Urinary ammonia excretion increases acutely during living donor liver transplantation

Liver International

Volumn 31, Issue 8, 2011, Pages 1150-1154

  Mpabanzi, Liliane ^a   van den Broek, Maartje A J ^a   Visschers, Ruben G J ^a   van de Poll, Marcel C G ^a   Nadalin, Silvio ^b,c   Saner, Fuat H ^b   Dejong, Cornelis H C ^a   Malago, Massimo ^b,d   Olde Damink, Steven W M ^a,b,d  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Ammonia; Hepatic encephalopathy; Kidney

Indexed keywords

AMMONIA;

ADULT; AMMONIA BLOOD LEVEL; ARTERIAL BLOOD; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; LIVER FAILURE; LIVER GRAFT; LIVER PERFUSION; LIVER RESECTION; LIVER TRANSPLANTATION; LIVING DONOR; MALE; URINARY EXCRETION;

ADULT; AGED; AMMONIA; BIOLOGICAL MARKERS; FEMALE; GERMANY; HEPATECTOMY; HEPATIC ENCEPHALOPATHY; HOMEOSTASIS; HUMANS; HYDROGEN-ION CONCENTRATION; HYPERAMMONEMIA; INTRAOPERATIVE PERIOD; KIDNEY; LIVER TRANSPLANTATION; LIVING DONORS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; TIME FACTORS; TREATMENT OUTCOME; UP-REGULATION;

EID: 79961210228     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2011.02544.x     Document Type: Article

References (24)

1. Lemberg A, Fernandez MA. Hepatic encephalopathy, ammonia, glutamate, glutamine and oxidative stress. Ann Hepatol 2009; 8: 95-102.
2. Mullen KD. Review of the final report of the 1998 Working Party on definition, nomenclature and diagnosis of hepatic encephalopathy. Aliment Pharmacol Ther 2007; 25(Suppl. 1): 11-6.
3. Jalan R, Olde Damink SW, Hayes PC, Deutz NE, Lee A. Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow. J Hepatol 2004; 41: 613-20.
4. Bachmann C. Mechanisms of hyperammonemia. Clin Chem Lab Med 2002; 40: 653-62.
5. Vince A, Dawson AM, Park N, O'Grady F. Ammonia production by intestinal bacteria. Gut 1973; 14: 171-7.
6. Olde Damink SW, Jalan R, Deutz NE, et al. The kidney plays a major role in the hyperammonemia seen after simulated or actual GI bleeding in patients with cirrhosis. Hepatology 2003; 37: 1277-85.
7. Dejong CH, Deutz NE, Soeters PB. Renal ammonia and glutamine metabolism during liver insufficiency-induced hyperammonemia in the rat. J Clin Invest 1993; 92: 2834-40.
8. Attmane-Elakeb A, Amlal H, Bichara M. Ammonium carriers in medullary thick ascending limb. Am J Physiol Renal Physiol 2001; 280: F1-9.
9. Karim Z, Szutkowska M, Vernimmen C, Bichara M. Renal handling of NH3/NH4+: recent concepts. Nephron Physiol 2005; 101: 77-81.
10. Fukuzawa K, Shimada M, Itasaka H, Takenaka K, Sugimachi K. Ammonia elimination as a rapid index of viability in liver grafts in dogs. J Surg Res 1991; 50: 88-92.
11. Bilir BM, Guinette D, Karrer F, et al. Hepatocyte transplantation in acute liver failure. Liver Transpl 2000; 6: 32-40.
12. Lock JF, Schwabauer E, Martus P, et al. Early diagnosis of primary nonfunction and indication for reoperation after liver transplantation. Liver Transpl 2010; 16: 172-80.
13. Kamath PS, Wiesner RH, Malinchoc M, et al. A model to predict survival in patients with end-stage liver disease. Hepatology 2001; 33: 464-70.
14. Nadalin S, Bockhorn M, Malago M, et al. Living donor liver transplantation. HPB 2006; 8: 10-21.
15. Malago M, Testa G, Frilling A, et al. Right living donor liver transplantation: an option for adult patients: single institution experience with 74 patients. Ann Surg 2003; 238: 853-62; discussion 862-853.
16. Dejong CH, Kampman MT, Deutz NE, Soeters PB. Altered glutamine metabolism in rat portal drained viscera and hindquarter during hyperammonemia. Gastroenterology 1992; 102: 936-48.
17. van de Poll MC, Ligthart-Melis GC, Olde Damink SW, et al. The gut does not contribute to systemic ammonia release in humans without portosystemic shunting. Am J Physiol Gastrointest Liver Physiol 2008; 295: G760-65.
18. Romero-Gomez M, Jover M, Galan JJ, Ruiz A. Gut ammonia production and its modulation. Metab Brain Dis 2009; 24: 147-57.
19. Olde Damink SW, Deutz NE, Dejong CH, Soeters PB, Jalan R. Interorgan ammonia metabolism in liver failure. Neurochem Int 2002; 41: 177-88.
20. Olde Damink SW, Jalan R, Redhead DN, et al. Interorgan ammonia and amino acid metabolism in metabolically stable patients with cirrhosis and a TIPSS. Hepatology 2002; 36: 1163-71.
21. Dejong CH, Deutz NE, Soeters PB. Metabolic adaptation of the kidney to hyperammonemia during chronic liver insufficiency in the rat. Hepatology 1993; 18: 890-902.
22. Tizianello A, De Ferrari G, Garibotto G, Gurreri G, Robaudo C. Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency. J Clin Invest 1980; 65: 1162-73.
23. Lemieux G, Vinay P, Cartier P. Renal hemodynamics and ammoniagenesis. Characteristics of the antiluminal site for glutamine extraction. J Clin Invest 1974; 53: 884-94.
24. Hamm LL, Simon EE. Ammonia transport in the proximal tubule. Miner Electrolyte Metab 1990; 16: 283-90.