. Diagn Pathol 2009; 4: 9.
38. Rosenthal FS. Aerosol probes of emphysema progression in dogs treated with all trans retinoic acid - an exploratory study. J Aerosol Med 2007; 20: 83-96. (Pubitemid 46870212)
39. Schmiedl A, Lempa T, Hoymann HG, et al. Elastase-induced lung emphysema in rats is not reduced by hematopoietic growth factors when applied preventionally. Virchows Arch 2008; 452: 675-688.
40. Yildirim AO, Muyal V, John G, et al. Palifermin induces alveolar maintenance programs in emphysematous mice. Am J Respir Crit Care Med 2010; 181: 705-717.
41. Yan X, Bellotto DJ, Foster DJ, et al. Retinoic acid induces nonuniform alveolar septal growth after right pneumonectomy. J Appl Physiol 2004; 96: 1080-1089. (Pubitemid 38248686)
42. Dane DM, Yan X, Tamhane RM, et al. Retinoic acid-induced alveolar cellular growth does not improve function after right pneumonectomy. J Appl Physiol 2004; 96: 1090-1096. (Pubitemid 38248687)
43. Tepper J, Pfeiffer J, Aldrich M, et al. Can retinoic acid ameliorate the physiologic and morphologic effects of elastase instillation in the rat? Chest 2000; 117: 242S-244S. (Pubitemid 30326967)
44. Yan X, Bellotto DJ, Dane DM, et al. Lack of response to all-trans retinoic acid supplementation in adult dogs following left pneumonectomy. J Appl Physiol 2005; 99: 1681-1688. (Pubitemid 41547163)
45. Dunsmore SE, Saarialho-Kere UK, Roby JD, et al. Matrilysin expression and function in airway epithelium. J Clin Invest 1998; 102: 1321-1331. (Pubitemid 28467560)
46. Frankenberger M, Hauck RW, Frankenberger B, et al. All transretinoic acid selectively down-regulates matrix metalloproteinase-9 (MMP-9) and up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) in human bronchoalveolar lavage cells. Mol Med 2001; 7: 263-270.
47. Cataldo D, Munaut C, Noel A, et al. MMP-2- and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary disease. Int Arch Allergy Immunol 2000; 123: 259-267.
48. Chen Y, Chen P, Hanaoka M, et al. Enhanced levels of prostaglandin E2 and matrix metalloproteinase-2 correlate with the severity of airflow limitation in stable COPD. Respirology 2008; 13: 1014-1021.
49. Braunhut SJ, Moses MA. Retinoids modulate endothelial cell production of matrix-degrading proteases and tissue inhibitors of metalloproteinases (TIMP). J Biol Chem 1994; 269: 13472-13479. (Pubitemid 24206122)
50. Coraux C, Martinella-Catusse C, Nawrocki-Raby B, et al. Differential expression of matrix metalloproteinases and interleukin-8 during regeneration of human airway epithelium in vivo. J Pathol 2005; 206: 160-169. (Pubitemid 40754019)
51. Chen P, McGuire JK, Hackman RC, et al. Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity. Am J Pathol 2008; 172: 1256-1270. (Pubitemid 351671539)
52. Rahman I. Regulation of nuclear factor-κB, activator protein-1, and glutathione levels by tumor necrosis factor-α and dexamethasone in alveolar epithelial cells. Biochem Pharmacol 2000; 60: 1041-1049.
53. Grivennikov SI, Kuprash DV, Liu ZG, et al. Intracellular signals and events activated by cytokines of the tumor necrosis factor superfamily: from simple paradigms to complex mechanisms. Int Rev Cytol 2006; 252: 129-161. (Pubitemid 44375088)
54. Birrell MA, Wong S, Hele DJ, et al. Steroid-resistant inflammation in a rat model of chronic obstructive pulmonary disease is associated with a lack of nuclear factor-κB pathway activation. Am J Respir Crit Care Med 2005; 172: 74-84. (Pubitemid 40923317)
55. Ishii Y, Itoh K, Morishima Y, et al. Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema. J Immunol 2005; 175: 6968-6975. (Pubitemid 41598943)
56. Plantier L, Marchand-Adam S, Antico VG, et al. Keratinocyte growth factor protects against elastase-induced pulmonary emphysema in mice. Am J Physiol Lung Cell Mol Physiol 2007; 293: L1230-L1239. (Pubitemid 350159407)
57. Moestrup SK, Moller HJ. CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response. Ann Med 2004; 36: 347-354. (Pubitemid 39233102)