In situ gene expression and localization of metalloproteinases MMP1, MMP2, MMP3, MMP9, and their inhibitors TIMP1 and TIMP2 in human renal cell carcinoma

Oncology Reports

Volumn 15, Issue 5, 2006, Pages 1379-1384

  Bhuvarahamurthy, Venugopal ^a   Kristiansen, Glen O ^a   Johannsen, Manfred ^a   Loening, Stefan A ^a   Schnorr, Dietmar ^a   Jung, Klaus ^a   Staack, Andrea ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Human renal cell carcinoma; Immunohistochemistry; in situ hybridisation; Matrix metalloproteinases; Tissue inhibitor of metalloproteinases

Indexed keywords

GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MESSENGER RNA; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ADULT; AGED; ARTICLE; COMPARATIVE STUDY; FEMALE; GENETICS; HUMAN; IN SITU HYBRIDIZATION; KIDNEY CARCINOMA; KIDNEY TUMOR; MALE; METABOLISM; MIDDLE AGED; RNA PROBE;

ADULT; AGED; CARCINOMA, RENAL CELL; FEMALE; HUMANS; IN SITU HYBRIDIZATION; KIDNEY NEOPLASMS; MALE; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; MIDDLE AGED; RNA PROBES; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TISSUE INHIBITOR OF METALLOPROTEINASES;

EID: 33744995009     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.15.5.1379     Document Type: Article

References (34)

1. Chen WT: Membrane proteases: roles in tissue remodeling and tumour invasion. Curr Opin Cell Biol 4: 802-809, 1992.
2. Liotta LA, Steeg PS and Stetler-Stevenson WG: Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64: 327-336, 1991. (Pubitemid 121001258)
3. Tryggvason K, Hoyhtya M and Pyke C: Type IV collagenases in invasive tumors. Breast Cancer Res Treat 24: 209-218, 1993. (Pubitemid 23062820)
4. Polette M, Nawrocki-Raby B, Gilles C, Clavel C and Birembaut P: Tumour invasion and matrix metalloproteinases. Crit Rev Oncol Hematol 49: 179-186, 2004. (Pubitemid 38251350)
5. Mott JD and Werb Z: Regulation of matrix biology by matrix metalloproteinases. Curr Opin Cell Biol 16: 558-564, 2004. (Pubitemid 39201241)
6. Holmbeck K, Bianco P, Yamada S and Birkedal-Hansen H: MT1-MMP: a tethered collagenase. J Cell Physiol 200: 11-19, 2004. (Pubitemid 38720617)
7. Egeblad M and Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2: 161-174, 2002. (Pubitemid 37328786)
8. Lambert E, Dasse E, Haye B and Petitfrere E: TIMPs as multifacial proteins. Crit Rev Oncol Hematol 49: 187-198, 2004. (Pubitemid 38251351)
9. DeClerck YA, Yean TD, Chan D, Shimada H and Langley KE: Inhibition of tumor invasion of smooth muscle cell layers by recombinant human metalloproteinase inhibitor. Cancer Res 51: 2151-2157, 1991.
10. Stetler-Stevenson WG, Krutzsch HC and Liotta LA: Tissue inhibitor of metalloproteinase (TIMP-2): a new member of the metalloproteinase inhibitor family. J Biol Chem 264: 17374-17378, 1989. (Pubitemid 19255571)
11. Sato H, Kida Y, Mai M, et al : Expression of genes encoding type IV collagen-degrading metalloproteinases and tissue inhibitors of metalloproteinases in various human tumor cells. Oncogene 7: 77-83, 1992.
12. Tsuchiya Y, Endo Y, Sato H, et al : Expression of type-IV collagenases in human tumor cell lines that can form liver colonies in chick embryos. Int J Cancer 56: 46-51, 1994. (Pubitemid 24044791)
13. Muller D, Wolf C, Abecassis J, et al: Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas. Cancer Res 53: 165-169, 1993. (Pubitemid 23019393)
14. Urbanski SJ, Edwards DR, Maitland A, Leco KJ, Watson A and Kossakowska AE: Expression of metalloproteinases and their inhibitors in primary pulmonary carcinomas. Br J Cancer 66: 1188-1194, 1992. (Pubitemid 23006167)
15. Kugler A, Hemmerlein B, Thelen P, Kallerhoff M, Radzun HJ and Ringert RH: Expression of metalloproteinase 2 and 9 and their inhibitors in renal cell carcinoma. J Urol 160: 1914-1918, 1998. (Pubitemid 128746786)
16. Gohji K, Nomi M, Hara I, Arakawa S and Kamidono S: Influence of cytokines and growth factors on matrix metalloproteinase-2 production and invasion of human renal cancer. Urol Res 26: 33-37, 1998. (Pubitemid 28218180)
17. Miyake H, Hara I, Yoshimura K, et al : Introduction of basic fibroblast growth factor gene into mouse renal cell carcinoma cell line enhances its metastatic potential. Cancer Res 56: 2440-2445, 1996. (Pubitemid 26154096)
18. Lein M, Nowak L, Jung K, et al: Metalloproteinases and tissue inhibitors of matrix-metalloproteinases in plasma of patients with prostate cancer and in prostate cancer tissue. Ann NY Acad Sci 878: 544-546, 1999. (Pubitemid 29353608)
19. Sobin LH and Fleming ID: TNM classification of malignant tumors. 5th edition (1997). Union Internationale Contre le Cancer and the American Joint Committee on Cancer. Cancer 80: 1803-1804, 1997.
20. Hogan B, Beddington R, Constantini F and Lacy E: Manipulating the mouse embryo: a laboratory manual. Cold Spring Harbor Laboratory Press, New York, NY, 1994.
21. Nomura H, Sato H, Seiki M, Mai M and Okada Y: Expression of membrane-type matrix metalloproteinase in human gastric carcinomas. Cancer Res 55: 3263-3266, 1995.
22. Davidson B, Goldberg I, Kopolovic J, et al: MMP-2 and TIMP-2 expression correlates with poor prognosis in cervical carcinoma: a clinicopathologic study using immunohistochemistry and mRNA in situ hybridization. Gynecol Oncol 73: 372-382, 1999. (Pubitemid 29272858)
23. Tokuraku M, Sato H, Watanabe Y and Seiki M: Expression of membrane-type matrix metalloproteinase (MT-MMP) and activation of MMP-2 in lung cancer. Nippon Rinsho 53: 1822-1826, 1995.
24. Ogata R, Torimura T, Kin M, et al : Increased expression of membrane type 1 matrix metalloproteinase and matrix metallo-proteinase-2 with tumor dedifferentiation in hepatocellular carcinomas. Hum Pathol 30: 443-450, 1999. (Pubitemid 29177825)
25. Gress TM, Muller-Pillasch F, Lerch MM, Friess H, Buchler M and Adler G: Expression and in situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer. Int J Cancer 62: 407- 413, 1995.
26. Wood M, Fudge K, Mohler JL, et al : In situ hybridization studies of metalloproteinases 2 and 9 and TIMP-1 and TIMP-2 expression in human prostate cancer. Clin Exp Metastasis 15: 246-258, 1997. (Pubitemid 27240355)
27. Grignon DJ, Sakr W, Toth M, et al : High levels of tissue inhibitor of metalloproteinase-2 (TIMP-2) expression are associated with poor outcome in invasive bladder cancer. Cancer Res 56: 1654-1659, 1996. (Pubitemid 26104031)
28. Murray GI, Duncan ME, Arbuckle E, Melvin WT and Fothergill JE: Matrix metalloproteinases and their inhibitors in gastric cancer. Gut 43: 791-797, 1998. (Pubitemid 28539658)
29. Shima I, Sasaguri Y, Kusukawa J, et al: Production of matrix metalloproteinase-2 and metalloproteinase-3 related to malignant behavior of esophageal carcinoma: a clinicopathologic study. Cancer 70: 2747-2753, 1992.
30. Okada A, Bellocq JP, Rouyer N, et al: Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Proc Natl Acad Sci USA 92: 2730-2734, 1995.
31. Heppner KJ, Matrisian LM, Jensen RA and Rodgers WH: Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response. Am J Pathol 149: 273-282, 1996. (Pubitemid 26230998)
32. Fong KM, Kida Y, Zimmerman PV and Smith PJ: TIMP1 and adverse prognosis in non-small cell lung cancer. Clin Cancer Res 2: 1369-1372, 1996. (Pubitemid 26299436)
33. Ree AH, Florenes VA, Berg JP, Maelandsmo GM, Nesland JM and Fodstad O: High levels of messenger RNAs for tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in primary breast carcinomas are associated with development of distant metastases. Clin Cancer Res 3: 1623-1628, 1997. (Pubitemid 27431572)
34. Kallakury BV, Karikehalli S, Haholu A, Sheehan CE, Azumi N and Ross JS: Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma. Clin Cancer Res 7: 3113-3119, 2001. (Pubitemid 32963832)