Notch gain of function in mouse periocular mesenchyme downregulates FoxL2 and impairs eyelid levator muscle formation, leading to congenital blepharophimosis

Journal of Cell Science

Volumn 124, Issue 15, 2011, Pages 2561-2572

  Zhang, Yujin ^a   Kao, Winston W Y ^a   Pelosi, Emanuele ^b   Schlessinger, David ^b   Liu, Chia Yang ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

BPES; Eyelid; FoxL2; Morphogenesis; Neural crest; Notch signaling

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NUCLEIC ACID BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXL2; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR HEY 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIRTH; BLEPHAROPHIMOSIS; BLEPHAROPHIMOSIS, PTOSIS AND EPICANTHUS INVERSUS SYNDROME; CELL PROLIFERATION; CONTROLLED STUDY; CORNEA; CORNEA STROMA; EMBRYO; EYE; EYELID; EYELID CLOSURE; EYELID DISEASE; EYELID LEVATOR MUSCLE; EYELID MUSCLE; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; INTRACELLULAR MEMBRANE; MESENCHYME CELL; MORPHOGENESIS; MOUSE; NEURAL CREST; NONHUMAN; PERIOCULAR MESENCHYMAL CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PTOSIS; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSGENIC ANIMAL;

ACTINS; ANIMALS; APOPTOSIS; BLEPHAROPHIMOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; EYELIDS; FORKHEAD TRANSCRIPTION FACTORS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; MUSCLE, SMOOTH; NIH 3T3 CELLS; RECEPTOR, NOTCH1;

MUS MUSCULUS;

EID: 79961151863     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.085001     Document Type: Article

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