Factors Related to Seizure in Tramadol Poisoning and Its Blood Concentration

Journal of Medical Toxicology

Volumn 7, Issue 3, 2011, Pages 183-188

  Taghaddosinejad, Fakhreddin ^a   Mehrpour, Omid ^b,c,f   Afshari, Reza ^d   Seghatoleslami, Alireza ^a   Abdollahi, Mohammad ^a   Dart, Richard C ^e  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b BIRJAND UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c BIRJAND UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^f BIRJAND UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Blood concentration; Poisoning; Seizure; Tramadol

Indexed keywords

TRAMADOL;

ADOLESCENT; ADULT; ARTICLE; CHILD; DOSE RESPONSE; DRUG ABUSE; DRUG BLOOD LEVEL; DRUG INTOXICATION; DRUG OVERDOSE; FEMALE; GLASGOW COMA SCALE; HUMAN; IRAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; OPIATE ADDICTION; PAIN; POISON CENTER; SCHOOL CHILD; SEIZURE; SELF POISONING; SUBSTANCE ABUSE; UNCONSCIOUSNESS;

ADOLESCENT; ADULT; AGE FACTORS; ANALGESICS, OPIOID; CHROMATOGRAPHY, GAS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLASGOW COMA SCALE; HUMANS; IRAN; MALE; MIDDLE AGED; OVERDOSE; POISONING; PROSPECTIVE STUDIES; SEIZURES; SEX FACTORS; TRAMADOL; YOUNG ADULT;

EID: 79961168278     PISSN: 15569039     EISSN: 19376995     Source Type: Journal    
DOI: 10.1007/s13181-011-0168-0     Document Type: Article

References (32)

1. Clarot F, Goullé JP, Vaz E, Proust B (2003) Fatal overdoses of tramadol: is benzodiazepine a risk factor of lethality. Forensic Sci Int 134(1): 57-61.
2. Musshoff F, Madea B (2001) Fatality due to ingestion of tramadol alone. Forensic Sci Int 116(2-3): 197-199.
3. Loughrey MB, Loughrey CM, Johnston S, O'Rourke D (2003) Fatal hepatic failure following accidental tramadol overdose. Forensic Sci Int 134(2-3): 232-233.
4. Michaud K, Augsburger M, Romain N, Giroud C, Mangin P (1999) Fatal overdose of tramadol and alprazolam. Forensic Sci Int 105(3): 185-189.
5. Shadnia S, Soltaninejad K, Heydari K, Sasanian G, Abdollahi M (2008) Tramadol intoxication: a review of 114 cases. Hum Exp Toxicol 27(3): 201-205.
6. Afshari R, Majdzadeh SR, Balali-Mood M (2004) Pattern of acute poisoning in Mashhad, Iran 1993-2000. J Toxicol Clin Toxicol 42(7): 965-975.
7. Koushesh HR, Afshari R, Afshari R (2009) A new illicit opioid dependence outbreak, evidence for a combination of opioids and steroids. Drug Chem Toxicol 32(2): 114-119.
8. Afshari R, Tashakori A, Shakiba AH (2008) Tramadol overdose induced CPK rise, haemodynamic and electocardiographic changes and seizure. Clin Toxicol 46: 369.
9. Talaie H, Panahandeh R, Fayaznouri M, Asadi Z, Abdollahi M (2009) Dose-independent occurrence of seizure with tramadol. J Med Toxicol 5(2): 63-67.
10. Talaie H, Panahandeh R, Fayaznouri MR, Asadi Z, Abdollahi M (2008) Seizure associated with tramadol use/abuse. J Clin Toxicol 46: 628.
11. Kroenke K, Krebs EE, Bair MJ (2009) Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews. Gen Hosp Psychiatry 31(3): 206-219.
12. Hara K, Minami K, Sata T (2005) The effects of tramadol and its metabolite on glycine, gamma-aminobutyric acidA, and N-methyl-d-aspartate receptors expressed in Xenopus oocytes. Anesth Analg 100(5): 1400-1405.
13. Rehni AK, Singh I, Kumar M (2008) Tramadol-induced seizurogenic effect: a possible role of opioid-dependent gamma-aminobutyric acid inhibitory pathway. Basic Clin Pharmacol Toxicol 103(3): 262-266.
14. Sun C, Mtchedlishvili Z, Erisir A, Kapur J (2007) Diminished neurosteroid sensitivity of synaptic inhibition and altered location of the alpha4 subunit of GABA(A) receptors in an animal model of epilepsy. J Neurosci 27(46): 12641-12650.
15. Miura M, Saino-Saito S, Masuda M, Kobayashi K, Aosaki T (2007) Compartment-specific modulation of GABAergic synaptic transmission by mu-opioid receptor in the mouse striatum with green fluorescent protein-expressing dopamine islands. J Neurosci 27(36): 9721-9728.
16. Frenk H (1983) Pro- and anticonvulsant actions of morphine and the endogenous opioids: involvement and interactions of multiple opiate and non-opiate systems. Brain Res 287(2): 197-210.
17. Kahn LH, Alderfer RJ, Graham DJ (1997) Seizures reported with tramadol. JAMA 278(20): 1661.
18. Raffa RB, Stone DJ Jr (2008) Unexceptional seizure potential of tramadol or its enantiomers or metabolites in mice. J Pharmacol Exp Ther 325(2): 500-506.
19. Hennies HH, Friderichs E, Schneider J (1988) Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids. Arzneimittelforschung 38(7): 877-880.
20. Mehrpour O, Abdollahi M (2011) Poison treatment centers in Iran. Hum Exp Toxicol (in press).
21. Ardakani YH, Rouini MR (2007) Pharmacokinetics of tramadol and its three main metabolites in healthy male and female volunteers. Biopharm Drug Dispos 28(9): 527-534.
22. Spiller HA, Gorman SE, Villalobos D, Benson BE, Ruskosky DR, Stancavage MM, Anderson DL (1997) Prospective multicenter evaluation of tramadol exposure. J Toxicol Clin Toxicol 35(4): 361-364.
23. Gholami K, Shalviri G, Zarbakhsh A, Daryabari N, Yousefian S (2007) New guideline for tramadol usage following adverse drug reactions reported to the Iranian Pharmacovigilance Center. Pharmacoepidemiol Drug Saf 16(2): 229-237.
24. Epstein DH, Preston KL, Jasinski DR (2006) Abuse liability, behavioral pharmacology, and physical-dependence potential of opioids in humans and laboratory animals: lessons from tramadol. Biol Psychol 73(1): 90-99.
25. Jovanović-Cupić V, Martinović Z, Nesić N (2006) Seizures associated with intoxication and abuse of tramadol. J Toxicol Clin Toxicol 44(2): 143-146.
26. Gardner JS, Blough D, Drinkard CR, Shatin D, Anderson G, Graham D, Alderfer R (2000) Tramadol and seizures: a surveillance study in a managed care population. Pharmacotherapy 20(12): 1423-1431.
27. Marquardt KA, Alsop JA, Albertson TE (2005) Tramadol exposures reported to statewide poison control system. Ann Pharmacother 39(6): 1039-1044.
28. Mehrpour M (2005) Intravenous tramadol-induced seizure: two case reports. Iran J Pharmacol Ther 4(2): 146-147.
29. Tjäderborn M, Jönsson AK, Hägg S, Ahlner J (2007) Fatal unintentional intoxications with tramadol during 1995-2005. Forensic Sci Int 173(2-3): 107-111.
30. Galer K, Krzyzanowski M (2004) Death attributed to toxic interaction of tramadol and other drugs. Arch Med Sadowej Kryminol 54(1): 73-78.
31. Afshari R, Good AM, Maxwell SR, Bateman DN (2005) Co-proxamol overdose is associated with a 10-fold excess mortality compared with other paracetamol combination analgesics. Br J Clin Pharmacol 60(4): 444-447.
32. Bateman DN, Afshari R (2003) Co-proxamol and suicide: licence needs to be changed. BMJ 327(7409): 287.