Case Files of the Medical Toxicology Fellowship at Drexel University

Journal of Medical Toxicology

Volumn 7, Issue 3, 2011, Pages 213-219

  Vearrier, David ^a,b   Curtis, John A ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

Antihistamines; Compartment syndrome; Diphenhydramine; Rhabdomyolysis

Indexed keywords

CREATINE KINASE; CREATININE; DIPHENHYDRAMINE; OXYCODONE PLUS PARACETAMOL; PHOSPHORUS; POTASSIUM;

ADULT; ARTICLE; CASE REPORT; COMPARTMENT SYNDROME; CREATINE KINASE BLOOD LEVEL; DRUG OVERDOSE; FASCIOTOMY; FEMALE; HEMODIALYSIS; HUMAN; INTERSTITIAL FLUID; KIDNEY FAILURE; LEG PAIN; LIMB WEAKNESS; MAJOR DEPRESSION; MYOGLOBINURIA; PARESTHESIA; PHOSPHATE BLOOD LEVEL; POTASSIUM BLOOD LEVEL; RHABDOMYOLYSIS; SUICIDE ATTEMPT; TACHYCARDIA; UREA NITROGEN BLOOD LEVEL;

EID: 79961171944     PISSN: 15569039     EISSN: 19376995     Source Type: Journal    
DOI: 10.1007/s13181-011-0157-3     Document Type: Article

References (76)

1. Hill SJ et al (1997) International Union of Pharmacology: XIII. Classification of histamine receptors. Pharmacol Rev 49(3): 253-278.
2. 1-antihistamines: inverse agonism, anti-inflammatory actions and cardiac effects. Clin Exp Allergy 32(4): 489-498.
3. Spector R et al (1980) Diphenhydramine in Orientals and Caucasians. Clin Pharmacol Ther 28(2): 229-234.
4. Akutsu T et al (2007) Identification of human cytochrome P450 isozymes involved in diphenhydramine N-demethylation. Drug Metab Dispos 35(1): 72-78.
5. Fischer D, Breyer-Pfaff U (1997) Variability of diphenhydramine N-glucuronidation in healthy subjects. Eur J Drug Metab Pharmacokinet 22(2): 151-154.
6. Armstrong SC, Cozza KL (2003) Antihistamines. Psychosomatics 44(5): 430-434.
7. Albert KS et al (1975) Pharmacokinetics of diphenhydramine in man. J Pharmacokinet Biopharm 3(3): 159-170.
8. 1-antihistamines. N Engl J Med 351(21): 2203-2217.
9. Meredith CG et al (1984) Diphenhydramine disposition in chronic liver disease. Clin Pharmacol Ther 35(4): 474-479.
10. Kubo N et al (1987) Antimuscarinic effects of antihistamines: quantitative evaluation by receptor-binding assay. Jpn J Pharmacol 43(3): 277-282.
11. Trottier RW, Malone MH (1969) Comparative in vitro evaluation of cryogenine, cyproheptadine, and diphenhydramine as antagonists of furtrethonium, histamine, and serotonin. J Pharm Sci 58(10): 1250-1253.
12. Giotti A, Zilletti L (1976) Antiarrhythmic actions of antihistamines. Pharmacol Ther B 2(4): 863-900.
13. Kuo CC, Huang RC, Lou BS (2000) Inhibition of Na(+) current by diphenhydramine and other diphenyl compounds: molecular determinants of selective binding to the inactivated channels. Mol Pharmacol 57(1): 135-143.
14. Taglialatela M, Timmerman H, Annunziato L (2000) Cardiotoxic potential and CNS effects of first-generation antihistamines. Trends Pharmacol Sci 21(2): 52-56.
15. 1 receptor antagonist diphenhydramine. J Pharmacol Exp Ther 288(2): 858-865.
16. Goldberg MJ, Spector R, Chiang CK (1987) Transport of diphenhydramine in the central nervous system. J Pharmacol Exp Ther 240(3): 717-722.
17. Feldman MD, Behar M (1986) a case of massive diphenhydramine abuse and withdrawal from use of the drug. J Am Med Assoc 255(22): 3119-3120.
18. Goetz CM et al (1990) Accidental childhood death from diphenhydramine overdosage. Am J Emerg Med 8(4): 321-322.
19. Krenzelok EP, Anderson GM, Mirick M (1982) Massive diphenhydramine overdose resulting in death. Ann Emerg Med 11(4): 212-213.
20. Joshi AK et al (2004) Case of polymorphic ventricular tachycardia in diphenhydramine poisoning. J Cardiovasc Electrophysiol 15(5): 591-593.
21. Clark RF, Vance MV (1992) Massive diphenhydramine poisoning resulting in a wide-complex tachycardia: Successful treatment with sodium bicarbonate. Ann Emerg Med 21(3): 318-321.
22. López-Barbeito B et al (2005) Diphenhydramine overdose and Brugada sign. Pacing Clin Electrophysiol 28(7): 730-732.
23. Wojciech Z et al (1997) Electrocardiographic findings in patients with diphenhydramine overdose. Am J Cardiol 80(9): 1168-1173.
24. John WS, Ijaz AK (2005) Prolonged QT interval with markedly abnormal ventricular repolarization in diphenhydramine overdose. Int J Cardiol 99(2): 333-335.
25. Khosla U, Ruel KS, Hunt DP (2003) Antihistamine-induced rhabdomyolysis. Southern Med J 96(10): 1023-1026.
26. Leybishkis B, Fasseas P, Ryan KF (2001) Doxylamine overdose as a potential cause of rhabdomyolysis. Am J Med Sci 322(1): 48-49.
27. Haas CE, Magram Y, Mishra A (2003) Rhabdomyolysis and acute renal failure following an ethanol and diphenhydramine overdose. Ann Pharmacother 37(4): 538-542.
28. Emadian SM, Caravati EM, Herr RD (1996) Rhabdomyolysis: a rare adverse effect of diphenhydramine overdose. Am J Emerg Med 14(6): 574-576.
29. Stucka KR et al (2003) Rhabdomyolysis associated with unintentional antihistamine overdose in a child. Pediatr Emerg Care 19(1): 25-26.
30. Jo Y-I et al (2007) Risk factors for rhabdomyolysis following doxylamine overdose. Hum Exp Toxicol 26(8): 617-621.
31. Curry SC, Chang D, Connor D (1989) Drug- and toxin-induced rhabdomyolysis. Ann Emerg Med 18(10): 1068-1084.
32. Urbano-Márquez A, Fernández-Solà J (2004) Effects of alcohol on skeletal and cardiac muscle. Muscle Nerve 30(6): 689-707.
33. Riggs JE (1998) Alcohol-associated rhabdomyolysis: ethanol induction of cytochrome P450 may potentiate myotoxicity. Clin Neuropharmacol 21(6): 363-364.
34. John RR (2000) Rhabdomyolysis and drugs of abuse. J Emerg Med 19(1): 51-56.
35. Brazeau GA, McArdle A, Jackson MJ (1995) Effects of cocaine on leakage of creatine kinase from skeletal muscle: In vitro and in vivo studies in mice. Life Sci 57(17): 1569-1578.
36. Reichenbach DD, Benditt EP (1970) Catecholamines and cardiomyopathy: the pathogenesis and potential importance of myofibrillar degeneration. Hum Pathol 1(1): 125-150.
37. Knochel JP, Schlein EM (1972) On the mechanism of rhabdomyolysis in potassium depletion. J Clin Invest 51(7): 1750-1758.
38. Agrawal S, Agrawal V, Taneja A (2006) Hypokalemia causing rhabdomyolysis resulting in life-threatening hyperkalemia. Pediatr Nephrol 21(2): 289-291.
39. Singhal PC et al (1990) Prevalence and predictors of rhabdomyolysis in patients with hypokalemia. N Engl J Med 323(21): 1488-1488.
40. da Silva P, de Oliveira IS, Waisberg J (2007) Hypokalemic rhabdomyolysis in a child due to amphotericin B therapy. Eur J Pediatr 166(2): 169-171.
41. Kao K-C et al (2000) Hypokalemic muscular paralysis causing acute respiratory failure due to rhabdomyolysis with renal tubular acidosis in a chronic glue sniffer. Clin Toxicol 38(6): 679-681.
42. Yasue H et al (2007) Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licorice. Intern Med 46(9): 575-578.
43. Kasap B et al (2010) Acute kidney injury following hypokalemic rhabdomyolysis: complication of chronic heavy cola consumption in an adolescent boy. Eur J Pediatr 169(1): 107-111.
44. Achar KN, Abduo TJ, Menon NK (1989) SEVERE hypokalemic rhabdomyolysis due to ingestion of liquorice during ramadan. Aust N Z J Med 19(4): 365-367.
45. Chubachi A et al (1992) Acute renal failure following hypokalemic rhabdomyolysis due to chronic glycyrrhizic acid administration. Intern Med 31(5): 708-711.
46. Lalande BM, Findling JW (1998) Amelioration of licorice-induced hypokalemic rhabdomyolysis with dexamethasone: case report and review of the literature. Endocrinologist 8(5): 359-364.
47. Bertorini TE (1997) Myoglobinuria, malignant hyperthermia, neuroleptic malignant syndrome and serotonin syndrome. Neurol Clin 15(3): 649-671.
48. Samson-Fang L, Gooch J, Norlin C (2000) Intrathecal baclofen withdrawal simulating neuroleptic malignant syndrome in a child with cerebral palsy. Dev Med Child Neurol 42(08): 561-565.
49. Warrell DA (2005) Treatment of bites by adders and exotic venomous snakes. BMJ 331(7527): 1244-1247.
50. Koya S, Crenshaw D, Agarwal A (2007) Rhabdomyolysis and acute renal failure after fire ant bites. J Gen Intern Med 22(1): 145-147.
51. Hiran S et al (1994) Rhabdomyolysis due to multiple honey bee stings. Postgrad Med J 70(830): 937.
52. Shilkin KB, Chen BT, Khoo OT (1972) Rhabdomyolysis caused by hornet venom. Br Med J 1(5793): 156-157.
53. Xuan BHN et al (2010) Swarming hornet attacks: shock and acute kidney injury'Äîa large case series from Vietnam. Nephrol Dial Transplant 25(4): 1146-1150.
54. Kim YO et al (2003) Severe rhabdomyolysis and acute renal failure due to multiple wasp stings. Nephrol Dial Transplant 18(6): 1235.
55. de Souza AL et al (2008) Loxosceles venom-induced cytokine activation, hemolysis, and acute kidney injury. Toxicon 51(1): 151-156.
56. Jennifer C, Sean B (2005) Case report: compartment syndrome after a suspected black widow spider bite. Ann Emerg Med 45(4): 414-416.
57. Gala S, Katelaris CH (1992) Rhabdomyolysis due to redback spider envenomation. Med J Aust 157(1): 66.
58. Bond GR (1992) Antivenin administration for Centruroides scorpion sting: risks and benefits. Ann Emerg Med 21(7): 788-791.
59. Logan JL, Ogden DA (1985) Rhabdomyolysis and acute renal failure following the bite of the giant desert centipede Scolopendra heros. West J Med 142(4): 549-550.
60. Bosch X, Poch E, Grau JM (2009) Rhabdomyolysis and acute kidney injury. N Engl J Med 361(1): 62-72.
61. Brown CVR et al (2004) Preventing renal failure in patients with rhabdomyolysis: do bicarbonate and mannitol make a difference? J Trauma 56(6): 1191-1196.
62. Dhawan SS, Wang BW (2007) Four-extremity gangrene associated with crack cocaine abuse. Ann Emerg Med 49(2): 186-189.
63. Golling M et al (2009) Crush syndrome due to drug-induced compartment syndrome: a rare condition not to be overlooked. Surg Today 39(7): 558-565.
64. Campbell BT et al (2008) Pediatric snakebites: lessons learned from 114 cases. J Pediatr Surg 43(7): 1338-1341.
65. Wagner CW, Golladay ES (1989) Crotalid envenomation in children: selective conservative management. J Pediatr Surg 24(1): 128-131, Discussion 131.
66. Otero R et al (2002) Complications of Bothrops, Porthidium, and Bothriechis snakebites in Colombia. A clinical and epidemiological study of 39 cases attended in a university hospital. Toxicon 40(8): 1107-1114.
67. Schroeder C et al (2001) The effects of creatine dietary supplementation on anterior compartment pressure in the lower leg during rest and following exercise. Clin J Sport Med 11(2): 87-95.
68. Hile AM et al (2006) Creatine supplementation and anterior compartment pressure during exercise in the heat in dehydrated men. J Athl Train 41(1): 30-35.
69. Robinson SJ (2000) Acute quadriceps compartment syndrome and rhabdomyolysis in a weight lifter using high-dose creatine supplementation. J Am Board Fam Pract 13(2): 134-137.
70. Do KD, Bellabarba C, Bhananker SM (2007) Exertional rhabdomyolysis in a bodybuilder following overexertion: a possible link to creatine overconsumption. Clin J Sport Med 17(1): 78-79.
71. Dart RC (2004) Can steel heal a compartment syndrome caused by rattlesnake venom? Ann Emerg Med 44(2): 105-107.
72. Garfin SR et al (1984) Rattlesnake bites and surgical decompression: results using a laboratory model. Toxicon 22(2): 177-182.
73. Stewart RM et al (1989) Antivenin and fasciotomy/debridement in the treatment of the severe rattlesnake bite. Am J Surg 158(6): 543-547.
74. David AT et al (2004) Fasciotomy worsens the amount of myonecrosis in a porcine model of crotaline envenomation. Ann Emer Med 44(2): 99-104.
75. Fulton JA, Hoffman RS (2005) Fasciotomy after envenomation: measure twice and cut once. Ann Emerg Med 45(3): 338-339, author reply 339.
76. Gold BS et al (2003) Resolution of compartment syndrome after rattlesnake envenomation utilizing non-invasive measures. J Emerg Med 24(3): 285-288.