Tramadol-induced seizurogenic effect: A possible role of opioid-dependent γ-aminobutyric acid inhibitory pathway

Basic and Clinical Pharmacology and Toxicology

Volumn 103, Issue 3, 2008, Pages 262-266

  Rehni, Ashish K ^a,b   Singh, Inderbir ^b   Kumar, Manoj ^b  

^a Chitkara College of Pharmacy ^*  (India)

^b CHITKARA UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; GABAPENTIN; NALOXONE; OPIATE RECEPTOR; PENTETRAZOLE; TRAMADOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CONVULSION; DEATH; DRUG POTENTIATION; DRUG RECEPTOR BINDING; EPILEPTOGENESIS; INVOLUNTARY MOVEMENT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEIZURE; SINGLE DRUG DOSE; STRAUB TAIL PHENOMENON;

AMINES; ANALGESICS, OPIOID; ANIMALS; CYCLOHEXANECARBOXYLIC ACIDS; GABA AGENTS; GAMMA-AMINOBUTYRIC ACID; MICE; MICE, INBRED STRAINS; NALOXONE; NARCOTIC ANTAGONISTS; PENTYLENETETRAZOLE; RECEPTORS, GABA; RECEPTORS, OPIOID; SEIZURES; TRAMADOL;

MUS;

EID: 49749101149     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2008.00276.x     Document Type: Article

References (14)

1. Raffa RB, Friderichs E, Reimann W, Shank RP, Codd EE, Vaught JL. Opioid and non-opioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. J Pharmacol Exp Ther 1992 260 : 275 85.
2. Driessen B, Reimann W, Giertz H. Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro. Br J Pharmacol 1993 108 : 806 11.
3. Potschka H, Friderichs E, Löscher W. Anticonvulsant and proconvulsant effects of tramadol, its enantiomers and its M1 metabolite in the rat kindling model of epilepsy. Br J Pharmacol 2000 131 : 203 12.
4. Hara K, Minami K, Sata T. The effects of tramadol and its metabolite on glycine, gamma-aminobutyric acid-A, and N-Methyl-D-Aspartate receptors expressed in xenopus oocytes. Anesth Analg 2005 100 : 1400 5.
5. Sun C, Mtchedlishvili Z, Erisir A, Kapur J. Diminished neurosteroid sensitivity of synaptic inhibition and altered location of the alpha4 subunit of GABA(A) receptors in an animal model of epilepsy. J Neurosci 2007 27 : 12641 50.
6. Miura M, Saino-Saito S, Masuda M, Kobayashi K, Aosaki T. Compartment-specific modulation of GABAergic synaptic transmission by mu-opioid receptor in the mouse striatum with green fluorescent protein-expressing dopamine islands. J Neurosci 2007 27 : 9721 8.
7. Frenk H. Pro- and anticonvulsant actions of morphine and the endogenous opioids: involvement and interactions of multiple opiate and non-opiate systems. Brain Res 1983 287 : 197 210.
8. Bastian JW, Krause WE, Ridlon SA, Ercoli N. CNS drug specificity as detrmined by the mouse intravenous pentylenetetrazole technique. J Pharmacol Exp Ther 1959 127 : 75 80.
9. Loscher W, Honack D, Fassbender CP, Nolting B. The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models. Epilepsy Res 1991 8 : 171 89.
10. Starzl TE, Niemer WT, Dell M, Forgrave PR. Cortical and subcortical electrical activity in experimental sezures induced by metrazole. J Neuropathol Exp Neurol 1953 12 : 262 76.
11. Daubin C, Quentin C, Goullé JP, Guillotin D, Lehoux P, Lepage O et al. Refractory shock and asystole related to tramadol overdose. Clin Toxicol (Phila) 2007 45 : 961 4.
12. Koussa S, Rizk T, Tohmé A. Tramadol-induced epileptic seizures. Rev Neurol (Paris) 2003 159 : 1053 4.
13. Ide S, Minami M, Ishihara K, Uhl GR, Sora I, Ikeda K. Mu opioid receptor-dependent and independent components in effects of tramadol. Neuropharmacology 2006 51 : 651 8.
14. Saboory E, Derchansky M, Ismaili M, Jahromi SS, Brull R, Carlen PL et al. Mechanisms of morphine enhancement of spontaneous seizure activity. Anesth Analg 2007 105 : 1729 35.