The Ets transcription factor ELF5 functions as a tumor suppressor in the kidney

Twin Research and Human Genetics

Volumn 14, Issue 4, 2011, Pages 316-322

  Lapinskas, Erika J ^a   Svobodova, Suzanne ^b   Davis, Ian D ^c   Cebon, Jonathan ^c   Hertzog, Paul J ^a   Pritchard, Melanie A ^a  

^a MONASH UNIVERSITY   (Australia)

^b AUSTIN HEALTH   (Australia)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

Author keywords

ELF5; Ets transcription factor; Renal carcinoma

Indexed keywords

TRANSCRIPTION FACTOR ELF5; TRANSCRIPTION FACTOR ETS; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CONTROLLED STUDY; GENE EXPRESSION; GENE FUNCTION; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; TUMOR SUPPRESSOR GENE;

ANIMALS; BLOTTING, WESTERN; CARCINOMA, RENAL CELL; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNOENZYME TECHNIQUES; KIDNEY; KIDNEY NEOPLASMS; MICE; MICE, SCID; PROTO-ONCOGENE PROTEINS C-ETS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 80051493407     PISSN: 18324274     EISSN: None     Source Type: Journal    
DOI: 10.1375/twin.14.4.316     Document Type: Article

References (37)

1. Audebert, M., Chevillard, S., Levalois, C., Gyapay, G., Vieillefond, A., Klijanienko, J., Vielh, P., El Naggar, A. K., Oudard, S., Boiteux, S., & Radicella, J. P. (2000). Alterations of the DNA repair gene OGG1 in human clear cell carcinomas of the kidney. Cancer Research, 60, 4740-4744.
2. Bhuvarahamurthy, V., Kristiansen, G. O., Johannsen, M., Loening, S. A., Schnorr, D., Jung, K., & Staack, A. (2006). In situ gene expression and localization of metalloproteinases MMP1, MMP2, MMP3, MMP9, and their inhibitors TIMP1 and TIMP2 in human renal cell carcinoma. Oncology Reports, 15, 1379-1384.
3. Bratslavsky, G., Sudarshan, S., Neckers, L., & Linehan, W. M. (2007). Pseudohypoxic pathways in renal cell carcinoma. Clinical Cancer Research, 13, 4667-1471.
4. Clifford, S. C., Prowse, A. H., Affara, N. A., Buys, C. H., & Maher, E. R. (1998). Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumorigenesis. Genes Chromosomes Cancer, 22, 200-209. (Pubitemid 28262196)
5. Discenza, M. T., Vaz, D., Hassell, J. A., & Pelletier, J. (2004). Activation of the WT1 tumor suppressor gene promoter by Pea3. FEBS Letters, 560, 183-191. (Pubitemid 38264315)
6. Donaldson, L. W., Petersen, J. M., Graves, B. J., & McIntosh, L. P. (1994). Secondary structure of the ETS domain places murine Ets-1 in the superfamily of winged helix-turn-helix DNA-binding proteins. Biochemistry, 33, 13509-13516. (Pubitemid 24381911)
7. Gemmill, R. M., Bemis, L. T., Lee, J. P., Sozen, M. A., Baron, A., Zeng, C., Erickson, P. F., Hooper, J. E., & Drabkin, H. A. (2002). The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. Oncogene, 21, 3507-3516. (Pubitemid 34587682)
8. Gnarra, J. R., Lerman, M. I., Zbar, B., & Linehan, W. M. (1995). Genetics of renal-cell carcinoma and evidence for a critical role for von Hippel-Lindau in renal tumorigenesis. Seminars in Oncology, 22, 3-8.
9. Gudmundsson, J., Barkardottir, R. B., Eiriksdottir, G., Baldursson, T., Arason, A., Egilsson, V., & Ingvarsson, S. (1995). Loss of heterozygosity at chromosome 11 in breast cancer: Association of prognostic factors with genetic alterations. British Journal of Cancer, 72, 696-701.
10. Harris, J., Stanford, P. M., Sutherland, K., Oakes, S. R., Naylor, M. J., Robertson, F. G., Blazek, K. D., Kazlauskas, M., Hilton, H. N., Wittlin, S., Alexander, W. S., Lindeman, G. J., Visvader, J. E., & Ormandy, C. J. (2006). Socs2 and elf5 mediate prolactin-induced mammary gland development. Molecular Endocrinology, 20, 1177-1187.
11. Hidalgo, M., & Rowinsky, E. K. (2000). The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene, 19, 6680-6686. (Pubitemid 32197708)
12. Honda, S., Kobayashi, T., Kajino, K., Urakami, S., Igawa, M., & Hino, O. (2003). Ets protein Elf-1 bidirectionally suppresses transcriptional activities of the tumor suppressor Tsc2 gene and the repair-related Nth1 gene. Molecular Carcinogenesis, 37, 122-129. (Pubitemid 36951357)
13. Karnik, P., Paris, M., Williams, B. R., Casey, G., Crowe, J., & Chen, P. (1998). Two distinct tumor suppressor loci within chromosome 11p15 implicated in breast cancer progression and metastasis. Human Molecular Genetics, 7, 895-903. (Pubitemid 28221254)
14. Land, S. C., & Tee, A. R. (2007). Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. Journal of Biological Chemistry, 282, 20534-20543. (Pubitemid 47100043)
15. Lapinskas, E. J., Palmer, J., Ricardo, S., Hertzog, P. J., Hammacher, A., & Pritchard, M. A. (2004). A major site of expression of the Ets transcription factor Elf5 is epithelia of exocrine glands. Histochemistry and Cell Biology, 122, 521-526. (Pubitemid 40174589)
16. Liou, L. S., Shi, T., Duan, Z. H., Sadhukhan, P., Der, S. D., Novick, A. A., Hissong, J., Skacel, M., Almasan, A., DiDonato, J. A. (2004). Microarray gene expression profiling and analysis in renal cell carcinoma. BMC Urology, 4, 9.
17. Ludwig, C. U., Raefle, G., Dalquen, P., Stulz, P., Stahel, R., & Obrecht, J. P. (1991). Allelic loss on the short arm of chromosome 11 in non-small-cell lung cancer. International Journal of Cancer, 49, 661-665.
18. Ma, X. J., Salunga, R., Tuggle, J. T., Gaudet, J., Enright, E., McQuary, P., Payette, T., Pistone, M., Stecker, K., Zhang, B. M., Zhou, Y. X., Varnholt, H., Smith, B., Gadd, M., Chatfield, E., Kessler, J., Baer, T. M., Erlander, M. G., Sgroi, D. C. (2003). Gene expression profiles of human breast cancer progression. Proceedings of the National Academy of Sciences U.S.A., 100, 5974-5979. (Pubitemid 36576916)
19. Metzger, D. E., Xu, Y., & Shannon, J. M. (2007). Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung. Developmental Dynamics, 236, 1175-1192. (Pubitemid 46750251)
20. Mikami, S., Oya, M., Mizuno, R., Murai, M., Mukai, M., & Okada, Y. (2006). Expression of Ets-1 in human clear cell renal cell carcinomas: Implications for angiogenesis. Cancer Science, 97, 875-82. (Pubitemid 44151268)
21. Mizui, M., Isaka, Y., Takabatake, Y., Sato, Y., Kawachi, H., Shimizu, F., Takahara, S., Ito, T., & Imai, E. (2006). Transcription factor Ets-1 is essential for mesangial matrix remodeling. Kidney International, 70, 298-305. (Pubitemid 44086579)
22. Mizushima, S., & Nagata, S. (1990). pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Research, 18, 5322. (Pubitemid 20270119)
23. Morrissey, C., Martinez, A., Zatyka, M., Agathanggelou, A., Honorio, S., Astuti, D., Morgan, N. V., Moch, H., Richards, F. M., Kishida, T., Yao, M., Schraml, P., Latif, F., & Maher, E. R. (2001). Epigenetic inactivation of the RASSF1A 3p21.3 tumor suppressor gene in both clear cell and papillary renal cell carcinoma. Cancer Research, 61, 7277-7281. (Pubitemid 32946526)
24. Oettgen, P., Kas, K., Dube, A., Gu, X., Grall, F., Thamrongsak, U., Akbarali, Y., Finger, E., Boltax, J., Endress, G., Munger, K., Kunsch, C., & Libermann, T. A. (1999). Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes. Journal of Biological Chemistry, 274, 29439-29452.
25. Pavlovich, C. P., & Schmidt, L. S. (2004). Searching for the hereditary causes of renal-cell carcinoma. Nature Reviews Cancer, 4, 381-393. (Pubitemid 38579484)
26. Rae, F. K., Stephenson, S. A., Nicol, D. L., & Clements, J. A. (2000). Novel association of a diverse range of genes with renal cell carcinoma as identified by differential display. International Journal of Cancer, 88, 726-732.
27. Ramirez-Solis, R., Liu, P., & Bradley, A. (1995). Chromosome engineering in mice. Nature, 378, 720-724. (Pubitemid 26001943)
28. Rathmell, W. K., & Godley, P. A. (2010). Recent updates in renal cell carcinoma. Current Opinion in Oncology, 22, 250-256.
29. +/- mammary glands during pregnancy identifies novel targets of Elf5. PLoS One, 5, e13150.
30. Schlehofer, B., Pommer, W., Mellemgaard, A., Stewart, J. H., McCredie, M., Niwa, S., Lindblad, P., Mandel, J. S., McLaughlin, J. K., & Wahrendorf, J. (1996). International renal-cell-cancer study. VI. The role of medical and family history. International Journal of Cancer, 66, 723-726. (Pubitemid 26197937)
31. Seth, A., & Watson, D. K. (2005). ETS transcription factors and their emerging roles in human cancer. European Journal of Cancer, 41, 2462-2478. (Pubitemid 41540623)
32. Shipman, R., Schraml, P., Colombi, M., Raefle, G., & Ludwig, C. U. (1993). Loss of heterozygosity on chromosome 11p13 in primary bladder carcinoma. Human Genetics, 91, 455-458. (Pubitemid 23220095)
33. Tanimoto, K., Makino, Y., Pereira, T., & Poellinger, L. (2000). Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. EMBO Journal, 19, 4298-4309. (Pubitemid 30623741)
34. Tummala, R., & Sinha, S. (2006). Differentiation-specific transcriptional regulation of the ESE-2 gene by a novel keratinocyte-restricted factor. Journal of Cell Biochemistry, 97, 766-781.
35. Winqvist, R., Hampton, G. M., Mannermaa, A., Blanco, G., Alavaikko, M., Kiviniemi, H., Taskinen, P. J., Evans, G. A., Wright, F. A., Newsham, I., & Cavenee, W. K. (1995). Loss of heterozygosity for chromosome 11 in primary human breast tumors is associated with poor survival after metastasis. Cancer Research, 55, 2660-2664.
36. Zhou, J., Ng, A.Y., Tymms, M. J., Jermiin, L. S., Seth, A. K., Thomas, R. S., & Kola, I. (1998). A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines. Oncogene, 17, 2719-2732. (Pubitemid 28554231)
37. Zhou, J., Chehab, R., Tkalcevic, J., Naylor, M. J., Harris, J., Wilson, T. J., Tsao, S., Tellis, I., Zavarsek, S., Xu, D., Lapinskas, E. J., Visvader, J., Lindeman, G. J., Thomas, R., Ormandy, C. J., Hertzog, P. J., Kola, I., & Pritchard, M. A. (2005). The mouse Elf5 gene is essential for early embryogenesis and mammary gland development during pregnancy and lactation. EMBO Journal, 24, 635-644. (Pubitemid 40343264)