Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 31, 2011, Pages 12949-12954

  Olesen, Emma T B ^a   Rützler, Michael R ^a   Moeller, Hanne B ^a   Praetorius, Helle A ^a   Fenton, Robert A ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Autocoid; Cell signaling; Drug development discovery; Lipid mediators; Water balance

Indexed keywords

6 ISOPROPOXY 9 OXO 2 XANTHENECARBOXYLIC ACID; AQUAPORIN 2; BUTAPROST; CAY 10580; CYCLIC AMP; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E2; UNCLASSIFIED DRUG; VASOPRESSIN; VASOPRESSIN V2 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EX VIVO STUDY; GLOMERULUS FILTRATION RATE; IN VITRO STUDY; IN VIVO CULTURE; KIDNEY CONCENTRATING CAPACITY; KIDNEY CORTEX; KIDNEY SLICE; MALE; NEPHROGENIC DIABETES INSIPIDUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; WATER TRANSPORT;

ALPROSTADIL; ANIMALS; AQUAPORIN 2; CELL LINE; CELL MEMBRANE; CYCLIC AMP; DIABETES INSIPIDUS, NEPHROGENIC; DINOPROSTONE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNOBLOTTING; KIDNEY; MALE; MICROSCOPY, CONFOCAL; PHOSPHORYLATION; PROTEIN TRANSPORT; PYRROLIDINONES; RATS; RATS, WISTAR; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; RECEPTORS, VASOPRESSIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VASOPRESSINS;

RATTUS;

EID: 79961238198     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1104691108     Document Type: Article

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