Unexceptional seizure potential of tramadol or its enantiomers or metabolites in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 325, Issue 2, 2008, Pages 500-506

  Raffa, Robert B ^a,c   Stone Jr , Dennis J ^b  

^a TEMPLE UNIVERSITY SCHOOL OF PHARMACY   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; AMITRIPTYLINE; BUPRENORPHINE; CODEINE; CYTOCHROME P450 2D6; DEXTROMETHORPHAN; DEXTROPROPOXYPHENE; DEXTRORPHAN; DIHYDROMORPHINE; DRUG METABOLITE; FLUOXETINE; HYDROCODONE; HYDROMORPHONE; LEVALLORPHAN; LEVOMETHORPHAN; LEVORPHANOL; METHADONE; MORPHINE; N DESMETHYLTRAMADOL; N,N DIDESMETHYLTRAMADOL; NALOXONE; NARCOTIC ANALGESIC AGENT; O NORTRAMADOL; O,N DIDESMETHYLTRAMADOL; O,N,N TRIDESMETHYLTRAMADOL; OXYCODONE; PETHIDINE; QUINIDINE; RESERPINE; TRAMADOL; UNCLASSIFIED DRUG; NARCOTIC ANTAGONIST;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG INHIBITION; DRUG MEGADOSE; DRUG POTENCY; DRUG STRUCTURE; MALE; MOUSE; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; SEIZURE; ANIMAL; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DRUG INTERACTION; HEAT; MOUSE STRAIN; PAIN; STEREOISOMERISM;

ANALGESICS, OPIOID; ANIMALS; CODEINE; CYTOCHROME P-450 CYP2D6; DRUG INTERACTIONS; HEAT; MALE; MICE; MICE, INBRED STRAINS; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; OXYCODONE; PAIN; QUINIDINE; RESERPINE; SEIZURES; STEREOISOMERISM; TRAMADOL;

EID: 42449134525     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.137273     Document Type: Article

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