Protein C inhibitor

Seminars in Thrombosis and Hemostasis

Volumn 37, Issue 4, 2011, Pages 349-354

  Meijers, Joost C M ^a   Herwald, Heiko ^b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b LUND UNIVERSITY   (Sweden)

Author keywords

inhibition; Protein C inhibitor; SERPIN

Indexed keywords

ANTICOAGULANT AGENT; ANTIFIBRINOLYTIC AGENT; ANTIINFECTIVE AGENT; AZUROCIDIN; BIOLOGICAL MARKER; DROTRECOGIN; GLYCOSAMINOGLYCAN; HIRUDIN; PHOSPHOLIPID; PLASMINOGEN ACTIVATOR INHIBITOR 3; RETINOIC ACID; SCATTER FACTOR; THROMBOPLASTIN;

ANGIOGENESIS; ANTICOAGULATION; ARTERY THROMBOSIS; BINDING AFFINITY; BINDING SITE; BLOOD CLOTTING; BRAIN ISCHEMIA; BRAIN VENTRICLE; CANCER RECURRENCE; CAROTID ARTERY DISEASE; CARTILAGE; DEEP VEIN THROMBOSIS; DISEASE CLASSIFICATION; DISEASE SEVERITY; DISSEMINATED INTRAVASCULAR CLOTTING; DOWN REGULATION; ESCHERICHIA COLI; FEMALE GENITAL SYSTEM; FERTILIZATION; GENE MUTATION; HEART; HEART INFARCTION; HEMODIALYSIS PATIENT; HEMOSTASIS; HEPARINIZATION; HOST RESISTANCE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTERSTITIAL LUNG DISEASE; KIDNEY; LIVER REGENERATION; LUNG EMBOLISM; MALE GENITAL SYSTEM; MALE INFERTILITY; MORPHOGENESIS; MULTIPLE SCLEROSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OOCYTE; PANCREAS; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PROTEOMICS; PULMONARY HYPERTENSION; REVIEW; SKELETAL MUSCLE; SKIN; SPERMATOGENESIS; SPERMATOZOON; STREPTOCOCCUS PYOGENES; THROMBOSIS; TISSUE REGENERATION; TISSUE REPAIR; UPREGULATION; UROGENITAL SYSTEM; VEIN THROMBOSIS;

ANIMALS; FIBRINOLYSIS; HEMOSTASIS; HUMANS; PROTEIN C; PROTEIN C INHIBITOR; THROMBOSIS;

EID: 79961061714     PISSN: 00946176     EISSN: 10989064     Source Type: Journal    
DOI: 10.1055/s-0031-1276583     Document Type: Review

References (69)

1. Suzuki K, Deyashiki J, Nishioka K et al. Characterization of a cDNA for human protein C inhibitor. A new member of the plasma serine protease inhibitor superfamily. J Biol Chem 1987 262 2 611-616 (Pubitemid 17005226)
2. Meijers J CM, Chung D W. Organization of the gene coding for human protein C inhibitor (plasminogen activator inhibitor-3). Assignment of the gene to chromosome 14. J Biol Chem 1991 266 23 15028-15034 (Pubitemid 21907613)
3. Marlar R A., Griffin J H. Deficiency of protein C inhibitor in combined factor V/VIII deficiency disease. J Clin Invest 1980 66 5 1186-1189 (Pubitemid 11233824)
4. Suzuki K, Nishioka J, Hashimoto S. Protein C inhibitor. Purification from human plasma and characterization. J Biol Chem 1983 258 1 163-168 (Pubitemid 13165816)
5. Suzuki K, Nishioka J, Kusumoto H, Hashimoto S. Mechanism of inhibition of activated protein C by protein C inhibitor. J Biochem 1984 95 1 187-195 (Pubitemid 14177969)
6. Meijers J CM, Kanters DHAJ, Vlooswijk R AA, van Erp H E., Hessing M, Bouma B N. Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor. Biochemistry 1988 27 12 4231-4237
7. Rezaie A R., Cooper S T., Church F C., Esmon C T. Protein C inhibitor is a potent inhibitor of the thrombin-thrombomodulin complex. J Biol Chem 1995 270 43 25336-25339
8. Elisen MGML, von dem Borne P AK, Bouma B N., Meijers J CM. Protein C inhibitor acts as a procoagulant by inhibiting the thrombomodulin-induced activation of protein C in human plasma. Blood 1998 91 5 1542-1547 (Pubitemid 28110317)
9. Stump D C., Thienpont M, Collen D. Purification and characterization of a novel inhibitor of urokinase from human urine. Quantitation and preliminary characterization in plasma. J Biol Chem 1986 261 27 12759-12766 (Pubitemid 17204238)
10. Heeb M J., España F, Geiger M, Collen D, Stump D C., Griffin J H. Immunological identity of heparin-dependent plasma and urinary protein C inhibitor and plasminogen activator inhibitor-3. J Biol Chem 1987 262 33 15813-15816 (Pubitemid 17165185)
11. Stief T W., Radtke K P., Heimburger N. Inhibition of urokinase by protein C-inhibitor (PCI). Evidence for identity of PCI and plasminogen activator inhibitor 3. Biol Chem Hoppe Seyler 1987 368 10 1427-1433
12. Mosnier L O., Elisen MGLM, Bouma B N., Meijers J CM. Protein C inhibitor regulates the thrombin-thrombomodulin complex in the up- and down regulation of TAFI activation. Thromb Haemost 2001 86 4 1057-1064 (Pubitemid 32975833)
13. Hermans J M., Jones R, Stone S R. Rapid inhibition of the sperm protease acrosin by protein C inhibitor. Biochemistry 1994 33 18 5440-5444 (Pubitemid 24162978)
14. Elisen MGLM, van Kooij R J., Nolte M A. et al. Protein C inhibitor may modulate human sperm-oocyte interactions. Biol Reprod 1998 58 3 670-677 (Pubitemid 28117064)
15. Ecke S, Geiger M, Resch I et al. Inhibition of tissue kallikrein by protein C inhibitor. Evidence for identity of protein C inhibitor with the kallikrein binding protein. J Biol Chem 1992 267 10 7048-7052
16. Luo L Y., Jiang W. Inhibition profiles of human tissue kallikreins by serine protease inhibitors. Biol Chem 2006 387 6 813-816 (Pubitemid 43964806)
17. Hobson J P., Netzel-Arnett S, Szabo R et al. Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes. J Biol Chem 2004 279 45 46981-46994 (Pubitemid 39518352)
18. Szabo R, Netzel-Arnett S, Hobson J P., Antalis T M., Bugge T H. Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity. Biochem J 2005 390 Pt 1 231-242 (Pubitemid 41192249)
19. Cardin A D., Weintraub H JR. Molecular modeling of protein- glycosaminoglycan interactions. Arteriosclerosis 1989 9 1 21-32 (Pubitemid 19046087)
20. Kuhn L A., Griffin J H., Fisher C L. et al. Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor. Proc Natl Acad Sci U S A 1990 87 21 8506-8510
21. Pratt C W., Church F C. Heparin binding to protein C inhibitor. J Biol Chem 1992 267 13 8789-8794
22. Shirk R A., Elisen MGLM, Meijers J CM, Church F C. Role of the H helix in heparin binding to protein C inhibitor. J Biol Chem 1994 269 46 28690-28695 (Pubitemid 24366704)
23. Elisen MGLM, Maseland M HH, Church F C., Bouma B N., Meijers J CM. Role of the A+helix in heparin binding to protein C inhibitor. Thromb Haemost 1996 75 5 760-766 (Pubitemid 26181547)
24. Huntington J A., Kjellberg M, Stenflo J. Crystal structure of protein C inhibitor provides insights into hormone binding and heparin activation. Structure 2003 11 2 205-215 (Pubitemid 36183644)
25. Li W, Adams T E., Kjellberg M, Stenflo J, Huntington J A. Structure of native protein C inhibitor provides insight into its multiple functions. J Biol Chem 2007 282 18 13759-13768 (Pubitemid 47100522)
26. Li W, Adams T E., Nangalia J, Esmon C T., Huntington J A. Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex. Proc Natl Acad Sci U S A 2008 105 12 4661-4666 (Pubitemid 351753803)
27. Huntington J A., Li W. Structural insights into the multiple functions of protein C inhibitor. Cell Mol Life Sci 2009 66 1 113-121
28. Jerabek I, Zechmeister-Machhart M, Binder B R., Geiger M. Binding of retinoic acid by the inhibitory serpin protein C inhibitor. Eur J Biochem 2001 268 22 5989-5996 (Pubitemid 33079337)
29. Geiger M. Protein C inhibitor, a serpin with functions in- and outside vascular biology. Thromb Haemost 2007 97 3 343-347 (Pubitemid 46437794)
30. Wakita T, Hayashi T, Yuasa H, Nishioka J, Kawamura J, Suzuki K. Molecular cloning, tissue distribution and androgen regulation of rat protein C inhibitor. FEBS Lett 1998 429 3 263-268 (Pubitemid 28300372)
31. Wagenaar G TM, van Vuuren A JH, Girma M et al. Characterization of transgenic mice that secrete functional human protein C inhibitor into the circulation. Thromb Haemost 2000 83 1 93-101 (Pubitemid 30045483)
32. Uhrin P, Dewerchin M, Hilpert M et al. Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility. J Clin Invest 2000 106 12 1531-1539 (Pubitemid 32038590)
33. Wagenaar G TM, Uhrin P, Weipoltshammer K et al. Expression patterns of protein C inhibitor in mouse development. J Mol Histol 2010 41 1 27-37
34. Hayashi T, Nishioka J, Nakagawa N et al. Protein C inhibitor directly and potently inhibits activated hepatocyte growth factor activator. J Thromb Haemost 2007 5 7 1477-1485 (Pubitemid 46965378)
35. España F, Vicente V, Tabernero D, Scharrer I, Griffin J H. Determination of plasma protein C inhibitor and of two activated protein C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease. Thromb Res 1990 59 3 593-608 (Pubitemid 20330338)
36. Tabernero D, España F, Vicente V, Estellés A, Gilabert J, Aznar J. Protein C inhibitor and other components of the protein C pathway in patients with acute deep vein thrombosis during heparin treatment. Thromb Haemost 1990 63 3 380-382 (Pubitemid 20214711)
37. Minamikawa K, Wada H, Wakita Y et al. Increased activated protein C-protein C inhibitor complex levels in patients with pulmonary embolism. Thromb Haemost 1994 71 2 192-194 (Pubitemid 24047325)
38. Carroll V A., Griffiths M R., Geiger M et al. Plasma protein C inhibitor is elevated in survivors of myocardial infarction. Arterioscler Thromb Vasc Biol 1997 17 1 114-118 (Pubitemid 27057332)
39. Meijers J CM, Marquart J A., Bertina R M., Bouma B N., Rosendaal F R. Protein C inhibitor (plasminogen activator inhibitor-3) and the risk of venous thrombosis. Br J Haematol 2002 118 2 604-609 (Pubitemid 34994671)
40. Strandberg K, Stenflo J, Nilsson C, Svensson P J. APC-PCI complex concentration is higher in patients with previous venous thromboembolism with factor V Leiden. J Thromb Haemost 2005 3 11 2578-2580 (Pubitemid 41727176)
41. Strandberg K, Svensson P J., Ohlin A K. Venous thromboembolism in carriers of the factor V Leiden mutation and in patients without known thrombophilic risk factor; prediction of recurrence and APC-PCI complex concentration and/or soluble thrombomodulin antigen and activity. Thromb Res 2007 121 2 145-151 (Pubitemid 350138070)
42. Kölbel T, Goncalves I, Dias N, Strandberg K, Acosta S, Gottsäter A. Coagulation activation and ultrasound characteristics in patients with carotid artery disease. Thromb Res 2010 125 2 171-177
43. Undén J, Strandberg K, Malm J et al. Explorative investigation of biomarkers of brain damage and coagulation system activation in clinical stroke differentiation. J Neurol 2009 256 1 72-77
44. Nilsson G, Strandberg K, Astermark J, Vernersson E, Stenflo J, Berntorp E. The APC-PCI complex concentration predicts outcome of aortic surgery. Thromb Res 2007 120 2 237-244 (Pubitemid 46754422)
45. Bakoush O, Ohlin A K., Strandberg K, Kurkus J. Low plasma activated protein C-protein C inhibitor complex concentration is associated with vascular access failure in hemodialysis patients. Nephron Clin Pract 2008 110 3 c151-c157
46. Matsumoto K, Yano Y, Gabazza E C. et al. Inverse correlation between activated protein C generation and carotid atherosclerosis in type 2 diabetic patients. Diabet Med 2007 24 12 1322-1328 (Pubitemid 350179442)
47. Blomstrand D, Kölbel T, Lindblad B, Gottsäter A. Activated protein C-protein C inhibitor complex in peripheral arterial disease. Ann Vasc Surg 2010 24 5 588-595
48. Schulman S, Eelde A, Blombäck M, Stenflo J. The plasma concentration of activated protein C appears normal in patients with haemophilia. Haemophilia 2009 15 2 566-570
49. Kölbel T, Strandberg K, Mattiasson I, Stenflo J, Lindblad B. Activated protein C-protein C inhibitor complex: a new biological marker for aortic aneurysms. J Vasc Surg 2006 43 5 935-939
50. Kölbel T, Donath T, Strandberg K et al. Is increased thrombin activation in patients with abdominal aortic aneurysms dependent on area or volume of aneurysm thrombus mass? Angiology 2010 61 1 113-118
51. Elf J L., Strandberg K, Svensson P J. The diagnostic performance of APC-PCI complex determination compared to D-dimer in the diagnosis of deep vein thrombosis. J Thromb Thrombolysis 2010 29 4 465-470
52. Uhrin P, Schöfer C, Zaujec J et al. Male fertility and protein C inhibitor/plasminogen activator inhibitor-3 (PCI): localization of PCI in mouse testis and failure of single plasminogen activator knockout to restore spermatogenesis in PCI-deficient mice. Fertil Steril 2007 88 4, Suppl 1049-1057 (Pubitemid 47513040)
53. España F, Navarro S, Medina P, Zorio E, Estellés A. The role of protein C inhibitor in human reproduction. Semin Thromb Hemost 2007 33 1 41-45 (Pubitemid 46184029)
54. Suzuki K, Kise H, Nishioka J, Hayashi T. The interaction among protein C inhibitor, prostate-specific antigen, and the semenogelin system. Semin Thromb Hemost 2007 33 1 46-52 (Pubitemid 46184030)
55. España F, Sánchez-Cuenca J, Fernández P J. et al. Inhibition of human sperm-zona-free hamster oocyte binding and penetration by protein C inhibitor. Andrologia 1999 31 4 217-223 (Pubitemid 29362065)
56. Gianotten J, Schimmel A W., van der Veen F, Lombardi M P., Meijers J CM. Absence of mutations in the PCI gene in subfertile men. Mol Hum Reprod 2004 10 11 807-813 (Pubitemid 40045013)
57. Bungum M, Giwercman A, Bungum L, Humaidan P, Rastkhani H, Giwercman Y L. Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure. Fertil Steril 2010 93 1 277-279
58. Fujimoto H, Gabazza E C., Hataji O et al. Thrombin-activatable fibrinolysis inhibitor and protein C inhibitor in interstitial lung disease. Am J Respir Crit Care Med 2003 167 12 1687-1694 (Pubitemid 36760684)
59. Nishii Y, Gabazza E C., Fujimoto H et al. Protective role of protein C inhibitor in monocrotaline-induced pulmonary hypertension. J Thromb Haemost 2006 4 11 2331-2339 (Pubitemid 44575425)
60. Kan M, Zhang G H., Zarnegar R et al. Hepatocyte growth factor/hepatopoietin A stimulates the growth of rat kidney proximal tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE. Biochem Biophys Res Commun 1991 174 1 331-337
61. Hamada T, Kamada H, Hayashi T et al. Protein C inhibitor regulates hepatocyte growth factor activator-mediated liver regeneration in mice. Gut 2008 57 3 365-373 (Pubitemid 351288103)
62. Han M H., Hwang S I., Roy D B. et al. Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature 2008 451 7182 1076-1081 (Pubitemid 351317445)
63. Rosenzweig C N., Zhang Z, Sun X et al. Predicting prostate cancer biochemical recurrence using a panel of serum proteomic biomarkers. J Urol 2009 181 3 1407-1414
64. Suzuki K, Hayashi T. Protein C and its inhibitor in malignancy. Semin Thromb Hemost 2007 33 7 667-672 (Pubitemid 350157010)
65. Nishioka J, Ning M, Hayashi T, Suzuki K. Protein C inhibitor secreted from activated platelets efficiently inhibits activated protein C on phosphatidylethanolamine of platelet membrane and microvesicles. J Biol Chem 1998 273 18 11281-11287 (Pubitemid 28204981)
66. Malleier J M., Oskolkova O, Bochkov V et al. Regulation of protein C inhibitor (PCI) activity by specific oxidized and negatively charged phospholipids. Blood 2007 109 11 4769-4776 (Pubitemid 46827770)
67. Baumgärtner P, Geiger M, Zieseniss S et al. Phosphatidylethanolamine critically supports internalization of cell-penetrating protein C inhibitor. J Cell Biol 2007 179 4 793-804 (Pubitemid 350146262)
68. Andersson E, Rydengård V, Sonesson A, Mörgelin M, Björck L, Schmidtchen A. Antimicrobial activities of heparin-binding peptides. Eur J Biochem 2004 271 6 1219-1226 (Pubitemid 38373054)
69. Malmström E, Mörgelin M, Malmsten M et al. Protein C inhibitora novel antimicrobial agent. PLoS Pathog 2009 5 12 e1000698