Phenotypic and functional evaluation of CD3 +CD4 -CD8 -T cells in human cd8 immunodeficiency

Haematologica

Volumn 96, Issue 8, 2011, Pages 1195-1203

  Bernardo, Iván ^a   Mancebo, Esther ^a   Aguiló, Ignacio ^b   Anel, Alberto ^b   Allende, Luis M ^a   Guerra Vales, Juan M ^a   Ruiz Contreras, Jesús ^a   Serrano, Antonio ^a   Talayero, Paloma ^a   de la Calle, Oscar ^c   Gonzalez Santesteban, Cecilia ^c   Paz Artal, Estela ^a  

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^b UNIVERSITY OF ZARAGOZA   (Spain)

^c HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

Author keywords

Cd8 immunodeficiency; Cytotoxic T lymphocyte proliferation; Double negative T lympho cytes; MHC class I

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CD8ALPHA ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANTIGEN EXPRESSION; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8 IMMUNEDEFICIENCY; CD8+ T LYMPHOCYTE; CELL ORGANELLE; CELL STRAIN; CELL STRAIN 293T; CONTROLLED STUDY; CYTOPLASM; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PROTEIN LOCALIZATION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; THYMUS; WILD TYPE;

ADOLESCENT; ADULT; ANTIGENS, CD8; CD8-POSITIVE T-LYMPHOCYTES; CYTOPLASM; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; IMMUNOPHENOTYPING; MUTATION; PHENOTYPE; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS;

EID: 79961094856     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2011.041301     Document Type: Article

References (32)

1. Davis MM, Bjorkman PJ. T-cell antigen receptor genes and T-cell recognition. Nature. 1988;334(6181):395-402
2. Gao GF, Tormo J, Gerth UC, Wyer JR, McMichael AJ, Stuart DI, et al. Crystal structure of the complex between human CD8 α (α) and HLA-A2. Nature. 1997; 387(6633):630-634
3. Wooldridge L, van den Berg HA, Glick M, Gostick E, Laugel B, Hutchinson SL, et al. Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface. J Biol Chem. 2005;280 (30):27491-27501
4. Anel A, O'Rourke AM, Kleinfeld AM, Mescher MF. T cell receptor and CD8-dependent tyrosine phosphorylation events in cytotoxic T lymphocytes: activation of p56lck by CD8 binding to class I protein. Eur J Immunol. 1996;26(10):2310-2319
5. Starr TK, Jameson SC, Hogquist KA. Positive and negative selection of T cells. Annu Rev Immunol. 2003;21:139-176
6. Goldrath AW, Hogquist KA, Bevan MJ. CD8 lineage commitment in the absence of CD8. Immunity. 1997;6(5):633-642
7. Moebius U, Kober G, Griscelli AL, Hercend T, Meuer SC. Expression of different CD8 isoforms on distinct human lymphocyte subpopulations. Eur J Immunol. 1991; 21(8):1793-1800
8. Zamoyska R. The CD8 coreceptor revisited: one chain good, two chains better. Immunity. 1994;1(4):243-246
9. Leishman AJ, Naidenko OV, Attinger A, Koning F, Lena CJ, Xiong Y, et al. T cell responses modulated through interaction between CD8aa and the nonclassical MHC class I molecule, TL. Science. 2001;294(5548):1936-1939
10. Hamann D, Baars PA, Rep MH, Hooibrink B, Kerkhof-Garde SR, Klein MR, van Lier RA. Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med. 1997;186(9):1407-1418
11. Tomiyama H, Takata H, Matsuda T, Takiguchi M. Phenotypic classification of human CD8+ T cells reflecting their function: inverse correlation between quantitative expression of CD27 and cytotoxic effector function. Eur J Immunol. 2004;34 (4):999-1010
12. Sallusto F, Lenig D, Förster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999; 401(6754):708-712
13. Fry TJ, Mackall CL. Interleukin-7: from bench to clinic. Blood. 2002;99(11):3892-3904
14. de la Calle-Martin O, Hernandez M, Ordi J, Casamitjana N, Arostegui JI, Caragol I, et al. Familial CD8 deficiency due to a mutation in the CD8a gene. J Clin Invest. 2001; 108(1):117-123
15. Mancebo E, Moreno-Pelayo MA, Mencía A, de la Calle-Martín O, Allende LM, Sivadorai P, et al. Gly111Ser mutation in CD8A gene causing CD8 immunodeficiency is found in Spanish Gypsies. Mol Immunol. 2008;45(2):479-484
16. Notarangelo LD, Fischer A, Geha RS, Casanova JL, Chapel H, Conley ME, et al.' for the International Union of Immuno - logical Societies Expert Committee on Primary Immunodeficiencies. Primary im - mu no deficiencies: 2009 update. J Allergy Clin Immunol. 2009;124(6):1161-1178
17. Douek DC, McFarland RD, Keisser PH, Gage EA, Massey JM, Haynes BF, et al. Changes in thymic function with age and during the treatment of HIV infection. Nature. 1998;396(6712):690-695
18. Paradela A, García-Peydró M, Vázquez J, Rognan D, López de Castro JA. The same natural ligand is involved in allorecognition of multiple HLA-B27 subtypes by a single T cell clone: role of peptide and the MHC molecule in alloreactivity. J Immunol. 1998; 161(10):5481-5490
19. Pardo J, Balkow S, Anel A, Simon MM. The differential contribution of granzyme A and granzyme B in CTL-mediated apoptosis is determined by the quality of target cells. Eur J Immunol. 2002;32(7):1980-1985
20. Hazenberg MD, Verschuren MC, Hamann D, Miedema F, van Dongen JJ. T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation. J Mol Med. 2001;79(11):631-640
21. Bleesing JJ, Brown MR, Dale JK, Straus SE, Lenardo MJ, Puck JM, et al. TcR-α/β(+) CD4(-)CD8(-) T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis. Clin Immunol. 2001;100(3): 314-324
22. Bleesing JJ, Brown MR, Novicio C, Guarraia D, Dale JK, Straus SE, et al. A composite picture of TcR α/β (+) CD4(-)CD8(-) T Cells (a/b-DNTCs) in humans with autoimmune lymphoproliferative syndrome. Clin Immu - nol. 2002;104 (1):21-30
23. Bristeau-Leprince A, Mateo V, Lim A, Magerus-Chatinet A, Solary E, Fischer A, et al. Human TCR α/β+ CD4-CD8-doublenegative T cells in patients with autoimmune lymphoproliferative syndrome express restricted Vβ TCR diversity and are clonally related to CD8+ T cells. J Im - munol. 2008;181(1):440-448
24. Fung-Leung WP, Kündig TM, Zinkernagel RM, Mak TW. Immune response against LCMV infection in mice without CD8 expression. J Exp Med. 1991;174(6):1425-1429
25. Fung-Leung WP, Louie MC, Limmer A, Ohashi PS, Ngo K, Chen L. The lack of CD8α cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes. Eur J Immunol. 1993;23(11):2834-2840
26. Riddle DS, Miller PJ, Vincent BG, Kepler TB, Maile R, Frelinger JA, Collins EJ, et al. Rescue of cytotoxic function in the CD8a knockout mouse by removal of MHC class II. Eur J Immunol. 2008;38 (6):1511-1521
27. Bachmann MF, Oxenius A, Mak TW, Zinkernagel RM. T cell development in CD8-/- mice. Thymic positive selection is biased toward the helper phenotype. J Immunol. 1995;155(8):3727-3733
28. Nakayama K, Nakayama K, Negishi I, Kuida K, Louie MC, Kanagawa O, et al. Requirement for CD8 beta chain in positive selection of CD8-lineage T cells. Science. 1994;263(5150):1131-1133
29. De Lau WB, Boom SE, Heije K, Griffioen AW, Braakman E, Bolhuis RL, et al. Heterodimeric complex formation with CD8 and TCR by bispecific antibody sustains paracrine IL-2-dependent growth of CD3+CD8+ T cells. J Immunol. 1992; 149(6):1840-1846
30. Hollsberg P, Weber WE, Dangond F, Batra V, Sette A, Hafler DA. Differential activation of proliferation and cytotoxicity in human Tcell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand. Proc Natl Acad Sci USA. 1995; 92(9):4036-4040
31. Tewari K, Walent J, Svaren J, Zamoyska R, Suresh M. Differential requirement for Lck during primary and memory CD8+ T cell responses. Proc Natl Acad Sci USA. 2006; 103(44):16388-16393
32. Gibbings D, Befus AD. CD4 and CD8: an inside-out coreceptor model for innate immune cells. J Leukoc Biol. 2009;86 (2): 251-259.