Insulin-like growth factor-type 1 receptor inhibitor NVP-AEW541 enhances radiosensitivity of PTEN wild-type but not PTEN-deficient human prostate cancer cells

International Journal of Radiation Oncology Biology Physics

Volumn 81, Issue 1, 2011, Pages 239-247

  Isebaert, Sofie F ^a   Swinnen, Johannes V ^b   McBride, William H ^c   Haustermans, Karin M ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

In vitro; Insulin like growth factor type 1 receptor inhibitor; Prostate cancer; PTEN; Radiosensitization

Indexed keywords

IN-VITRO; INSULIN-LIKE GROWTH FACTOR-TYPE 1 RECEPTOR INHIBITOR; PROSTATE CANCERS; PTEN; RADIO-SENSITIZATION;

CELL CULTURE; CELL PROLIFERATION; DISEASES; ENZYMES; EXPERIMENTS; FREE RADICALS; INSULIN; IONIZING RADIATION; MONOCLONAL ANTIBODIES; PEPTIDES; RADIOTHERAPY; SIGNALING;

CELLS;

NVP AEW 541; PROTEIN KINASE B; SOMATOMEDIN C RECEPTOR; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IONIZING RADIATION; MALE; PATIENT SELECTION; PHOSPHORYLATION; PRIORITY JOURNAL; RADIATION DOSE; RADIOSENSITIVITY; SIGNAL TRANSDUCTION;

CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DOWN-REGULATION; HUMANS; MALE; NEOPLASM PROTEINS; PROSTATIC NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; PYRIMIDINES; PYRROLES; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; RECEPTOR, IGF TYPE 1;

EID: 79961104237     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.03.030     Document Type: Article

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