Physiology of clinical dysfunction of the cerebellum

Handbook of Clinical Neurology

Volumn 103, Issue , 2012, Pages 37-62

  Massaquoi, Steve G ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79961133338     PISSN: 00729752     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-444-51892-7.00002-4     Document Type: Chapter

References (124)

1. Allen G.I., Tsukahara N. Cerebrocerebellar communication systems. Physiol Rev 1974, 54:957-1006.
2. Anderson N.E., Posner J.B., Sidtis J.J., et al. The metabolic anatomy of paraneoplastic degeneration. Ann Neurol 1988, 23:533-540.
3. Angel R.W. Barognosis in a patient with hemiataxia. Ann Neurol 1980, 7:73-77.
4. Babinski J. Asynergie et inertie cérébelleuse. Rev Neurol 1906, 14:685-686.
5. Barto A., Fagg A., Sitkoff N., et al. A cerebellar model of timing and prediction in the control of reaching. Neural Comput 1999, 11:565-594.
6. Bastian A., Thach W. Structure and function of the cerebellum. The Cerebellum and its Disorders 2002, 49-66. Cambridge University Press, Cambridge. M. Manto, M. Pandolfo (Eds.).
7. Belknap D.B., McCrea R.A. Anatomical connections of the prepositus and abducens nuclei in the squirrel monkey. J Comp Neurol 2004, 268:13-28.
8. Berthier N.E., Singh S.P., Barto A.G., et al. Distributed representation of limb motor programs in arrays of adaptable pattern generators. J Cogn Neurosci 1993, 5:56-78.
9. Bloedel J. Functional heterogeneity with structural homogeneity: how does the cerebellum operate?" Behav Brain Sci 1992, 15:666-678.
10. Bloedel J.R., Bracha V. Duality of cerebellar motor and cognitive functions. The Cerebellum and Cognition 1997, 613-634. Academic Press, San Diego. J.D. Schmahmann (Ed.).
11. Bracha V., Kolb E., Irwin K.B., et al. Inactivation of interposed nuclei in the cat: classically conditioned withdrawal reflexes, voluntary limb movements and the action primitive hypothesis. Exp Brain Res 1999, 126:77-92.
12. Braitenberg V. Is the cerebellar cortex a biological clock in the millisecond range?. Prog Brain Res 1967, 25:334-346.
13. Brazis P.W., Masdeu J.C., Biller J. Localization in Clinical Neurology 2007, Lippincott Willams & Wilkins, Philadelphia.
14. Broich K., Hartmann A., Biersack H.J., et al. Crossed cerebello-cerebral diaschisis in a patient with cerebellar infarction. Neurosci Lett 1987, 83:7-12.
15. Burk K., Fetter M., Skalej M., et al. Saccade velocity in idiopathic and autosomal dominant cerebellar ataxia. J Neurol Neurosurg Psychiatry 1997, 62:662-664.
16. Cannon S.C., Robinson D.A. An improved neural-network model for the neural integrator of the oculomotor system: More realistic neuron behavior. Biol Cybern 1985, 53:93-108.
17. Cannon S.C., Robinson D.A., Shamma S. A proposed neural network for the integrator of the oculomotor system. Biol Cybern 1983, 49:127-136.
18. Carrea R.M.E., Mettler F.A. Physiologic consequences following extensive removal of the cerebellar cortex and deep cerebellar nuclei and effect of secondary cerebral ablations in the primate. J Comp Neurol 1947, 87:169.
19. Carrea R.M.E., Mettler F.A. Function of the primate brachium conjunctivum and related structures. J Comp Neurol 1955, 102:151.
20. Chiu M.J., Chen R.C., Tseng C.Y. Clinical correlates of quantitative acoustic analysis in ataxic dysarthria. Eur Neurol 1996, 36:310-314.
21. Contreras-Vidal J.L., Grossberg S., Bullock D. A neural model of cerebellar learning for arm movement control: cortico-spino-cerebellar dynamics. Learn Mem 1997, 3:475-502.
22. Daum I., Ackermann H. Neuropsychological abnormalities in cerebellar syndromes - fact or fiction?. The Cerebellum and Cognition 1997, 455-471. Academic Press, San Diego. J.D. Schmahmann (Ed.).
23. Dean P. Modelling the role of the cerebellar fastigial nuclei in producing accurate saccades: the importance of burst timing. Neuroscience 1995, 68:1059-1077.
24. de Carvalho M.J.L. Dynamical Systems and Automatic Control 1993, Prentice Hall, New York.
25. Deuschl G., Toro S., Valls-Solé J., et al. Symptomatic and essential palatal tremor 1. Clinical, physiological and MRI analysis. Brain 1994, 117:775-788.
26. Dichgans J., Diener H.C. Clinical evidence for functional compartmentalization of the cerebellum. Cerebellar Functions 1984, 126-147. Springer-Verlag, Berlin. J.R. Bloedel, J. Dichgans, W. Precht (Eds.).
27. Diener H.C., Hore J., Ivry R., et al. Cerebellar dysfunction of movement and perception. Can J Neurol Sci 1993, 20:S62-S69.
28. Dimitrov M., Grafman J., Kossell P., et al. Preserved cognitive processes in cerebellar degeneration. Behav Brain Res 1996, 79:131-135.
29. Doyon J. Functional anatomy of visuomotor skill learning in human subjects evaluated with positron emission tomography. The Cerebellum and Cognition 1997, 273-294. Academic Press, San Diego. J.D. Schmahmann (Ed.).
30. Eccles J.C., Ito M., Szentágothai J. The Cerebellum as a Neuronal Machine 1967, Springer-Verlag, New York.
31. Ectors L. Rev Neurol 1946, 78:14.
32. Fortier P.A., Kalaska J.F., Smith A.M. Cerebellar neuronal activity related to whole-arm reaching movements in the monkey. J Neurophysiol 1989, 62:198-211.
33. Fujita M. Adaptive filter model of the cerebellum. Biol Cybern 1982, 45:195-206.
34. Fujita M. Simulation of adaptive modification of the vestibulo-ocular reflex with an adaptive filter model of the cerebellum. Biol Cybern 1982, 45:207-214.
35. Gandolfo F., Li C.S., Benda B.J., et al. Cortical correlates of learning in monkeys adapting to a new dynamical environment. Proc Natl Acad Sci U S A 2000, 97:2259-2263.
36. Gerloff C., Altenmuller E., Dichgans J. Disintegration and reorganization of cortical motor processing in two patients with cerebellar stroke. Electroencephalogr Clin Neurophysiol 1996, 98:59-68.
37. Gilman S., MacDonald W.I. Cerebellar facilitation of muscle spindle activity. J Neurophysiol 1967, 30:1494-1512.
38. Gomi H., Kawato M. Adaptive feedback control models of the vestibulocerebellum and spinocerebellum. Biol Cybern 1992, 68:105-114.
39. Goodkin H., Thach W. Cerebellar control of constrained and unconstrained movements. I. Nuclear inactivation. J Neurophysiol 2003, 89:884-895.
40. Goodwin G.C., Sin K.S. Adaptive Filtering Prediction and Control 1984, Prentice Hall, Englewood Cliffs, NJ.
41. Gormezano I., Kehoe E., Marshall B.S. Twenty years of classical conditioning research with the rabbit. Progress in Psychobiology and Physiological Psychology 1983, 197-225. Academic Press, New York. J. Sprague, A. Epstein (Eds.).
42. Grill S.E., Hallett M., Marcus C., et al. Disturbances of kinaesthesia in patients with cerebellar disorders. Brain 1994, 117:1433-1447.
43. Grill S.E., Hallett M., McShane L.M. Timing of onset of afferent responses and of use of kinesthetic information for control of movement in normal and cerebellar-impaired subjects. Exp Brain Res 1997, 113:33-47.
44. Hallett M., Grafman J. Executive function and motor skill learning. The Cerebellum and Cognition 1997, 297-323. Academic Press, San Diego. J.D. Schmahmann (Ed.).
45. Hallett M., Berardelli A., Matheson J., et al. Physiological analysis of simple rapid movements in patients with cerebellar deficits. J Neurol Neurosurg Psychiatry 1991, 53:124-133.
46. Hoffer J.A., Andreassen S. Regulation of cat soleus muscle stiffness in premamillary cats: intrinsic and reflex components. J Neurophysiol 1981, 45:267-285.
47. Hogan N., Doeringer J.A., Krebs H.I. Arm movement control is both continuous and discrete. Cognitive Studies 1999, 6:254-273.
48. Holmes G. The symptoms of acute cerebellar injuries due to gunshot injuries. Brain 1917, 40:461-535.
49. Holmes G. Clinical symptoms of cerebellar disease and their interpretation. The Croonian Lectures. I. Lancet 1922, 1:1231-1237.
50. Holmes G. The cerebellum of man. Brain 1939, 62:1-30.
51. Horak F., Nashner L.M. Central programming of postural movements: adaptation to altered support-surface configurations. J Neurophysiol 1986, 55:1369-1381.
52. Hore J., Wild B., Diener H.C. Cerebellar dysmetria at the elbow, wrist and fingers. J Neurophysiol 1991, 65:563-571.
53. Houk J.C., Barto A. Distributed sensorimotor learning. Tutorials in Motor Behavior 2 1992, Elsevier, New York. G. Stelmach, J. Requin (Eds.).
54. Houk J.C., Keifer J., Barto A.G. Distributed motor commands in the limb premotor network. Trends Neurosci 1993, 16:27-33.
55. Ilg W., Giese M., Gizewski E.R., et al. The influence of focal cerebellar lesions on the control and adaptation of gait. Brain 2008, 131:2913-2927.
56. Ito M. The Cerebellum and Neural Control 1984, Raven Press, New York.
57. Ito M. Cerebellar microcomplexes. The Cerebellum and Cognition 1997, 475-487. Academic Press, San Diego. J.D. Schmahmann (Ed.).
58. Ito M., Kano M. Long-lasting depression of parallel fiber-Purkinje cell transmission induced by conjunctive stimulation of parallel fibers in the cerebellar cortex. Neurosci Lett 1982, 33:253-258.
59. Ito M., Sakurai M., Tongroach P. Climbing fiber induced depression of both mossy fiber responsiveness and glutamate sensitivity of cerebellar Purkinje cells. J Physiol 1982, 324:113-134.
60. Ivry R. Cerebellar timing systems. The Cerebellum and Cognition 1997, 555-573. Academic Press, San Diego. J.D. Schmahmann (Ed.).
61. Jo S., Massaquoi S.G. A model of cerebellum-mediated long-loop control of upright balance 2002.
62. Kadota O., Sakaki S., Kumon Y., et al. Large cystic cavernous angioma of the cerebellum - case report. Neurol Med Chir (Tokyo) 1994, 34:768-772.
63. Keele S., Ivry R. Does the cerebellum provide a common computation for diverse tasks?. Ann N Y Acad Sci 1990, 608:179-211.
64. Keifer J., Houk J.C. Motor function of the cerebellorubrospinal system. Physiol Rev 1994, 74:509-542.
65. Kettner R.E., Mahamud S., Leung H.C., et al. Prediction of complex two-dimensional trajectories by a cerebellar model of smooth pursuit eye movement. J Neurophysiol 1997, 77:2115-2130.
66. Lechtenberg R., Gilman S. Speech disorders in cerebellar disease. Ann Neurol 1978, 3:285.
67. Leigh J.R., Zee D.A. The Neurology of Eye Movements 1991, FA Davis, Philadelphia.
68. Li C.S., Padoa-Schioppa C., Bizzi E. Neuronal correlates of motor performance and motor learning in the primary motor cortex of monkeys adapting to an external force field. Neuron 2001, 30:593-607.
69. Llinas R., Precht W., Clarke M. Cerebellar Purkinje cell responses to physiological stimulation of the vestibular system in the frog. Exp Brain Res 1971, 13:408-431.
70. MacKay W.A., Murphy J.T. Response of interpositus neurons to passive muscle stretch. J Neurophysiol 1974, 37:1410-1423.
71. Mai N., Bolsinger P., Avarello M., et al. Control of isometric finger force in patients with cerebellar disease. Brain 1988, 111:973-998.
72. Massaquoi S.G., Hallett M. Kinematics of initiating a two-joint arm movement in patients with cerebellar ataxia. Can J Neurol Sci 1996, 23:3-14.
73. Massaquoi S.G., Hallett M. Ataxia and other cerebellar syndromes. Parkinson's Disease and Movement Disorders 2002, 523-686. Williams & Wilkins, Baltimore. J. Jankovic, E. Tolosa (Eds.).
74. Massaquoi S.G., Topka H. Models of cerebellar function. The Cerebellum and its Disorders 2002, 69-94. Cambridge University Press, Cambridge. M. Pandolfo, M. Manto (Eds.).
75. Mauk MD, Buonomano DV The neural basis of temporal processing. Annu Rev Neurosci 2004, 27:307-340.
76. Mauritz K.H., Schmitt C., Dichgans J., et al. Delayed and enhanced long latency reflexes as the possible cause of postural tremor in late cerebellar atrophy. Brain 1981, 104:97-116.
77. Mayer J., Wildgruber D., Riecker A., et al. Prosody production and perception: converging evidence from fmri studies 2002, 487-490. Aix-en-Provence, France.
78. Medina J., Mauk M. Computer simulation of cerebellar information processing. Nat Neurosci 2000, 3:1205-1211.
79. Medina J., Garcia K., Nores W.L., et al. Timing mechanisms in the cerebellum: testing predictions of a large-scale computer simulation. J Neurosci 2000, 20:5516-5525.
80. Mettens P., Godaux D., Cheron G., et al. Effect of muscimol microinjections into the prepositus hypoglossi and the medial vestibular nuclei on cat eye movements. J Neurophysiol 1994, 72:785-802.
81. Meyer-Lohmann J., Conrad K., Matsunami K., et al. Effects of dentate cooling on precentral unit activity following torque pulse injections into elbow movements. Brain Res 1975, 94:237-251.
82. Miall R.C., Weir D.J., Wolpert D.M., et al. Is the cerebellum a Smith predictor?. J Mot Behav 1993, 25:203-216.
83. Miall R.C., Weir D.J., Stein J.F. Intermittency in human manual tracking tasks. J Mot Behav 1993, 25:53-63.
84. Nagao S. Effects of vestibulocerebellar lesions upon dynamic characteristics and adaptation of vestibulo-ocular and optokinetic responses in pigmented rabbits. Exp Brain Res 1983, 53:36-46.
85. Nakamura N., Ohta S., Matsumoto M., et al. A 63-year-old man with progressive gait disturbance and dysarthria. No To Shinkei 1996, 48:865-875.
86. Ogata K. Modern Control Engineering 1990, Prentice Hall, Englewood Cliffs, NJ.
87. Ohyama T., Nores W., Mauk M.D. Stimulus generalization of conditioned eyelid responses produced without cerebellar cortex: implications for plasticity in the cerebellar nuclei. Learn Mem 2003, 10:346-354.
88. Ohyama T., Nores W.L., Medina J.F., et al. Learning induced plasticity in deep cerebellar nuclei. J Neurosci 2006, 26:12656-12663.
89. Oscarsson O. Functional units of the cerebellum-sagittal zones and microzones. Trends Neurosci 1979, 2:143-145.
90. Paulin M. A Kalman filter theory of the cerebellum. Dynamic Interactions in Neural Networks: Models and Data 1989, Springer-Verlag, New York. M.A. Arbib, S. Amari (Eds.).
91. Paulin M.G. The role of the cerebellum in motor control and perception. Brain Behav Evol 1993, 41:39-50.
92. Reis D.J., Golanov E.V. Autonomic and vasomotor regulation. The Cerebellum and Cognition 1997, 121-149. Academic Press, San Diego. J.D. Schmahmann (Ed.).
93. Robinson D.A. Adaptive gain control of the vestibuloocular reflex by the cerebellum. J Neurophysiol 1976, 39:954-969.
94. Robinson D.A. The functional behavior of the peripheral oculomotor apparatus: a review. Disorders of Ocular Motility: Neurophysiological and Clinical Aspects 1978, 43-61. Bermann-Verlag, Munich. G. Kommerell (Ed.).
95. Robinson D.A. Integrating with neurons. Annu Rev Neurosci 1989, 12:33-45.
96. Robinson F.R., Straube A., Fuchs A.F. Role of the caudal fastigial nucleus in saccade generation. II. Effects of muscimol inactivation. J Neurophysiol 1993, 70:1741-1758.
97. Rousseaux M., Steinling M. Crossed hemispheric diaschisis in unilateral cerebellar lesions. Stroke 1992, 23:511-514.
98. Sasaki K. Cerebro-cerebellar interaction and organization of a fast an stable hand movement: cerebellar participation in voluntary movement and motor learning. Cerebellar Functions 1985, 70-85. Springer-Verlag, Berlin. J. Bloedel, J. Dichgans, W. Precht (Eds.).
99. Schieber M.H., Thach W.T.T. Trained slow tracking. II Bidirectional discharge patterns of cerebellar nuclear, motor cortex, and spindle afferent neurons. J Neurophysiol 1985, 54:1228-1270.
100. The Cerebellum and Cognition. International Review of Neurobiology 1997, Academic Press, San Diego. J.D. Schmahmann (Ed.).
101. Schmahmann J.D. The role of the cerebellum in affect and psychosis. The Cerebellum and Its Disorders 2002, 136-157. Cambridge University Press, Cambridge. M. Pandolfo, M. Manto (Eds.).
102. Schmahmann J.D., Pandya D.N. The cerebrocerebellar system. The Cerebellum and Cognition 1997, 31-60. Academic Press, San Diego. J.D. Schmahmann (Ed.).
103. Schmahmann J.D., Sherman J.C. The cerebellar cognitive affective syndrome. Brain 1998, 121:561-579.
104. Schweighofer N., Arbib M.A., Dominey P.F. A model of the cerebellum in adaptive control of saccadic gain I. The model and its biological substrate. Biol Cybern 1996, 75:19-28.
105. Schweighofer N., Arbib M.A., Dominey P.F. A model of the cerebellum in adaptive control of saccadic gain II. Simulation results. Biol Cybern 1996, 75:29-36.
106. Schweighofer N., Arbib M.A., Kawato M. Role of the cerebellum in reaching movements in humans. I. Distributed inverse dynamics control. Eur J Neurosci 1998, 10:86-94.
107. Schweighofer N., Spoelstra J., Arib M.A., et al. Role of the cerebellum in reaching movements in humans. II. A neural model of the intermediate cerebellum. Eur J Neurosci 1998, 10:95-105.
108. Slotine J.J.E., Li W. Applied Nonlinear Control 1991, Prentice Hall, Englewood Cliffs, NJ.
109. Smith M.A., Shadmehr R. Intact ability to learn intact models of arm dynamics in Huntington's disease, but not cerebellar degeneration. J Neurophysiol 2004, 93:2809-2821.
110. Smith M., Brandt J., Shadmehr R. The motor dysfunction in Huntington's disease begins as a disorder in error feedback control. Nature 2000, 403:544-549.
111. Smith M., Ghazizadeh A., Shadmehr R. Interacting adaptive processes with different timescales underlie short-term motor learning. PLoS Biol 2006, 4:e179.
112. Strick P. The influence of motor preparation on the response of cerebellar neurons to limb displacements. J Neurosci 1983, 3:2007-2020.
113. Subramony S.H. The inherited ataxias. Parkinson's Disease and Movement Disorders - 3 1997, Williams & Wilkins, Baltimore, MD. J. Jankovic, E. Tolosa (Eds.).
114. Thach W.T. Correlation of neural discharge with pattern and force of muscular activity, joint position and direction of intended next movement in motor cortex and cerebellum. J Neurophysiol 1978, 41:654-676.
115. Thach W.T., Kane S.A., Mink J.W., et al. Cerebellar output: multiple maps and modes of control in movement coordination. The Cerebellum Revisited 1992, Springer Verlag, New York. R. Llinas, C. Sotelo (Eds.).
116. Thach W.T., Goodkin H.P., Keating J.G. The cerebellum and the adaptive coordination of movement. Annu Rev Neurosci 1992, 15:403-442.
117. Thompson R.F., Bao S., Chen L., et al. Associative learning. The Cerebellum and Cognition 1997, 151-189. Academic Press, San Diego. J.D. Schmahmann (Ed.).
118. Topka H., Konczak J., Schneider K., et al. Multijoint arm movements in cerebellar ataxia: abnormal control of movement dynamics. Exp Brain Res 1998, 119:493-503.
119. Topka H., Massaquoi S.G., Benda N., et al. Motor skill learning in patients with cerebellar degeneration. J Neurol Sci 1998, 158:164-172.
120. Topka H., Mescheriakov S., Boose A., et al. A cerebellar-like terminal and postural tremor induced in normal man by transcranial magnetic stimulation. Brain 1999, 122:1551-1562.
121. Triarhou L.C. Cerebellar grafts. The Cerebellum and its Disorders 2002, 369-384. Cambridge University Press, Cambridge. M. Manto, M. Pandolfo (Eds.).
122. Weir C.R., Knox P.C., Dutton G.N. Does extraocular muscle proprioception influence oculomotor control?. Br J Ophthalmol 2000, 84:1071-1074.
123. Wolpert D.M., Kawato M. Multiple paired forward and inverse models for motor control. Neural Netw 1998, 11:1317-1329.
124. Woodruff-Pak D.S. Classical conditioning. The Cerebellum and Cognition 1997, 341-366. Academic Press, San Diego. J.D. Schmahmann (Ed.).