Knocking out the door to tunicamycin entry

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 29, 2011, Pages 11731-11732

  Bassik, Michael C ^a   Kampmann, Martin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MFSDA2A PROTEIN; PROTEIN; SHORT HAIRPIN RNA; TUNICAMYCIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; APOPTOSIS; CELL MEMBRANE; ENDOPLASMIC RETICULUM STRESS; GENE DELETION; GENE DISRUPTION; GLYCOSYLATION; HUMAN; MUTAGENESIS; NOTE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN LOCALIZATION; RNA INTERFERENCE; UNFOLDED PROTEIN RESPONSE;

CELL LINE; ENDOPLASMIC RETICULUM; GLYCOSYLATION; HUMANS; MEMBRANE TRANSPORT PROTEINS; PROTEIN FOLDING; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS; TUNICAMYCIN;

EID: 79961056466     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1109035108     Document Type: Note

References (14)

1. Ma Y, Hendershot LM (2004) The role of the unfolded protein response in tumour development: Friend or foe? Nat Rev Cancer 4:966-977. (Pubitemid 39626220)
2. Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8:519-529. (Pubitemid 46985379)
3. Zhang K, Kaufman RJ (2006) The unfolded protein response: A stress signaling pathway critical for health and disease. Neurology 66 (Suppl 1):S102-S109. (Pubitemid 43739994)
4. Takatsuki A, Arima K, Tamura G (1971) Tunicamycin, a new antibiotic. I. Isolation and characterization of tunicamycin. J Antibiot (Tokyo) 24:215-223.
5. Heifetz A, Keenan RW, Elbein AD (1979) Mechanism of action of tunicamycin on the UDP-GlcNAc:dolichylphosphate Glc-NAc-1-phosphate transferase. Biochemistry 18:2186-2192.
6. Keller RK, Boon DY, Crum FC (1979) N-acetylglucosamine- 1-phosphate transferase from hen oviduct: Solubilization, characterization, and inhibition by tunicamycin. Biochemistry 18:3946-3952. (Pubitemid 10224110)
7. Brandish PE, et al. (1996) Modes of action of tunicamycin, liposidomycin B, and mureidomycin A: Inhibition of phospho-N-acetylmuramyl-pentapeptide translocase from Escherichia coli. Antimicrob Agents Chemother 40:1640-1644. (Pubitemid 26227349)
8. Reiling JH, et al. (2011)Ahaploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin. Proc Natl Acad Sci USA 108:11756-11765.
9. Carette JE, et al. (2009) Haploid genetic screens in human cells identify host factors used by pathogens. Science 326:1231-1235.
10. Carette JE, et al. (2011) Global gene disruption in human cells to assign genes to phenotypes by deep sequencing. Nat Biotechnol 29:542-546.
11. Law CJ, Maloney PC, Wang DN (2008) Ins and outs of major facilitator superfamily antiporters. Annu Rev Microbiol 62:289-305.
12. Esnault C, et al. (2008) A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2. Proc Natl Acad Sci USA 105:17532-17537.
13. Spinola M, et al. (2010) MFSD2A is a novel lung tumor suppressor gene modulating cell cycle and matrix attachment. Mol Cancer 9:62.
14. Angers M, Uldry M, Kong D, Gimble JM, Jetten AM (2008) Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. Biochem J 416:347-355.