Local convection-enhanced delivery of chemotherapeutic agent transiently opens blood-brain barrier and improves efficacy of systemic chemotherapy in intracranial xenograft tumor model

Cancer Letters

Volumn 310, Issue 1, 2011, Pages 77-83

  Nakamura, Taigen ^a   Saito, Ryuta ^a   Sugiyama, Shin ichiro ^a   Sonoda, Yukihiko ^a   Kumabe, Toshihiro ^a   Tominaga, Teiji ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

ACNU; Blood brain barrier; Brain tumor; Convection enhanced delivery; Local chemotherapy

Indexed keywords

DOXORUBICIN; NIMUSTINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CANCER SURVIVAL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG EXTRAVASATION; DRUG PENETRATION; GLIOSARCOMA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTEMIC THERAPY; THERMODYNAMICS; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CELL LINE, TUMOR; CONVECTION; DOXORUBICIN; DRUG DELIVERY SYSTEMS; GLIOSARCOMA; KAPLAN-MEIER ESTIMATE; MALE; NIMUSTINE; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; TREATMENT OUTCOME; XENOGRAFT MODEL ANTITUMOR ASSAYS;

RATTUS; RODENTIA;

EID: 79961125980     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.06.018     Document Type: Article

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