Alboserpin, a factor Xa inhibitor from the mosquito vector of yellow fever, binds heparin and membrane phospholipids and exhibits antithrombotic activity

Journal of Biological Chemistry

Volumn 286, Issue 32, 2011, Pages 27998-28010

  Calvo, Eric ^a   Mizurini, Daniella M ^b   Sá Nunes, Anderson ^a,c   Ribeiro, José M C ^a   Andersen, John F ^a   Mans, Ben J ^a,d   Monteiro, Robson Q ^b   Kotsyfakis, Michail ^a,e   Francischetti, Ivo M B ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d ONDERSTEPOORT VETERINARY INSTITUTE   (South Africa)

^e INSTITUTE OF PARASITOLOGY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PARTIAL THROMBOPLASTIN TIME; ANNEXINS; ANTITHROMBOTIC; BRIDGING MECHANISM; CAROTID ARTERY; CELL ACTIVATION; COFACTORS; DOSE-DEPENDENT MANNER; EFFECTIVE CONCENTRATION; EX-VIVO; FACTOR XA; FACTOR XA INHIBITOR; FERRIC CHLORIDE; HIGH AFFINITY BINDING; IN-VITRO; MEMBRANE PHOSPHOLIPIDS; MOLECULAR MECHANISM; MOSQUITO VECTORS; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PHOSPHOLIPID VESICLES; PROTEASE INHIBITOR; PROTEIN LOCALIZATION; PROTHROMBIN TIME; PROTHROMBINASE; SALIVARY GLANDS; THROMBUS FORMATION; TIGHT BINDING;

CHLORINATION; CHLORINE COMPOUNDS; LIPOSOMES; MOSQUITO CONTROL; PHOSPHOLIPIDS;

POLYSACCHARIDES;

ALBOSERPIN; ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; FERRIC CHLORIDE; HEPARIN; MEMBRANE PHOSPHOLIPID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PLASMINOGEN ACTIVATOR INHIBITOR 2; PLASMINOGEN ACTIVATOR INHIBITOR 3; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

AEDES ALBOPICTUS; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; BINDING AFFINITY; BINDING SITE; BLOOD CLOTTING; CAROTID ARTERY INJURY; CAROTID ARTERY THROMBOSIS; CATALYSIS; CELL ACTIVATION; CONTROLLED STUDY; DISEASE CARRIER; DOSE RESPONSE; DRUG ACTIVITY; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME SPECIFICITY; FEMALE; MOSQUITO; MOUSE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PHYLOGENY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTHROMBIN TIME; SEQUENCE ANALYSIS; STOICHIOMETRY; YELLOW FEVER;

AEDES; ANIMALS; BLOOD COAGULATION; FACTOR XA; FIBRINOLYTIC AGENTS; HEPARIN; HUMANS; INSECT PROTEINS; INSECT VECTORS; MICE; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PHOSPHATIDYLSERINES; PROTEIN BINDING; SERPINS; YELLOW FEVER;

AEDES ALBOPICTUS;

EID: 80051491019     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.247924     Document Type: Article

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