Identification of a 3.2 kb 5'-flanking region of the murine keratocan gene that directs β-galactosidase expression in the adult corneal stroma of transgenic mice

Gene

Volumn 250, Issue 1-2, 2000, Pages 85-96

  Liu, Chia Yang ^a   Arar, Hisham ^a   Kao, Candace ^a   Kao, Winston W Y ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Corneal stroma; Gene regulation; Keratocan promoter; Keratocyte; TGF 2; Transgenic mice

Indexed keywords

BETA GALACTOSIDASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CORNEA CELL; CORNEA STROMA; DNA FLANKING REGION; DNA SEQUENCE; EMBRYO DEVELOPMENT; EYE DEVELOPMENT; GENE ACTIVITY; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSGENIC MOUSE;

ANIMALS; BASE SEQUENCE; BETA-GALACTOSIDASE; CELLS, CULTURED; CORNEA; CORNEAL STROMA; EMBRYO; GENE EXPRESSION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IN SITU HYBRIDIZATION; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTEOGLYCANS; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID; TISSUE DISTRIBUTION; TRANSGENES;

ANIMALIA; MAMMALIA; MURINAE; MUS MUSCULUS; RODENTIA;

EID: 0034732903     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(00)00165-7     Document Type: Article

References (29)

1. Beales M.P., Funderburgh J.L., Jester J.V., Hassell J.R. Proteoglycan synthesis by bovine keratocytes and corneal fibroblasts: maintenance of the keratocyte phenotype in culture. Invest. Ophthalmol. Vis. Sci. 40:1999;1658-1663.
2. Boesch J.S., Lee C., Lindahl R.G. Constitutive expression of class 3 aldehyde dehydrogenase in cultured rat corneal epithelium. J. Biol. Chem. 271:1996;5150-5157.
3. Boyd A.L., Samid D. Review: molecular biology of transgenic animals. J. Anim. Sci. 71:(suppl. 3):1993;1-9.
4. Breitman M.L., Bryce D.M., Giddens E., Clapoff S., Goring D., Tsui L.C., Klintworth G.K., Bernstein A. Analysis of lens cell fate and eye morphogenesis in transgenic mice ablated for cells of the lens lineage. Development. 106:1989;457-463.
5. Breitman M.L., Rombola H., Maxwell I.H., Klintworth G.K., Bernstein A. Genetic ablation in transgenic mice with an attenuated diphtheria toxin A gene. Mol. Cell. Biol. 10:1990;474-479.
6. Charkravarti S., Magnuson T., Lass J.H., Jepsen K.J., LaMantia C., Carroll H. Lumican regulates collagen fibril assembly: Sikin fragility and corneal opacity in the absence of lumican. J. Cell Biol. 112:1998;987-996.
7. Courtois S.J., Lafontaine D.A., Lemaigre F.P., Durviaux S.M., Rousseau G.G. Nuclear factor-I and activator protein-2 bind in a mutually exclusive way to overlapping promoter sequences and trans-activate the human growth hormone gene. Nucleic Acids Res. 18:1990;57-64.
8. Funderburgh J.L., Funderburgh M.L., Brown S.J., Vergnes J.P., Hassell J.R., Mann M.M., et al. Sequence and structural implications of a bovine corneal keratan sulfate proteoglycan core protein. Protein 37B represents bovine lumican and proteins 37A and 25 are unique. J. Biol. Chem. 268:1993;8974-8980.
9. Hayashi K., Sueishi K., Tanaka K., Inomata H. Immunohistochemical evidence of the origin of human corneal endothelial cells and keratocytes. Graef's Arch. Clin. Exp. Ophthalmol. 224:1986;452-456.
10. Iozzo R.V. Matrix proteoglycans: from molecular design to cellular function. Annu. Rev. Biochem. 67:1998;609-652.
11. Iozzo R.V., Pillarisetti J., Sharma B., Murdoch A.D., Danielson K.G., Uitto J., Mauviel A. Structural and functional characterization of the human perlecan gene promoter. Transcriptional activation by transforming growth factor-beta via a nuclear factor 1-binding element. J. Biol. Chem. 272:1997;5219-5228.
12. Kays W.T., Piatigorsky J. Aldehyde dehydrogenase class 3 expression: identification of a cornea-specific gene promoter in transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 94:1997;13 594-13 599.
13. Keeton M.R., Curriden S.A., van Zonneveld A.J., Loskutoff D.J. Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor-beta. J. Biol. Chem. 266:1991;23 048-23 052.
14. Landel C.P., Zhao J., Bok D., Evans G.A. Lens-specific expression of recombinant ricin induces developmental defects in the eyes of transgenic mice. Genes Dev. 2:1988;1168-1178.
15. Lee K.A., Pierce R.A., Mecham R.P., Parks W.C. Increased mesenchymal cell density accompanies induction of tropoelastin expression in developing elastic tissue. Dev. Dyn. 200:1994;53-67.
16. Liu C.-Y., Zhu G., Westerhausen-Larson A., Converse R., Kao C.W., Sun T.-T., Kao W.W.-Y. Cornea-specific expression of K12 keratin during mouse development. Curr. Eye Res. 12:1993;963-974.
17. Liu C.-Y., Shiraishi A., Kao C.W., Converse R.L., Funderburgh J.L., Corpuz L.M, Conrad G.W., Kao W.W.-Y. The cloning of mouse keratocan cDNA and genomic DNA and the characterization of its expression during eye development. J. Biol. Chem. 273:1998;22 584-22 588.
18. Marigo V., Volpin D., Vitale G., Bressan G.M. Identification of a TGF-beta responsive element in the human elastin promoter. Biochem. Biophys. Res. Commun. 199:1994;1049-1056.
19. Ross S.R., Graves R.A., Spiegelman B.M. Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity. Genes Dev. 7:1993;1028-1034.
20. Rossi P., Karsenty G., Roberts A.B., Roche N.S., Sporn M.B., de Crombrugghe B.A. Nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-beta. Cell. 52:1988;405-414.
21. Saika S. Ascorbic acid and proliferation of cultured rabbit keratocytes. Cornea. 12:1993;191-198.
22. Saika S., Shiraishi A., Saika S., Liu C.-Y., Funderburgh J.L., Kao C.W.-C., Converse R.L., Kao W.W.-Y. Role of lumican in the corneal epithelium during wound healing. J. Biol. Chem. 275:2000;2607-2612.
23. Sanford L.P., Ormsby I., Gittenberger-de Groot A.C., Sariola H., Friedman R., Boivin G.P., Cardell E.L., Doetschman T. TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes. Development. 95:1997;2659-2670.
24. Sax C.M., Salamon C., Kays W.T., Guo J., Yu F.X., Cuthbertson R.A., Piatigorsky J. Transketolase is a major protein in the mouse cornea. J. Biol. Chem. 271:1996;33 568-33 574.
25. Schwarz R.I. Cell-to-cell signaling in the regulation of procollagen expression in primary avian tendon cells. In Vitro Cell Dev. Biol. A: 27:1991;698-706.
26. Shiraishi A., Converse R.L., Liu C.-Y., Zhou F., Kao C.W.-C., Kao W.W.-Y. Identification of the cornea-specific Keratin 12 promoter by in vivo particle-mediated gene transfer. Invest. Ophthalmol. Vis. Sci. 39:1998;2554-2561.
27. Srinivasan Y., Lovicu F.J., Overbeek P.A. Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts. J. Clin. Invest. 101:1998;625-634.
28. Usukura J., Khoo W., Abe T., Breitman M.L., Shinohara T. Cone cells fail to develop normally in transgenic mice showing ablation of rod photoreceptor cells. Cell Tissue Res. 275:1994;79-90.
29. Windle J.J., Weiner R.I., Mellon P.L. Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice. Mol. Endocrinol. 4:1990;597-603.