Biotransformation of a taxadiene by Ginkgo cell cultures and the tumor multi-drug resistant reversal activities of the metabolites

Chemical and Pharmaceutical Bulletin

Volumn 59, Issue 8, 2011, Pages 1038-1041

  Xie, Dan ^a   Zhang, Yi ^a   Zou, Jianhua ^a   Yin, Dali ^a   Chen, Xiaoguang ^a   Dai, Jungui ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Biotransformation; Cell suspension culture; Ginkgo biloba; Taxadiene; Tumor multi drug resistant reversal agent

Indexed keywords

2ALPHA,5ALPHA DIACETOXY 10BETA,11 EPOXY 14 OXO TAXA 4 (20),12 (13)DIENE; 2ALPHA,5ALPHA DIACETOXY 10BETA,11 EPOXY 18 HYDROXY 14 OXO TAXA 4 (20),12 (13)DIENE; 2ALPHA,5ALPHA DIACETOXY 4BETA, 20 EPOXY 10BETA HYDROXY 14 OXO TAXA 11 (12)ENE; 2ALPHA,5ALPHA,10BETA TRIACETOXY 14 OXO TAXA 4 (20) 11 DIENE; 2ALPHA,5ALPHA,10BETA TRIACETOXY 14 OXO TAXA 4 (20),12 (13)DIENE; ALKENE DERIVATIVE; ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; BREAST CARCINOMA; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CULTURE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG TRANSFORMATION; GINKGO BILOBA; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; METABOLITE; PROTON NUCLEAR MAGNETIC RESONANCE; TUMOR CELL;

ALKENES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOTRANSFORMATION; CELL LINE, TUMOR; CELLS, CULTURED; DITERPENES; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GINKGO BILOBA; HUMANS; PACLITAXEL;

EID: 79961116064     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.59.1038     Document Type: Article

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