Proteomic analyses of lung lysates from short-term exposure of fischer 344 rats to cigarette smoke

Journal of Proteome Research

Volumn 10, Issue 8, 2011, Pages 3720-3731

  Carter, Charleata A ^a   Misra, Manoj ^a   Pelech, Steven ^b,c  

^a LORILLARD TOBACCO COMPANY   (United States)

^b Kinexus Bioinformatics Corporation   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

apoptosis; biomarkers; cell signaling; cytoskeleton; inflammation; microarrays; protein kinases; proteomics

Indexed keywords

ANTIBODY; CASPASE 5; CIGARETTE SMOKE; COLLAPSIN RESPONSE MEDIATOR PROTEIN 2; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 60; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; PHOSPHOPROTEIN PHOSPHATASE; PP1CBETA ENZYME; PP4 ENZYME; PROTEIN KINASE C ALPHA; PROTEIN KINASE C GAMMA; PROTEIN SERINE KINASE; RAC1 PROTEIN; RIBOSOMAL PROTEIN S6 KINASE 1; S6 KINASE; STAT2 PROTEIN; TPL2 KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LYSATE; CONTROLLED STUDY; IMMUNOBLOTTING; LUNG; MICROARRAY ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LUNG; MALE; PROTEOMICS; RATS; RATS, INBRED F344; SMOKE; TOBACCO;

ANIMALIA; RATTUS;

EID: 79961226778     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr200345y     Document Type: Article

References (56)

1. Battershill, J. M. The Multiple Chemicals and Actions Model of carcinogenesis. A possible new approach to developing prevention strategies for environmental carcinogenesis Hum. Exp. Toxicol. 2005, 24 (11) 547-58 (Pubitemid 41729636)
2. Granville, C. A.; Dennis, P. A. An overview of lung cancer genomics and proteomics Am. J. Respir. Cell Mol. Biol. 2005, 32 (3) 169-76 (Pubitemid 40387642)
3. Conrad, D. H.; Goyette, J.; Thomas, P. S. Proteomics as a method for early detection of cancer: a review of proteomics, exhaled breath condensate, and lung cancer screening J. Gen. Intern. Med. 2008, 23 (Suppl 1) 78-84 (Pubitemid 350295398)
4. Lin, J. L.; Bonnichsen, M. H.; Nogeh, E. U.; Raftery, M. J.; Thomas, P. S. Proteomics in detection and monitoring of asthma and smoking-related lung diseases Expert. Rev. Proteomics 2010, 7 (3) 361-72
5. Pelech, S.; Jelinkova, L.; Susor, A.; Zhang, H.; Shi, X.; Pavlok, A.; Kubelka, M.; Kovarova, H. Antibody microarray analyses of signal transduction protein expression and phosphorylation during porcine oocyte maturation J. Proteome Res. 2008, 7 (7) 2860-71
6. Kikuchi, T.; Carbone, D. P. Proteomics analysis in lung cancer: challenges and opportunities Respirology 2007, 12 (1) 22-8 (Pubitemid 44968195)
7. Wingren, C.; Borrebaeck, C. A. High-throughput proteomics using antibody microarrays Expert Rev. Proteomics 2004, 1 (3) 355-64 (Pubitemid 43832583)
8. Xu, N. Y.; Zhang, S. P.; Dong, L.; Nie, J. H.; Tong, J. Proteomic analysis of lung tissue of rats exposed to cigarette smoke and radon J. Toxicol. Environ. Health, Part A 2009, 72 (11-12) 752-8
9. Chang, W. C.; Lee, Y. C.; Liu, C. L.; Hsu, J. D.; Wang, H. C.; Chen, C. C.; Wang, C. J. Increased expression of iNOS and c-fos via regulation of protein tyrosine phosphorylation and MEK1/ERK2 proteins in terminal bronchiole lesions in the lungs of rats exposed to cigarette smoke Arch. Toxicol. 2001, 75 (1) 28-35
10. Marwick, J. A.; Kirkham, P. A.; Stevenson, C. S.; Danahay, H.; Giddings, J.; Butler, K.; Donaldson, K.; Macnee, W.; Rahman, I. Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs Am. J. Respir. Cell Mol. Biol. 2004, 31 (6) 633-42 (Pubitemid 39587493)
11. Stevenson, C. S.; Docx, C.; Webster, R.; Battram, C.; Hynx, D.; Giddings, J.; Cooper, P. R.; Chakravarty, P.; Rahman, I.; Marwick, J. A.; Kirkham, P. A.; Charman, C.; Richardson, D. L.; Nirmala, N. R.; Whittaker, P.; Butler, K. Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation Am. J. Physiol. Lung Cell Mol. Physiol. 2007, 293 (5) L1183-93
12. Kelsen, S. G.; Duan, X.; Ji, R.; Perez, O.; Liu, C.; Merali, S. Cigarette smoke induces an unfolded protein response in the human lung: a proteomic approach Am. J. Respir. Cell Mol. Biol. 2008, 38 (5) 541-50 (Pubitemid 351758672)
13. Carter, C. A.; Misra, M. Effects of short-term cigarette smoke exposure on Fischer 344 rats and on selected lung proteins Toxicol. Pathol. 2010, 38 (3) 402-15
14. Carter, C. A.; Kane, C. J. Therapeutic potential of natural compounds that regulate the activity of protein kinase C Curr. Med. Chem. 2004, 11 (21) 2883-902 (Pubitemid 39377888)
15. Teicher, B. A. Protein kinase C as a therapeutic target Clin. Cancer Res. 2006, 12 (18) 5336-45 (Pubitemid 44497246)
16. Gutcher, I.; Webb, P. R.; Anderson, N. G. The isoform-specific regulation of apoptosis by protein kinase C Cell. Mol. Life Sci. 2003, 60 (6) 1061-70 (Pubitemid 36791911)
17. Martelli, A. M.; Mazzotti, G.; Capitani, S. Nuclear protein kinase C isoforms and apoptosis Eur. J. Histochem. 2004, 48 (1) 89-94
18. Hasham, M. I.; Pelech, S. L.; Koide, H. B.; Krieger, C. Activation of protein kinase C by intracellular free calcium in the motoneuron cell line NSC-19 Biochim. Biophys. Acta 1997, 1360 (2) 177-91 (Pubitemid 27171150)
19. Finch, G. L.; Lundgren, D. L.; Barr, E. B.; Chen, B. T.; Griffith, W. C.; Hobbs, C. H.; Hoover, M. D.; Nikula, K. J.; Mauderly, J. L. Chronic cigarette smoke exposure increases the pulmonary retention and radiation dose of 239Pu inhaled as 239PuO2 by F344 rats Health Phys. 1998, 75 (6) 597-609 (Pubitemid 28531683)
20. Edmiston, J. S.; Flora, J. W.; Scian, M. J.; Li, G.; Rana, G. S.; Langston, T. B.; Sengupta, T. K.; McKinney, W. J. Cigarette smoke extract induced protein phosphorylation changes in human microvascular endothelial cells in vitro Anal. Bioanal. Chem. 2009, 394 (6) 1609-20
21. Carter, C. A.; Hamm, J. T. Multiplexed quantitative high content screening reveals that cigarette smoke condensate induces changes in cell structure and function through alterations in cell signaling pathways in human bronchial cells Toxicology 2009, 261 (3) 89-102
22. Wong, L. S.; Green, H. M.; Feugate, J. E.; Yadav, M.; Nothnagel, E. A.; Martins-Green, M. Effects of "second-hand" smoke on structure and function of fibroblasts, cells that are critical for tissue repair and remodeling BMC Cell Biol. 2004, 5, 13
23. Wong, L. S.; Martins-Green, M. Firsthand cigarette smoke alters fibroblast migration and survival: implications for impaired healing Wound Repair Regen. 2004, 12 (4) 471-84 (Pubitemid 39007048)
24. Carter, C. A. Protein kinase C as a drug target: implications for drug or diet prevention and treatment of cancer Curr. Drug Targets 2000, 1 (2) 163-83
25. Dempsey, E. C.; Cool, C. D.; Littler, C. M. Lung disease and PKCs Pharmacol. Res. 2007, 55 (6) 545-59 (Pubitemid 46962310)
26. Nakashima, S. Protein kinase C alpha (PKC alpha): regulation and biological function J. Biochem. 2002, 132 (5) 669-75 (Pubitemid 35408487)
27. Vander Top, E. A.; Wyatt, T. A.; Gentry-Nielsen, M. J. Smoke exposure exacerbates an ethanol-induced defect in mucociliary clearance of Streptococcus pneumoniae Alcohol.: Clin. Exp. Res. 2005, 29 (5) 882-7 (Pubitemid 40686559)
28. Elliott, M. K.; Sisson, J. H.; West, W. W.; Wyatt, T. A. Differential in vivo effects of whole cigarette smoke exposure versus cigarette smoke extract on mouse ciliated tracheal epithelium Exp. Lung Res. 2006, 32 (3-4) 99-118
29. Wang, X. Y.; Repasky, E.; Liu, H. T. Antisense inhibition of protein kinase Calpha reverses the transformed phenotype in human lung carcinoma cells Exp. Cell Res. 1999, 250 (1) 253-63 (Pubitemid 29391589)
30. Krotova, K. Y.; Zharikov, S. I.; Block, E. R. Classical isoforms of PKC as regulators of CAT-1 transporter activity in pulmonary artery endothelial cells Am. J. Physiol. Lung Cell Mol. Physiol. 2003, 284 (6) L1037-44
31. Hatzoglou, M.; Fernandez, J.; Yaman, I.; Closs, E. Regulation of cationic amino acid transport: the story of the CAT-1 transporter Annu. Rev. Nutr. 2004, 24, 377-99 (Pubitemid 38938797)
32. Zhuang, L.; Peng, J. B.; Tou, L.; Takanaga, H.; Adam, R. M.; Hediger, M. A.; Freeman, M. R. Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies Lab. Invest. 2002, 82 (12) 1755-64 (Pubitemid 35462988)
33. Ludwicka-Bradley, A.; Tourkina, E.; Suzuki, S.; Tyson, E.; Bonner, M.; Fenton, J. W., 2nd; Hoffman, S.; Silver, R. M. Thrombin upregulates interleukin-8 in lung fibroblasts via cleavage of proteolytically activated receptor-I and protein kinase C-gamma activation Am. J. Respir. Cell Mol. Biol. 2000, 22 (2) 235-43 (Pubitemid 30351487)
34. Lin, C. H.; Sheu, S. Y.; Lee, H. M.; Ho, Y. S.; Lee, W. S.; Ko, W. C.; Sheu, J. R. Involvement of protein kinase C-gamma in IL-1beta-induced cyclooxygenase-2 expression in human pulmonary epithelial cells Mol. Pharmacol. 2000, 57 (1) 36-43
35. Mazzoni, E.; Adam, A.; Bal de Kier Joffe, E.; Aguirre-Ghiso, J. A. Immortalized mammary epithelial cells overexpressing protein kinase C gamma acquire a malignant phenotype and become tumorigenic in vivo Mol. Cancer Re. 2003, 1 (10) 776-87 (Pubitemid 37025596)
36. Liu, J.; Lei, D.; Waalkes, M. P.; Beliles, R. P.; Morgan, D. L. Genomic analysis of the rat lung following elemental mercury vapor exposure Toxicol. Sci. 2003, 74 (1) 174-81 (Pubitemid 36850267)
37. Ziegler, W. H.; Tigges, U.; Zieseniss, A.; Jockusch, B. M. A lipid-regulated docking site on vinculin for protein kinase C J. Biol. Chem. 2002, 277 (9) 7396-404 (Pubitemid 34953136)
38. Zhang, S.; Xu, N.; Nie, J.; Dong, L.; Li, J.; Tong, J. Proteomic alteration in lung tissue of rats exposed to cigarette smoke Toxicol. Lett. 2008, 178 (3) 191-6
39. Filippi, M. D.; Szczur, K.; Harris, C. E.; Berclaz, P. Y. Rho GTPase Rac1 is critical for neutrophil migration into the lung Blood 2007, 109 (3) 1257-64 (Pubitemid 46220678)
40. Micucci, C.; Orciari, S.; Catalano, A. Semaphorins and their receptors in stem and cancer cells Curr. Med. Chem. 2010, 17 (30) 3462-75
41. Mercer, B. A.; Kolesnikova, N.; Sonett, J.; D'Armiento, J. Extracellular regulated kinase/mitogen activated protein kinase is up-regulated in pulmonary emphysema and mediates matrix metalloproteinase-1 induction by cigarette smoke J. Biol. Chem. 2004, 279 (17) 17690-6 (Pubitemid 38568101)
42. Monick, M. M.; Mallampalli, R. K.; Bradford, M.; McCoy, D.; Gross, T. J.; Flaherty, D. M.; Powers, L. S.; Cameron, K.; Kelly, S.; Merrill, A. H., Jr. ; Hunninghake, G. W. Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity J. Immunol. 2004, 173 (1) 123-35 (Pubitemid 38797333)
43. Takatsu, Y.; Nakamura, M.; Stapleton, M.; Danos, M. C.; Matsumoto, K.; O'Connor, M. B.; Shibuya, H.; Ueno, N. TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development Mol. Cell. Biol. 2000, 20 (9) 3015-26 (Pubitemid 30215014)
44. Mihindukulasuriya, K. A.; Zhou, G.; Qin, J.; Tan, T. H. Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation J. Biol. Chem. 2004, 279 (45) 46588-94 (Pubitemid 39518303)
45. George, D.; Salmeron, A. Cot/Tpl-2 protein kinase as a target for the treatment of inflammatory disease Curr. Top. Med. Chem. 2009, 9 (7) 611-22
46. Sourvinos, G.; Tsatsanis, C.; Spandidos, D. A. Overexpression of the Tpl-2/Cot oncogene in human breast cancer Oncogene 1999, 18 (35) 4968-73 (Pubitemid 29425303)
47. Ohara, R.; Hirota, S.; Onoue, H.; Nomura, S.; Kitamura, Y.; Toyoshima, K. Identification of the cells expressing cot proto-oncogene mRNA J. Cell Sci. 1995, 108 (Pt 1) 97-103
48. Tsatsanis, C. A.; Spandidos, D. A. Signal transduction pathways in cancer cells; novel targets for therapeutic intervention Gene Ther. Mol. Biol. 2000, 5, 111-120
49. Arredondo, J.; Chernyavsky, A. I.; Marubio, L. M.; Beaudet, A. L.; Jolkovsky, D. L.; Pinkerton, K. E.; Grando, S. A. Receptor-mediated tobacco toxicity: regulation of gene expression through alpha3beta2 nicotinic receptor in oral epithelial cells Am. J. Pathol. 2005, 166 (2) 597-613 (Pubitemid 40189055)
50. Lin, X. Y.; Choi, M. S.; Porter, A. G. Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma J. Biol. Chem. 2000, 275 (51) 39920-6 (Pubitemid 32064613)
51. Takada, Y.; Fang, X.; Jamaluddin, M. S.; Boyd, D. D.; Aggarwal, B. B. Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor J. Biol. Chem. 2004, 279 (38) 39541-54 (Pubitemid 39258221)
52. Barbieri, S. S.; Weksler, B. B. Tobacco smoke cooperates with interleukin-1beta to alter beta-catenin trafficking in vascular endothelium resulting in increased permeability and induction of cyclooxygenase-2 expression in vitro and in vivo FASEB J 2007, 21 (8) 1831-43 (Pubitemid 46855629)
53. Gosens, R.; Dueck, G.; Rector, E.; Nunes, R. O.; Gerthoffer, W. T.; Unruh, H.; Zaagsma, J.; Meurs, H.; Halayko, A. J. Cooperative regulation of GSK-3 by muscarinic and PDGF receptors is associated with airway myocyte proliferation Am. J. Physiol. Lung Cell Mol. Physiol. 2007, 293 (5) L1348-58
54. Cappello, F.; Di Stefano, A.; David, S.; Rappa, F.; Anzalone, R.; La Rocca, G.; D'Anna, S. E.; Magno, F.; Donner, C. F.; Balbi, B.; Zummo, G. Hsp60 and Hsp10 down-regulation predicts bronchial epithelial carcinogenesis in smokers with chronic obstructive pulmonary disease Cancer 2006, 107 (10) 2417-24 (Pubitemid 44748525)
55. Stabile, L. P.; Siegfried, J. M. Sex and gender differences in lung cancer J. Gend. Specif. Med. 2003, 6 (1) 37-48 (Pubitemid 36410481)
56. Gharaee-Kermani, M.; Hatano, K.; Nozaki, Y.; Phan, S. H. Gender-based differences in bleomycin-induced pulmonary fibrosis Am. J. Pathol. 2005, 166 (6) 1593-606 (Pubitemid 40734383)