Long-term simvastatin attenuates lung injury and oxidative stress in murine acute lung injury models induced by oleic acid and endotoxin

Respiratory Care

Volumn 56, Issue 8, 2011, Pages 1156-1163

  Altintas, Neriman Defne ^a   Atilla, Pergin ^a   Iskit, Alper Bektas ^a   Topeli, Arzu ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Glutathione; Lipid peroxidation; Lung histopathology; Malondialdehyde; Myeloperoxidase; Statin

Indexed keywords

GLUTATHIONE; MALONALDEHYDE; MYELOPEROXIDASE; SIMVASTATIN;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD SAMPLING; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; HISTOPATHOLOGY; INFLAMMATION; LUNG PROTECTION; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PROPHYLAXIS; SCORING SYSTEM; TISSUE LEVEL;

ACUTE LUNG INJURY; ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXINS; FOLLOW-UP STUDIES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INJECTIONS, INTRAPERITONEAL; MICE; OLEIC ACID; OXIDATIVE STRESS; SIMVASTATIN; TIME FACTORS;

EID: 80051534221     PISSN: 00201324     EISSN: 19433654     Source Type: Journal    
DOI: 10.4187/respcare.00770     Document Type: Article

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