Loxosceles venom-induced cytokine activation, hemolysis, and acute kidney injury

Toxicon

Volumn 51, Issue 1, 2008, Pages 151-156

  de Souza, A L ^a   Malaque, C M ^a,c   Sztajnbok, J ^a   Romano, C C ^b   Duarte, A J ^b   Seguro, A C ^a,b  

^a INSTITUTO DE INFECTOLOGIA EMÍLIO RIBAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c INSTITUTO BUTANTAN   (Brazil)

Author keywords

Acute; Blood coagulation disorders; Cytokines; Hemolysis; Kidney failure; Rhabdomyolysis; Spider venom Loxosceles venom

Indexed keywords

ANTITHROMBIN III; BILIRUBIN; CREATINE KINASE; CREATININE; CYTOKINE; D DIMER; HEMOGLOBIN; INTERLEUKIN 6; LACTATE DEHYDROGENASE; POTASSIUM; PROTEIN C; PROTEIN S; SPIDER VENOM; SPIDER VENOM ANTISERUM; TUMOR NECROSIS FACTOR ALPHA; UREA;

ACUTE KIDNEY FAILURE; ADULT; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; CASE REPORT; CONCENTRATION (PARAMETERS); ELECTROLYTE DISTURBANCE; HEMODIALYSIS; HEMOGLOBIN BLOOD LEVEL; HEMOLYSIS; HUMAN; INTERNATIONAL NORMALIZED RATIO; KIDNEY INJURY; LABORATORY; LEUKOCYTE COUNT; MALE; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RHABDOMYOLYSIS; SKIN NECROSIS; SPIDER; SPIDER BITE; THROMBOCYTE COUNT; URINALYSIS;

ADULT; ANIMALS; ARACHNIDISM; CYTOKINES; HEMOLYSIS; HUMANS; KIDNEY FAILURE, ACUTE; MALE; PHOSPHORIC DIESTER HYDROLASES; SPIDER VENOMS; SPIDERS;

ARANEAE; LOXOSCELES;

EID: 38049035912     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2007.08.011     Document Type: Article

References (15)

1. Annane D., Bellissant E., and Cavaillon J.M. Septic shock. Lancet 365 9453 (2005) 63-78
2. Barbaro K.C., and Cardoso J.L.C. Mecanismo de ação do veneno de Loxosceles e aspectos clínicos do loxoscelismo. In: Cardoso J.L.C., Siqueira França F.O., Wen F.H., Sant'Ana Málaque C.M., and Haddad Jr V. (Eds). Animais Peçonhentos no Brasil (2003), Sarvier/FAPESP, São Paulo 160-174
3. Cotran R.S., Kumar V., and Robbins S.L. Diseases of red cells and bleeding disorders. In: Cotran R.S., Kumar V., and Robbins S.L. (Eds). Robbins Pathologic Basis of Disease. fifth ed (1994), Saunders, Philadelphia 518-522
4. da Silva P.H., da Silveira R.B., Appel M.H., Mangili O.C., Gremski W., and Veiga S.S. Brown spiders and loxoscelism. Toxicon 44 7 (2004) 693-709
5. Hogan C.J., Barbaro K.C., and Winkel K. Loxoscelism: old obstacles, new directions. Ann. Emerg. Med. 44 6 (2004) 608-624
6. Hostetler M.A., Dribben W., Wilson D.B., and Grossman W.J. Sudden unexplained hemolysis occurring in an infant due to presumed Loxosceles envenomation. J. Emerg. Med. 25 3 (2003) 277-282
7. Malaque C.M., Ori M., Santos S.A., and Andrade D.R. Production of TNF-alpha by primary cultures of human keratinocytes challenged with Loxosceles gaucho venom. Rev. Inst. Med. Trop. Sao Paulo 41 3 (1999) 179-182
8. Malaque C.M., Castro-Valencia J.E., Cardoso J.L., Francca F.O., Barbaro K.C., and Fan H.W. Clinical and epidemiological features of definitive and presumed loxoscelism in São Paulo, Brazil. Rev. Inst. Med. Trop. Sao Paulo 44 3 (2002) 139-143
9. Pauli I., Puka J., Gubert I.C., and Minozzo J.C. The efficacy of antivenom in loxoscelism treatment. Toxicon 48 2 (2006) 123-137
10. Swanson D.L., and Vetter R.S. Bites of brown recluse spiders and suspected necrotic arachnidism. N. Engl. J. Med. 352 7 (2005) 700-707
11. Tambourgi D.V., Petricevich V.L., Magnoli F.C., Assaf S.L., Jancar S., and Dias Da Silva W. Endotoxemic-like shock induced by Loxosceles spider venoms: pathological changes and putative cytokine mediators. Toxicon 36 2 (1998) 391-403
12. Tambourgi D.V., Morgan B.P., de Andrade R.M., Magnoli F.C., and van Den Berg C.W. Loxosceles intermedia spider envenomation induces activation of an endogenous metalloproteinase, resulting in cleavage of glycophorins from the erythrocyte surface and facilitating complement-mediated lysis. Blood 95 2 (2000) 683-691
13. Tambourgi D.V., Pedrosa M.F., de Andrade R.M., Billington S.J., Griffiths M., and van den Berg C.W. Sphingomyelinases D induce direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis. Mol. Immunol. 44 4 (2007) 576-582
14. Waage A., Brandtzaeg P., Halstensen A., Kierulf P., and Espevik T. The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome. J. Exp. Med. 169 1 (1989) 333-338
15. Zanetti V.C., da Silveira R.B., Dreyfuss J.L., Haoach J., Mangili O.C., Veiga S.S., and Gremski W. Morphological and biochemical evidence of blood vessel damage and fibrinogenolysis triggered by brown spider venom. Blood Coagul. Fibrinol. 13 2 (2002) 135-148