Endotoxin-induced digital vasoconstriction in horses: Associated changes in plasma concentrations of vasoconstrictor mediators

Equine Veterinary Journal

Volumn 36, Issue 3, 2004, Pages 273-278

  Menzies Gow, N J ^a   Bailey, S R ^a   Katz, L M ^a   Marr, C M ^a   Elliott, J ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

5 HT; Endothelin; Endotoxin; Horse; Thromboxane; Vasoconstriction

Indexed keywords

ENDOTHELIN; ENDOTOXIN; SEROTONIN; THROMBOXANE B2; TUMOR NECROSIS FACTOR ALPHA; VASOCONSTRICTOR AGENT;

ANIMAL EXPERIMENT; ARTERIAL BLOOD; ARTICLE; BLOOD FLOW; BLOOD SAMPLING; BODY TEMPERATURE; CONTROLLED STUDY; DOPPLER FLOWMETRY; FEMALE; HOOF AND CLAW; HORSE; MALE; MEDIATOR RELEASE; NONHUMAN; PERFUSION; THROMBOCYTE; VASOCONSTRICTION; VENOUS BLOOD;

ANIMALIA; EQUIDAE; EQUUS CABALLUS;

EID: 2542528573     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/0425164044877260     Document Type: Article

References (43)

1. Allen, D., Clark, E.S., Moore, J.N. and Prasse, K.W. (1990) Evaluation of equine digital Starling forces and hemodynamics during early laminitis. Am. J. vet. Res. 51, 1930-1934.
2. Bailey, S.R. (1998) A Study of the Vascular Effects and Factors Regulating the Concentration of 5-hydroxytryptamine in the Equine Digital Circulation. PhD Thesis, University of London.
3. Bailey, S.R. and Elliott, J. (1998) Plasma 5-hydroxytryptamine constricts equine digital blood vessels in vitro: implications for the pathogenesis of acute laminitis. Equine vet. J. 30, 124-130.
4. Bailey, S.R. and Elliott, J. (1999) The role of prostanoids and nitric oxide in mediating the response of equine digital blood vessels to LPS. Equine vet. J. 31, 212-218.
5. Bailey, S.R., Cunningham, F.M. and Elliott, J. (2000) LPS and dietary amines may increase plasma 5-hydroxytryptamine in the horse. Equine vet. J. 32, 497-504.
6. Bailey, S.R., Marr, C.M., Menzies-Gow, N.J. and Elliott, J. (2002) Effects of vasoactive amines from the equine hindgut on digital blood flow in the normal horse. J. vet. int. Med. 16, 355.
7. Bailey, S.R., Menzies-Gow, N.J., Marr, C.M. and Elliott, J. (2002) The effects of vasoactive amines found in the equine hindgut on digital blood flow in the normal horse. Equine vet. J. 36, 267-272.
8. Bottoms, G.D., Templeton, C.B., Fessler, J.F., Johnson, M.A., Roesel, O.F., Ewert, K.M. and Adams, S.B. (1982) Thromboxane, prostaglandin 12 (epoprostanol) and the haemodynamic changes in equine endotoxic shock. Am. J. vet. Res. 43, 999-1002.
9. Bottoms, G.D., Johnson, M.A., Lamar, C.H., Fessler, J.F. and Turek, J.J. (1985) LPS-induced eicosanoid production by equine vascular endothelial cells and neutrophils. Circ. Shock. 15, 155-62.
10. Burrows, G.E. (1981) Therapeutic effect of phenylbutazone on experimental acute Escherichia coli endotoxemia in ponies. Am. J. vet. Res. 42, 94-99.
11. Cochard, T., Toal, R.L. and Saxton, A.M. (2000) Doppler ultrasonographic features of thoracic limb arteries in clinically normal horses. J. Am. vet. med. Ass. 61, 183-190.
12. Duncan, S.G., Meyers, K.M., Reed, S.M. and Grant, B. (1985) Alterations in coagulation and haemograms of horses given LPS for 24 hours via portal infusions. Am. J. vet. Res. 46, 1287-1293.
13. Eik-Nes, S.H., Marsal, K. and Kristoffersen, K. (1984) Methodology and basic problems related to blood flow studies in human fetus. Ultrasound Med. Biol. 10, 329-337.
14. Fessler, J.F., Bottoms, G.D., Coppoc, G.L., Gimarc, S., Latshaw, H.S. and Noble, J.K. (1989) Plasma LPS concentrations in experimental and clinical equine subjects. Equine vet. J., Suppl. 7, 24-28.
15. Friberg, P. (1987) The use of quantitative assay in LPS testing. In: Detection of Bacterial LPS with the Limulus Amebocyte Lysate Test, Ed: S. Watson, A.R. Liss, New York, USA. pp 149-169.
16. Gill, R.W. (1985) Measurement of blood flow by ultrasound: accuracy and sources of error. Ultrasound Med. Biol. 11, 625-641.
17. Hoffman, K.L., Wood, A.K.W., Griffiths, K.A., Evans, D.L., Gill, R.W. and Kirby, A.C. (2001) Doppler sonographic measurements of arterial blood flow and their repeatability in the equine foot during weight bearing and non-weight bearing. Res. vet. Sci. 70, 199-203.
18. Holm, A.S., Eades, S.C., Venugopal, C.S., Koch, C.E. and Moore, R.M. (2002) Endothelin-1 induces vasoconstriction in the normal equine digit. In: Proceedings of the 7th International Equine Colic Research Symposium, Equine Veterinary Journal, Newmarket. pp 106-107.
19. Hood, D.M., Wagner, I.P. and Brumbaugh, G.W. (2001) Evaluation of hoof wall surface temperature as an index of digital vascular perfusion during the prodromal and acute phases of carbohydrate-induced laminitis in horses. Am. J. vet. Res. 62, 1167-1172.
20. Hunt, J.M., Edwards, G.B. and Clarke, K.W. (1986) Incidence, diagnosis and treatment of postoperative complications in colic cases. Equine vet. J. 18, 249-252.
21. Hunt, R.J., Allen, D. and Moore, J.N. (1990) Effect of LPS administration on equine digital hemodynamics and starling forces. Am. J. vet. Res. 51, 1703-1707.
22. Ingle-Fehr, J.E. and Baxter, G.M. (1998) Evaluation of digital and laminar blood flow in horses given a low dose of LPS. Am. J. vet. Res. 59, 192-196.
23. Jarvis, G.E., Evans, R.J. and Heath, F.M. (1996) The role of ADP in endotoxin-induced platelet aggregation. Eur. J. Pharmacol. 315, 203-212.
24. Katz, L.M., Elliott, J. and Marr, C.M. (2002) Measurement of plasma endothelin-1 from normal and laminitic horses and ponies using a quantitative sandwich enzyme immunoassay technique. J. vet. int. Med. 16, 355.
25. Katz, L.M., Marr, C.M. and Elliott, J. (2003) Characterization and comparison of the responses of equine digital arteries and veins to endothelin-1. Am. J. vet. Res. 64, 1438-1443.
26. Landoni, M.F., Foot, R., Frean, S. and Lees, P. (1996) Effects of flunixin, tolfenamic acid, R(-) and S(+) ketoprofen on the response of equine synoviocytes to lipopolysaccharide stimulation. Equine vet. J. 28, 468-475.
27. Lees, P., Ewins, C.P., Taylor, J.B. and Sedgwick, A.D. (1987) Serum thromboxane in the horse and its inhibition by aspirin, phenylbutazone and flunixin. Brit. vet. J. 143, 462-476.
28. Levy, B.I., Vallachares, M.R, Ghaem, A. and Martinaud, J.P. (1979) Comparison of plethysmographic methods with pulsed Doppler flowmetry. Am. J. Physiol. 236, H899-H903.
29. Lewis, P., Psaila, J.V., Davies, W.T., McCarty, K. and Woodcock, J.P. (1986) Measurement of volume flow in the human common femoral artery using a duplex ultrasound system. Ultrasound Med. Biol. 12, 777-784.
30. MacKay, R.J., Merritt, A.M., Zertuche, J.M., Whittington, M. and Skelley, L.A. (1991) Tumour necrosis factor activity in the circulation of horses given LPS. Am. J. vet. Res. 52, 533-538.
31. Molyneux, G.S., Haller, C.J., Mogg, K.C. and Pollitt, C.C. (1994) The structure, innervation and location of arteriovenous anastomoses in the equine foot. Equine vet. J. 26, 305-312.
32. Morris, D.D., Crowe, N. and Moore, J.N. (1990) Correlation of clinical and laboratory data with serum tumour necrosis factor activity in horses with experimentally induced endotoxemia. Am. J. vet. Res. 51, 1935-1940.
33. Raisis, A.L., Young, L.E., Meire, H.B., Taylor, P.M., Walsh, K. and Leukeux, P. (2000a) Variability of Doppler ultrasound measurements of hind limb blood flow in conscious horses. Equine vet. J. 32, 125-132.
34. Raisis, A.L., Young, L.E., Blissett, K.J., Brearley, J.C., Meire, H.B., Taylor, P.M. and Leukeux, P. (2000b) A comparison of the haemodynamic effects of isoflurane and halothane anaesthesia in horses. Equine vet. J. 32, 318-326.
35. Raisis, A.L., Young, L.E., Blissett, K.J., Walsh, K., Meire, H.B., Taylor, P.M. and Leukeux, P. (2000c) Effect of a 30-minute infusion of dobutamine hydrochloride on hindlimb blood flow and haemodynamics in halothane-anaesthetised horses. Am. J. vet. Res. 61, 1282-1287.
36. Ramaswamy, C.M., Eades, S.C., Venugopal, C.S., Hosgood, G.L., Garza, F., Barker, S.A. and Moore, R.M. (2002) Plasma concentrations of endothelin-like immunoreactivity in healthy horses and horses with naturally acquired gastrointestinal tract disorders. Am. J. vet. Res. 63, 454-458.
37. Sprouse, R.F., Garner, H.E. and Green, E.M. (1987) Plasma LPS levels in horses subjected to carbohydrate induced laminitis. Equine vet. J. 19, 25-28.
38. Steverink, P.J.G.M., Salden, H.J.M., Sturk, A., Klein, W.R., van der Velden, M.A. and Nemeth, F. (1994) Laboratory and clinical evaluation of a chromogenic LPS assay for horses with acute intestinal disorders. Vet. Quart. 16, S117-S121.
39. Tetens, J., Eades, S.C., Hosgood, G., Koch, C.E., Garza, F. and Moore, R.M. (2002) Cephalic venous plasma endothelin-1 concentrations and digital haemodynamic responses to ATP-MgC12 administration after low-dose LPS infusion in horses. In: Proceedings of the 7th International Colic Research Symposium, Equine Veterinary Journal, Newmarket. pp 107-108.
40. Thrusfield, M.V. (1997) In: Veterinary Epidemiology, 2nd edn., Blackwell Science Ltd, London. pp 236-237.
41. Wagner, O.F., Christ, G., Wojta, J., Vierhapper, H., Parzer, S., Nowotny, P.J., Schneider, B., Waldhaus, I.W. and Binder, B.R. (1992) Polar secretion of endothelin-1 by cultured endothelial cells. J. Biol. Chem. 267, 1606-1608.
42. Walker, M. and Geiser, D. (1986) Effects of acetylpromazine on the haemodynamics of the equine metatarsal artery, as determined by two-dimensional real-time and pulsed Doppler ultrasonography. Am. J. vet. Res. 47, 1075-1078.
43. Zierler, B.K., Kirkman, T.R., Kraiss, L.W., Reiss, W.G., Horn, J.R., Bauer, L.A., Clowes, A.W. and Kohler, T.R. (1992) Accuracy of duplex scanning for measurement of arterial volume flow. J. vasc. Surg. 16, 520-526.