Chemical synthesis enables biochemical and antibacterial evaluation of streptolydigin antibiotics

Journal of the American Chemical Society

Volumn 133, Issue 31, 2011, Pages 12172-12184

  Pronin, Sergey V ^a   Martinez, Anthony ^a   Kuznedelov, Konstantin ^b   Severinov, Konstantin ^b,c   Shuman, Howard A ^a   Kozmin, Sergey A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUSSIAN ACADEMY OF SCIENCES   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-BACTERIAL ACTIVITY; BACTERIAL TRANSCRIPTION; BIOLOGICAL EVALUATION; CHEMICAL AGENT; CHEMICAL SYNTHESIS; IN-VITRO; LINEAR SEQUENCE; ORGANIC SYNTHESIS; RNA POLYMERASE; STREPTOLIC ACIDS; SYNTHETIC EFFICIENCY; TETRAMIC ACIDS;

ANTIBIOTICS; BACTERIOLOGY; BIOLOGY; ORGANIC ACIDS; RNA; TRANSCRIPTION;

SYNTHESIS (CHEMICAL);

10,11 DIHYDROSTREPTOLYDIGIN; ANTIBIOTIC BU 2313; ANTIINFECTIVE AGENT; BACTERIAL RNA; RNA POLYMERASE; STREPTOLIC ACID; STREPTOLYDIGIN; STREPTOLYDIGINONE; TETRAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BIOCHEMISTRY; DRUG SYNTHESIS; MOUSE; NONHUMAN; STREPTOCOCCUS SALIVARIUS;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; DNA-DIRECTED RNA POLYMERASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STREPTOCOCCUS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMUS;

EID: 79961156356     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2041964     Document Type: Article

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