Protection and reversal of hepatic fibrosis by red wine polyphenols in hyperhomocysteinemic mice

Journal of Nutritional Biochemistry

Volumn 22, Issue 9, 2011, Pages 856-864

  Noll, Christophe ^a   Raaf, Lamia ^a   Planque, Chris ^a   Benard, Ludovic ^b   Secardin, Lise ^a   Petit, Emile ^a   Dairou, Julien ^a   Paul, Jean Louis ^c,d   Samuel, Jane Lise ^b   Delcayre, Claude ^b   Rodrigues Lima, Fernando ^a   Janel, Nathalie ^a  

^a Groupe Hospitalier Pitié Salpêtrière   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^d UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Catalase; E NOS; Fibrosis; Homocysteine; Matrix metalloproteinase 2; Polyphenols; Zymography

Indexed keywords

3 NITROTYROSINE; CATALASE; CYSTATHIONINE BETA SYNTHASE; GELATINASE A; HOMOCYSTEINE; METHIONINE; PEROXYNITRITE; POLYPHENOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HYPERHOMOCYSTEINEMIA; LIVER DYSFUNCTION; LIVER FIBROSIS; LIVER PROTECTION; MOUSE; NONHUMAN; NUTRITION; OXIDATIVE STRESS; PROTEIN EXPRESSION; RED WINE;

ANIMALS; CYSTATHIONINE BETA-SYNTHASE; HYPERHOMOCYSTEINEMIA; LIVER CIRRHOSIS; MATRIX METALLOPROTEINASE 2; METHIONINE; MICE; MICE, TRANSGENIC; POLYPHENOLS; WINE;

MURINAE; MUS;

EID: 80051471610     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2010.07.010     Document Type: Article

References (37)

1. Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999, 19:217-246.
2. Welch G.N., Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med 1998, 15:1042-1050.
3. Klatstin G., Conn H.O. Hepatic lesions in disorders of protein and amino acid metabolism. In: Histopathology of the liver 1993, 241-245. Oxford University Press, New York, United States.
4. Robert K., Nehmé J., Bourdon E., Pivert G., Friguet B., Delcayre C., et al. Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver. Gastroenterology 2005, 5:1405-1415.
5. Watanabe M., Osada J., Aratani Y., Kluckman K., Reddick R., Malinow M.R., et al. Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia. Proc Natl Acad Sci USA 1995, 5:1585-1589.
6. Ovechkin A.V., Tyagi N., Sen U., Lominadze D., Steed M.M., Moshal K.S., et al. 3-Deazaadenosine mitigates arterial remodeling and hypertension in hyperhomocysteinemic mice. Am J Physiol Lung Cell Mol Physiol 2006, 5:L905-911.
7. Préaux A.M., Mallat A., Nhieu J.T., D'Ortho M.P., Hembry R.M., Mavier P. Matrix metalloproteinase-2 activation in human hepatic fibrosis regulation by cell-matrix interactions. Hepatology 1999, 4:944-950.
8. Galli A., Svegliati-Baroni G., Ceni E., Milani S., Ridolfi F., Salzano R., et al. Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism. Hepatology 2005, 5:1074-1084.
9. Li Z., Li L., Zielke H.R., Cheng L., Xiao R., Crow M.T., et al. Increased expression of 72-kd Type IV collagenase (MMP-2) in human aortic atherosclerotic lesions. Am J Pathol 1996, 1:121-128.
10. Nagase H. Cell surface activation of progelatinase A (proMMP-2) and cell migration. Cell Res 1998, 3:179-186.
11. Oak M.H., El Bedoui J., Anglard P., Schini-Kerth V.B. Red wine polyphenolic compounds strongly inhibit pro-matrix metalloproteinase-2 expression and its activation in response to thrombin via direct inhibition of membrane Type 1-matrix metalloproteinase in vascular smooth muscle cells. Circulation 2004, 13:1861-1867.
12. El Bedoui J., Oak M.H., Anglard P., Schini-Kerth V.B. Catechins prevent vascular smooth muscle cell invasion by inhibiting MT1-MMP activity and MMP-2 expression. Cardiovasc Res 2005, 2:317-325.
13. Dell'Aica I., Donà M., Sartor L., Pezzato E., Garbisa S. (-)Epigallocatechin-3-gallate directly inhibits MT1-MMP activity, leading to accumulation of nonactivated MMP-2 at the cell surface. Lab Invest 2002, 12:1685-1693.
14. Zhen M.C., Huang X.H., Wang Q., Sun K., Liu Y.J., Li W., et al. Green tea polyphenol epigallocatechin-3-gallate suppresses rat hepatic stellate cell invasion by inhibition of MMP-2 expression and its activation. Acta Pharmacol Sin 2006, 12:1600-1607.
15. Walter A., Etienne-Selloum N., Sarr M., Kane M.O., Beretz A., Schini-Kerth V.B. Angiotensin II induces the vascular expression of VEGF and MMP-2 in vivo: preventive effect of red wine polyphenols. J Vasc Res 2008, 5:386-394.
16. Hamelet J., Demuth K., Dairou J., Ledru A., Paul J.L., Dupret J.M., et al. Effects of catechin on homocysteine metabolism in hyperhomocysteinemic mice. Biochem Biophys Res Commun 2007, 1:221-227.
17. Noll C., Hamelet J., Matulewicz E., Paul J.L., Delabar J.M., Janel N. Effects of red wine polyphenolic compounds on paraoxonase-1 and lectin-like oxidized low-density lipoprotein receptor-1 in hyperhomocysteinemic mice. J Nutr Biochem 2009, 20:586-596.
18. Auger C., Caporiccio B., Landrault N., Teissedre P.L., Laurent C., Cros G., et al. Red wine phenolic compounds reduce plasma lipids and apolipoprotein B and prevent early aortic atherosclerosis in hypercholesterolemic golden Syrian hamsters (Mesocricetus auratus). J Nutr 2002, 132:1207-1213.
19. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001, 29:2002-2007.
20. Iwai M., Chen R., Li Z., Shiuchi T., Suzuki J., Ide A., et al. Deletion of angiotensin II Type 2 receptor exaggerated atherosclerosis in apolipoprotein E-null mice. Circulation 2005, 112:1636-1643.
21. Kolbeck R.C., She Z.W., Callahan L.A., Nosek T.M. Increased superoxide production during fatigue in the perfused rat diaphragm. Am J Respir Crit Care Med 1997, 156:140-145.
22. Mu H., Wang X., Lin P., Yao Q., Chen C. Nitrotyrosine promotes human aortic smooth muscle cell migration through oxidative stress and ERK1/2 activation. Biochim Biophys Acta 2008, 9:1576-1584.
23. Kinsell L.W., Harper H.A., Barton H.C., Michaels G.D., Weiss H.A. Rate of disappearance from plasma of intravenously administered methionine in patients with liver damage. Science 1947, 106:589-590.
24. Lambert D., Benhayoun S., Adjalla C., Gélot M.M., Renkes P., Gérard P., et al. Alcoholic cirrhosis and cobalamin metabolism. Digestion 1997, 1:64-71.
25. Likogianni V., Janel N., Ledru A., Beaune P., Louis Paul J., Demuth K. Thiol compounds metabolism in mice, rats and humans: comparative study and potential explanation of rodents protection against vascular diseases. Clin Chim Acta 2006, 372:140-146.
26. Doronzo G., Russo I., Mattiello L., Trovati M., Anfossi G. Homocysteine rapidly increases matrix metalloproteinase-2 expression and activity in cultured human vascular smooth muscle cells. Role of phosphatidyl inositol 3-kinase and mitogen activated protein kinase pathways. Thromb Haemost 2005, 6:1285-1293.
27. Hijova E. Matrix metalloproteinases: their biological functions and clinical implications. Bratisl Lek Listy 2005, 3:127-132.
28. Bescond A., Augier T., Chareyre C., Garçon D., Hornebeck W., Charpiot P. Influence of homocysteine on matrix metalloproteinase-2: activation and activity. Biochem Biophys Res Commun 1999, 2:498-503.
29. Hamelet J., Seltzer V., Petit E., Noll C., Andreau K., Delabar J.M., et al. Cystathionine beta synthase deficiency induces catalase-mediated hydrogen peroxide detoxification in mice liver. Biochim Biophys Acta 2008, 7-8:482-488.
30. Cao C., Leng Y., Kufe D. Catalase activity is regulated by c-Abl and Arg in the oxidative stress response. J Biol Chem 2003, 32:29667-29675.
31. Lin H.I., Chou S.J., Wang D., Feng N.H., Feng E., Chen C.F. Reperfusion liver injury induces down-regulation of eNOS and up-regulation of iNOS in lung tissues. Transplant Proc 2006, 7:2203-2206.
32. Upchurch G.R., Welch G.N., Fabian A.J., Freedman J.E., Johnson J.L., Keaney J.F., et al. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem 1997, 27:17012-17017.
33. Nakamuta M., Higashi N., Kohjima M., Fukushima M., Ohta S., Kotoh K., et al. Epigallocatechin-3-gallate, a polyphenol component of green tea, suppresses both collagen production and collagenase activity in hepatic stellate cells. Int J Mol Med 2005, 4:677-681.
34. Floreani M., Napoli E., Quintieri L., Palatini P. Oral administration of trans-resveratrol to guinea pigs increases cardiac DT-diaphorase and catalase activities, and protects isolated atria from menadione toxicity. Life Sci 2003, 24:2741-2750.
35. Kasdallah-Grissa A., Mornagui B., Aouani E., Hammami M., El May M., Gharbi N., et al. Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver. Life Sci 2007, 11:1033-1039.
36. Madeira S.V., Auger C., Anselm E., Chataigneau M., Chataigneau T., Soares de Moura R., et al. eNOS Activation Induced by a Polyphenol-Rich Grape Skin Extract in Porcine Coronary Arteries. J Vasc Res 2009, 5:406-416.
37. Agouni A., Lagrue-Lak-Hal A.H., Mostefai H.A., Tesse A., Mulder P., Rouet P., et al. Red wine polyphenols prevent metabolic and cardiovascular alterations associated with obesity in Zucker fatty rats (Fa/Fa). PLoS ONE 2009, 5:e5557.