Statistical assessment of the stability of neural movement representations

Journal of Neurophysiology

Volumn 106, Issue 2, 2011, Pages 764-774

  Stevenson, Ian H ^a   Cherian, Anil ^a   London, Brian M ^a   Sachs, Nicholas A ^b   Lindberg, Eric ^a   Reimer, Jacob ^c   Slutzky, Marc W ^a,d   Hatsopoulos, Nicholas G ^c   Miller, Lee E ^a,b   Kording, Konrad P ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Northwestern University   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Neurons; Poisson noise; Primary motor cortex; Sensory stimuli; Spatial tuning curves; Tuning curves

Indexed keywords

ARTICLE; ELECTRODE; HAPLORHINI; LEARNING; LIMB MOVEMENT; MOTOR ACTIVITY; NERVE CELL; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; SIMULATION; TUNING CURVE;

ACTION POTENTIALS; ANIMALS; ELECTRODES, IMPLANTED; HAPLORHINI; MODELS, NEUROLOGICAL; MOTOR CORTEX; MOVEMENT; NEURONS;

EID: 80051503932     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00626.2010     Document Type: Article

References (58)

1. Ahern GP, Klyachko VA, Jackson MB. cGMP and S-nitrosylation: two routes for modulation of neuronal excitability by NO. Trends Neurosci 25: 510-517, 2002.
2. Amirikian B, Georgopulos AP. Directional tuning profiles of motor cortical cells. Neurosci Res 36: 73-79, 2000.
3. Barnes CA, McNaughton BL, Goddard GV, Douglas RM, Adamec R. Circadian rhythm of synaptic excitability in rat and monkey central nervous system. Science 197: 91-92, 1977.
4. Berens P. CircStat: a MATLAB toolbox for circular statistics. J Stat Softw 31: 1-21, 2009.
5. Brown E, Nguyen D, Frank L, Wilson M, Solo V. An analysis of neural receptive field plasticity by point process adaptive filtering. Proc Natl Acad Sci USA 98: 12261-12266, 2001.
6. Caminiti R, Johnson PB, Urbano A. Making arm movements within different parts of space: dynamic aspects in the primate motor cortex. J Neurosci 10: 2039-2058, 1990.
7. Carmena J, Lebedev M, Henriquez C, Nicolelis M. Stable ensemble performance with single-neuron variability during reaching movements in primates. J Neurosci 25: 10712-10716, 2005.
8. Chase S, Schwartz A, Kass R. Latent inputs improve estimates of neural encoding in motor cortex. J Neurosci 30: 13873-13882, 2010.
9. Cheng S, Sabes P. Calibration of visually guided reaching is driven by error-corrective learning and internal dynamics. J Neurophysiol 97: 3057-3069, 2007.
10. Chestek CA, Batista AP, Santhanam G, Yu BM, Afshar A, Cunningham JP, Gilja V, Ryu SI, Churchland MM, Shenoy KV. Single-neuron stability during repeated reaching in macaque premotor cortex. J Neurosci 27: 10742-10750, 2007.
11. Churchland M, Shenoy K. Temporal complexity and heterogeneity of singleneuron activity in premotor and motor cortex. J Neurophysiol 97: 4235-4257, 2007.
12. Cronin B, Stevenson IH, Sur M, Kording KP. Hierarchical Bayesian modeling and Markov chain Monte Carlo sampling for tuning-curve analysis. J Neurophysiol 103: 591-602, 2010.
13. Davison A, Hinkley D. Reviews of Bootstrap Methods and Their Application. Cambridge, MA: Cambridge University Press, 1997.
14. Dickey A, Suminski A, Amit Y, Hatsopoulos N. Single-unit stability using chronically implanted multielectrode arrays. J Neurophysiol 102: 1331-1339, 2009.
15. Eden U, Frank L, Barbieri R, Solo V, Brown E. Dynamic analysis of neural encoding by point process adaptive filtering. Neural Comput 16: 971-998, 2004.
16. Efron B, Tibshirani R. An Introduction to the Bootstrap. New York: Chapman& Hall, 1997.
17. Fisher N. Statistical Analysis of Circular Data. Cambridge, MA: Cambridge University Press, 1996.
18. Ganguly K, Carmena JM. Emergence of a stable cortical map for neuroprosthetic control. PLoS Biol 7: e1000153, 2009.
19. Georgopoulos AP, Kalaska JF, Caminiti R, Massey JT. On the relations between the direction of two-dimensional arm movements and cell discharge in primate motor cortex. J Neurosci 2: 1527-1537, 1982.
20. Georgopoulos AP, Kettner RE, Schwartz AB. Primate motor cortex and free arm movements to visual targets in three-dimensional space. II. Coding of the direction of movement by a neuronal population. J Neurosci 8: 2928-2937, 1988.
21. Georgopoulos AP, Schwartz AB, Kettner RE. Neuronal population coding of movement direction. Science 233: 1416-1419, 1986.
22. Hamel-Pâquet C, Sergio LE, Kalaska JF. Parietal area 5 activity does not reflect the differential time-course of motor output kinetics during armreaching and isometric-force tasks. J Neurophysiol 95: 3353-3370, 2006.
23. Hatsopoulos N, Joshi J, O'Leary JG. Decoding continuous and discrete motor behaviors using motor and premotor cortical ensembles. J Neurophysiol 92: 1165-1174, 2004.
24. Hatsopoulos NG, Xu Q, Amit Y. Encoding of movement fragments in the motor cortex. J Neurosci 27: 5105-5114, 2007.
25. Haykin S. Adaptive Filter Theory. Englewood Cliffs, NJ: Prentice Hall, 1996.
26. Jarosiewicz B, Chase SM, Fraser GW, Velliste M, Kass RE, Schwartz AB. Functional network reorganization during learning in a brain-computer interface paradigm. Proc Natl Acad Sci USA 105: 19486-19491, 2008.
27. Jiang C, Haddad GG. A direct mechanism for sensing low oxygen levels by central neurons. Proc Natl Acad Sci USA 91: 7198-7201, 1994.
28. Johnson MTV, Mason CR, Ebner TJ. Central processes for the multiparametric control of arm movements in primates. Curr Opin Neurobiol 11: 684-688, 2001.
29. Kakei S, Hoffman DS, Strick PL. Muscle and movement representations in the primary motor cortex. Science 285: 2136-2139, 1999.
30. Kalaska JF, Cohen DAD, Hyde ML, Prud'homme M. A comparison of movement direction-related versus load direction-related activity in primate motor cortex, using a two-dimensional reaching task. J Neurosci 9: 2080-2102, 1989.
31. Kalaska JF, Hyde ML. Area 4 and area 5: differences between the load direction-dependent discharge variability of cells during active postural fixation. Exp Brain Res 59: 197-202, 1985.
32. Kim S-P, Wood F, Fellows M, Donoghue JP, Black MJ. Statistical analysis of the non-stationarity of neural population codes. IEEE 811-816, 2006.
33. Kulkarni JE, Paninski L. Common-input models for multiple neural spiketrain data. Network 18: 375-407, 2007.
34. Li CSR, Padoa-Schioppa C, Bizzi E. Neuronal correlates of motor performance and motor learning in the primary motor cortex of monkeys adapting to an external force field. Neuron 30: 593-607, 2001.
35. Morrow MM, Jordan LR, Miller LE. Direct comparison of the taskdependent discharge of M1 in hand space and muscle space. J Neurophysiol 97: 1786-1798, 2007.
36. Nordhausen CT, Maynard EM, Normann RA. Single unit recording capabilities of a 100 microelectrode array. Brain Res 726: 129-140, 1996.
37. Otieno B, Anderson-Cook C. On Bootstrap Confidence Interval Estimation of Preferred Direction for Circular Data (Paper 805). Allendale, MI: Grand Valley State University, Dept. of Statistics, 2008.
38. Paninski L, Fellows MR, Hatsopoulos NG, Donoghue JP. Spatiotemporal tuning of motor cortical neurons for hand position and velocity. J Neurophysiol 91: 515-532, 2003.
39. Paz R, Vaadia E. Learning-induced improvement in encoding and decoding of specific movement directions by neurons in the primary motor cortex. PLoS Biol 2: E45, 2004.
40. Pohlmeyer EA, Solla SA, Perreault EJ, Miller LE. Prediction of upper limb muscle activity from motor cortical discharge during reaching. J Neural Eng 4: 369-379, 2007.
41. Rokni U, Richardson AG, Bizzi E, Seung HS. Motor learning with unstable neural representations. Neuron 54: 653-666, 2007.
42. Rubino D, Robbins KA, Hatsopoulos NG. Propagating waves mediate information transfer in the motor cortex. Nat Neurosci 9: 1549-1557, 2006.
43. Saleh M, Takahashi K, Amit Y, Hatsopoulos NG. Encoding of coordinated grasp trajectories in primary motor cortex. J Neurosci 30: 17079-17090, 2010.
44. Scheidt R, Reinkensmeyer D, Conditt M, Rymer W, Mussa-Ivaldi F. Persistence of motor adaptation during constrained, multi-joint, arm movements. J Neurophysiol 84: 853-862, 2000.
45. Schummers J, Cronin B, Wimmer K, Stimberg M, Martin R, Obermayer K, Koerding K, Sur M. Dynamics of orientation tuning in cat v1 neurons depend on location within layers and orientation maps. Front Neurosci 1: 145-159, 2007.
46. Scott SH. Apparatus for measuring and perturbing shoulder and elbow joint positions and torques during reaching. J Neurosci Methods 89: 119-127, 1999.
47. Scott SH, Kalaska JF. Reaching movements with similar hand paths but different arm orientations. I. Activity of individual cells in motor cortex. J Neurophysiol 77: 826-852, 1997.
48. Sergio L, Hamel-Paquet C, Kalaska J. Motor cortex neural correlates of output kinematics and kinetics during isometric-force and arm-reaching tasks. J Neurophysiol 94: 2353-2578, 2005.
49. Stevens CF, Zador AM. Input synchrony and the irregular firing of cortical neurons. Nat Neurosci 1: 210-217, 1998.
50. Stevenson I, Cronin B, Sur M, Kording K. Sensory adaptation and short term plasticity as Bayesian correction for a changing brain. PLoS One 5: e12436, 2010.
51. Swindale NV. Orientation tuning curves: empirical description and estimation of parameters. Biol Cybern 78: 45-56, 1998.
52. Tolias A, Ecker A, Siapas A, Hoenselaar A, Keliris G, Logothetis N. Recording chronically from the same neurons in awake, behaving primates. J Neurophysiol 98: 3780-3790, 2007.
53. Truccolo W, Eden UT, Fellows MR, Donoghue JP, Brown EN. A point process framework for relating neural spiking activity to spiking history, neural ensemble, and extrinsic covariate effects. J Neurophysiol 93: 1074-1089, 2005.
54. Wei K, Körding K. Relevance of error: what drives motor adaptation? J Neurophysiol 101: 655-664, 2009.
55. Wise SP, Moody SL, Blomstrom KJ, Mitz AR. Changes in motor cortical activity during visuomotor adaptation. Exp Brain Res 121: 285-299, 1998.
56. Wu W, Hatsopoulos N. Evidence against a single coordinate system representation in the motor cortex. Exp Brain Res 175: 197-210, 2006.
57. Wu W, Hatsopoulos N. Real-time decoding of nonstationary neural activity in motor cortex. IEEE Trans Neural Syst Rehabil Eng 16: 213-222, 2008.
58. Zacksenhouse M, Lebedev MA, Carmena JM, O'Doherty JE, Henriquez C, Nicolelis MAL. Cortical modulations increase in early sessions with brain-machine interface. PLoS One 2: e619, 2007.